Abstract:
A disposable endotracheal airway adapter for use in proximity of a patient's mouth in the measurement of the concentraton of respiratory gases. The disposable airway adapter of the invention provides a conduit for patient respiratory gases and allows the passage of infrared radiation through the gases for measuring the constituent concentration of the respiratory gases while keeping the patient gases from coming in contact with the analyzer mechanism. The body of the airway adapter is designed to connect in series with the airway tubing which connects a patient to a mechanical respirator or anesthesia breathing circuit. The body of the airway adapter is very light in weight and is formed of inexpensive material such as polyethylene or polypropylene so that it may be manufactured inexpensively and discarded after each use. An inexpensive optical window in the adapter is also formed of material such as polyethylene or polypropylene so that the gas analyzer can pass light into the sample for analysis. Preferably, the optical windows of the invention are made of the same material as the adapter body. Since the adapter of the invention may be disposed of after use on a single patient, sterilization expenses and cross-contamination may be minimized. Also, calibrating integrity is maintained through a calibration process which accounts for the non-linearity of the absorption spectra of the window material in the region of interest.
Abstract:
A water separator adapted for use in a gas monitor includes a gas inlet port, a gas outlet port, a two-stage gas/water separator section, and a fluid reservoir. The two-stage gas/water separator section includes a first portion defining a first chamber which communicates with the gas inlet and gas outlet ports via a connecting conduit, a second portion defining a second chamber which communicates with the first chamber and the fluid reservoir, and an intermediate portion interposed between the first and second portions and defining a constricted passage between the first and second chambers. The second chamber has a frusto-conical shape in longitudinal cross section.
Abstract:
The percentage gas concentration within a sample as measured in a conventional optical bench is derived from the composite signal of the reference beam and sample beam transmitted through a sample cell in the optical bench. The primary source, which generates the reference beam and the secondary source which generates the sample beam are driven ninety degrees out of phase. The composite signal derived from the detector in the optical bench is digitized and then integrated according to the quadrature of the primary component of the composite signal derived from the reference beam, and is also integrated according to the quadrature of the secondary component of the composite signal derived from the sample beam. What is obtained is the integral of the absolute value of the secondary component and the integral of the absolute value of the primary component of the composite signal over one cycle of the reference beam and sample beam. The ratio of these component signals is computed to obtain a signal which is related to the percentage concentration of reference gas contained within the sample.
Abstract:
A fluid handling system for use in bodily fluid analysis. The system comprises a first fluid handling module configured to interface with a main instrument. The first fluid handling module has a first fluid handling network and the first fluid handling network includes an infusate passage and an infusion fluid pressure member suitable for moving fluid within the infusate passage. The fluid handling system also has a second fluid handling module separate from the first module which is configured to interface with the main instrument. The second fluid handling module has a second fluid handling network and at least one sample analysis cell which is accessible via the second fluid handling network. The first and second modules are configured to interconnect and provide fluid communication between the first and second fluid handling network and the sample cells.
Abstract:
Systems and methods for analyzing multiple components of a fluid sample are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a first component of a fluid sample received from a patient and measure second analyte data in a second component of a fluid sample. In some embodiments, one or more portions of an optical system is movable with respect to other portions of the system in order to optically and/or electrochemically analyze multiple components of a fluid sample. In other embodiments, optical and/or electrochemical analysis can be performed simultaneously on multiple components of a fluid sample. In some embodiments, a first analyte can be measured in a sample (e.g., whole blood) before the sample is separated into its components (e.g., plasma, red blood cells, etc.), and a second analyte can be measured in a component of the sample after separation.
Abstract:
A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
Abstract:
Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
Abstract:
In certain embodiments, a method of maintaining health of a patient uses an analyte detection system. The analyte detection system is coupled to the patient such that a bodily fluid of the patient is accessible to the analyte detection system. The method includes automatically initiating and conducting a measurement of an analyte in the bodily fluid using the analyte detection system. The method further includes determining a treatment dose for the patient based on the measurement using the analyte detection system.
Abstract:
A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
Abstract:
In certain embodiments, a method samples a body fluid of a patient. The method includes providing a fluid handling system having one or more fluid passageways. The method further includes infusing an infusion fluid by way of a fluid handling system into a patient through one or more fluid passageways. The method further includes obtaining a sample of body fluid by way of a fluid handling system from a patient through one or more fluid passageways. The obtained sample is no more than 5 milliliters in volume. The method further includes analyzing at least an analyzed portion of the obtained sample by way of an analyte detection system operatively associated with the fluid handling system to determine a concentration of at least one analyte.