公开(公告)号：US5695968A

公开(公告)日：1997-12-09

申请号：US479638

申请日：1995-06-07

Applicant: Hirokazu Nanba ,  Yukio Yamada ,  Masayuki Takano ,  Yasuhiro Ikenaka ,  Satomi Takahashi ,  Kazuyoshi Yajima

Inventor： Hirokazu Nanba ,  Yukio Yamada ,  Masayuki Takano ,  Yasuhiro Ikenaka ,  Satomi Takahashi ,  Kazuyoshi Yajima

IPC: C12N1/21 ,  C12N9/80 ,  C12N15/55 ,  C12P13/04 ,  C12P41/00 ,  C07H19/00 ,  C12N1/20 ,  C12P21/06

CPC classification number: C12P41/009 ,  C12N9/80 ,  C12P13/04

Abstract: The present invention is directed to a gene which is related to a D-N-carbamoyl-.alpha.-amino acid amidohydrolase which is an enzyme capable of converting D-N-carbamoyl-.alpha.-amino acids into D-.alpha.-amino acids; a recombinant plasmid in which a DNA fragment containing the gene is incorporated into a vector; a microorganism belonging to the genus Escherichia, Pseudomonas, Flavobacterium, Bacillus, Serratia, Corynebacterium, or Brevibacterium, which is transformed by incorporating the recombinant plasmid thereinto; a process for the production of D-N-carbamoyl-.alpha.-amino acid amidohydrolases, comprising the steps of cultivating the transformed microorganism and collecting the desired product therefrom; a D-N-carbamoyl-.alpha.-amino acid amidohydrolase obtained by the method; and a process for the production of D-.alpha.-amino acids with the aid of an action of the enzyme. The D-N-carbamoyl-.alpha.-amino acid amidohydrolase can be fixed on a support for immobilization and used as an immobilized enzyme.

Abstract translation: 本发明涉及与D-N-氨基甲酰基-α-氨基酸酰胺水解酶相关的基因，其是能够将D-N-氨基甲酰基-α-氨基酸转化为D-α-氨基酸的酶; 将含有该基因的DNA片段并入载体的重组质粒; 通过将重组质粒并入而转化的属于埃希氏杆菌属，假单胞菌属，黄杆菌属，芽孢杆菌属，沙雷氏菌属，棒状杆菌属或短杆菌属的微生物; 制备D-N-氨基甲酰基-α-氨基酸酰胺水解酶的方法，包括培养转化的微生物并从其中收集所需产物的步骤; 通过该方法获得的D-N-氨基甲酰基-α-氨基酸酰胺水解酶; 以及借助于酶的作用生产D-氨基酸的方法。 D-N-氨基甲酰基-α-氨基酸酰胺水解酶可以固定在用于固定的载体上并用作固定化酶。

公开(公告)号：US5496719A

公开(公告)日：1996-03-05

申请号：US68395

申请日：1993-05-27

Applicant: Yukio Yamada ,  Osamu Asami ,  Hidehiko Sugiyama ,  Chie Idekoba ,  Fumihiko Hoshino ,  Masana Hirai ,  Tsutomu Kajino ,  Takao Imaeda ,  Kiyoko Sarai

Inventor： Yukio Yamada ,  Osamu Asami ,  Hidehiko Sugiyama ,  Chie Idekoba ,  Fumihiko Hoshino ,  Masana Hirai ,  Tsutomu Kajino ,  Takao Imaeda ,  Kiyoko Sarai

IPC: C12N9/90 ,  A61K38/00 ,  C07K1/00 ,  C12N9/00

CPC classification number: C12N9/90

Abstract: A highly thermostable polypeptide possessing protein disulfide isomerase (PDI) activity, a gene coding for the polypeptide and a process for producing the polypeptide are provided. The polypeptide possessing PDI activity is characterized by A) having a capability of catalyzing a disulfide exchange in proteins, B) recognizing mainly ribonuclease A as a substrate, C) having a suitable active temperature of 20.degree. to 70.degree. C., D) being stable at a pH value of 6 to 9, and E) having a molecular weight of about 60,000 to 62,000. Since it has a higher thermostability and exhibits a stable activity in a wider dithiothreitol concentration range as compared with the conventional PDI, it is possible to provide a novel enzyme active protein which can be advantageously used for a refolding reaction of certain proteins. Further, a process which enables the polypeptide possessing PDI activity to be efficiently produced using Humicola insolens or a transformant transformed with an expression vector containing the above-described gene is also provided.

