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    Adding photoregulated amino acids to the genetic code
    61.
    发明申请
    Adding photoregulated amino acids to the genetic code 审中-公开
    将光调节氨基酸添加到遗传密码中

    公开(公告)号：US20060134746A1

    公开(公告)日：2006-06-22

    申请号：US11233508

    申请日：2005-09-21

    Applicant: Alexander Deiters ,  Ning Wu ,  Peter Schultz ,  David King ,  T. Cropp ,  Mohua Bose ,  Dan Groff ,  Jianming Xie ,  Eric Brustad

    Inventor： Alexander Deiters ,  Ning Wu ,  Peter Schultz ,  David King ,  T. Cropp ,  Mohua Bose ,  Dan Groff ,  Jianming Xie ,  Eric Brustad

    IPC: C12P21/06 ,  C07H21/04 ,  C12N9/22 ,  C12N15/74 ,  C12N1/21

    CPC classification number: C12N9/93

    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal leucyl-tRNAs, orthogonal leucyl-aminoacyl-tRNA synthetases, and orthogonal pairs of leucyl-tRNAs/synthetases, which incorporate photoregulated amino acids, OMe-L-tyrosine, α-aminocaprylic acid, or o-nitrobenzyl cysteine into proteins are provided in response to an amber selector codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with a photoregulated amino acid, OMe-L-tyrosine, α-aminocaprylic acid, or o-nitrobenzyl cysteine using these orthogonal pairs.

    Abstract translation: 生成蛋白质生物合成机理成分的组合物和方法，包括正交亮氨酰-tRNA，正交亮氨酰 - 氨基-tRNA合成酶和亮氨酰-tRNAs /合成酶的正交对，其结合光调节氨基酸，OMe-L-酪氨酸，α-氨基辛酸 酸或O-硝基苄基半胱氨酸进入蛋白质是响应于琥珀选择密码子而提供的。 还提供了用于鉴定这些正交对的方法以及使用这些正交对产生具有光调节氨基酸，OMe-L-酪氨酸，α-氨基辛酸或邻硝基苄基半胱氨酸的蛋白质的方法。

    Site-specific incorporation of redox active amino acids into proteins
    65.
    发明申请
    Site-specific incorporation of redox active amino acids into proteins 有权
    将氧化还原活性氨基酸的位点特异性掺入蛋白质

    公开(公告)号：US20050227318A1

    公开(公告)日：2005-10-13

    申请号：US10965218

    申请日：2004-10-13

    Applicant: Lital Alfonta ,  Peter Schultz ,  Zhiwen Zhang

    Inventor： Lital Alfonta ,  Peter Schultz ,  Zhiwen Zhang

    IPC: C07H21/04 ,  C12N20060101 ,  C12N1/21 ,  C12N9/00 ,  C12N9/10 ,  C12N15/74 ,  C12P21/02 ,  C12P21/06

    CPC classification number: C12N9/93 ,  C12P21/02

    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.

    Abstract translation: 提供了将氧化还原活性氨基酸掺入蛋白质的蛋白质生物合成机理组分的组成和方法，其中包括正交tRNA，正交氨基-tRNA合成酶和tRNA /合成酶正交对。 还提供了用于鉴定这些正交对的方法以及使用这些正交对产生具有氧化还原活性氨基酸的蛋白质的方法。

    Catalytic and reactive polypeptides and methods for their preparation and use
    69.
    发明授权
    Catalytic and reactive polypeptides and methods for their preparation and use 失效
    催化和反应性多肽及其制备和使用方法

    公开(公告)号：US5302516A

    公开(公告)日：1994-04-12

    申请号：US988643

    申请日：1992-12-10

    Applicant: Peter Schultz

    Inventor： Peter Schultz

    IPC: A61K47/48 ,  C07K14/00 ,  C07K16/00 ,  C12N9/00 ,  C12N9/86 ,  C12N15/10 ,  C12P21/08 ,  C12P1/00

    CPC classification number: C12N9/86 ,  A61K47/48369 ,  A61K47/48507 ,  C07K16/00 ,  C12N15/10 ,  C12N9/0002

    Abstract: Catalytic and reactive polypeptides include a binding site specific for a reactant or reactive intermediate involved in a chemical reaction of interest. The polypeptides further include at least one active functionality proximate the binding site, where the active functionality is capable of catalyzing or chemically participating in the chemical reaction in such a way that the reaction rate is enhanced. Methods for preparing the catalytic peptides include chemical synthesis, site-directed mutagenesis of antibody and enzyme genes, covalent attachment of the functionalities through particular amino acid side chains, and the like.

    Abstract translation: 催化和反应性多肽包括对涉及感兴趣的化学反应的反应物或反应性中间特异性的结合位点。 多肽还包括邻近结合位点的至少一个活性官能团，其中活性官能团能够以增加反应速率的方式催化或化学参与化学反应。 制备催化肽的方法包括化学合成，抗体和酶基因的定点诱变，通过特定氨基酸侧链的功能的共价连接等。

    Catalytic and reactive polypeptides and methods for their preparation and use
    70.
    发明授权
    Catalytic and reactive polypeptides and methods for their preparation and use 失效
    催化和反应性聚合物及其制备和使用方法

    公开(公告)号：US5215889A

    公开(公告)日：1993-06-01

    申请号：US404920

    申请日：1989-09-08

    Applicant: Peter Schultz

    Inventor： Peter Schultz

    IPC: A61K47/48 ,  C07K14/00 ,  C07K16/00 ,  C12N9/00 ,  C12N9/86 ,  C12N15/10 ,  C12P21/08

    CPC classification number: C12N9/86 ,  A61K47/48369 ,  A61K47/48507 ,  C07K16/00 ,  C12N15/10 ,  C12N9/0002

    Abstract: Catalytic and reactive polypeptides include a binding site specific for a reactant or reactive intermediate involved in a chemical reaction of interest. The polypeptides further include at least one active functionality proximate the biThis invention was made with Government support under Grant Contract No. AI-24695 awarded by the Department of Health and Human Services, under Grant Contract No. N 00014-87-K-0256, awarded by the Office of Naval Research. The Government has certain rights in this invention, under Grant Contract CHE 8822412 awarded by the National Science Foundation, and under Grant Subcontract C87-101226 awarded by the Department of Energy.

    Abstract translation: 催化和反应性多肽包括对涉及感兴趣的化学反应的反应物或反应性中间特异性的结合位点。 多肽还包括邻近结合位点的至少一个活性官能团，其中活性官能团能够以增加反应速率的方式催化或化学参与化学反应。 制备催化肽的方法包括化学合成，抗体和酶基因的定点诱变，通过特定氨基酸侧链的功能的共价连接等。

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