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    EDIBLE ANIMAL CHEWS AND METHODS OF MAKING AND USING SAME
    62.
    发明申请
    EDIBLE ANIMAL CHEWS AND METHODS OF MAKING AND USING SAME 审中-公开
    可食用动物黄瓜及其使用方法

    公开(公告)号：US20170042192A1

    公开(公告)日：2017-02-16

    申请号：US15229677

    申请日：2016-08-05

    Applicant: NESTEC SA

    Inventor： Manjuan Jenny She ,  Michael E. Leiweke

    IPC: A23K40/25 ,  A23K50/42 ,  A23K20/105 ,  A23K20/158 ,  A23K20/26 ,  A23K20/24 ,  A23K10/30 ,  A23K10/20

    Abstract: Edible chews having a polygon-shaped cross-section, such as a star-shaped cross section. This cross-sectional shape provides an increased surface area and forms edges, and these features clean teeth of an animal such as a dog. These edible chews have a soft chewy texture which avoids or significantly reduces gum bleeding which is caused by known dental treats with typically have a hard texture.

    Abstract translation: 具有多边形横截面的可食用咀嚼物，例如星形横截面。 该横截面形状提供了增加的表面积并形成边缘，并且这些特征清洁了诸如狗的动物的牙齿。 这些食用咀嚼物具有柔软的耐嚼质地，其避免或显着减少由通常具有硬纹理的已知牙科治疗引起的牙龈出血。

    METHODS AND COMPOSITIONS USING FRESH OR FROZEN MEAT TO IMPROVE FOOD EFFICIENCY IN ANIMALS SUCH AS DOGS
    63.
    发明申请
    METHODS AND COMPOSITIONS USING FRESH OR FROZEN MEAT TO IMPROVE FOOD EFFICIENCY IN ANIMALS SUCH AS DOGS 审中-公开
    使用新鲜或冷冻肉类的方法和组合物，以提高动物中的食物效率，如狗

    公开(公告)号：US20170020163A1

    公开(公告)日：2017-01-26

    申请号：US15073085

    申请日：2016-03-17

    Applicant: NESTEC SA

    Inventor： Jean-Christophe Bouthegourd ,  Mark Alan Roos ,  Nathalie Clety ,  Karine Doare-Broux ,  Gwendal Lorcy

    IPC: A23K50/42 ,  A61K38/17 ,  A23K10/20 ,  A23K10/30 ,  A23K20/147 ,  A23K40/25

    CPC classification number: A23K50/42 ,  A23K10/20 ,  A23K10/30 ,  A23K20/147 ,  A23K40/25 ,  A61K38/1709

    Abstract: Methods and compositions improve amino and fatty acids availability, for example by achieving better blood enrichment in limiting amino acids, such as arginine and lysine, and essential fatty acids, such as linoleic acid. A higher fat digestibility was observed when rendered meat meal in pet food was replaced with a fresh or frozen meat slurry. A slurry can be made by subjecting fresh or frozen meat to size reduction, cooking with direct steam injection to increase the moisture of the meat, and emulsification of the steam-injected meat; and the slurry can be added to a dry blend comprising one or more of meat meals, grains, vegetable proteins, fiber, vitamins, minerals or fats in a preconditioner. The mixture formed by adding the slurry to the dry blend can be extrusion-cooked, cut into pieces, and dried to form a dry pet food kibbles.

    Abstract translation: 方法和组合物可改善氨基和脂肪酸的可用性，例如通过在限制氨基酸（例如精氨酸和赖氨酸）和必需脂肪酸（如亚油酸）中实现更好的血液富集。 当用新鲜或冷冻的肉浆代替宠物食品中的肉粉时，观察到较高的脂肪消化率。 可以通过对新鲜或冷冻的肉进行尺寸减小，直接蒸汽注射烹饪以增加肉的水分和蒸汽注射的肉的乳化来制备浆料; 并且可以在预处理器中将浆料加入到包含肉粉，谷物，植物蛋白，纤维，维生素，矿物质或脂肪中的一种或多种的干混合物中。 通过将浆料加入到干混合物中形成的混合物可以挤出煮熟，切成块，并干燥以形成干燥的宠物食品。

    METHODS AND FORMULATIONS FOR TREATMENT, REDUCTION, AND PREVENTION OF CANCER IN A COMPANION ANIMAL AND FOR THE REDUCTION OF POSTPRANDIAL BLOOD GLUCOSE IN A COMPANION ANIMAL
    65.
    发明申请
    METHODS AND FORMULATIONS FOR TREATMENT, REDUCTION, AND PREVENTION OF CANCER IN A COMPANION ANIMAL AND FOR THE REDUCTION OF POSTPRANDIAL BLOOD GLUCOSE IN A COMPANION ANIMAL 审中-公开
    用于公司动物治疗，减少和预防癌症的方法和制剂，以及在公司动物中减少血浆葡萄糖

