公开(公告)号：US09731036B2

公开(公告)日：2017-08-15

申请号：US14287901

申请日：2014-05-27

申请人： Gal Markel

发明人： Gal Markel

IPC分类号： A01N63/00 ,  A61K48/00 ,  A61K51/10 ,  A61K49/00 ,  C07K16/30 ,  G01N33/569 ,  G01N33/574 ,  A61K38/17 ,  A61K35/17 ,  C07K14/705 ,  C12N5/0781 ,  C12N5/0783 ,  A61K51/04 ,  A61K51/08 ,  A61K35/12

CPC分类号： A61K51/10 ,  A61K35/17 ,  A61K38/1774 ,  A61K49/0004 ,  A61K49/0052 ,  A61K49/0056 ,  A61K49/0058 ,  A61K51/04 ,  A61K51/088 ,  A61K2035/122 ,  C07K14/70503 ,  C07K16/3007 ,  C07K2317/54 ,  C07K2317/732 ,  C12N5/0635 ,  C12N5/0636 ,  G01N33/56972 ,  G01N33/574 ,  G01N33/57492 ,  G01N2333/70596

摘要： The presently described technology relates to the modulation of specific immune responses to create a protective immunity in the treatment of autoimmune diseases and diseases requiring the transplantation of tissue. In particular, the present technology relates to the supression of immune responses in a targeted fashion, by increasing the functional concentration of the CEACAM1 protein in a target tissue to create a localized protective immunity for the treatment of autoimmune diseases and diseases requiring the transplantation of tissue.

公开(公告)号：US20170218336A1

公开(公告)日：2017-08-03

申请号：US15272051

申请日：2016-09-21

申请人： ROCHE DIAGNOSTICS GMBH

发明人： Roland Buelow

IPC分类号： C12N5/0781 ,  A01K67/027

CPC分类号： C12N5/0635 ,  A01K67/0275 ,  A01K67/0276 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/052 ,  A01K2217/054 ,  A01K2217/072 ,  A01K2227/107 ,  A01K2267/01 ,  A61K39/00 ,  C07H21/04 ,  C07K14/70503 ,  C09K5/045 ,  C09K2205/126 ,  C12N15/79 ,  C12N15/85 ,  C12N15/8509 ,  C12N2510/02 ,  C12N2510/04 ,  C12N2517/02

摘要： The present invention describes transgenic animals with human(ized) immunoglobulin loci and transgenes encoding human(ized) Igα and/or Igβ sequences. Of particular interest are animals with transgenic heavy and light chain immunoglobulin loci capable of producing a diversified human(ized) antibody repertoire that have their endogenous production of Ig and/or endogenous Igα and/or Igβ sequences suppressed. Simultaneous expression of human(ized) immunoglobulin and human(ized) Igα and/or Igβ results in normal B-cell development, affinity maturation and efficient expression of human(ized) antibodies.

公开(公告)号：US20170188554A1

公开(公告)日：2017-07-06

申请号：US15326762

申请日：2016-04-18

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： JIA-WANG WANG ,  RICHARD F. LOCKEY

IPC分类号： A01K67/027 ,  G01N33/50 ,  G01N33/58 ,  C12N5/0781

CPC分类号： A01K67/0278 ,  A01K67/0275 ,  A01K2217/00 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2217/203 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2227/106 ,  A01K2267/0387 ,  A01K2267/0393 ,  C12N5/0635 ,  C12N15/907 ,  C12N2800/30 ,  G01N15/1459 ,  G01N33/5052 ,  G01N33/582 ,  G01N2015/1006 ,  G01N2500/10

摘要： The invention concerns a non-human animal model useful for modeling complex human diseases; compositions comprising cell populations from the animal model having different genotypes for the same gene; methods for producing the animal model; and methods for studying a phenotype using an animal model or compositions of the invention.

