公开(公告)号：US08187673B2

公开(公告)日：2012-05-29

申请号：US11933251

申请日：2007-10-31

申请人： Chad A. Mirkin ,  Richard Piner ,  Seunghun Hong

发明人： Chad A. Mirkin ,  Richard Piner ,  Seunghun Hong

IPC分类号： B05D3/00

CPC分类号： B82B3/00 ,  B05D1/007 ,  B05D1/185 ,  B05D1/26 ,  G01Q80/00 ,  G03F7/0002 ,  G03F7/165 ,  Y10S977/849 ,  Y10S977/853 ,  Y10S977/854 ,  Y10S977/855 ,  Y10S977/856 ,  Y10S977/857 ,  Y10S977/86 ,  Y10S977/88 ,  Y10S977/884 ,  Y10S977/885 ,  Y10S977/886 ,  Y10S977/895 ,  Y10T428/24802

摘要： The invention provides a lithographic method referred to as “dip pen” nanolithography (DPN). DPN utilizes a scanning probe microscope (SPM) tip (e.g., an atomic force microscope (AFM) tip) as a “pen,” a solid-state substrate (e.g., gold) as “paper,” and molecules with a chemical affinity for the solid-state substrate as “ink.” Capillary transport of molecules from the SPM tip to the solid substrate is used in DPN to directly write patterns consisting of a relatively small collection of molecules in submicrometer dimensions, making DPN useful in the fabrication of a variety of microscale and nanoscale devices. The invention also provides substrates patterned by DPN, including submicrometer combinatorial arrays, and kits, devices and software for performing DPN. The invention further provides a method of performing AFM imaging in air. The method comprises coating an AFM tip with a hydrophobic compound, the hydrophobic compound being selected so that AFM imaging performed using the coated AFM tip is improved compared to AFM imaging performed using an uncoated AFM tip. Finally, the invention provides AFM tips coated with the hydrophobic compounds.

摘要翻译： 本发明提供了称为“浸笔”纳米光刻（DPN）的光刻方法。 DPN使用扫描探针显微镜（SPM）尖端（例如，原子力显微镜（AFM）尖端）作为“笔”，固态基底（例如，金）作为“纸”，并且具有化学亲和力的分子 固体底物作为“墨水”。DPN中使用分子从SPM尖端到固体基质的毛细管转运，以直接写入由亚微米尺寸的相对小的分子集合组成的图案，使得DPN可用于制造 各种微米级和纳米级器件。 本发明还提供由DPN图案化的衬底，包括亚微米组合阵列，以及用于执行DPN的试剂盒，装置和软件。 本发明还提供了一种在空气中进行AFM成像的方法。 该方法包括用疏水性化合物涂覆AFM尖端，选择疏水性化合物，使得与使用未涂覆的AFM尖端进行的AFM成像相比，使用涂覆的AFM尖端进行的AFM成像得到改善。 最后，本发明提供涂覆有疏水化合物的AFM尖端。

公开(公告)号：US20070122833A1

公开(公告)日：2007-05-31

申请号：US11627735

申请日：2007-01-26

申请人： James Hainfeld

发明人： James Hainfeld

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12P3/00

CPC分类号： G01N33/5438 ,  B82Y5/00 ,  C12P3/00 ,  C12Q1/001 ,  C12Q1/28 ,  C12Q1/6816 ,  G01N33/573 ,  G01N33/57496 ,  G01N33/581 ,  G01N33/587 ,  G01N33/84 ,  Y10S435/975 ,  Y10S977/885 ,  C12Q2563/137

摘要： Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally disclosed is how to use enzymes to accumulate metal particles. The alteration of metal particles by enzymes interacting with the organic shell of the particles is also described. These methods enable a wide range of applications including sensitive detection of genes and proteins, use as probes for microscopy, nanofabrication, biosensors, and remediation.

