公开(公告)号：US20180018582A1

公开(公告)日：2018-01-18

申请号：US15293553

申请日：2016-10-14

Applicant: Intuit Inc.

Inventor： Cem Unsal ,  Saikat Mukherjee ,  Roger Charles Meike

IPC: G06N99/00 ,  G06F17/24 ,  G06Q40/00

CPC classification number: G06N20/00 ,  G06F17/24 ,  G06F17/243 ,  G06F17/2705 ,  G06F17/2785 ,  G06N3/123 ,  G06Q40/123

Abstract: A method and system learns functions to be associated with data fields of forms to be incorporated into an electronic document preparation system. The functions are essentially sets of operations required to calculate the data field. The method and system receive form data related to a data field that expects data values resulting from performing specific operations. The method and system utilize machine learning and training set data to generate, test, and evaluate candidate functions to determine acceptable functions.

公开(公告)号：US20180002748A1

公开(公告)日：2018-01-04

申请号：US15626021

申请日：2017-06-16

Applicant: Microsoft Technology Licensing, LLC

Inventor： Kris K. Ganjam

IPC: C12Q1/68 ,  G06F19/20

CPC classification number: C12Q1/6869 ,  C12N15/902 ,  C12Q1/6806 ,  C12Q1/6897 ,  C12Q2563/179 ,  G06F9/4498 ,  G06F21/602 ,  G06F21/6218 ,  G06N3/123 ,  G16B25/00 ,  C12Q2521/507

Abstract: Gene expression can be identified by analyzing a DNA sequence. The DNA sequence can include a barcode sequence that corresponds to a particular gene. The barcode sequence can be produced during the expression of a gene by first adding a Homologous Directed Repair (HDR) template including the barcode sequence into the DNA sequence of the gene and then splicing the barcode sequence out of an RNA precursor during the expression of the gene. As the barcode sequence is made available from the RNA precursor, it can be added to the DNA strand using HDR. The resulting DNA strand can be sequenced and the sequence data can be analyzed to identify the barcode sequence within the DNA sequence, which provides an indicator of the expression of the gene in DNA rather than RNA.

公开(公告)号：US09535920B2

公开(公告)日：2017-01-03

申请号：US14959162

申请日：2015-12-04

Applicant: Good Start Genetics, Inc.

Inventor： Caleb Kennedy ,  Niru Chennagiri

IPC: H03M7/30 ,  G06F17/30 ,  G06F19/28 ,  G06F19/00 ,  H04L29/08 ,  G06F19/10 ,  G06N3/12 ,  C12Q1/44 ,  G06F19/18 ,  C12Q1/68 ,  G06F19/22 ,  C12N15/10

CPC classification number: G06F17/30153 ,  C12N15/10 ,  C12Q1/44 ,  C12Q1/6827 ,  C12Q1/6883 ,  G06F17/3012 ,  G06F19/00 ,  G06F19/10 ,  G06F19/18 ,  G06F19/22 ,  G06F19/28 ,  G06F19/32 ,  G06N3/123 ,  H03M7/30 ,  H03M7/3059 ,  H03M7/70 ,  H04L67/10

Abstract: The present invention generally relates to storing sequence read data. The invention can involve obtaining a plurality of sequence reads from a sample, identifying one or more sets of duplicative sequence reads within the plurality of sequence reads, and storing only one of the sequence reads from each set of duplicative sequence reads in a text file using nucleotide characters.

Abstract translation: 本发明一般涉及存储序列读取数据。 本发明可以涉及从样本中获得多个序列读取，识别多个序列读取中的一个或多个重复序列读取集合，并且仅使用一组重复序列读取将序列读取中的一个存储在文本文件中，使用 核苷酸字符。

公开(公告)号：US20160358055A1

公开(公告)日：2016-12-08

申请号：US15175430

申请日：2016-06-07

Applicant: President and Fellows of Harvard College

Inventor： George M. Church

IPC: G06K19/02 ,  G06F19/22 ,  G06N3/12

CPC classification number: G06K19/022 ,  G06F19/22 ,  G06K19/00 ,  G06N3/123

Abstract: The present invention relates to methods of storing data using one or more nucleic acids.

