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公开(公告)号：US20170368332A1
公开(公告)日：2017-12-28
申请号：US15674294
申请日：2017-08-10
Applicant: Oculeve, Inc.
Inventor： Douglas Michael ACKERMANN , James Donald LOUDIN , John WARDLE , Janusz KUZMA
IPC: A61N1/05 , A61N1/36 , A61H21/00 , A61H23/02 , A61F7/12 , H02J7/00 , A61N1/04 , A61N1/378 , A61H9/00 , A61H1/00 , A61N7/00 , A61M31/00
CPC classification number: A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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公开(公告)号：US20170340884A1
公开(公告)日：2017-11-30
申请号：US15676910
申请日：2017-08-14
Applicant: Oculeve, Inc.
Inventor： Manfred FRANKE , James Donald LOUDIN , John WARDLE , Mark Jeffrey HOLDBROOK
CPC classification number: A61N1/36046 , A61N1/0526 , A61N1/0546 , A61N1/3606 , A61N1/36146 , A61N1/37205 , A61N1/37247 , A61N1/3756 , A61N1/3758
Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.
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公开(公告)号：US09717627B2
公开(公告)日：2017-08-01
申请号：US14207072
申请日：2014-03-12
Applicant: Oculeve, Inc.
Inventor： Janusz Kuzma , Douglas Michael Ackermann , Christopher William Stivers
CPC classification number: A61F9/007 , A61F2/14 , A61F2/141 , A61F2/148 , A61F2/1662 , A61F9/0017 , A61M31/007 , A61M2210/0612
Abstract: Systems, devices, and methods for delivering an implant to the orbit. In some instances, the systems may include a delivery device having a tongue member and a handle. The delivery device may further include an ejector configured to deliver an implant from the tongue member. The delivery device may also include a piercing member configured to create an opening in tissue. The systems may further include a piercing member for creating an opening in tissue. In some instances, the piercing member may have a first blade member rotatably connected to a second blade member.
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公开(公告)号：US20170157401A1
公开(公告)日：2017-06-08
申请号：US15367030
申请日：2016-12-01
Applicant: Oculeve, Inc.
Inventor： James Donald LOUDIN , Manfred FRANKE , Douglas Michael ACKERMANN
IPC: A61N1/36 , A61B5/053 , A61B5/0488 , A61N1/05 , A61B5/00
CPC classification number: A61N1/36046 , A61B5/0488 , A61B5/053 , A61B5/0538 , A61B5/4848 , A61B5/6819 , A61B2562/04 , A61N1/0546 , A61N1/36014 , A61N1/36031 , A61N1/36034
Abstract: Described here are devices and methods for increasing ocular mucin and other tear protein release using intranasally delivered electrical stimulation. Generally, the devices may deliver electrical stimulation to the nasal mucosa. Intranasal stimulation may trigger degranulation of conjunctival goblet cells, which in turn releases secretory mucins into the tear fluid. The intranasal stimulation may also trigger release of lysozyme, lactoferrin, and other tear proteins into the aqueous layer of the tear film. The methods may further comprise obtaining feedback relating to the efficacy of the delivered electrical stimulation by measuring impedance or an electromyogram (EMG) signal.
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公开(公告)号：US20160114163A1
公开(公告)日：2016-04-28
申请号：US14920852
申请日：2015-10-22
Applicant: Oculeve, Inc.
Inventor： Manfred FRANKE , James Donald LOUDIN , Janusz KUZMA , Paul Taehyun YUN , Douglas Michael ACKERMANN
CPC classification number: A61N1/36046 , A61N1/3606 , A61N1/37205 , A61N1/3756 , A61N2001/37294
Abstract: Described here are systems, devices, and methods for implanting a nasal stimulator into nasal tissue and electrically stimulating nasal tissue. In some variations, a nasal microstimulator implantation system may comprise an implantation tool and an implantable microstimulator. An implantation tool may comprise a shaft and features to releasably attach a microstimulator. A microstimulator may comprise a passive stimulation circuit and one or more electrodes. In other variations, a nasal implantation system may additionally comprise one or more additional devices, such as a controller, an electrical probe, and/or a dissection tool.
Abstract translation: 这里描述了用于将鼻刺激剂植入鼻组织并电刺激鼻组织的系统，装置和方法。 在一些变型中，鼻微型刺激器植入系统可以包括植入工具和可植入微型刺激器。 植入工具可以包括轴和用于可释放地附接微刺激器的特征。 微型激励器可以包括无源刺激电路和一个或多个电极。 在其他变型中，鼻部植入系统可另外包括一个或多个附加装置，例如控制器，电探针和/或解剖工具。
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Patent Agency Ranking
公开(公告)号：US20160022992A1
公开(公告)日：2016-01-28
申请号：US14809109
申请日：2015-07-24
Applicant: Oculeve, Inc.
