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    Method and apparatus for positioning radioactive fluids within a body lumen
    61.
    发明授权
    Method and apparatus for positioning radioactive fluids within a body lumen 失效
    将放射性流体定位在体腔内的方法和装置

    公开(公告)号：US06413203B1

    公开(公告)日：2002-07-02

    申请号：US09154267

    申请日：1998-09-16

    Applicant: Ronald A. Sahatjian

    Inventor： Ronald A. Sahatjian

    IPC: A61N500

    CPC classification number: A61M25/104 ,  A61M2025/0004 ,  A61M2025/004 ,  A61M2025/105 ,  A61M2025/1072 ,  A61N5/1002 ,  A61N2005/1003 ,  A61N2005/1021

    Abstract: A device and method for providing radiation to selected radial portions of a segment of the interior wall of a body lumen. In a preferred embodiment, an intravascular catheter is positioned within a desired blood vessel adjacent to a lesion. A radioactive fluid is then injected into the catheter, and the catheter directs the radioactive fluid about the central axis of the vessel in the area of the lesion. This allows selected radial portions of a vessel to have a higher radiation exposure than other portions, which is particularly useful when a lesion does not uniformly extend around the entire circumference of a vessel.

    Abstract translation: 一种用于向体腔的内壁的段的选定径向部分提供辐射的装置和方法。 在优选实施例中，血管内导管位于与病变相邻的期望血管内。 然后将放射性流体注射到导管中，并且导管将放射性流体围绕血管的中心轴引导到损伤区域。 这允许血管的选定的径向部分具有比其他部分更高的辐射照射，当损伤在血管的整个圆周上不均匀地延伸时特别有用。

    Drug delivery
    62.
    发明授权
    Drug delivery 失效
    药物递送

    公开(公告)号：US06409716B1

    公开(公告)日：2002-06-25

    申请号：US08946207

    申请日：1997-10-07

    Applicant: Ronald A. Sahatjian ,  James J. Barry

    Inventor： Ronald A. Sahatjian ,  James J. Barry

    IPC: A61M3100

    CPC classification number: A61M25/104 ,  A61F2/90 ,  A61F2230/0013 ,  A61F2250/0067 ,  A61K9/0024 ,  A61K38/49 ,  A61K48/00 ,  A61L29/085 ,  A61L29/145 ,  A61L29/16 ,  A61L31/10 ,  A61L31/145 ,  A61L31/16 ,  A61L33/0023 ,  A61L33/0029 ,  A61L2300/256 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/622 ,  A61M16/0481 ,  A61M25/0045 ,  A61M2025/0046 ,  A61M2025/0057 ,  A61M2025/09183 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2205/0266 ,  C08L33/02 ,  C08L35/00

    Abstract: The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is expandable to a controlled pressure to fill the cross-section of the body lumen and press against the wall of the body lumen. In one embodiment, at least a portion of the exterior surface of the expandable portion is defined by a coating of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer and drug are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating during compression of the hydrogel polymer coating against the wall of the lumen when the expandable portion is expanded. In other embodiments the polymer is released from the expandable portion in response to pressure, to coat the wall of the body lumen.

    Abstract translation: 本发明的特征在于导管和用于将药物递送到体腔壁的所需位置处的组织的方法。 导管被构造成用于插入体腔，并且具有导管轴和安装在导管轴上的可扩张部分。 可膨胀部分可膨胀至受控的压力以填充体腔的横截面并压靠身体腔的壁。 在一个实施例中，可膨胀部分的外表面的至少一部分由强力粘附的可溶胀水凝胶聚合物的涂层限定。 掺入水凝胶聚合物中的是待递送至组织或斑块的预选药物的水溶液。 选择水凝胶聚合物和药物，以便当可膨胀部分膨胀时，水凝胶聚合物涂层在水凝胶聚合物涂层压靠内腔壁时，从水凝胶聚合物涂层快速释放所需剂量的药物。 在其它实施方案中，聚合物响应于压力从可膨胀部分释放，以涂覆体腔的壁。

    Dilatation catheter balloon made from pen based homopolymer or random copolymer
    63.
    发明授权
    Dilatation catheter balloon made from pen based homopolymer or random copolymer 失效
    由笔式均聚物或无规共聚物制成的扩张导管球囊

    公开(公告)号：US06358227B1

    公开(公告)日：2002-03-19

    申请号：US08927662

    申请日：1997-09-10

    Applicant: David A. Ferrera ,  Ronald a. Sahatjian ,  Andrew J. Campbell ,  George C. Michaels