公开(公告)号：US09292527B2

公开(公告)日：2016-03-22

申请号：US14604165

申请日：2015-01-23

Applicant: Good Start Genetics, Inc.

Inventor： Caleb J. Kennedy ,  Niru Chennagiri

IPC: H03M7/30 ,  G06F17/30 ,  G06F19/28 ,  G06F19/00 ,  H04L29/08 ,  G06F19/10 ,  C12Q1/44 ,  G06F19/18 ,  C12Q1/68 ,  G06F19/22 ,  C12N15/10

CPC classification number: G06F17/30153 ,  C12N15/10 ,  C12Q1/44 ,  C12Q1/6827 ,  C12Q1/6883 ,  G06F17/3012 ,  G06F19/00 ,  G06F19/10 ,  G06F19/18 ,  G06F19/22 ,  G06F19/28 ,  G06F19/32 ,  G06N3/123 ,  H03M7/30 ,  H03M7/3059 ,  H03M7/70 ,  H04L67/10

Abstract: The present invention generally relates to storing sequence read data. The invention can involve obtaining a plurality of sequence reads from a sample, identifying one or more sets of duplicative sequence reads within the plurality of sequence reads, and storing only one of the sequence reads from each set of duplicative sequence reads in a text file using nucleotide characters.

公开(公告)号：US20150133315A1

公开(公告)日：2015-05-14

申请号：US14536128

申请日：2014-11-07

Applicant: Massachusetts Institute of Technology

Inventor： Joseph M. Jacobson ,  Noah Jakimo ,  Naama Kanarek ,  David Sabatini

IPC: C12Q1/68 ,  C12N15/70

CPC classification number: C12Q1/6874 ,  C12N15/102 ,  C12N15/63 ,  C12N15/70 ,  C12Q1/6897 ,  G06N3/123

Abstract: The present invention relates to a cell based genomic Recorded Accumulative Memory (geRAM) system (also referred to herein as Genomically Encoded Memory (GEM)) for recoding data (i.e., changes in nucleic acid sequences in cellular DNA in response to physical and/or chemical signal(s)) from the cellular environment.

Abstract translation: 本发明涉及用于重新编码数据的基于细胞的基因组记录累积存储器（geRAM）系统（本文中也称为基因编码存储器（GEM）））（即，响应于物理和/或数据的细胞DNA中的核酸序列的变化） 化学信号）。

公开(公告)号：US20140114585A1

公开(公告)日：2014-04-24

申请号：US14142531

申请日：2013-12-27

Applicant: Emerald Therapeutics, Inc.

Inventor： Daniel J. KLEINBAUM

IPC: G06F19/22 ,  G06N3/12

CPC classification number: G06N3/002 ,  B82Y10/00 ,  C12Q1/6837 ,  G06F19/22 ,  G06N3/123

Abstract: Improvement is effected for a nucleic acid-based molecular computing system that is comprised of (i) a nucleic acid structure, (ii) at least one polynucleotide displacement molecule that can bind with the nucleic acid structure under hybridizing conditions, and (iii) a clashing polynucleotide molecule that competes with the polynucleotide displacement molecule for binding the nucleic acid structure under the hybridizing conditions. The method for such improvement entails incorporating chemical modification that inhibits the binding of the clashing molecule and the nucleic acid structure or facilitating the binding of the displacement molecule and the nucleic structure.

Abstract translation: 对于基于核酸的分子计算系统进行改进，其包括（i）核酸结构，（ii）可以在杂交条件下与核酸结构结合的至少一个多核苷酸置换分子，和（iii） 与多核苷酸置换分子竞争结合核酸结构的杂交多核苷酸分子与杂交条件下结合。 用于这种改进的方法需要引入化学修饰，其抑制冲突分子和核酸结构的结合或促进置换分子和核酸结构的结合。

公开(公告)号：US20140066490A1

公开(公告)日：2014-03-06

申请号：US13966337

申请日：2013-08-14

Applicant: YEDA Research and Development Co. Ltd.