Inventor： Manfred FRANKE , James Donald LOUDIN
CPC classification number: A61N1/36046 , A61N1/0526 , A61N1/0546 , A61N1/3606 , A61N1/36146 , A61N1/3756
Abstract: Described herein are electrical stimulation patterns and methods of use thereof for treating dry eye disease, tired eye, or other forms of ocular discomfort. The methods generally include applying patterned stimulation to an anatomical structure located in an ocular region or a nasal region to increase tear production.
Abstract translation: 本文描述的是电刺激模式及其用于治疗干眼病，疲劳的眼睛或其它形式的眼部不适的方法。 所述方法通常包括将图案刺激应用于位于眼部区域或鼻部区域中的解剖结构以增加泪液产生。
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公开(公告)号：US20150238754A1
公开(公告)日：2015-08-27
申请号：US14630471
申请日：2015-02-24
Applicant: Oculeve, Inc.
Inventor： James Donald LOUDIN , Amitava GUPTA , John WARDLE , Christopher William STIVERS , Anand DORAISWAMY , Marie Dvorak CHRIST , F. Richard CHRIST
CPC classification number: A61N1/0546 , A61N1/0456 , A61N1/0496 , A61N1/36014 , C08F220/54 , C08F230/08 , H01B1/125 , Y10T29/49826 , Y10T29/49885 , C08F226/10 , C08F220/20 , C08F2222/1013 , C08F2230/085
Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.
Abstract translation: 本文描述的是用于促进鼻或鼻窦组织的电刺激的聚合物制剂。 聚合物制剂可以是通过UV交联方法制备的水凝胶。 可以将水凝胶作为鼻刺激装置的组分包含，以刺激泪腺以改善泪液的产生并治疗干眼症。 此外，本文描述了用于制造鼻刺激器的装置和方法，包括水凝胶的成形。
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公开(公告)号：US20140371812A1
公开(公告)日：2014-12-18
申请号：US14313937
申请日：2014-06-24
Applicant: Oculeve, Inc.
Inventor： Douglas Michael ACKERMANN , James Donald LOUDIN , John WARDLE , Jarren Armond BALDWIN , Daniel N. HAMILTON , Janusz KUZMA , Christopher William STIVERS , Manfred FRANKE
CPC classification number: A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
Abstract translation: 这里描述了通过向鼻腔或鼻窦组织提供刺激来治疗一种或多种病症（如干眼症）或改善眼部健康的装置，系统和方法。 通常，设备可以是手持式的或可植入的。 在一些变型中，手持装置可以具有刺激器主体和具有一个或多个鼻插入尖端的刺激器探针。 当装置和系统用于治疗干眼症时，可以刺激鼻或鼻窦组织以增加泪液产生，减少干眼症状和/或改善眼部表面的健康。
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公开(公告)号：US20140316485A1
公开(公告)日：2014-10-23
申请号：US14256915
申请日：2014-04-18
Applicant: Oculeve, Inc.
Inventor： Douglas Michael ACKERMANN , James Donald LOUDIN , John WARDLE , Jarren Armond BALDWIN , Daniel N. HAMILTON , Janusz KUZMA , Christopher William STIVERS
IPC: A61N1/36
CPC classification number: A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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公开(公告)号：US20140257433A1
公开(公告)日：2014-09-11
申请号：US14201753
申请日：2014-03-07
Applicant: OCULEVE, INC.
Inventor： Douglas Michael ACKERMANN , James Donald LOUDIN
CPC classification number: A61N1/37217 , A61N1/0526 , A61N1/36046
Abstract: Described here are devices, systems, and methods for treating a condition in an animal. Generally the systems include a stimulator that is implantable in the animal and a controller system configured to transmit one or more signals to the implanted stimulator. The controller system may have a controller configured to generate the one or more signals. The controller system may include one or more collars, bridles, horse hoods, cages, animal beds, and/or food bowls. The systems may be used to treat one or more conditions such as dry eye, and may treat the conditions in an animal such as a horse, dog, or cat.
Abstract translation: 这里描述了用于治疗动物状况的装置，系统和方法。 通常，系统包括可植入动物的刺激器和被配置为将一个或多个信号传输到植入的刺激器的控制器系统。 控制器系统可以具有被配置为产生一个或多个信号的控制器。 控制器系统可以包括一个或多个衣领，绷腿，马罩，笼子，动物床和/或食物碗。 该系统可用于治疗一种或多种病症如干眼症，并且可以治疗动物如马，狗或猫的病症。
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