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    Compositions and Methods for Prophylaxis and Treatment of Addictions
    66.
    发明申请
    Compositions and Methods for Prophylaxis and Treatment of Addictions 审中-公开
    预防和治疗痴呆症的组合和方法

    公开(公告)号：US20130296347A1

    公开(公告)日：2013-11-07

    申请号：US13853585

    申请日：2013-03-29

    申请人： Omeros Corporation

    发明人： Roberto Ciccocioppo

    IPC分类号： A61K31/485 ,  A61K45/06 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/519

    CPC分类号： A61K31/4439 ,  A61K31/00 ,  A61K31/135 ,  A61K31/137 ,  A61K31/138 ,  A61K31/195 ,  A61K31/197 ,  A61K31/35 ,  A61K31/4015 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/426 ,  A61K31/445 ,  A61K31/4748 ,  A61K31/485 ,  A61K31/519 ,  A61K31/55 ,  A61K31/70 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to methods of treating or preventing addiction and relapse use of addictive agents, and treating or preventing addictive or compulsive behaviour and relapse practice of an addictive behaviour or compulsion, by administering a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, alone or in combination with another therapeutic agent, such as, for example, an opioid receptor antagonist or an antidepressant, or an addictive agent, such as, for example, an opioid agonist. The present invention also includes pharmaceutical compositions for treating or preventing addiction or relapse that include a PPARγ agonist and one or more other therapeutic or addictive agents, as well as unit dosage forms of such pharmaceutical compositions, which contain a dosage effective in treating or preventing addiction or relapse. The methods and compositions of the invention are useful in the treatment or prevention of addiction to any agent, including alcohol, nicotine, marijuana, cocaine, and amphetamines, as well as compulsive and addictive behaviours, including pathological gambling and pathological overeating.

    摘要翻译： 本发明涉及通过施用过氧化物酶体增殖物激活受体γ（PPARγ）激动剂来治疗或预防成瘾性成瘾和复发使用的方法，以及治疗或预防成瘾性或强迫性行为和上瘾行为或强迫的复发实践， 单独或与另一种治疗剂（例如阿片样物质受体拮抗剂或抗抑郁药）或成瘾剂（例如阿片样物质激动剂）联合使用。 本发明还包括用于治疗或预防成瘾或复发的药物组合物，其包括PPARγ激动剂和一种或多种其它治疗或上瘾剂，以及该药物组合物的单位剂型，其含有有效治疗或预防成瘾的剂量 或复发。 本发明的方法和组合物可用于治疗或预防任何药物（包括酒精，尼古丁，大麻，可卡因和苯丙胺）的成瘾，以及强迫和上瘾行为，包括病理性赌博和病态暴饮暴食。

    COMPOSITION AND METHOD FOR DIVERSIFICATION OF TARGET SEQUENCES
    67.
    发明申请
    COMPOSITION AND METHOD FOR DIVERSIFICATION OF TARGET SEQUENCES 有权
    用于目标序列多样化的组合物和方法

    公开(公告)号：US20130261012A1

    公开(公告)日：2013-10-03

    申请号：US13802255

    申请日：2013-03-13

    申请人： University of Washington Through Its Center for Commercialization ,  OMEROS CORPORATION

    发明人： Daniel S. Allison ,  W. Jason Cummings ,  John B. Leppard ,  Nancy Maizels ,  Larry W. Tjoelker ,  Christi L. Wood ,  Munehisa Yabuki

    IPC分类号： C12N15/10

    CPC分类号： C12N15/1082 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/92

    摘要： The disclosure relates generally to the targeting of genes to, and their integration into, an immunoglobulin (antibody) heavy chain locus. In particular, the methods described herein contemplate replacing the single rearranged heavy chain V, D, and J genes of a B cell lymphoma such as DT40 with independently rearranged VH-D-JH genes of chicken, in a system for generating immunoglobulin diversity. Also contemplated is replacement of the chicken VH-D-JH with rearranged VH-D-JH genes of other vertebrates including human in a system for generating immunoglobulin diversity, with the exception of any substitution disclosed and claimed in PCT application WO 2009/029315 A2. Also described is construction of a diverse chicken immunoglobulin heavy chain VDJ library in DT40 by homologous gene replacement of the single endogenous rearranged VDJ gene with a chicken VDJ repertoire using the described targeting vectors.

    摘要翻译： 本公开一般涉及将基因靶向于免疫球蛋白（抗体）重链基因座并将其整合入免疫球蛋白（抗体）重链基因座。 特别地，本文描述的方法考虑在用于产生免疫球蛋白多样性的系统中将具有独立重排的鸡的VH-D-JH基因的B细胞淋巴瘤（例如DT40）的单重排列重链V，D和J基因替换为鸡的VH-D-JH基因。 还考虑到，除了在PCT申请WO 2009/029315A2中公开和要求保护的任何替代物之外，在用于产生免疫球蛋白多样性的系统中替换包括人在内的其他脊椎动物的重排的VH-D-JH基因的鸡VH-D-JH 。 还描述了通过使用所述靶向载体与单个内源重排的VDJ基因与鸡VDJ库的同源基因替换来构建DT40中的多种鸡免疫球蛋白重链VDJ文库。