摘要翻译： 公开了利用酶对溶液中的金属离子起作用以使离子还原成金属的方法和材料。 另外公开了如何使用酶积累金属颗粒。 还描述了通过与颗粒的有机壳相互作用的酶改变金属颗粒。 这些方法可以广泛应用，包括基因和蛋白质的敏感检测，用作显微镜，纳米制造，生物传感器和修复的探针。

公开(公告)号：US20050172704A1

公开(公告)日：2005-08-11

申请号：US10951031

申请日：2004-09-28

申请人： Chad Mirkin ,  Richard Piner ,  Seunghun Hong

发明人： Chad Mirkin ,  Richard Piner ,  Seunghun Hong

IPC分类号： B05D1/00 ,  B05D1/18 ,  B05D1/26 ,  B82B3/00 ,  G01Q10/00 ,  G01Q60/00 ,  G01Q70/06 ,  G01Q70/16 ,  G01Q80/00 ,  G03F7/00 ,  G03F7/16 ,  G03F7/20 ,  H01L21/027 ,  G01B5/28

CPC分类号： B82B3/00 ,  B05D1/007 ,  B05D1/185 ,  B05D1/26 ,  G01Q80/00 ,  G03F7/0002 ,  G03F7/165 ,  Y10S977/849 ,  Y10S977/853 ,  Y10S977/854 ,  Y10S977/855 ,  Y10S977/856 ,  Y10S977/857 ,  Y10S977/86 ,  Y10S977/88 ,  Y10S977/884 ,  Y10S977/885 ,  Y10S977/886 ,  Y10S977/895 ,  Y10T428/24802

摘要： The invention provides a lithographic method referred to as “dip pen” nanolithography (DPN). DPN utilizes a scanning probe microscope (SPM) tip (e.g., an atomic force microscope (AFM) tip) as a “pen,” a solid-state substrate (e.g., gold) as “paper,” and molecules with a chemical affinity for the solid-state substrate as “ink.” Capillary transport of molecules from the SPM tip to the solid substrate is used in DPN to directly write patterns consisting of a relatively small collection of molecules in submicrometer dimensions, making DPN useful in the fabrication of a variety of microscale and nanoscale devices. The invention also provides substrates patterned by DPN, including submicrometer combinatorial arrays, and kits, devices and software for performing DPN. The invention further provides a method of performing AFM imaging in air. The method comprises coating an AFM tip with a hydrophobic compound, the hydrophobic compound being selected so that AFM imaging performed using the coated AFM tip is improved compared to AFM imaging performed using an uncoated AFM tip. Finally, the invention provides AFM tips coated with the hydrophobic compounds.

摘要翻译： 本发明提供了称为“浸笔”纳米光刻（DPN）的光刻方法。 DPN使用扫描探针显微镜（SPM）尖端（例如，原子力显微镜（AFM）尖端）作为“笔”，固态基底（例如，金）作为“纸”，并且具有化学亲和力的分子 固态基板为“墨水”。 在DPN中使用分子从SPM尖端到固体基质的毛细管传输，以直接写入由亚微米尺寸的相对小的分子集合组成的图案，使得DPN可用于制造各种微尺寸和纳米尺寸的器件。 本发明还提供由DPN图案化的衬底，包括亚微米组合阵列，以及用于执行DPN的试剂盒，装置和软件。 本发明还提供了一种在空气中进行AFM成像的方法。 该方法包括用疏水性化合物涂覆AFM尖端，选择疏水性化合物，使得与使用未涂覆的AFM尖端进行的AFM成像相比，使用涂覆的AFM尖端进行的AFM成像得到改善。 最后，本发明提供涂覆有疏水化合物的AFM尖端。

公开(公告)号：US20020122873A1

公开(公告)日：2002-09-05

申请号：US10059593

申请日：2002-01-28

发明人： Chad A. Mirkin ,  Seunghun Hong ,  Vinayak P. Dravid

IPC分类号： A61L002/00 ,  B05D005/00

CPC分类号： G03F7/0002 ,  B05D1/007 ,  B05D1/185 ,  B05D1/26 ,  B82B3/00 ,  G01Q80/00 ,  G03F7/165 ,  Y10S977/85 ,  Y10S977/857 ,  Y10S977/86 ,  Y10S977/862 ,  Y10S977/863 ,  Y10S977/878 ,  Y10S977/882 ,  Y10S977/884 ,  Y10S977/885 ,  Y10S977/886