公开(公告)号：US09637540B2

公开(公告)日：2017-05-02

申请号：US14549726

申请日：2014-11-21

申请人： Elwha LLC

发明人： Roderick A. Hyde ,  Wayne R. Kindsvogel

IPC分类号： C12N15/63 ,  C07K16/18 ,  A61K39/00 ,  C12N5/0781 ,  C07K16/00 ,  C07K16/10 ,  C07K16/12 ,  C07K16/30 ,  C07K16/44 ,  G01N33/68

CPC分类号： C07K16/18 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/5156 ,  C07K16/00 ,  C07K16/1018 ,  C07K16/109 ,  C07K16/1271 ,  C07K16/3069 ,  C07K16/44 ,  C07K2317/14 ,  C07K2317/76 ,  C12N5/0635 ,  C12N2510/00 ,  G01N33/6854

摘要： Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen.

公开(公告)号：US20170107231A1

公开(公告)日：2017-04-20

申请号：US15312482

申请日：2015-05-22

申请人： Genzyme Corporation

发明人： Paul Mason ,  Kara Carter ,  Alexandra Joseph ,  Yiding Hu ,  Jill Gregory ,  Zhong Zhao ,  Christopher Yee ,  Mohamud Mohamud ,  Yibin Xiang ,  Sanjay Danthi ,  Yinyin Huang ,  Andrew Papoulis

IPC分类号： C07D498/10 ,  G01N33/50 ,  C12N5/0781 ,  C07D491/107 ,  G01N33/60

CPC分类号： C07D498/10 ,  C07D491/107 ,  C07D491/20 ,  C12N5/0635 ,  G01N33/5008 ,  G01N33/60

摘要： The invention features compounds of Formula (I), Formula (I)-A and Formula (I)-B as disclosed herein, as well as methods of synthesis, therapy, diagnostics, and assays.

公开(公告)号：US20160355783A1

公开(公告)日：2016-12-08

申请号：US15178715

申请日：2016-06-10

申请人： Elwha LLC

发明人： Roderick A. Hyde ,  Wayne R. Kindsvogel

IPC分类号： C12N5/0781 ,  A61K35/17 ,  C12N15/85

CPC分类号： C12N5/0635 ,  A61K35/17 ,  A61K39/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  C07K16/00 ,  C07K16/1018 ,  C07K16/109 ,  C07K16/1271 ,  C07K16/18 ,  C07K16/3069 ,  C07K16/44 ,  C07K2317/14 ,  C07K2317/76 ,  C12N15/85 ,  C12N2510/00

摘要： Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.

摘要翻译： 本文公开了在分离的细胞毒性B淋巴细胞系中产生一种或多种免疫球蛋白的组合物和方法。 分离的细胞系包括能够表达至少一种外源掺入的膜免疫球蛋白的分离的B淋巴细胞细胞系，其对第一抗原具有反应性，并且至少一种内源性分泌的免疫球蛋白可与第二抗原反应，并且还能够表达至少一种外源重组的重组 信号表达细胞毒性效应分子的B细胞受体。

公开(公告)号：US09493741B2

公开(公告)日：2016-11-15

申请号：US14499736

申请日：2014-09-29

申请人： GALPHARMA CO., LTD.

发明人： Mitsuomi Hirashima ,  Toshiro Niki ,  Tomohiro Arikawa ,  Souichi Oomizu ,  Takeshi Kadowaki

IPC分类号： C12N5/078 ,  A61K35/17 ,  C12N5/07 ,  C12N5/0783 ,  G01N33/68 ,  A61K49/00 ,  C12N5/0781 ,  C12N5/0784 ,  G01N33/50 ,  G01N33/569 ,  C12N5/0786

摘要： The object of the present invention is to provide a cell that can exhibit physiological activity based on galectin-9, a method for producing the cell, and use of the cell. In order to achieve the above object, the cell of the present invention contains galectin-9, and the galectin-9 is expressed on a cell surface.