Abstract translation: 提供了具有蛋白质二硫键异构酶（PDI）活性的高度热稳定的多肽，编码多肽的基因和产生多肽的方法。 具有PDI活性的多肽的特征在于：A）具有催化蛋白质中二硫键交换的能力，B）主要以核糖核酸酶A为底物，C）具有20〜70℃的合适的活性温度，D）为 在pH值为6〜9的条件下稳定，E）分子量约为60,000〜62,000。 由于与常规PDI相比，具有较高的热稳定性并且在更宽的二硫苏糖醇浓度范围内表现出稳定的活性，因此可以提供可有利地用于某些蛋白质的重折叠反应的新型酶活性蛋白质。 此外，还提供了能够使用Humicola insolens或使用含有上述基因的表达载体转化的转化体有效地产生具有PDI活性的多肽的方法。

公开(公告)号：US5073823A

公开(公告)日：1991-12-17

申请号：US583595

申请日：1990-09-17

Applicant: Yukio Yamada ,  Akio Furukawa ,  Kazuki Isono

Inventor： Yukio Yamada ,  Akio Furukawa ,  Kazuki Isono

IPC: G03B15/03 ,  H04N5/225 ,  H04N5/232

CPC classification number: H04N5/232 ,  H04N5/2256 ,  Y10S358/906

Abstract: A video camera apparatus for use in a video camera or a video tape recorder having a built-in type camera in which a video light apparatus is detachably mounted to the body of the video camera, includes a circuit whereby the video light apparatus is automatically turned ON or OFF when the video camera apparatus is in a standby mode in response to a remote control signal, so that the video camera apparatus is easy to use and the video light apparatus can be operated for a longer period of time.

公开(公告)号：US4959279A

公开(公告)日：1990-09-25

申请号：US297949

申请日：1989-01-17

Applicant: Yasuzo Tanaka ,  Kaname Matsumoto ,  Yukio Yamada

Inventor： Yasuzo Tanaka ,  Kaname Matsumoto ,  Yukio Yamada

IPC: H01L39/24

CPC classification number: H01L39/2406 ,  Y10S148/901 ,  Y10S428/93 ,  Y10T29/49014 ,  Y10T428/12486 ,  Y10T428/12806

Abstract: A superconducting wire containing a multifilamentary superconducting alloy, comprising at least one composite containing a first matrix in which a plurality of superconducting alloy filaments have been arranged and a second matrix in which at least one composite is embedded; wherein said first matrix consists essentially of a metal or an alloy which does not form any intermetallic compound with the superconducting alloy filament. As the superconducting alloy filament, a Nb-Ti alloy filament may preferably be selected; the first matrix may preferably consist of one selected from the group of Nb, Ta and a Nb-Ta alloy; and the second matrix may preferably consist of Cu, A Cu-Ni alloy, Al, or an Al alloy.

Abstract translation: 一种含有多丝超导合金的超导线，包括至少一种复合材料，所述复合材料含有其中布置有多种超导合金细丝的第一基体和至少一种复合材料嵌入其中的第二基体; 其中所述第一基质基本上由不与所述超导合金细丝形成任何金属间化合物的金属或合金组成。 作为超导合金丝，优选选择Nb-Ti合金丝; 第一基体优选由选自Nb，Ta和Nb-Ta合金中的一种构成; 并且第二基体可以优选由Cu，A Cu-Ni合金，Al或Al合金组成。

公开(公告)号：US4925969A

公开(公告)日：1990-05-15

申请号：US324497

申请日：1989-03-16

Applicant: Satomi Takahashi ,  Yasuyoshi Ueda ,  Kazuhiko Yamada ,  Yukio Yamada ,  Takehiko Yamane ,  Yoshifumi Yanagita ,  Yoshio Shimada ,  Kiyoshi Watanabe ,  Michio Nomura ,  Takehisa Ohashi ,  Kenji Inoue

Inventor： Satomi Takahashi ,  Yasuyoshi Ueda ,  Kazuhiko Yamada ,  Yukio Yamada ,  Takehiko Yamane ,  Yoshifumi Yanagita ,  Yoshio Shimada ,  Kiyoshi Watanabe ,  Michio Nomura ,  Takehisa Ohashi ,  Kenji Inoue

IPC: C07C227/08 ,  C07C233/46 ,  C07C271/06

CPC classification number: C07C233/46 ,  C07C227/08 ,  C07C271/06

Abstract: Ethyl-.beta.-benzoyacrylate is reacted with an alkali metal salt of (S)-alanine or an alkali metal salt of N.sup.6 -trifluoroacetyl-L-lysine to form the corresponding Michael addition product, and not less than an equivalent amount of acid is added after completion of the Michael addition to prevent conversion of the (S,S) form of the product to the (R,S) form.

