公开(公告)号：US20150034488A1

公开(公告)日：2015-02-05

申请号：US14448606

申请日：2014-07-31

Applicant: SURMODICS, INC.

Inventor： Aleksey V. Kurdyumov

IPC: C25D9/02 ,  C25D7/06

CPC classification number: C25D13/18 ,  C09D5/4476

Abstract: Embodiments of the invention include conductive polymeric coatings and methods of making the same. In an embodiment, the invention includes a method of electrodepositing a conductive polymeric coating onto a substrate surface. The method can include contacting the substrate surface with a solution comprising a monomer, a counterion, and a solvent; exposing the solution to an electrical potential, wherein the surface serves as an electrode in the application of the electrical potential; and alternating the electrical potential between a lower potential and a higher potential to form the conductive polymeric coating on the substrate surface. Other embodiments are also included herein.

Abstract translation: 本发明的实施方案包括导电聚合物涂层及其制备方法。 在一个实施方案中，本发明包括将导电聚合物涂层电沉积到基底表面上的方法。 该方法可以包括使基底表面与包含单体，抗衡离子和溶剂的溶液接触; 将溶液暴露于电位，其中所述表面在施加电位时用作电极; 并且在较低电位和较高电位之间交替电位以在衬底表面上形成导电聚合物涂层。 本文还包括其它实施例。

公开(公告)号：US20140121597A1

公开(公告)日：2014-05-01

申请号：US14063113

申请日：2013-10-25

Applicant: SurModics, Inc.

Inventor： Ralph A. Chappa ,  Mark F. Carlson

IPC: A61M25/10

CPC classification number: A61M25/1029 ,  A61L2400/10 ,  A61L2420/02 ,  A61M25/0009 ,  A61M25/0045 ,  A61M2025/1031 ,  B05B13/0228 ,  B05D1/002

Abstract: Embodiments of the invention include apparatus and methods for coating medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit including a fluid applicator; a first rotation mechanism and a second rotation mechanism; and a controller, wherein the controller causes the first rotation mechanism and the second rotation mechanism to rotate a medical device at substantially the same speed, wherein the speed is greater than 500 rotations per minute. In an embodiment, the invention includes a method of coating a medical device including rotating a medical device with a rotation mechanism at a speed of greater than 500 rotations per minute; contacting the medical device with a fluid applicator; and applying a coating solution to the device. In an embodiment, the invention includes a medical device. In some embodiments a surface of a shaft of the device comprises high points and low points.

Abstract translation: 本发明的实施例包括用于涂覆医疗装置的装置和方法。 在一个实施例中，本发明包括涂覆装置，其包括涂布施加单元，其包括流体施加器; 第一旋转机构和第二旋转机构; 以及控制器，其中所述控制器使得所述第一旋转机构和所述第二旋转机构以基本上相同的速度旋转医疗装置，其中所述速度大于每分钟500转。 在一个实施例中，本发明包括一种涂覆医疗装置的方法，包括以大于每分钟500转的速度旋转具有旋转机构的医疗装置; 使所述医疗装置与流体施加器接触; 并将涂布溶液涂布到该装置上。 在一个实施例中，本发明包括医疗装置。 在一些实施例中，装置的轴的表面包括高点和低点。

公开(公告)号：US20130302529A1

公开(公告)日：2013-11-14

申请号：US13886031

申请日：2013-05-02

Applicant: SurModics, Inc.

Inventor： Aleksey V. Kurdyumov

IPC: C09D5/00

CPC classification number: C09D5/00 ,  C07F5/003 ,  C07F5/02 ,  C07F5/022 ,  C07F5/025 ,  C08J7/123 ,  C08J7/18

Abstract: Embodiments of the invention include linking agents including borate, borazine, or boronate groups and coatings and devices that incorporate such linking agents, along with related methods. Other embodiments are also included herein.

Abstract translation: 本发明的实施方案包括连接剂，包括硼酸盐，环硼氮烷或硼酸酯基团，以及包含这种连接剂的涂料和装置以及相关方法。 本文还包括其它实施例。

公开(公告)号：US20040203075A1

公开(公告)日：2004-10-14

申请号：US10412063

申请日：2003-04-10

Applicant: SurModics, Inc.

Inventor： Stephen J. Chudzik ,  Dale G. Swan

IPC: G01N033/53

CPC classification number: A61K9/5026 ,  A61K9/1635 ,  A61K47/32 ,  Y10S516/911 ,  Y10S522/904 ,  Y10S623/92

Abstract: Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic null cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.

Abstract translation: 提供了具有引发剂基团和配体基团的引发剂聚合物。 引发剂聚合物能够特异性结合表面上的受体。 使用大分子单体体系，引发剂聚合物可用于在材料表面上形成聚合物基质。 特别地，提供对胰腺β细胞具有特异性的引发剂聚合物，并且可用于包封用于移植和治疗糖尿病的细胞。

公开(公告)号：US20040202774A1

公开(公告)日：2004-10-14

申请号：US10412081

申请日：2003-04-10

Applicant: SurModics, Inc.

Inventor： Stephen J. Chudzik ,  Ronald F. Ofstead ,  Dale G. Swan

IPC: B05D003/00 ,  C12N011/04

CPC classification number: C12N11/08 ,  A61K2035/126

Abstract: Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.