公开(公告)号：US09487583B2

公开(公告)日：2016-11-08

申请号：US14008567

申请日：2012-03-28

申请人： Nobuyuki Kurosawa ,  Masaharu Isobe

发明人： Nobuyuki Kurosawa ,  Masaharu Isobe

IPC分类号： C07K16/26 ,  C07K16/18 ,  C12N5/0781

CPC分类号： C07K16/26 ,  C07K16/18 ,  C07K2317/10 ,  C07K2317/20 ,  C07K2317/56 ,  C07K2317/565 ,  C12N5/0635

摘要： [Problem] To provide a method that efficiently produces antigen-specific monoclonal antibodies from a wide range of animal species, and to provide a new antigen-specific monoclonal antibody using this technique. [Solution] A nonhuman animal is immunized with a target antigen, lymph fluid or the like is collected from the immunized nonhuman animal, or lymph fluid or the like is collected from a human having antibodies to the target antigen, the collected lymph fluid or the like is combined with (1) a labeled target antigen and (2) a marker that can selectively binds to plasma cells and/or plasmablasts, and cells that have bound to (1) the labeled target antigen and (2) the marker are then selected. The plasma cells and or the plasmablasts that have specifically bound to the target antigen by the method are selected, an gene of an antibody for the target antigen is collected from the selected cells, the base sequence thereof is identified, an antibody or antibody fragment is prepared on the basis of the base sequence of the identified gene, and an antibody or antibody fragment specific to the target antigen is produced.

摘要翻译： 提供一种从广泛的动物物种有效地产生抗原特异性单克隆抗体的方法，并使用该技术提供新的抗原特异性单克隆抗体。 [解决方案]用目标抗原免疫非人动物，从免疫的非人动物收集淋巴液等，或者从具有针对靶抗原的抗体，收集的淋巴液或 结合（1）标记的靶抗原和（2）可以选择性结合浆细胞和/或浆细胞的标记，以及结合（1）标记的靶抗原的细胞和（2）标记物 选择。 选择通过该方法特异性结合靶抗原的浆细胞和或浆细胞，从所选择的细胞中收集靶抗原的抗体基因，鉴定其碱基序列，抗体或抗体片段为 基于所鉴定的基因的碱基序列制备，并产生对靶抗原特异性的抗体或抗体片段。

公开(公告)号：US20160250248A1

公开(公告)日：2016-09-01

申请号：US14777605

申请日：2014-03-18

申请人： Northeastern University

发明人： Michail V. SITKOVSKY ,  Robert Koehler ABBOTT ,  Stephen Matthew HATFIELD

IPC分类号： A61K31/7076 ,  C12N5/0781 ,  A61K45/06 ,  A61K39/39

CPC分类号： A61K31/7076 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/55511 ,  C12N5/0635 ,  C12N2501/05

摘要： Methods and composition for potentiating germinal centers are disclosed herein. The methods include potentiating germinal centers to enhance antibody production in response to a vaccine, to increase antibody titer in response to a vaccine, and to enhance B cell class switching.

摘要翻译： 本文公开了增强生发中心的方法和组合物。 所述方法包括增强生发中心以增加针对疫苗的抗体产生，以增加针对疫苗的抗体效价，并增强B细胞类别切换。

公开(公告)号：US09416188B2

公开(公告)日：2016-08-16

申请号：US14993917

申请日：2016-01-12

申请人： The University of Washington through its Center for Commercialization

发明人： Jay Chaplin ,  Martha Hayden-Ledbetter ,  Jeffrey Ledbetter ,  Edward A. Clark

IPC分类号： A61K39/395 ,  C07K16/28 ,  C12N5/0781 ,  C07K16/30 ,  A61K39/00

CPC分类号： C07K16/2896 ,  A61K39/39541 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/74 ,  C12N5/0635 ,  C12N2501/056 ,  C12N2501/599

摘要： Disclosed herein are novel CD180 binding molecules, methods for their identification, and methods for their use.

摘要翻译： 本文公开了新颖的CD180结合分子，其鉴定方法及其使用方法。