    公开(公告)号：US20160082058A1

    公开(公告)日：2016-03-24

    申请号：US14857253

    申请日：2015-09-17

    Applicant: NESTEC SA

    Inventor： Yuanlong Pan

    IPC: A61K36/02 ,  A61K9/00 ,  A61K47/26 ,  A61K47/42 ,  A61K47/36 ,  A61K36/48 ,  A61K47/14

    CPC classification number: A61K36/02 ,  A23K50/40 ,  A23K50/42 ,  A61K9/0053 ,  A61K9/009 ,  A61K36/03 ,  A61K36/48 ,  A61K47/14 ,  A61K47/26 ,  A61K47/36 ,  A61K47/42

    Abstract: The invention provides methods for the treatment of cancer, reduction of cancer risk, or prevention of cancer in a companion animal, comprising: identifying the companion animal having cancer or at risk for cancer and feeding a dietary formulation in a therapeutically effective amount to the animal. The dietary formulation can comprise 20% to 60% protein; 10% to 40% fat; 10% to 50% carbohydrates; and 0.01% to 5% alpha-amylase inhibitor, and optionally 1% to 50% resistant starch. The therapeutically effective amount can be effective for the treatment of cancer, the prevention of cancer, or the reduction of cancer risk in the companion animal by lowering the postprandial blood glucose of the companion animal as compared to the postprandial blood glucose of the companion animal ingesting a comparable dietary formulation that excludes the alpha-amylase inhibitor.

    Abstract translation: 本发明提供了用于治疗癌症，减少癌症风险或预防伴侣动物中的癌症的方法，其包括：鉴定具有癌症或有癌症风险的伴侣动物，并将治疗有效量的膳食制剂喂给动物 。 膳食制剂可以包含20％至60％的蛋白质; 10％至40％的脂肪; 10％至5​​0％碳水化合物; 和0.01％至5％的α-淀粉酶抑制剂和任选的1％至50％抗性淀粉。 与伴侣动物摄食的餐后血糖相比，通过降低伴侣动物的餐后血糖来治疗癌症，预防癌症或降低伴侣动物的癌症风险，治疗有效量是有效的 排除α-淀粉酶抑制剂的可比较的膳食制剂。

    Methods for managing weight loss and body mass
    68.
    发明授权
    Methods for managing weight loss and body mass 有权
    减肥和体重管理方法

    公开(公告)号：US09173426B2

    公开(公告)日：2015-11-03

    申请号：US14600761

    申请日：2015-01-20

    Applicant: Nestec SA

    Inventor： Yuanlong Pan

    IPC: A23L1/29 ,  G09B19/00 ,  A23K1/18

    CPC classification number: A23L1/293 ,  A23K50/40 ,  A23L33/30 ,  A23V2002/00 ,  G09B19/0092

    Abstract: The invention provides methods for promoting weight loss by an animal, promoting weight loss by an animal while preventing or minimizing loss of lean body mass by the animal, preventing a reduction in energy metabolism by an animal, reducing the risk of regaining weight by an animal after weight loss, and ameliorating undesirable animal behaviors associated with reduced caloric intake by intermittently feeding an animal a first diet containing calories that meet the animal's maintenance energy requirements and a second diet containing calories that do not meet the animal's maintenance energy requirements. In preferred embodiments, the described feeding pattern and diets are fed in conjunction with one or more weight loss agents.

    Abstract translation: 本发明提供了促进动物体重减轻的方法，促进了动物的体重减轻，同时防止或最小化动物的瘦体重的损失，防止了动物的能量代谢降低，降低了动物体重的风险 减肥后，通过间歇地给动物喂养含有满足动物维持能量需求的卡路里的第一饮食和含有不符合动物维持能量需求的卡路里的第二饮食来改善与减少热量摄入相关的不期望的动物行为。 在优选的实施方案中，所描述的进食模式和饮食与一种或多种减肥剂一起进料。

    HER2Delta16 peptides
    70.
    发明授权
    HER2Delta16 peptides 有权
    HER2Delta16肽

    公开(公告)号：US09062096B2

    公开(公告)日：2015-06-23

    申请号：US13901210

    申请日：2013-05-23

    Applicant: Nestec SA

    Inventor： Nicholas Chi-Kwan Ling

    IPC: C07K14/71 ,  C07K16/32 ,  C07K7/64

    CPC classification number: C07K7/64 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/48569 ,  A61K47/6851 ,  C07K14/71 ,  C07K14/82 ,  C07K16/32 ,  C07K2317/24 ,  G01N33/57415

    Abstract: The present invention provides cyclic peptides comprising a dimer of peptides, each peptide comprising a sequence corresponding to the HER2 splice variant HER2Delta16, wherein the cyclic peptide is cyclized via a disulfide bond between the peptides and via an amino acid linking the peptides. The invention also provides methods of making antibodies that specifically bind to HER2Delta16 homodimers using said cyclic peptides.

    Abstract translation: 本发明提供了包含肽二聚体的环肽，每个肽包含对应于HER2剪接变体HER2Delta16的序列，其中环肽通过肽之间的二硫键和连接肽的氨基酸环化。 本发明还提供使用所述环肽制备特异性结合HER2Delta16同源二聚体的抗体的方法。

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