Inventor： Ehud Y. SHAPIRO ,  Maya KANAN-HANUM ,  Yehonatan DOUEK ,  Rivka ADAR

IPC: C12N15/113 ,  C12N15/10

CPC classification number: C12N15/1136 ,  B82Y10/00 ,  C12N15/1089 ,  C12N15/111 ,  C12N15/1135 ,  C12N2310/127 ,  C12N2310/3519 ,  C12N2310/531 ,  C12N2320/13 ,  C12N2320/50 ,  C12N2330/31 ,  G06N3/123 ,  G16B50/00

Abstract: A system and method for programming DNAzymes to be utilized as programmable drugs, which are active only in the presence of specific input combinations and/or certain conditions.

Abstract translation: 用于编程用作可编程药物的DNA酶的系统和方法，其仅在存在特定输入组合和/或某些条件时是有效的。

公开(公告)号：US07272511B2

公开(公告)日：2007-09-18

申请号：US10601327

申请日：2003-06-19

Applicant: Luigi Occhipinti ,  Francesco Buonocore ,  Vincenzo Vinciguerra ,  Gianguido Rizzotto ,  Giuseppe Panzera ,  Floriana San Biagio ,  Francesco Italia

Inventor： Luigi Occhipinti ,  Francesco Buonocore ,  Vincenzo Vinciguerra ,  Gianguido Rizzotto ,  Giuseppe Panzera ,  Floriana San Biagio ,  Francesco Italia

IPC: B81B7/02 ,  C12Q1/68 ,  G11B3/70 ,  G06F19/00

CPC classification number: G11C13/025 ,  B82Y10/00 ,  G06N3/123 ,  G11C13/0014 ,  G11C13/0019 ,  G11C2213/77 ,  G11C2213/81 ,  H01L27/28 ,  H01L51/0048 ,  H01L51/0093 ,  H01L51/0595 ,  Y10S977/855 ,  Y10S977/885

Abstract: Described herein are a molecular memory obtained using DNA strand molecular switches and carbon nanotubes, and a manufacturing method thereof. In particular, the nonvolatile memory is manufactured according to an architecture that envisages the use of carbon nanotubes as electrical connectors and DNA strands as physical means on which to write the information. In other words, the nonvolatile memory is made by means of a set of molecular DNA strand switches, the addressing of which is controlled by molecular wires made up of carbon nanotubes.

Abstract translation: 本文描述了使用DNA链分子开关和碳纳米管获得的分子记忆及其制造方法。 特别地，非易失性存储器是根据设计将碳纳米管用作电连接器和DNA链的结构来制造的，作为在其上写入信息的物理手段。 换句话说，非易失性存储器是通过一组分子DNA链开关制成的，其分配线由碳纳米管组成的分子线控制。

公开(公告)号：US20070094161A1

公开(公告)日：2007-04-26

申请号：US11190744

申请日：2005-07-27

Applicant: Antonino Calabro ,  Federico Rivoli ,  Fabio Tripodi

Inventor： Antonino Calabro ,  Federico Rivoli ,  Fabio Tripodi

IPC: G06N3/12

CPC classification number: G06N3/123 ,  B82Y10/00

Abstract: A hardware device is for performing crossover and mutation operations based upon a genetic algorithm. The hardware device may include a random or pseudo-random number generator, and a crossover block, conditioned with a random crossover index, for generating output crossover bit-strings from current bit-strings. The device may also include a mutation block, conditioned with a random mutation index, for generating output bit-strings by switching at least one bit of each input bit-string pointed to by the mutation index. A memory may temporarily store the current bit-strings and the output bit-strings. In addition, the hardware device may include a control unit, interfaced with the random number generator, the crossover block, the mutation block and the memory and managing their functioning by generating respective control signals therefor.

Abstract translation: 硬件设备用于基于遗传算法执行交叉和变异操作。 硬件设备可以包括随机或伪随机数生成器，以及用随机交叉索引调节的交叉块，用于从当前位串生成输出交叉位串。 该设备还可以包括利用随机突变索引调节的突变块，用于通过切换由突变索引指向的每个输入位串的至少一位来产生输出位串。 存储器可以临时存储当前位串和输出位串。 此外，硬件设备可以包括与随机数生成器接口的控制单元，交叉块，变异块和存储器，并通过产生相应的控制信号来管理它们的功能。