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    Oligo-2′-deoxynucleotides and their use as pharmaceutical agents with antiviral activity
    63.
    发明授权
    Oligo-2′-deoxynucleotides and their use as pharmaceutical agents with antiviral activity 失效
    寡脱氧核苷酸及其作为具有抗病毒活性的药物的用途

    公开(公告)号：US06329346B1

    公开(公告)日：2001-12-11

    申请号：US08991183

    申请日：1997-12-16

    申请人： Klasu Muhlegger ,  Herbert Von Der Eltz ,  Frank Seela ,  Helmut Rosemeyer

    发明人： Klasu Muhlegger ,  Herbert Von Der Eltz ,  Frank Seela ,  Helmut Rosemeyer

    IPC分类号： A01N4304

    CPC分类号： C07H19/10 ,  C07H19/20 ,  C07H21/00

    摘要： Oligodeoxyribonucleotides in which at least two 2′-deoxy-&bgr;-D-erythro-pentofuranosyl groups are replaced by 2′-deoxy-&bgr;-D-threo-pentofuranosyl groups at both the 5′ end and 3′ end, and oligodeoxyribonucleotides in which at least 20% of the 2′-deoxy-&bgr;-D-erythro-pentofuranosyl groups in consecutive nucleotide building blocks are replaced by 2′-deoxy-&bgr;-D-threo-pentofuranosyl groups and which are composed of 6 to 100 nucleotide building blocks, are suitable for the inhibition of the expression of viral genes and oncogenes by the antisense principle and can be used for the production of pharmaceutical agents with antiviral activity.

    摘要翻译： 在5'末端和3'末端两个脱氧-β-D-赤 - 呋喃糖基被2'-脱氧-β-D-苏 - 戊呋喃糖基取代的寡脱氧核糖核苷酸和其中的寡脱氧核糖核苷酸 连续核苷酸构建单元中2'-脱氧-β-D-赤型 - 戊呋喃糖基的至少20％被2'-脱氧-β-D-苏糖 - 呋喃糖基取代，它们由6至100个核苷酸构建 适用于通过反义原理抑制病毒基因和癌基因的表达，并可用于生产具有抗病毒活性的药剂。

    Substrate for phospholipase
    65.
    发明授权
    Substrate for phospholipase 失效
    磷脂基质

    公开(公告)号：US5091527A

    公开(公告)日：1992-02-25

    申请号：US318075

    申请日：1989-03-02

    申请人： Martina Junius ,  Ulrich Neumann ,  Herbert von der Eltz

    发明人： Martina Junius ,  Ulrich Neumann ,  Herbert von der Eltz

    IPC分类号： C07C305/10 ,  C07C323/12 ,  C07C327/28 ,  C07F9/09 ,  C07F9/10 ,  C12Q1/44

    CPC分类号： C07C305/10 ,  C07C323/12 ,  C07F9/10 ,  C12Q1/44

    摘要： The present invention provides phospholipase substrates of the general formula: ##STR1## wherein A is an alkylene or alkenylene radical containing up to 16 carbon atoms, R is a hydrgen atom or an alkyl, alkenyl or acyl radical containing up to 20 carbon atoms or an optionally alkyl-substituted aryl or aralkyl radical containing up to 8 carbon atoms in the alkyl moiety, X is the residue of an aromatic hydroxy or thiol compound and each Y, independently of one another, is an oxygen or sulphur atom and Z is --SO.sub.3.sup..crclbar. or a radical of the general formula: ##STR2## wherein R.sup.1 can be a hydrogen atom or a radical of the general formula --(CH.sub.2).sub.n NR.sub.3.sup.2, in which n is 2, 3 or 4 and R.sup.2 is a hydrogen atom or a methyl radical, or is an inositol or serine (--CH.sub.2 --CH(NH.sub.2)--COOH) or glycerol residue.The present invention also provides a process for the optical determination of phospholipases using these substrates, as well as a reagent containing them.

