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公开(公告)号：US10781003B2
公开(公告)日：2020-09-22
申请号：US15171015
申请日：2016-06-02
IPC分类号： B65B7/16 , B65B3/00 , B65B7/28 , B65D1/02 , B65D41/28 , B65B55/04 , B65B55/02 , B65D51/00 , B65B55/08 , B65B55/10
摘要： In one general aspect, a method is disclosed for processing a pharmaceutical substance in a pharmaceutical processing system that includes lyophilizing a plurality of containers provided in a nest. A first controlled environment enclosure in the pharmaceutical processing system is isolated against an external environment, and a controlled environmental condition is established in the first controlled environment enclosure. The pharmaceutical substance is deposited into at least a portion of the plurality of containers in the first container nest at a filling station within the first controlled environment enclosure. The deposited pharmaceutical substance is lyophilized in the first container nest.
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公开(公告)号：US10751436B2
公开(公告)日：2020-08-25
申请号：US13424107
申请日：2012-03-19
申请人： Shaun Sweeney
发明人： Shaun Sweeney
摘要： The present invention is directed at methods of preventing damages of a sterilization wrap for surgical instruments by utilizing tray belts. The tray belts are composed of an elongate member of substantially same width and a fastening means for connecting the two ends of the member. The methods comprise the steps of placing surgical instruments inside a sterilization tray, securely the tray belts around the tray, and wrapping a sterile wrap around the tray to form a sterilization pack. The methods may further comprise securing additional tray belts around the sterilization pack.
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公开(公告)号：US20200262609A1
公开(公告)日：2020-08-20
申请号：US16383847
申请日：2019-04-15
发明人： Frank BOTTGER , Benjamin BOBST
摘要： A method for filling dual-chamber systems in pre-sterilizable carrier systems includes providing at least one washed, siliconized and sterilized dual-chamber system in a magazine. The dual-chamber system includes respective separating elements separating the two chambers from each other. The magazine accommodates at least one dual-chamber system and is arranged in a container that is sealed with a closing element. The method additionally includes introducing the container into a clean room; opening the container and filling a first chamber of the at least one dual-chamber system; and closing the first chamber. The method further includes filling a second chamber of the at least one dual-chamber system; closing the second chamber; and removing the system from the clean room.
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公开(公告)号：US20200261883A1
公开(公告)日：2020-08-20
申请号：US16648521
申请日：2018-10-09
发明人： Karl Pflanz , Florian Hebenstreit , Andreas Pickl
摘要： The present invention relates to a diatomaceous earth composition with a low endotoxin content, comprising an agglomerated mixture of calcined diatomaceous earth particles and water, wherein the mass ratio of calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the endotoxin content of the diatomaceous earth composition is equal to or less than 0.5 EU/mL. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition with a low endotoxin content. In another aspect, the present invention relates to the use of the diatomaceous earth composition with a low endotoxin content as a precoat agent for the precoat filtration in biopharmaceutical applications.
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55.发明申请公开(公告)号：US20200165021A1
公开(公告)日：2020-05-28
申请号：US16697707
申请日：2019-11-27
申请人： Robert Bosch GmbH
发明人： Peter Mueller
摘要： A method for sterilizing closure elements (3) for packaging containers (1), wherein the closure elements (3) are collected individually by a holding mechanism (25) in the region of a sterile chamber (12) and are placed onto an opening (4) of a filled packaging container (1) and connected to the latter, and wherein the closure elements (3), while being conveyed inside the sterile chamber (12), are treated by means of at least one sterilizing medium (6, 7, 52) during a sterilizing process.
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56.发明申请公开(公告)号：US20200156812A1
公开(公告)日：2020-05-21
申请号：US16431549
申请日：2019-06-04
摘要： Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.
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57.发明授权公开(公告)号：US10577140B2
公开(公告)日：2020-03-03
申请号：US15670910
申请日：2017-08-07
申请人： ALTACOR LIMITED
摘要： The invention relates to a method and a device for packaging a flexible hydrophilic intraocular lens (1) placed flat on an injection support (4) which is adapted to carry out folding of the lens (1) during its implantation. The lens is immersed in a bath of liquid conserving solution contained in a sealed flask (30) which is itself enclosed in a packaging envelope (48), the assembly being steam-sterilized.
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公开(公告)号：US20190231922A1
公开(公告)日：2019-08-01
申请号：US16272302
申请日：2019-02-11
IPC分类号： A61L24/04 , A61L24/10 , A61K9/16 , A61L24/00 , B65B55/02 , B65B5/12 , B65B3/00 , A61K38/48 , A61K9/19 , A61K9/00 , A61K38/39
CPC分类号： A61L24/043 , A61K9/0014 , A61K9/1658 , A61K9/19 , A61K38/39 , A61K38/4833 , A61L24/0015 , A61L24/10 , A61L24/106 , A61L2300/418 , A61L2300/802 , A61L2400/04 , A61L2400/06 , B65B3/003 , B65B5/12 , B65B55/02 , C12Y304/21005 , Y10T428/13
摘要： Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a first component comprising a dry preparation of a coagulation inducing agent, b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) providing said first component and said second component in a combined form in a final container, c1) either by filling said first component and said second component into said final container so as to obtain a dry mixture in said final container, c2) or by providing said first component or said second component in said final container and adding said second component or said first component so as to obtain a combination of said first component with said second component in said final container, d) finishing the final container to a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition.
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公开(公告)号：US20190210754A1
公开(公告)日：2019-07-11
申请号：US16244114
申请日：2019-01-10
申请人： Carl Freudenberg KG
CPC分类号： B65B55/02 , B65B11/48 , D04H1/44 , D04H1/56 , D10B2505/10
摘要： A packaging for sterile packaging application includes: a single layer nonwoven fabric obtained from a nonwoven, the nonwoven including meltblown polymer fibers having an average fiber diameter between 2 μm to 10 μm and a standard deviation of the fiber diameter of at least 100%. The nonwoven is thermally bonded.
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公开(公告)号：US10322835B1
公开(公告)日：2019-06-18
申请号：US14836508
申请日：2015-08-26
申请人： LifeCell Corporation
发明人： Wendell Sun , Jerome Connor , Qing-Qing Qiu , Rick T. Owens
IPC分类号： B65B55/02 , B65B55/22 , B65B55/08 , B65B55/16 , A61L2/08 , A61L2/18 , A61L2/00 , A61L27/36 , B65B31/02
摘要： The present disclosure provides a variety of methods and compositions useful for making, sterilizing, and preserving tissues. The disclosure also features the acellular tissue matrices made by the methods.
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