摘要： In one aspect, a method of nanolithography is provided using a driving force to control the movement of a deposition compound from a scanning probe microscope tip to a substrate. Another aspect of the invention provides a tip for use in nanolithography having an internal cavity and an aperture restricting movement of a deposition compound from the tip to the substrate. The rate and extent of movement of the deposition compound through the aperture is controlled by a driving force.

摘要翻译： 一方面，使用驱动力来提供纳米光刻的方法，以控制沉积化合物从扫描探针显微镜尖端到基底的移动。 本发明的另一方面提供了一种用于纳米光刻的尖端，其具有内腔和限制沉积化合物从尖端到基底的运动的孔。 沉积化合物通过孔的运动速度和程度由驱动力控制。

公开(公告)号：US07842344B2

公开(公告)日：2010-11-30

申请号：US10788414

申请日：2004-03-01

申请人： Chad A. Mirkin ,  Jung-Hyurk Lim ,  David S. Ginger ,  Jwa-Min Nam ,  Ki-Bum Lee ,  Linette Demers ,  Albena Ivanisevic

发明人： Chad A. Mirkin ,  Jung-Hyurk Lim ,  David S. Ginger ,  Jwa-Min Nam ,  Ki-Bum Lee ,  Linette Demers ,  Albena Ivanisevic

IPC分类号： B05D1/36

CPC分类号： G03B27/42 ,  Y10S977/857 ,  Y10S977/884 ,  Y10S977/885 ,  Y10S977/886

摘要： The present invention relates to the use of direct-write lithographic printing of proteins and peptides onto surfaces. In particular, the present invention relates to methods for creating protein and peptide arrays and compositions derived therefrom. Nanoscopic tips can be used to deposit the peptide or protein onto the surface to produce a pattern. The pattern can be dots or lines having dot diameter and line width of less than 1,000 nm. The tips and the substrate surfaces can be adapted for the peptide and protein lithography.

摘要翻译： 本发明涉及将蛋白质和肽直接写入平版印刷在表面上的用途。 特别地，本发明涉及用于产生蛋白质和肽阵列的方法和由其衍生的组合物。 可以使用纳米尖端将肽或蛋白质沉积到表面上以产生图案。 图案可以是点直径和线宽小于1,000nm的点或线。 尖端和底物表面可适用于肽和蛋白质光刻。

公开(公告)号：US07816151B2

公开(公告)日：2010-10-19

申请号：US11199413

申请日：2005-08-08

申请人： Andras Guttman ,  Zsolt Ronai ,  Csaba Barta

发明人： Andras Guttman ,  Zsolt Ronai ,  Csaba Barta

IPC分类号： H01L21/00 ,  H01L21/76

CPC分类号： C07K17/00 ,  B01J19/0093 ,  B01J35/065 ,  B01J2219/00641 ,  B01J2219/00835 ,  B01J2219/00844 ,  B01J2219/00907 ,  B01J2219/0095 ,  B01J2219/00952 ,  B01L3/5023 ,  B01L2300/12 ,  B01L2400/0421 ,  G01N33/48707 ,  Y10S977/704 ,  Y10S977/885 ,  Y10S977/893 ,  Y10T428/249953 ,  Y10T436/25

摘要： Reactors and methods for miniaturized reactions having enhanced reaction kinetics. In particular the subject matter is directed to chemical and biological reactions conducted in a nanoporous membrane environment. The subject matter contemplates methods for modifying the kinetics of reactions and devices for conducting reactions having modified kinetics. The subject matter also provides systems for rapid miniaturized reactions. Further the subject matter includes methods and kits for conducting a reaction with enhanced throughput and methods of conducting miniaturized, high throughput analyses of reaction products, and the like. Reactions performed on or within a nanoporous membrane exhibits improved kinetic characteristics.