    摘要翻译： 本发明提供以下通式的磷脂酶底物：其中A是含有至多16个碳原子的亚烷基或亚烯基，R是氢原子或烷基，烯基或 含有至多20个碳原子的酰基或在烷基部分含有至多8个碳原子的任选的烷基取代的芳基或芳烷基，X是芳族羟基或硫醇化合物的残基，每个Y彼此独立地是 氧原子或硫原子，Z为-SO 3（ - ）或下式通式的基团：其中R 1可以是氢原子或通式为 - （CH 2）n NR 33的基团，其中n为2， 3或4，R2为氢原子或甲基，或为肌醇或丝氨酸（-CH2-CH（NH2）-COOH）或甘油残基。 本发明还提供了使用这些底物光学测定磷脂酶的方法以及含有它们的试剂。

    Reactive iridoid derivatives; process for manufacture and application of same
    67.
    发明授权
    Reactive iridoid derivatives; process for manufacture and application of same 失效
    活性环烯醚萜衍生物; 其制造和应用的过程

    公开(公告)号：US4401825A

    公开(公告)日：1983-08-30

    申请号：US285989

    申请日：1981-07-23

    申请人： Klaus Weinges ,  Herbert von der Eltz ,  Hermann Jaggy

    发明人： Klaus Weinges ,  Herbert von der Eltz ,  Hermann Jaggy

    IPC分类号： C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D311/94 ,  C07H17/04 ,  C07D309/12

    CPC分类号： C07H17/04 ,  C07C405/00 ,  C07D311/94

    摘要： Reactive iridoid derivates represented by the following general formula ##STR1## (wherein R represents a hydrogen atom, an alkyl group with 1 to 5 carbon atoms, an acyl group with 2 to 6 C atoms, an unsubstituted aralkyl group with 7 to 12 C atoms, a methanesulfonyl- or toluenesulfonyl group, a benzoyl-, a preferably para-substituted nitrobenzoyl- or chlorobenzoyl group, or a tetrahydropyranyl group), process for the manufacture of said derivatives starting from catapol as an easily obtainable natural substance and use of said derivatives as intermediates for the manufacture of prostanoids.

    摘要翻译： 由下列通式（IMAGE）（其中R表示氢原子，具有1至5个碳原子的烷基，具有2至6个C原子的酰基，未取代的具有7至12个C原子的芳烷基）表示的活性环状烯烃衍生物 ，甲磺酰基或甲苯磺酰基，苯甲酰基，优选对位取代的硝基苯甲酰基或氯代苯甲酰基或四氢吡喃基），从卡波醇起始制备所述衍生物作为容易获得的天然物质的方法和使用所述衍生物 作为制备前列腺素的中间体。

    Reagents for lysis of bacterial cells
    68.
    发明授权
    Reagents for lysis of bacterial cells 有权
    细菌细胞溶解试剂

    公开(公告)号：US09371509B2

    公开(公告)日：2016-06-21

    申请号：US12855803

    申请日：2010-08-13

    申请人： Christian Birkner ,  Herbert von der Eltz ,  Monika Soukupova

    发明人： Christian Birkner ,  Herbert von der Eltz ,  Monika Soukupova

    IPC分类号： C12N1/06

    CPC分类号： C12N1/06 ,  C12N1/20

    摘要： The invention provides a composition containing an aqueous liquid phase, bacterial cells, and an ionic compound dissolved in the liquid phase. The ionic compound is selected from the group consisting of 1-butyl-3-methyl-imidazolium-thiocyanate, 1-butyl-3-methyl-imidazolium-2(2-methoxy-ethoxy)ethylsulfate, 1-methyl-1-[4-(3-methyl-3H-imidazol-1-ium)-but-1-yl]-3H-imidazolium-di(toluylsulfate), and 1-butyl-3-methyl-imidazolium-octylsulfate. The compositions of the invention are advantageously used for preparing lysates of biological cells, particularly bacterial cells.

    摘要翻译： 本发明提供一种含有水相液相，细菌细胞和溶于液相的离子化合物的组合物。 离子化合物选自1-丁基-3-甲基 - 咪唑鎓 - 硫氰酸酯，1-丁基-3-甲基 - 咪唑鎓-2（2-甲氧基 - 乙氧基）乙基硫酸酯，1-甲基-1- [4 - （3-甲基-3H-咪唑-1-基） - 丁-1-基] -3H-咪唑鎓 - 二（甲苯基硫酸盐）和1-丁基-3-甲基 - 咪唑鎓辛基硫酸盐。 本发明的组合物有利地用于制备生物细胞，特别是细菌细胞的裂解物。