公开(公告)号：US20170333558A1

公开(公告)日：2017-11-23

申请号：US15524651

申请日：2015-11-06

Applicant: Scholar Rock, Inc.

Inventor： Michelle Straub ,  Dong Yun Lee ,  William K. McConaughy ,  Jared J. Sheehan ,  Katherine Jane Turner ,  Nagesh K. Mahanthappa ,  Gregory J. Carven ,  Justin W. Jackson

IPC: A61K39/395 ,  C07K14/475 ,  G01N33/74 ,  C07K16/22

CPC classification number: A61K39/39533 ,  A61K2039/505 ,  C07K14/475 ,  C07K16/22 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/74 ,  G01N2800/10

Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.

公开(公告)号：US20170333371A1

公开(公告)日：2017-11-23

申请号：US15525375

申请日：2015-11-12

Applicant: The Brigham and Women`s Hospital, Inc.

Inventor： Mauricio Farez ,  Francisco J. Quintana ,  Jorge Correale

IPC: A61K31/165 ,  C07D209/16 ,  A61K31/343 ,  G01N33/74 ,  A61K31/4045 ,  A61K45/06

CPC classification number: A61K31/165 ,  A61K31/202 ,  A61K31/343 ,  A61K31/4045 ,  A61K45/06 ,  C07D209/16 ,  G01N33/74 ,  G01N2800/285 ,  G01N2800/50 ,  G01N2800/52

Abstract: Methods for treating, or reducing risk of developing, seasonal worsening of multiple sclerosis (MS) in a subject who has MS, comprising administering a melatonin agonist to a subject.

公开(公告)号：US09821042B2

公开(公告)日：2017-11-21

申请号：US14932101

申请日：2015-11-04

Applicant: Massachusetts Institute of Technology

Inventor： Ki Ann Goosens

IPC: A61K39/00 ,  A61K38/00 ,  A61K45/00 ,  G01N33/74 ,  A61K38/17

CPC classification number: A61K39/0005 ,  A61K38/1796 ,  A61K39/00 ,  A61K45/00 ,  A61K2039/545 ,  G01N33/74 ,  G01N2333/60 ,  G01N2800/7004

Abstract: The invention relates to methods of protecting against chronic stress in a subject and treating stress sensitive disorders in a subject by antagonizing ghrelin or ghrelin receptor.

公开(公告)号：US20170322225A1

公开(公告)日：2017-11-09

申请号：US15493661

申请日：2017-04-21

Applicant: Hoffmann-La Roche Inc.

Inventor： Thomas Dieterle ,  Eric J. Niesor ,  Rosemarie Kientsch-Engel ,  Horst Klima ,  Fabian Model ,  Gabriela Bucklar ,  Vinzent Rolny

IPC: G01N33/68 ,  G01N33/74

CPC classification number: G01N33/6893 ,  G01N33/6815 ,  G01N33/74 ,  G01N2333/4737 ,  G01N2333/58 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/50

Abstract: Subject of the present invention are biomarkers and methods for the identification of risk for subsequent cardiovascular event (e.g. coronary heart disease death, non-fatal myocardial infarction, ischemic stroke, hospitalizations for unstable angina pectotis, cardiac arrest) in patients that have experienced an acute coronary syndrome, comprising the detecting the level of NT-proBNP, homocysteine and CRP.

公开(公告)号：US09810699B2

公开(公告)日：2017-11-07

申请号：US14672801

申请日：2015-03-30

Applicant: B.R.A.H.M.S GmbH

Inventor： Andreas Bergmann ,  Joachim Struck

IPC: G01N33/74

CPC classification number: G01N33/74 ,  G01N2333/585 ,  G01N2800/32 ,  G01N2800/325

Abstract: A diagnostic method for the identification of a subject suffering from a primary non-infectious disease having an increased risk of an adverse outcome potentially being induced by the administration of an antibiotic to said subject comprising the determination of the level of Procalcitonin (PCT) or a fragment thereof or a precursor or fragment thereof having a length of at least 12 amino acid residues in a sample of a bodily fluid from said subject and the correlation of the determined level to a potential risk induced by the administration of an antibiotic, as well as a kit for performing the method and methods of treatment based thereon.

公开(公告)号：US20170314079A1

公开(公告)日：2017-11-02

申请号：US15630773

申请日：2017-06-22

Applicant: Merrimack Pharmaceuticals, Inc.

Inventor： Raghida BUKHALID ,  Michael J. FELDHAUS ,  Anne KING ,  Neeraj KOHLI ,  Eric M. KRAULAND ,  Jeffrey D. KEARNS ,  Alexey Alexandrovich LUGOVSKOY ,  Ulrik B. NIELSEN

IPC: C12Q1/68 ,  A61K39/395 ,  G01N33/74 ,  G01N33/574 ,  C07K16/30 ,  C07K16/32 ,  A61K9/00 ,  C07K16/28 ,  A61K39/00 ,  C07K14/71

CPC classification number: C12Q1/6886 ,  A61K9/0019 ,  A61K39/3955 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/507 ,  C07K14/71 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q1/686 ,  C12Q2600/106 ,  G01N33/57484 ,  G01N33/57496 ,  G01N33/74 ,  G01N2333/485 ,  G01N2333/495 ,  G01N2333/71 ,  G01N2800/52 ,  A61K2300/00

Abstract: Anti-EGFR antibodies, therapeutic compositions comprising combinations of anti-EGFR antibodies, as well as methods for using such antibodies and compositions to treat EGFR-related disorders (e.g., cancers), are disclosed.