摘要翻译： 用于具有增强的反应动力学的小型化反应的反应器和方法。 特别地，主题涉及在纳米多孔膜环境中进行的化学和生物反应。 主题考虑了用于改变反应动力学的方法和用于进行具有改性动力学的反应的装置。 主题还提供了用于快速小型化反应的系统。 此外，主题包括用于进行具有增强的产量的反应的方法和试剂盒以及进行反应产物的小型化，高通量分析的方法等。 在纳米多孔膜上或内部进行的反应表现出改善的动力学特性。

公开(公告)号：US07524534B2

公开(公告)日：2009-04-28

申请号：US10937877

申请日：2004-09-10

申请人： Chad A. Mirkin ,  Richard Piner ,  Seunghun Hong

发明人： Chad A. Mirkin ,  Richard Piner ,  Seunghun Hong

IPC分类号： B05D1/26

CPC分类号： B82B3/00 ,  B05D1/007 ,  B05D1/185 ,  B05D1/26 ,  G01Q80/00 ,  G03F7/0002 ,  G03F7/165 ,  Y10S977/849 ,  Y10S977/853 ,  Y10S977/854 ,  Y10S977/855 ,  Y10S977/856 ,  Y10S977/857 ,  Y10S977/86 ,  Y10S977/88 ,  Y10S977/884 ,  Y10S977/885 ,  Y10S977/886 ,  Y10S977/895 ,  Y10T428/24802

摘要： The invention provides a lithographic method referred to as “dip pen” nanolithography (DPN), which utilizes a scanning probe microscope (SPM) tip (e.g., an atomic force microscope (AFM) tip) as a “pen,” a solid-state substrate (e.g., gold) as “paper,” and molecules with a chemical affinity for the solid-state substrate as “ink.” Capillary transport of molecules from the SPM tip to the solid-state substrate is used in DPN to directly write patterns consisting of a relatively small collection of molecules in submicrometer dimensions, making DPN useful in the fabrication of a variety of microscale and nanoscale devices. The invention also provides substrates patterned by DPN, including submicrometer combinatorial arrays, and kits, devices and software for performing DPN. The invention further provides a method of performing AFM imaging in air. The method comprises coating an AFM tip with a hydrophobic compound, the hydrophobic compound being selected so that AFM imaging performed using the coated AFM tip is improved compared to AFM imaging preformed using an uncoated AFM tip. Finally, the invention provides AFM tips coated with the hydrophobic compounds.

摘要翻译： 本发明提供一种称为“浸笔”纳米光刻（DPN）的光刻方法，其使用扫描探针显微镜（SPM）尖端（例如，原子力显微镜（AFM）尖端）作为“笔”，固态 衬底（例如，金）作为“纸”，以及对固态衬底具有化学亲和力的分子作为“油墨”。 在DPN中使用分子从SPM尖端到固态基底的毛细管转运，以直接写入由亚微米尺寸的相对小的分子集合组成的图案，使得DPN可用于制造各种微米级和纳米尺寸的器件。 本发明还提供由DPN图案化的衬底，包括亚微米组合阵列，以及用于执行DPN的试剂盒，装置和软件。 本发明还提供了一种在空气中进行AFM成像的方法。 该方法包括用疏水化合物涂覆AFM尖端，选择疏水性化合物，使得与使用未涂覆的AFM尖端预成型的AFM成像相比，使用涂覆的AFM尖端进行的AFM成像得到改善。 最后，本发明提供涂覆有疏水化合物的AFM尖端。

公开(公告)号：US07272511B2

公开(公告)日：2007-09-18

申请号：US10601327

申请日：2003-06-19

申请人： Luigi Occhipinti ,  Francesco Buonocore ,  Vincenzo Vinciguerra ,  Gianguido Rizzotto ,  Giuseppe Panzera ,  Floriana San Biagio ,  Francesco Italia

