公开(公告)号：US20160017268A1

公开(公告)日：2016-01-21

申请号：US14774059

申请日：2014-03-14

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION ,  ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Deok-Ho KIM ,  Michael LAFLAMME ,  Junseok CHAE ,  Kshitiz GUPTA

IPC: C12M1/42 ,  C12M1/34

CPC classification number: C12M35/02 ,  C12M23/12 ,  C12M41/46 ,  G01N33/4836

Abstract: The present invention relates to the devices and method comprising microelectrode arrays for the differentiation, maturation and functional analysis of electroconductive cells, including muscle cells (including, but not limited to, cardiomyocytes, skeletal muscle myocytes and smooth muscle myocytes) and neuronal cells. The microelectrode present on the arrays can be used to stimulate and record from cells cultured on the substrate. In some embodiments, the substrate has a substantially smooth surface, and in other embodiments the substrate is nanotextured, including an array of substantially parallel grooves and ridges of nanometer-micrometer widths.

Abstract translation: 本发明涉及包括用于导电细胞（包括肌细胞（包括但不限于心肌细胞，骨骼肌肌细胞和平滑肌肌细胞））和神经元细胞的分化，成熟和功能分析的微电极阵列的装置和方法。 存在于阵列上的微电极可以用于刺激和记录在基质上培养的细胞。 在一些实施例中，衬底具有基本平滑的表面，并且在其它实施例中，衬底是纳米纹理的，包括基本上平行的纳米微米宽度的凹槽和脊。

公开(公告)号：US09082989B2

公开(公告)日：2015-07-14

申请号：US14499896

申请日：2014-09-29

Applicant: Arizona Board of Regents for and on behalf of Arizona State University

Inventor： Jian Li ,  Zixing Wang

IPC: C07F15/00 ,  H01L51/00 ,  C09K11/06 ,  H01L51/50

CPC classification number: H01L51/0087 ,  C07F15/0086 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1029 ,  C09K2211/1037 ,  C09K2211/1044 ,  C09K2211/185 ,  H01L51/5012 ,  Y02B20/181

Abstract: Synthesis of platinum(II) di(2-pyrazolyl)benzene chloride and analogs includes forming a 1,3-di-substituted benzene including two aromatic five-membered heterocycles, and reacting the 1,3-di-substituted benzene with an acidic platinum-containing solution to form a luminescent platinum(II) complex. The luminescent platinum(II) complex is capable of emitting blue and white light and can be used as an emitter in a light emitting device.

Abstract translation: 铂（II）二（2-吡唑基）苯氯化物和类似物的合成包括形成包含两个芳族五元杂环的1,3-二取代的苯，并使1,3-二取代的苯与酸性铂 以形成发光的铂（II）络合物。 发光的铂（II）络合物能够发射蓝色和白色光，并且可以用作发光器件中的发射极。

公开(公告)号：US20150099990A1

公开(公告)日：2015-04-09

申请号：US14376568

申请日：2013-02-04

Applicant: Arizona Board of Regents, for and on Behalf of, Arizona State University ,  Mayo Foundation for Medical Education and Research

Inventor： Jianming Liang ,  Nima Tajbakhsh ,  Wenzhe Xue ,  Hong Wu ,  Eileen McMahon ,  Marek Belohlavek

IPC: A61B5/11 ,  A61B5/00 ,  A61B5/02

CPC classification number: A61B5/1102 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/7282 ,  A61B8/065 ,  A61B8/0883 ,  A61B2576/023 ,  G06T7/0016 ,  G06T7/246 ,  G06T2207/10016 ,  G06T2207/10132 ,  G06T2207/20076 ,  G06T2207/20224 ,  G06T2207/30048 ,  G06T2207/30241

Abstract: Receiving a plurality of images of a first wall of the patient's heart, the plurality including a first image captured at a time ij and a second image captured at a time t2, determining based on the plurality of images, a first characteristic of movement of at least a wall portion of the first wall during a time period spanning time t1 and time t2, the first characteristic of movement being determined by using one or more image processing techniques, and the first, characteristic of movement being based on at least one of: (i) a shape of the wall portion in the first image and a shape of the wall portion in the second image, and (ii) a location of the wall portion in the first image and a location of the wall portion in the second image: and outputting an indication of the first characteristic of movement.

Abstract translation: 接收患者心脏的第一壁的多个图像，所述多个图像包括在时间ij捕获的第一图像和在时间t2捕获的第二图像，基于所述多个图像确定所述多个图像的运动的第一特征 在跨越时间t1和时间t2的时间段期间，第一壁的至少壁部分，通过使用一个或多个图像处理技术确定移动的第一特征，并且第一移动特征基于以下中的至少一个： （i）第一图像中的壁部的形状和第二图像中的壁部的形状，以及（ii）第一图像中的壁部的位置和第二图像中的壁部的位置 并输出运动的第一特征的指示。

公开(公告)号：US20150090125A1

公开(公告)日：2015-04-02

申请号：US14478763

申请日：2014-09-05

Applicant: The Arizona Board of Regents for and on behalf of Arizona State University

Inventor： Jerry Y.S. Lin ,  Jose Ortiz-Landeros ,  Xue-Liang Dong

IPC: B01D53/22 ,  B01D69/12 ,  B01D69/04

CPC classification number: B01D53/228 ,  B01D53/22 ,  B01D53/229 ,  B01D69/04 ,  B01D69/12 ,  B01D71/024 ,  B01D2257/504 ,  B01D2258/0283 ,  Y02C10/10

Abstract: Embodiments for a tubular ceramic-carbonate dual-phase membrane and methods for manufacturing the tubular ceramic-carbonate dual-phase membrane are disclosed.

