公开(公告)号：US09233100B2

公开(公告)日：2016-01-12

申请号：US13754969

申请日：2013-01-31

Applicant: MERIAL INC.

Inventor： Mark David Soll ,  Diane Larsen ,  Susan Mancini Cady ,  Peter Cheifetz ,  Izabela Galeska ,  Saijun Gong

IPC: A61K45/06 ,  A61K31/27 ,  A61K31/365 ,  A61K31/42 ,  A61K31/4985 ,  A61K31/7048 ,  C07D261/04 ,  A61K31/437 ,  A61K9/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/36 ,  A61K47/44 ,  A61K31/194

CPC classification number: A61K31/42 ,  A01N43/80 ,  A23K20/00 ,  A61K9/0056 ,  A61K9/0068 ,  A61K31/194 ,  A61K31/27 ,  A61K31/325 ,  A61K31/365 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/7048 ,  A61K45/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/36 ,  A61K47/42 ,  A61K47/44 ,  C07D261/04 ,  A61K2300/00

Abstract: This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

Abstract translation: 本发明涉及用于对抗动物体内寄生虫和内寄生虫的口服兽药组合物，其包含与药学上可接受的载体组合的至少一种全身作用的活性剂。 本发明还提供了用于消除，控制和预防动物中的寄生虫感染和侵染的改进方法，包括将本发明的组合物施用于有需要的动物。

公开(公告)号：US20150273045A1

公开(公告)日：2015-10-01

申请号：US14668656

申请日：2015-03-25

Applicant: MERIAL, INC.

Inventor： Tammy Kolander ,  Paulraj Lawrence ,  Russell Bey

IPC: A61K39/102 ,  C12N1/36 ,  C12N1/38 ,  A61K45/06

CPC classification number: A61K39/102 ,  A61K45/06 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C12N1/36 ,  C12N1/38

Abstract: This disclosure provides attenuated Histophilus somni strains, compositions comprising same, and methods of production and use thereof. The attenuated strains may express lower or no levels of various virulence-associated genes, relative to the corresponding pathogenic bacteria Advantageously, the attenuated Histophilus somni strains may be administered orally, intranasally, intra-tracheally, or subcutaneously.

Abstract translation: 本公开提供减毒的嗜热索氏杆菌菌株，包含其的组合物，及其生产和使用方法。 相对于相应的致病菌，减毒菌株可以表达较低或没有各种毒力相关基因的水平。有利的是，减毒的Histophilus somni菌株可以口服，鼻内，气管内或皮下给药。

公开(公告)号：US20190070117A1

公开(公告)日：2019-03-07

申请号：US16182868

申请日：2018-11-07

Applicant: Merial, Inc.

Inventor： Noel Yves Henri Jean Genin

IPC: A61K9/19 ,  F26B5/06 ,  C12N7/00 ,  A61K9/00 ,  A61K35/00 ,  A61K35/13

Abstract: The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the present invention relates to methods for vitrifying biological preparations, including peptides, antigens, antibodies, cells, and the like.

公开(公告)号：US10213509B2

公开(公告)日：2019-02-26

申请号：US16125911

申请日：2018-09-10

Applicant: Merial, Inc.

Inventor： Noel Yves Henri Jean Genin

IPC: A61K47/26 ,  A61K9/46 ,  A61K9/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/17 ,  A61K39/215 ,  A61K39/255 ,  A61K39/275 ,  A61K9/20

Abstract: The present invention relates to novel stable compressed vaccine composition comprising at least one anhydrous antigenic component comprising a stabilizer susceptible to foaming when the composition is mixed with liquid diluent; and an effective amount of a sugar alcohol.

公开(公告)号：US10206928B2

公开(公告)日：2019-02-19

申请号：US15801109

申请日：2017-11-01

Applicant: MERIAL INC.

Inventor： Rolf Valter Attstrom ,  Hugo De Bruyn

IPC: A61K31/5377 ,  A61K8/49 ,  A61Q11/00

Abstract: Use of a compound having the formula (I) in a medicament for the prevention or treatment of a disease caused by oral bacteria in an animal wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20180354917A1

公开(公告)日：2018-12-13

申请号：US15946642

申请日：2018-04-05

Applicant: MERIAL INC.

Inventor： Roelof Johannes Gorter de Vries ,  Bruno Baillon ,  Sylvaine Lafont ,  Myriam Gay de Saint Michel ,  Stephane Kozlovic

IPC: C07D261/04

Abstract: The present invention provides crystalline forms of compound of formula (Ia) and processes of making the crystalline forms. Also provided are compositions comprising the crystalline forms and methods of use of the crystalline forms.

公开(公告)号：US20180304061A1

公开(公告)日：2018-10-25

申请号：US15769664

申请日：2016-10-21

Applicant: MERIAL INC.

Inventor： Christophe Sautereau

IPC: A61M35/00 ,  B65D1/09

CPC classification number: A61M35/003 ,  A61J1/065 ,  A61M39/00 ,  B65D1/09

Abstract: A storage and manual dispenser apparatus for dispensing a pharmaceutical liquid under atmospheric pressure. This apparatus retains the liquid in a controlled and stable environment during storage.

公开(公告)号：US10080798B2

公开(公告)日：2018-09-25

申请号：US15265545

申请日：2016-09-14

Applicant: MERIAL, INC.

Inventor： Frederic David ,  Zahia Hannas-Djebbara ,  Herve Poulet ,  Jules Maarten Minke

IPC: A61K39/23 ,  C07K14/005 ,  C12N7/00 ,  A61K39/135 ,  A61K39/12 ,  A61K39/00

CPC classification number: A61K39/23 ,  A61K39/12 ,  A61K39/135 ,  A61K2039/525 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/575 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14323 ,  C12N2750/14334 ,  C12N2750/14371 ,  C12N2770/32123 ,  C12N2770/32134

Abstract: The present invention encompasses canine parvovirus (CPV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing CPV virus-like particle (VLP), and a preparation method and a use thereof. The CPV VLPs provided by the invention are formed by the CPV VP2 protein. Further, the invention broadly encompasses vaccines comprising combinations of MLV and VLP, which are capable of overcoming MDA against a variety of pathogens, which infect a variety of different species.

公开(公告)号：US10071582B2

公开(公告)日：2018-09-11

申请号：US15498933

申请日：2015-10-30

Applicant: MERIAL INC.

Inventor： Andy Brehm ,  Julie Campbell ,  Ed Schindler ,  Dennis Jerome Freeman

IPC: B41M5/24 ,  B41J3/407 ,  A61J1/18

CPC classification number: B41M5/24 ,  A61J1/18 ,  A61J2200/44 ,  B41J3/4075 ,  B41M5/26 ,  B41M5/267

Abstract: This invention relates to an apparatus and method for applying writings and other markings to a frozen vial or ampoule, which is filled with biological material, and which is held at temperatures between about −70° C. and about −196° C. More particularly, the invention relates to a laser marking method that allows frozen vials to be labeled, while maintaining the integrity of the biological material contained therein.

公开(公告)号：US20180250382A1

公开(公告)日：2018-09-06

申请号：US15846735

申请日：2016-06-23

Applicant: MERIAL INC.

Inventor： Yu-Wei Chiang ,  David Cureton ,  Herve Poulet

IPC: A61K39/145 ,  A61P31/16 ,  G01N33/569

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/70 ,  A61P31/16 ,  C12N2760/16134 ,  G01N33/56983

Abstract: The present invention relates to canine influenza virus strains, and vaccines and compositions. The present invention also relates to reagents and methods allowing their detection, methods of vaccination as well as methods of producing these reagents and vaccines.