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61.发明申请公开(公告)号：US20100267099A1
公开(公告)日：2010-10-21
申请号：US12825537
申请日：2010-06-29
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12P7/6427 , C12N9/0083 , C12N15/8247
Abstract: The present invention relates to Δ8 desaturase genes, which have the ability to convert eicosadienoic acid (EDA; 20:2 ω-6) to dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) and/or eicosatrienoic acid (ETrA; 20:3 ω-3) to eicosatetraenoic acid (ETA; (20:3 ω-3). Isolated nucleic acid fragments and recombinant DNA constructs comprising such fragments encoding Δ8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ8 desaturases in oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将二十碳二烯酸（EDA; 20：2ω-6）转化为二高-γ-亚麻酸（DGLA; 20：3ω-6）和/或二十碳三烯酸的能力的Dgr .8去饱和酶基因 分离的核酸片段和重组DNA构建体，其包含编码“Dgr。8”去饱和酶的片段，以及一种制备长链多糖的方法， 公开了在含油酵母中使用这些＆Dgr。8去饱和酶的链多不饱和脂肪酸（PUFA）。
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62.发明申请公开(公告)号：US20100267098A1
公开(公告)日：2010-10-21
申请号：US12825523
申请日：2010-06-29
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12N9/1029 , A23D9/00 , A23D9/007 , A23K20/158 , A23L33/12 , A23V2002/00 , A23V2250/1862 , A23V2250/187 , A23V2250/1868
Abstract: The present invention relates to Δ49 elongases, which have the ability to convert linoleic acid (LA; 18:2 ω-6) to eicosadienoic acid (EDA; 20:2 ω-6) and/or α-linolenic acid (ALA; 18:3 ω-3) to eicosatrienoic acid (ETrA; 20:3 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ9 elongases in oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将亚油酸（LA; 18：2ω-6）转化成二十碳五烯酸（EDA;20:2ω-6）和/或α-亚麻酸（ALA）的能力的“ ; 18：3ω-3）至二十碳三烯酸（ETrA; 20：3ω-3）。 公开了分离的核酸片段和重组构建体，其包含编码'Dgr。9延伸酶的这种片段以及在含油酵母中使用这些＆Dgr.9延伸酶制备长链多不饱和脂肪酸（PUFA）的方法。
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63.发明授权公开(公告)号：US07794701B2
公开(公告)日：2010-09-14
申请号：US12102879
申请日：2008-04-15
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12N9/1029 , A23D9/00 , A23D9/007 , A23K20/158 , A23L33/12 , A23V2002/00 , A23V2250/1862 , A23V2250/187 , A23V2250/1868
Abstract: The present invention relates to Δ9 elongases, which have the ability to convert linoleic acid (LA; 18:2 ω-6) to eicosadienoic acid (EDA; 20:2 ω-6) and/or α-linolenic acid (ALA; 18:3 ω-3) to eicosatrienoic acid (ETrA; 20:3 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ9 elongases in oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将亚油酸（LA; 18：2ω-6）转化成二十碳烯酸（EDA;20:2ω-6）和/或α-亚麻酸（ALA）的能力的Dgr。 ; 18：3ω-3）至二十碳三烯酸（ETrA; 20：3ω-3）。 公开了分离的核酸片段和重组构建体，其包含编码'Dgr。9延伸酶的这种片段以及在含油酵母中使用这些＆Dgr.9延伸酶制备长链多不饱和脂肪酸（PUFA）的方法。
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64.发明授权Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids 有权突变和Dgr; 8去饱和酶基因通过靶向诱变工程改造，并用于制备多不饱和脂肪酸公开(公告)号：US07709239B2
公开(公告)日：2010-05-04
申请号：US11635258
申请日：2006-12-07
Applicant: Howard Glenn Damude , Hongxian He , Der-Ing Liao , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Hongxian He , Der-Ing Liao , Quinn Qun Zhu
IPC: C12P21/00 , C12Q1/26 , C12N15/00 , C12P7/64 , C12N5/04 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/19 , C07H21/00 , C12N9/02 , C07K14/00
CPC classification number: C12N9/0083
Abstract: The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 ω-3, ETrA] to eicosatetraenoic acid [20:3 ω-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ8 desaturase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these mutant Δ8 desaturases in plants and oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将二十碳二烯酸[20:2ω-6，EDA]转化为二高-γ-亚麻酸[20:3，DGLA]和/或二十碳三烯酸[ 20：3ω-3，ETrA]至二十碳四烯酸[20：3ω-3，ETA]。 公开了分离的核酸片段和重组构建体，其包含编码“Dgr”8去饱和酶的片段以及使用这些突变体和Dgr。8去饱和酶在植物和油质酵母中制备长链多不饱和脂肪酸（PUFA）的方法。
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65.发明授权公开(公告)号：US07678560B2
公开(公告)日：2010-03-16
申请号：US11748629
申请日：2007-05-15
Applicant: Howard Glenn Damude , Dana M. Walters Pollak , Zhixiong Xue , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Dana M. Walters Pollak , Zhixiong Xue , Quinn Qun Zhu
CPC classification number: A23L1/182 , A23K10/30 , A23L7/196 , A23L19/03 , A23V2002/00 , C12N9/0071 , C12N9/0083 , C12P7/6427 , C12P7/6472 , C12Y114/19
Abstract: The present invention relates to a Δ5 desaturase, which has the ability to convert dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) to arachidonic acid (ARA; 20:4 ω-6) and/or eicosatetraenoic acid (ETA; 20:4 ω-3) to eicosapentaenoic acid (EPA; 20:5 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this Δ5 desaturase in oleaginous yeast are disclosed.