Abstract translation: 乙基-β-苯甲酸酯与（S） - 丙氨酸的碱金属盐或N6-三氟乙酰基-L-赖氨酸的碱金属盐反应形成相应的迈克尔加成产物，加入不少于等量的酸 完成迈克尔加成以防止（S，S）形式的产物转化为（R，S）形式。

公开(公告)号：US08978580B2

公开(公告)日：2015-03-17

申请号：US13145949

申请日：2010-04-12

Applicant: Yukio Yamada

Inventor： Yukio Yamada

IPC: B05B5/04 ,  B05B5/053 ,  B05B3/10 ,  B05B15/02

CPC classification number: B05B5/0535 ,  B05B3/1064 ,  B05B5/0403 ,  B05B5/0407 ,  B05B5/0426 ,  B05B5/0533 ,  B05B5/057 ,  B05B15/50

Abstract: A rotary atomizing head is mounted on a fore end side of a motor. A shaping air ring having a plurality of air outlet holes at fixed intervals is provided on a rear side of the rotary atomizing head. Outer surfaces of the air motor and outer surfaces of the shaping air ring are enshrouded over the entire circumference by a cover member formed of an electrically insulating material. An external electrode assembly is provided radially outwardly of the cover member. An annular projecting portion which projects forward is provided on the shaping air ring over the entire circumference. The air outlet holes are open in a fore distal end of this annular projecting portion. As a result, a corona discharge can be generated by allowing an electric field to be concentrated at the fore distal end of the annular protecting portion.

Abstract translation: 旋转雾化头安装在电动机的前端侧。 在旋转雾化头的后侧设有具有固定间隔的多个排气孔的整形空气环。 气动马达的外表面和成形气环的外表面通过由电绝缘材料形成的盖构件在整个圆周上被遮蔽。 外部电极组件设置在盖构件的径向外侧。 在整个圆周上的成形用空气环上设置有向前方突出的环状的突出部。 排气孔在该环状突出部的前端部开口。 结果，可以通过允许电场集中在环形保护部分的前远端处来产生电晕放电。

公开(公告)号：US08720796B2

公开(公告)日：2014-05-13

申请号：US12811127

申请日：2009-05-21

Applicant: Yukio Yamada

Inventor： Yukio Yamada

IPC: B05B3/02

CPC classification number: B05B3/1042 ,  B05B3/1064 ,  B05B5/0407 ,  F16D1/076 ,  F16D1/108

Abstract: A rotation restricting mechanism is provided between a mounting shaft section of a rotational shaft and a mounting tube section of a rotary atomizing head. The rotation restricting mechanism includes a male spline member provided on the outer peripheral side of the mounting shaft section, and a female spline member provided on the inner peripheral side of the mounting tube section. By meshing engagement of the male spline member with the female spline member, the rotation restricting mechanism restricts rotational displacements of the rotary atomizing head relative to the rotational shaft.

Abstract translation: 旋转限制机构设置在旋转轴的安装轴部和旋转雾化头的安装管部之间。 旋转限制机构包括设置在安装轴部的外周侧的阳花键部件和设置在安装管部的内周侧的阴花键部件。 通过将阳花键构件与雌花键构件啮合，旋转限制机构限制旋转雾化头相对于旋转轴的旋转位移。

公开(公告)号：US20130184272A1

公开(公告)日：2013-07-18

申请号：US13823915

申请日：2011-09-16

Applicant: Masahiro Oka ,  Yukio Yamada

Inventor： Masahiro Oka ,  Yukio Yamada

IPC: A61K31/4162 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/4709

CPC classification number: A61K31/4162 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/5377 ,  C07D495/04

Abstract: The problem of the present invention is to provide a compound useful for the prophylaxis or treatment of diseases related to the control of the differentiation of muscle cell or adipocyte differentiation, such as diabetes, obesity, dyslipidemia, and having a superior efficacy.The present invention provides an agent for the prophylaxis or treatment of diabetes, obesity or dyslipidemia, containing a compound represented by the formula (I) wherein each symbol is as defined in the DESCRIPTION, or a salt thereof or a prodrug thereof.