Abstract translation: 提供具有聚合引发剂基团和阳离子部分的带正电荷的引发剂聚合物。 引发剂聚合物可以与用于在表面上形成聚合物基质的可聚合材料一起使用。 引发剂聚合物特别适用于使用大分子单体的细胞包封。

公开(公告)号：US20030099949A1

公开(公告)日：2003-05-29

申请号：US09972116

申请日：2001-10-05

Applicant: Surmodics, Inc.

Inventor： Patrick E. Guire ,  Kristin S. Taton

IPC: C12Q001/68 ,  G01N033/53 ,  G01N033/542 ,  B05D003/00

CPC classification number: B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00382 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00641 ,  B01J2219/00644 ,  B01J2219/00648 ,  B01J2219/00659 ,  C40B60/14

Abstract: Arrays including microparticles having probe moieties are used for the detection of a target in a sample. Microparticles are immobilized in clustered arrangements on at least a portion of a substrate. A detection scheme is performed to detect a marker associated with the target which can be bound to a probe of a clustered arrangement.

Abstract translation: 包括具有探针部分的微粒的阵列用于检测样品中的靶。 微粒在基底的至少一部分上以聚集的方式被固定。 执行检测方案以检测与可以绑定到聚类布置的探针的目标相关联的标记。

公开(公告)号：US20030073086A1

公开(公告)日：2003-04-17

申请号：US09972687

申请日：2001-10-05

Applicant: Surmodics, Inc.

Inventor： Patrick E. Guire ,  Kristin S. Taton ,  John V. Wall

IPC: C12Q001/68 ,  G01N033/53 ,  G01N033/542 ,  B05D003/00 ,  C12M001/34

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00725 ,  B82Y5/00 ,  B82Y10/00 ,  C12Q1/6837 ,  G01N33/54366 ,  Y10S530/81 ,  Y10S530/811 ,  Y10S530/815 ,  Y10S530/816 ,  C12Q2563/149

Abstract: Arrays including microparticles having probe and marker moieties are used for the detection of a target in a sample. Microparticles are randomly immobilized on at least a portion of a substrate. A detection scheme is performed to detect the marker associated with the microparticle and the identity of the probe, and any target bound to the probe.

Abstract translation: 包括具有探针和标记物部分的微粒的阵列用于检测样品中的靶。 微粒随机固定在底物的至少一部分上。 执行检测方案以检测与微粒相关的标记和探针的身份以及与探针结合的任何靶标。

公开(公告)号：US11819590B2

公开(公告)日：2023-11-21

申请号：US15930128

申请日：2020-05-12

Applicant: Surmodics, Inc.

Inventor： Michael Militello ,  Ralph A. Chappa ,  Alvin A. Kucera

IPC: A61L31/00 ,  B05C21/00 ,  B05C5/02

CPC classification number: A61L31/005 ,  B05C5/0216 ,  B05C21/00 ,  A61L2420/02 ,  B05C5/0241

Abstract: Aspects herein relate to apparatus and methods for coating medical devices. In an embodiment, a coating system is included having a two-part fluid applicator defining a central channel, the two-part fluid applicator can include a first part having a first degree of flexibility; and a second part having a second degree of flexibility. The system can further include a fluid supply conduit in fluid communication with the fluid applicator; and a fluid supply reservoir in fluid communication with the fluid supply conduit. Other embodiments are also included herein.

公开(公告)号：US11730943B2

公开(公告)日：2023-08-22

申请号：US17007770

申请日：2020-08-31

Applicant: Surmodics, Inc.

Inventor： Charles Olson

IPC: A61M39/06 ,  A61B17/34 ,  A61M39/00

CPC classification number: A61M39/0606 ,  A61B17/3423 ,  A61M39/0613 ,  A61M2039/0072 ,  A61M2039/062 ,  A61M2039/064 ,  A61M2039/066 ,  A61M2039/068 ,  A61M2039/0626 ,  A61M2039/0653 ,  A61M2205/0222 ,  A61M2207/00

Abstract: Aspects herein relate to a low-friction septum for providing a leak-resistant seal for use in a vascular access device. In an embodiment, a device for vascular access hemostasis is included having an enclosure defining a cavity and configured to at least partially receive a medical device. The device can include a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The device can include a barrel in structural communication with the second seal portion, the second seal portion including a septum seal. The second seal portion can define two or more discrete portions, each separated by one or more split lines. The discrete portions can include a mating surface to interface with mating surfaces of other discrete portions. The mating surface can include a surface topology including raised portions and depressions. Other embodiments are also included herein.

公开(公告)号：US11554249B2

公开(公告)日：2023-01-17

申请号：US16413205

申请日：2019-05-15

Applicant: Surmodics, Inc.

Inventor： Karl V. Ganske

IPC: A61M25/00

Abstract: A catheter assembly includes a catheter shaft having shaft proximal and distal portions. A hub is coupled with the catheter shaft proximate the shaft proximal portion. A graduated strain relief fitting is coupled between the catheter shaft and the hub. The graduated strain relief fitting includes at least a first flexural modulus proximate the hub and a fitting proximal portion. The graduated strain relief fitting includes a second flexural modulus proximate the catheter shaft and a fitting distal portion. The second flexural modulus is less than the first flexural modulus and less than or equal to a catheter shaft flexural modulus. The first and second flexural moduli are modulated with one or more of a taper, flexure joints, fitting frame of the fitting or material of the fitting body.