Abstract translation: 本发明涉及一种具有将二硫-γ-亚麻酸（DGLA; 20：3ω-6）转化成花生四烯酸（ARA; 20：4ω-6）和/或二十碳四烯酸 酸（ETA; 20：4ω-3）至二十碳五烯酸（EPA; 20：5ω-3）。 公开了分离的核酸片段和重组构建体，其包含编码“Dgr。5去饱和酶”的片段以及在含油酵母中使用该Dgr。5去饱和酶制备长链多不饱和脂肪酸（PUFA）的方法。
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Patent Agency Ranking
66.发明申请DGAT GENES FROM OLEAGINOUS ORGANISMS FOR INCREASED SEED STORAGE LIPID PRODUCTION AND ALTERED FATTY ACID PROFILES IN OILSEED PLANTS 有权来自有机体的DGAT基因，用于增加种子储存脂肪生产和改变油脂植物中的脂肪酸分布公开(公告)号：US20090293151A1
公开(公告)日：2009-11-26
申请号：US12470517
申请日：2009-05-22
Applicant: KNUT MEYER , HOWARD GLENN DAMUDE , KEVIN G. RIPP , KEVIN L. STECCA
Inventor： KNUT MEYER , HOWARD GLENN DAMUDE , KEVIN G. RIPP , KEVIN L. STECCA
CPC classification number: C12N15/8247 , C12N9/1029 , C12Y203/0102
Abstract: Transgenic soybean seed having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of non-transgenic, null segregant soybean seed are described. DGAT genes from oleaginous organisms are used to achieve the increase in seed storage lipids.
Abstract translation: 描述了与非转基因，无偏分离大豆种子的总脂肪酸含量相比，具有至少10％的总脂肪酸含量增加和改变的脂肪酸分布的转基因大豆种子。 来自含油生物的DGAT基因用于实现种子储存脂质的增加。
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67.发明申请DELTA-8 DESATURASE AND ITS USE IN MAKING POLYUNSATURATED FATTY ACIDS 审中-公开DELTA-8去饱和酶及其在制备多糖脂肪酸中的用途公开(公告)号：US20090264666A1
公开(公告)日：2009-10-22
申请号：US12431813
申请日：2009-04-29
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12P7/6472 , A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , C12N9/0083 , C12N15/8247 , C12P7/6427 , A23V2300/21
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this delta-8 desaturase in plants and oleaginous yeast.
Abstract translation: 分离的核酸片段和包含编码Δ-8去饱和酶的片段的重组构建物以及使用该植物中的δ-8去饱和酶和油质酵母制备长链多不饱和脂肪酸（PUFA）的方法。
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68.发明申请DELTA-5 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS 有权DELTA-5 DESATURASES及其在制备聚氨酯脂肪酸中的应用公开(公告)号：US20080274259A1
公开(公告)日：2008-11-06
申请号：US12111228
申请日：2008-04-29
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12N9/0071 , A23D9/00 , A23D9/02 , A23K20/158 , A23L33/115 , C12N9/0083 , C12N15/8247 , C12Y114/19
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-5 desaturases in plants are disclosed.
Abstract translation: 公开了分离的核酸片段和包含编码Δ-5去饱和酶的片段的重组构建物以及在植物中使用这些Δ-5去饱和酶制备长链多不饱和脂肪酸（PUFA）的方法。
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公开(公告)号：US20080254191A1
公开(公告)日：2008-10-16
申请号：US12061738
申请日：2008-04-03
Applicant: Howard Glenn Damude , Anthony J. Kinney , Kevin G. Ripp , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Anthony J. Kinney , Kevin G. Ripp , Quinn Qun Zhu
IPC: A23L2/00 , C12N9/00 , C12N9/04 , C12N9/10 , C12N9/16 , C12N15/11 , C12N15/00 , C12N5/04 , C12Q1/34 , C12P7/64 , C12N1/00 , C12N15/82 , C12N15/74 , A01H5/00 , C11B1/00 , A23D7/00
CPC classification number: C12P7/6427 , C12N9/0071 , C12N9/93 , C12N15/62 , C12N15/8247 , C12Y114/19001
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding multizymes (i.e., single polypeptides having at least two independent and separable enzymatic activities) along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these multizymes in plants and oleaginous yeast are disclosed.
Abstract translation: 分离的核酸片段和包含编码多片段的片段的重组构建体（即具有至少两个独立和可分离的酶活性的单一多肽）以及使用这些多重酶在植物和油质酵母中制备长链多不饱和脂肪酸（PUFA）的方法 被披露。
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70.发明申请Production of Very Long Chain Polyunsaturated Fatty Acids in Oil Seed Plants 有权油种子植物中非常长链多不饱和脂肪酸的生产公开(公告)号：US20080220143A1
公开(公告)日：2008-09-11
申请号：US11673843
申请日：2007-02-12
Applicant: Anthony J. Kinney , Edgar Benjamin Cahoon , Howard Glenn Damude , William D. Hitz , Zhan-Bin Liu , Charles W. Kolar
Inventor： Anthony J. Kinney , Edgar Benjamin Cahoon , Howard Glenn Damude , William D. Hitz , Zhan-Bin Liu , Charles W. Kolar
CPC classification number: A23K20/158 , A23L2/52 , A23L33/115 , A23L33/12
Abstract: Oilseed plants which have been transformed to produce at least 8.0% arachidonic acid (ARA) as well as uses of oils and seeds obtained from such transformed plants in a variety of food and feed applications are described.
Abstract translation: 已经转化生产至少8.0％花生四烯酸（ARA）的油籽植物以及在各种食品和饲料应用中从这种转化植物获得的油和种子的用途被描述。
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