Abstract translation: 本发明的问题在于提供一种可用于预防或治疗与控制肌肉细胞或脂肪细胞分化如糖尿病，肥胖，血脂异常并具有优异功效的分化有关的疾病的化合物。 本发明提供一种预防或治疗糖尿病，肥胖症或血脂异常的药剂，其含有由式（I）表示的化合物，其中每个符号如说明书中所定义，或其盐或其前药。

公开(公告)号：US20120055703A1

公开(公告)日：2012-03-08

申请号：US13242712

申请日：2011-09-23

Applicant: Tomoyuki Ishimatsu ,  Yukio Yamada

Inventor： Tomoyuki Ishimatsu ,  Yukio Yamada

IPC: H05K1/09 ,  H05K3/10

CPC classification number: H05K3/361 ,  H05K3/28 ,  H05K3/323 ,  H05K2201/09154 ,  H05K2201/099 ,  Y10T29/49117 ,  Y10T29/49126 ,  Y10T29/4913 ,  Y10T29/49144 ,  Y10T29/49155

Abstract: A method for producing a joined structure, containing: after placing an anisotropic conductive film in the predetermined manner, placing a wiring member containing a wiring plate formed thereon, where the wiring plate has a resist region in which the wiring plate is covered with a resist layer, and a second electrode region in which the wiring plate is not covered with the resist layer, so that the edge of the resist region at a boundary with the second electrode region comes above the chamfer part of the substrate; and heating and compressing the anisotropic conductive film from the side of the wiring member to melt and make the anisotropic conductive film flow into the side of the resist region to thereby cover the second electrode region with the anisotropic conductive film, so as to electrically connect the first electrode region and the second electrode region.

Abstract translation: 一种接合结构体的制造方法，其特征在于，具有：在以规定的方式配置各向异性导电膜之后，配置包含布线板的配线构件，所述布线构件具有在所述布线板被抗蚀剂覆盖的抗蚀剂区域 以及布线板未被抗蚀剂层覆盖的第二电极区域，使得与第二电极区域的边界处的抗蚀剂区域的边缘位于基板的倒角部分的上方; 并且从布线部件的侧面加热和压缩各向异性导电膜以熔化，使各向异性导电膜流入抗蚀剂区域的侧面，从而利用各向异性导电膜覆盖第二电极区域，从而将 第一电极区域和第二电极区域。

公开(公告)号：US20120017842A1

公开(公告)日：2012-01-26

申请号：US13146921

申请日：2010-02-01

Applicant: Yukio Yamada ,  Hitoshi Shimizu ,  Takeshi Kimura

Inventor： Yukio Yamada ,  Hitoshi Shimizu ,  Takeshi Kimura

IPC: A01K1/03 ,  G01N21/01 ,  G01J3/44

CPC classification number: G01N21/01 ,  A01K1/0613 ,  A46D3/00 ,  A61B5/0071 ,  A61B5/0073 ,  A61B2503/40 ,  A61B2560/06 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/1787 ,  G01N2021/651

Abstract: A measurement object holder that holds a measurement object in an optical measurement instrument, wherein the optical measurement instrument takes, as the measurement object, a living body in which isotropic scattering of light occurs inside and receives light emitted from the measurement object is disclosed. The measurement object holder includes a block that is formed in a predetermined outer shape by a material having optical properties in which the isotropic scattering of light occurs inside; and a cavity portion that is formed inside the block, that has an inner shape following the outer shape of the measurement object and in which the measurement object is accommodated.

Abstract translation: 本发明公开了一种将测量对象保持在光学测量仪器中的测量对象保持器，其中所述光学测量仪器作为所述测量对象，将生物体作为测量对象的内部发生光的各向同性散射并接收从测量对象发射的光。 测量对象保持器包括通过具有光学特性的材料形成为预定的外部形状的块，其中发生光的各向同性散射; 以及形成在所述块内的空腔部，所述空腔部具有与所述测量对象的外部形状相邻并且容纳所述测量对象的内部形状。