Abstract translation: 公开了管状陶瓷 - 碳酸酯双相膜的实施方案和管状陶瓷 - 碳酸酯双相膜的制造方法。

公开(公告)号：US20150025422A1

公开(公告)日：2015-01-22

申请号：US14460007

申请日：2014-08-14

Applicant: Arizona Board of Regents for and on Behalf of Arizona State University

Inventor： William James P. TYLER

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B5/0476 ,  A61B5/4836 ,  A61N5/0613 ,  A61N5/062 ,  A61N5/0622 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0653 ,  A61N2005/067 ,  A61N2007/0021 ,  A61N2007/0026 ,  A61N2007/0073 ,  A61N2007/0078 ,  C12N5/0619 ,  C12N13/00

Abstract: The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities. Devices of the present invention comprise one or more components for generating ultrasound waves, such as ultrasonic emitters, transducers or piezoelectric transducers, composite transducers, CMUTs, and which may be provided as single or multiple transducers or in an array configurations. The ultrasound waves may be of any shape, and may be focused or unfocused.

Abstract translation: 本发明包括用于调节活细胞的活性或活性的方法和装置，例如在人，动物，植物，昆虫，微生物和其他生物体中发现或衍生的细胞。 本发明的方法包括使用超声波（例如低强度，低频超声波）对活细胞的应用来影响细胞并调节细胞的活性。 本发明的装置包括用于产生超声波的一个或多个部件，例如超声波发射器，换能器或压电换能器，复合换能器，CMUT，并且其可被提供为单个或多个换能器或阵列配置。 超声波可以是任何形状，并且可以被聚焦或未被聚焦。

公开(公告)号：US20190150794A1

公开(公告)日：2019-05-23

申请号：US16097552

申请日：2017-04-28

Applicant: Arizona Board of Regents for and on behalf of Arizona State University

Inventor： Sarma Vrudhula ,  Shihui Yin ,  Jae-sun Seo ,  Sang Joon Kim ,  Chisung Bae

IPC: A61B5/117 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/00 ,  G06K9/00 ,  G06F21/32 ,  G06N3/04 ,  G06N3/08

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for obtaining an electrocardiographic (ECG) signal of a user; obtaining a feature vector of the ECG signal of the user with neural network based feature extraction. Comparing the feature vector of the ECG signal with a stored feature vector of a registered user. Authenticating the user in response to determining that a similarity of the ECG feature vector of the ECG signal and the stored ECG feature vector of the registered user exceeds a pre-defined threshold value.

公开(公告)号：US10296030B2

公开(公告)日：2019-05-21

申请号：US15289121

申请日：2016-10-07

Applicant: University of Utah Research Foundation ,  Arizona Board of Regents for and on behalf of Arizona State University

Inventor： Masood Parvania ,  Anna Scaglione

IPC: G05F1/66 ,  H02J3/00

Abstract: An operating configuration for a power system during a particular time period may be derived from a net load forecast for the power system during the particular time period. The operating configuration may be based on characteristics of power generation units (PGUs) available within the power system (e.g., power generators). The characteristics of a PGU may include a generation trajectory for the PGU that defines, inter alia, power generated by the PGU as the PGU ramps up power production within the power system. The generation trajectory of PGUs may be evaluated in view of the net load forecast to ensure that adequate power resources are available within the power system and avoid ramping scarcity conditions.

公开(公告)号：US10125373B2

公开(公告)日：2018-11-13

申请号：US14762128

申请日：2014-01-22

Applicant: THE ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY ,  Hugh Mason ,  Charles Arntzen ,  Sun Hee Rosenthal ,  Sean Winkle ,  Andrew Diamos

Inventor： Hugh Mason ,  Charles Arntzen ,  Sun Hee Rosenthal ,  Sean Winkle ,  Andrew Diamos

IPC: C12N15/82 ,  C07K16/28 ,  C12N7/00

Abstract: A single vector or multiple separate vectors that contain two or more non-competing replicons for transient expression of the heavy and light chains of Rituximab in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures to optimize the expression is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of the multi-replicon single vector system for producing Rituximab in plant cells.

公开(公告)号：US20180320189A1

公开(公告)日：2018-11-08

申请号：US15850957

申请日：2017-12-21

Applicant: The Arizona Board of Regents for and on Behalf of Arizona State University ,  The Washington University

Inventor： Roy Curtiss, III ,  Shifeng Wang ,  Soo-young Wanda ,  Wei Kong

IPC: C12N15/74 ,  A61K39/00 ,  C12N1/36

CPC classification number: C12N15/74 ,  A61K35/74 ,  A61K39/00 ,  A61K2035/11 ,  A61K2039/522 ,  A61K2039/523 ,  C12N1/36

Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.

公开(公告)号：US20170306338A1

公开(公告)日：2017-10-26

申请号：US15423675

申请日：2017-02-03

Applicant: The Arizona Board of Regents for and on Behalf of Arizona State University

Inventor： Roy Curtiss, III ,  Wei Kong

IPC: C12N15/74 ,  A61K35/74 ,  C12N1/36 ,  C12R1/42

CPC classification number: C12N15/74 ,  A61K35/74 ,  C12N1/36 ,  C12R1/42

Abstract: The present invention encompasses a recombinant bacterium capable of reducing tumor growth.