公开(公告)号：US09790470B2

公开(公告)日：2017-10-17

申请号：US14429869

申请日：2013-09-16

Applicant: Cambridge Enterprise Limited

Inventor： Ludovic Vallier ,  Hsin-hua Cho

IPC: C12N5/071 ,  A61K35/39 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/74

CPC classification number: C12N5/0678 ,  A61K35/39 ,  C12N5/0676 ,  C12N2500/30 ,  C12N2500/38 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/40 ,  C12N2501/41 ,  C12N2506/02 ,  C12Q1/6881 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/5038 ,  G01N33/507 ,  G01N33/74

Abstract: This invention relates to the in vitro differentiation of pluripotent cells into pancreatic progenitors by i) culturing pluripotent cells in a definitive endoderm (DE) medium comprising a TGFp ligand, fibroblast growth factor (FGF), bone morphogenetic protein (BMP), a PI3K inhibitor and optionally a GSK3 β inhibitor to produce a population of definitive endoderm cells, ii) culturing the definitive endoderm cells in a first pancreatic medium comprising an activin antagonist; FGF; retinoic acid; and a BMP inhibitor to produce a population of dorsal foregut cells; iii) culturing the dorsal foregut cells in a second pancreatic medium comprising FGF, retinoic acid, a BMP inhibitor, and a hedgehog signalling inhibitor, and; iv) culturing the endoderm cells in a third pancreatic medium comprising FGF. The progenitor cells thus produced may be further differentiated into pancreatic endocrine cells. These methods may be useful, for example, in producing pancreatic cells for therapy or disease modelling.

公开(公告)号：US09789164B2

公开(公告)日：2017-10-17

申请号：US14776566

申请日：2014-03-17

Applicant: Longevity Biotech, Inc.

Inventor： Scott Shandler ,  Samuel H. Gellman ,  John M. Gledhill

IPC: A61K38/22 ,  A61J1/00 ,  C07K14/575 ,  G01N33/74

CPC classification number: A61K38/2278 ,  A61J1/00 ,  C07K14/57563 ,  G01N33/74 ,  G01N2500/04 ,  G01N2500/10

Abstract: This invention relates to novel compositions comprising analogs of naturally occurring polypeptides, wherein the analog comprises an α-amino acid and at least one β-amino acid. Administration of the compositions may be used for effecting treatment or prevention of a plurality of disease states caused by dysfunctional biochemical or biological pathways. The compositions and methods of this invention are particularly useful to identify novel therapeutic modulators of in-vivo receptor activity with extended half-lives and relevant bioactivity as compared to the naturally translated polypeptides upon which the analogs are derived.

公开(公告)号：US09778270B2

公开(公告)日：2017-10-03

申请号：US14850598

申请日：2015-09-10

Applicant: SENOMYX, INC.

Inventor： Jon Elliot Adler

IPC: C07K14/705 ,  G01N33/74 ,  C07H21/04 ,  G01N33/566 ,  G01N33/58 ,  A61K38/00

CPC classification number: G01N33/74 ,  A01K2217/05 ,  A61K38/00 ,  C07H21/04 ,  C07K14/705 ,  C07K2319/00 ,  G01N33/566 ,  G01N33/582 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2500/04

Abstract: Newly identified mammalian taste-cell-specific G Protein-Coupled Receptors and the genes encoding said receptors are described. Specifically, T2R taste G Protein-Coupled Receptors that are believed to be involved in bitter taste sensation, and the genes encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating a novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes.

公开(公告)号：US09773399B2

公开(公告)日：2017-09-26

申请号：US14776579

申请日：2014-03-05

Applicant: Church & Dwight Co., Inc.

Inventor： Mathew Palmer ,  Giles H. W. Sanders ,  Nicholas J. Wooder ,  Albert R. Nazareth ,  Timothy Snowden ,  Ovidiu Romanoschi

IPC: G08B23/00 ,  G08B21/18 ,  G01N33/74 ,  A61B5/00 ,  A61B5/145 ,  G01N33/543 ,  G08B3/00

CPC classification number: G08B21/18 ,  A61B5/145 ,  A61B5/741 ,  A61B5/7415 ,  G01N33/54386 ,  G01N33/74 ,  G08B3/00

Abstract: Diagnostic test devices improve communication to a user thereof through provision of audible output. The test device can include a test member, such as lateral flow assay test strip. The test device further includes an electronic communication circuit that can comprise an audio output element as well as a microcontroller. Other elements in the electronic communication circuit includes one or more sensor elements, a display element, and one or more switching elements.—Methods provide indicia for operation of a test device that comprise steps for assembly of a diagnostic test device that provides for audio output.