    Inventor： David A. Ferrera ,  Ronald a. Sahatjian ,  Andrew J. Campbell ,  George C. Michaels

    IPC: A61M2900

    CPC classification number: A61L29/049 ,  A61L29/06 ,  A61M25/10 ,  Y10T428/1334 ,  Y10T428/1352 ,  C08L67/02

    Abstract: A balloon for a medical device has a structural layer of a highly crystallized PEN polymer material. The PEN polymer material being a polyethylene naphthalate homopolymer or a crystallizable copolyester made up of residues of ethylene glycol, naphthalene dicarboxylic acid (NDC) and at least one member of the group (PA) consisting of terephthalic acid and isophthalic acid. The NDC groups make up about 5% or more of the sum of NDC and PA groups in the copolymer. The balloon is characterized by an ability to withstand a hoop stress of at least 35,000 psi without bursting.

    Abstract translation: 用于医疗装置的气囊具有高度结晶的PEN聚合物材料的结构层。 PEN聚合物材料是聚萘二甲酸乙二醇酯均聚物或由乙二醇，萘二甲酸（NDC）和由对苯二甲酸和间苯二甲酸组成的组（PA）的至少一个组分的残基组成的可结晶共聚酯。 NDC组在共聚物中占NDC和PA基团的总和的约5％以上。 气球的特征在于能够承受至少35,000psi的环向应力而不发生爆裂。

    Balloon catheter
    64.
    发明授权
    Balloon catheter 失效
    气球导管

    公开(公告)号：US5693014A

    公开(公告)日：1997-12-02

    申请号：US441603

    申请日：1995-05-15

    Applicant: John E. Abele ,  Ronald A. Sahatjian

    Inventor： John E. Abele ,  Ronald A. Sahatjian

    IPC: A61F2/958 ,  A61M25/00 ,  A61M29/02 ,  A61M29/00

    CPC classification number: A61M25/104 ,  A61M25/1002 ,  A61M25/1038 ,  A61M2025/0047 ,  A61M2025/1031 ,  A61M2025/1086 ,  A61M25/0043 ,  A61M25/1029

    Abstract: An expansible balloon catheter has at least a first exterior surface with a given coefficient of friction and a second exterior surface with a greater coefficient of friction. In a compact form only the first exterior surface is exposed to produce a low coefficient of friction during transfer of the collapsed or uninflated balloon to and across a lesion. When inflated, the second surface dominates the first surface and produces an increased coefficient of friction overall thereby to stabilize the balloon in the lesion.

    Abstract translation: 可膨胀球囊导管至少具有给定摩擦系数的第一外表面和具有更大摩擦系数的第二外表面。 在紧凑形式中，仅将第一外表面暴露以在将塌缩或未膨胀的气囊转移到病变处和穿过病变处产生低摩擦系数。 当膨胀时，第二表面支配第一表面并产生增加的摩擦系数，从而使气囊在病变中稳定。

    Implantable or insertable medical device resistant to microbial growth and biofilm formation
    69.
    发明授权
    Implantable or insertable medical device resistant to microbial growth and biofilm formation 有权
    可植入或可插入的医疗器械抗微生物生长和生物膜形成

    公开(公告)号：US08105520B2

    公开(公告)日：2012-01-31

    申请号：US11040864

    申请日：2005-01-21

    Applicant: Kathleen M. Miller ,  Gregory T. Sydney ,  Kurt Geitz ,  Peter L. Dayton ,  Ronald A. Sahatjian

    Inventor： Kathleen M. Miller ,  Gregory T. Sydney ,  Kurt Geitz ,  Peter L. Dayton ,  Ronald A. Sahatjian

    IPC: B29C63/06

    CPC classification number: A61L2/232 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/21 ,  A61L2300/404 ,  A61L2300/45 ,  Y10T428/1334 ,  Y10T428/1352 ,  Y10T428/1372 ,  Y10T428/1379 ,  Y10T428/1386 ,  Y10T428/1393

    Abstract: Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

    Abstract translation: 公开了可植入或可插入的医疗装置，其在装置的环境和环境中提供对微生物生长的抵抗力，并且抵抗微生物附着和在装置上的生物膜形成。 特别地，本发明公开了可植入或可插入的医疗装置，其包括至少一个生物相容性基质聚合物区域，用于提供对微生物生长的抗性的抗微生物剂和用于抑制微生物附着的微生物粘附/生物膜合成抑制剂以及合成和积累 生物膜在医疗器械的表面上。 还公开了在基本上防止任何所述生物活性剂优先分配到生物相容性基质聚合物的表面并基本上防止所述生物活性剂的化学修饰的条件下制造这种装置的方法。

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