发明人： Luigi Occhipinti ,  Francesco Buonocore ,  Vincenzo Vinciguerra ,  Gianguido Rizzotto ,  Giuseppe Panzera ,  Floriana San Biagio ,  Francesco Italia

IPC分类号： B81B7/02 ,  C12Q1/68 ,  G11B3/70 ,  G06F19/00

CPC分类号： G11C13/025 ,  B82Y10/00 ,  G06N3/123 ,  G11C13/0014 ,  G11C13/0019 ,  G11C2213/77 ,  G11C2213/81 ,  H01L27/28 ,  H01L51/0048 ,  H01L51/0093 ,  H01L51/0595 ,  Y10S977/855 ,  Y10S977/885

摘要： Described herein are a molecular memory obtained using DNA strand molecular switches and carbon nanotubes, and a manufacturing method thereof. In particular, the nonvolatile memory is manufactured according to an architecture that envisages the use of carbon nanotubes as electrical connectors and DNA strands as physical means on which to write the information. In other words, the nonvolatile memory is made by means of a set of molecular DNA strand switches, the addressing of which is controlled by molecular wires made up of carbon nanotubes.

摘要翻译： 本文描述了使用DNA链分子开关和碳纳米管获得的分子记忆及其制造方法。 特别地，非易失性存储器是根据设计将碳纳米管用作电连接器和DNA链的结构来制造的，作为在其上写入信息的物理手段。 换句话说，非易失性存储器是通过一组分子DNA链开关制成的，其分配线由碳纳米管组成的分子线控制。

公开(公告)号：US06670113B2

公开(公告)日：2003-12-30

申请号：US09822131

申请日：2001-03-30

申请人： James F. Hainfeld

发明人： James F. Hainfeld

IPC分类号： C12Q100

CPC分类号： G01N33/5438 ,  B82Y5/00 ,  C12P3/00 ,  C12Q1/001 ,  C12Q1/28 ,  C12Q1/6816 ,  G01N33/573 ,  G01N33/57496 ,  G01N33/581 ,  G01N33/587 ,  G01N33/84 ,  Y10S435/975 ,  Y10S977/885 ,  C12Q2563/137

摘要： Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally, disclosed is how to use enzymes to accumulate metal particles. The alteration of metal particles by enzymes interacting with the organic shell of the particles is also described. These methods enable a wide range of applications including sensitive detection of genes and proteins, use as probes for microscopy, nanofabrication, biosensors, and remediation.

公开(公告)号：US06248529B1

公开(公告)日：2001-06-19

申请号：US09315750

申请日：1999-05-20

申请人： Dennis Michael Connolly

发明人： Dennis Michael Connolly

IPC分类号： C12Q168

CPC分类号： H01L51/0595 ,  B82Y10/00 ,  C12N15/10 ,  C12Q1/68 ,  G11C13/0014 ,  G11C13/0019 ,  H01L51/0002 ,  H01L51/0093 ,  Y10S977/885 ,  Y10S977/925 ,  Y10S977/941

摘要： The present invention provides nano-scale devices, including electronic circuits, using DNA molecules as a support structure. DNA binding proteins are used to mask regions of the DNA as a material, such as a metal is coated onto the DNA. Included in the invention are DNA based transistors, capacitors, inductors and diodes. The present invention also provides methods of making integrated circuits using DNA molecules as a support structure. Methods are also included for making DNA based transistors, capacitors, inductors and diodes.

摘要翻译： 本发明提供使用DNA分子作为支持结构的纳米级装置，包括电子电路。 DNA结合蛋白用于掩盖DNA的区域作为材料，例如将金属包被在DNA上。 本发明包括基于DNA的晶体管，电容器，电感器和二极管。 本发明还提供了使用DNA分子作为支持结构的集成电路的方法。 还包括用于制造基于DNA的晶体管，电容器，电感器和二极管的方法。