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公开(公告)号：US20190042826A1
公开(公告)日：2019-02-07
申请号：US16054833
申请日：2018-08-03
摘要： Provided herein are systems and computer-implemented methods for quantitative analyses of tissue sections (including, histopathology samples, such as immunohistochemically labeled or H&E stained tissue sections), involving automatic unsupervised segmentation of image(s) of the tissue section(s), measurement of multiple features for individual nuclei within the image(s), clustering of nuclei based on extracted features, and/or analysis of the spatial arrangement and organization of features in the image based on spatial statistics. Also provided are computer-readable media containing instructions to perform operations to carry out such methods. A quantitative image analysis pipeline for tumor purity estimation is also described
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公开(公告)号：US20180355348A1
公开(公告)日：2018-12-13
申请号：US16000505
申请日：2018-06-05
IPC分类号： C12N15/10
CPC分类号： C12N15/1065 , C12N15/1093 , C12Q1/6806 , C12Q1/6874 , C12Q2523/125 , C40B50/18 , C12Q2523/101 , C12Q2525/191 , C12Q2535/122 , C12Q2537/143 , C12Q2537/159 , C12Q2563/159 , C12Q2563/179
摘要： Provided herein are methods for preparing sequencing libraries for determining the methylation status of nucleic acids from a plurality of single cells. The present methods combine split-and-pool combinatorial indexing and bisulfite treatment techniques to characterize the methylation profiles of large numbers of single cells quickly, accurately and inexpensively.
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公开(公告)号：US10137177B2
公开(公告)日：2018-11-27
申请号：US15113200
申请日：2015-01-21
申请人： Oregon Health & Science University , The United States of America as respresented by the Department of Veterans Affairs
摘要： Methods of treating neuroinflammation by administration of a selective protein C activator, such as recombinant human WE thrombin and optionally one or more of its cofactors are disclosed. Also disclosed are pharmaceutical compositions for use in the treatment of mammals that exhibit symptoms of neurological inflammation. The pharmaceutical compositions and pharmacological dose comprise a safe and effective amount of WE thrombin.
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公开(公告)号：US20180327854A1
公开(公告)日：2018-11-15
申请号：US15774978
申请日：2016-11-10
发明人： Max GORDON , Paul TARDI , Jeffrey TYNER , Lawrence MAYER
IPC分类号： C12Q1/6886 , A61P35/02 , A61K9/127 , A61K31/7068 , A61K31/704 , A61K31/5377 , A61K31/407
CPC分类号： C12Q1/6886 , A61K9/127 , A61K31/407 , A61K31/44 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/553 , A61K31/704 , A61K31/7068 , A61P35/02 , C12Q1/68 , C12Q2600/106 , C12Q2600/156 , A61K2300/00
摘要： Diagnostic methods for identifying cancer bearing subjects appropriate for treatment with CPX-351 include genetic and ex vivo testing of cells from a candidate subject. Combination treatment with CPX-351 and FLT-3 inhibitors improve CPX-351 uptake and toxicity.
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公开(公告)号：US09970059B2
公开(公告)日：2018-05-15
申请号：US14540302
申请日：2014-11-13
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Arizona Board of Regents on behalf of the University of Arizona , Queen Mary University of London , Board of Regents of the University of Nebraska , Oslo University Hospital HF , Oregon Health & Science University , University of Rochester , Hospital Clinic de Barcelona , Universitat De Barcelona , British Columbia Cancer Agency Branch , Julius-Maximilians-University of Wuerzburg
发明人： Lisa Rimsza , Andrew T. Lister , Wing C. Chan , Dennis Weisenburger , Jan Delabie , Erlend B. Smeland , Harald Holte , Stein Kvaloy , Rita M. Braziel , Richard I. Fisher , Pedro Jares , Armando Lopez-Guillermo , Elias Campo Guerri , Elaine S. Jaffe , Georg Lenz , Wyndham H. Wilson , George Wright , Sandeep S. Dave , Louis M. Staudt , Randy D. Gascoyne , Joseph M. Connors , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , German Ott
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
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公开(公告)号：US09926360B2
公开(公告)日：2018-03-27
申请号：US14973033
申请日：2015-12-17
申请人： Oregon Health & Science University , The United States Government as Represented by the Department of Veterans Affairs
IPC分类号： A61K39/00 , C07K14/705 , C07K14/74 , C12N15/62 , C12N15/86
CPC分类号： C07K14/705 , A61K39/0008 , C12N15/62 , C12N15/86
摘要： The present invention provides, in particular embodiments, for modified recombinant T cell receptor (TCR) ligands (RTLs) comprising a MHC class I or MHC class II component. The modified RTLs have redesigned surface features that preclude or reduce aggregation, wherein the modified molecules retain the ability to bind Ag-peptides, target antigen-specific T cells, inhibit T cell proliferation in an Ag-specific manner and have utility to treat, inter alia, autoimmune disease and other conditions mediated by antigen-specific T cells in vivo.
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67.发明申请公开(公告)号：US20180023119A1
公开(公告)日：2018-01-25
申请号：US15656947
申请日：2017-07-21
IPC分类号： C12Q1/68
摘要： Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells. In one embodiment, the sequencing library includes whole genome nucleic acids from the plurality of single cells. In one embodiment, the method includes generating nucleosome-depleted nuclei by chemical treatment while maintaining integrity of the nuclei. Also provided herein are compositions, such as compositions that include chemically treated nucleosome-depleted isolated nuclei.
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公开(公告)号：US20180009760A1
公开(公告)日：2018-01-11
申请号：US15440458
申请日：2017-02-23
申请人： Oregon Health & Science University , The United States Government as Represented by the Department of Veterans Affairs
发明人： Michael K. Riscoe , Rolf W. Winter , Sovitj Pou , David J. Hinrichs , Jane Xu Kelly , Yuexin Li , Aaron Nilsen
IPC分类号： C07D215/46 , C07D401/12 , A61K31/47
CPC分类号： C07D215/46 , A61K31/47 , C07D401/12 , Y02A50/411
摘要： Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed.
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公开(公告)号：US09862972B2
公开(公告)日：2018-01-09
申请号：US14086602
申请日：2013-11-21
发明人： Louis Picker , Klaus Früh , Scott Hansen
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5256 , C12N7/00 , C12N2710/16121 , C12N2710/16143 , C12N2740/15034 , C12N2740/15071 , C12N2800/204 , Y02A50/386 , Y02A50/388 , Y02A50/394 , Y02A50/412 , Y02A50/466
摘要： Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of the heterologous antigen. The CMV vector may comprise a deleterious mutation in the US11 glycoprotein or a homolog thereof.
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公开(公告)号：US20170333009A1
公开(公告)日：2017-11-23
申请号：US15599387
申请日：2017-05-18
发明人： David L. Simons
CPC分类号： A61B10/0045 , F04B9/02 , F04B17/03 , F04B19/04 , F04B19/22 , F04B49/06 , F16H19/04 , F16H31/001
摘要： Disclosed are instruments used in collecting fluid samples from a subject such as, for example, aqueous humor samples. The instrument involves a linear actuator that, when engaged by the user via a switch, causes a syringe held within the instrument to collect a defined amount of sample. Kits comprising the instrument as well as methods of using the instrument to collect fluid samples are also disclosed.
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