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322 条记录 (耗时 0.031 秒)

    Method of detecting cancer
    64.
    发明申请
    Method of detecting cancer 审中-公开
    检测癌症的方法

    公开(公告)号：US20050048480A1

    公开(公告)日：2005-03-03

    申请号：US10333015

    申请日：2001-07-18

    申请人： Yasuhhiro Tsubosa ,  Kazuhiko Aoyagi ,  Hiroki Sasaki ,  Masaaki Terada ,  Junichi Mineno ,  Kiyozo Asada ,  Ikunoshin Kato

    发明人： Yasuhhiro Tsubosa ,  Kazuhiko Aoyagi ,  Hiroki Sasaki ,  Masaaki Terada ,  Junichi Mineno ,  Kiyozo Asada ,  Ikunoshin Kato

    IPC分类号： C12N15/12 ,  C12Q1/68 ,  C12Q1/6837 ,  C12Q1/6886

    CPC分类号： C12Q1/6886 ,  C12Q1/6837 ,  C12Q2600/158

    摘要： To provide a method for selecting a marker gene useful for cancer classification; a method for classifying cancer using the gene; a method for detecting cancer; a kit usable for the classification method or detection method; and a DNA array carrying the gene. According to the present invention, there can be obtained a gene, wherein expression of the above gene is altered independently from genes each of which expression is altered specifically during cell proliferation and expression level of the above gene is specifically altered depending on every type of cancer samples to be tested, whereby the classification or detection of cancer can be carried out conveniently and quickly without giving surgical treatment. Therefore, the present invention is useful for the diagnosis, the treatment, and the like of cancer.

    摘要翻译： 提供选择用于癌症分类的标记基因的方法; 使用该基因分类癌症的方法; 一种检测癌症的方法; 可用于分类方法或检测方法的试剂盒; 和携带该基因的DNA阵列。 根据本发明，可以获得上述基因的表达独立于在细胞增殖期间特异性改变的基因的各基因的变化，并且根据每种类型的癌症特异性地改变上述基因的表达水平 待测试的样品，从而可以方便快捷地进行癌症的分类或检测，而无需外科治疗。 因此，本发明对癌症的诊断，治疗等有用。

    Processes of screening for an antimycotic agent
    66.
    发明授权
    Processes of screening for an antimycotic agent 失效
    筛选抗真菌剂的方法

    公开(公告)号：US06432664B1

    公开(公告)日：2002-08-13

    申请号：US09447223

    申请日：1999-11-23

    申请人： Takashi Okado ,  Kazutoh Takesako ,  Ikunoshin Kato

    发明人： Takashi Okado ,  Kazutoh Takesako ,  Ikunoshin Kato

    IPC分类号： C12Q118

    CPC分类号： C07K14/40 ,  A61K38/00 ,  C07K14/37 ,  C07K16/14 ,  Y10S435/822 ,  Y10S435/911 ,  Y10S530/824

    摘要： The invention provides an isolated gene coding for a protein regulating aureobasidin sensitivity; a process for cloning the gene with the use of the gene or a part of the same as a probe; a nucleic acid probe being hybridizable with the gene; an antisense DNA or RNA of the gene; a recombinant or transformant having the gene contained therein; an isolated protein regulating aureobasidin sensitivity and a process for producing the same by using the transformant; an antibody for the protein; a process for detecting the protein or the gene; and a process for screening an antimycotic by using the protein or the transformant. The invention is useful in the diagnosis and treatment of diseases including mycoses.

    摘要翻译： 本发明提供编码调节金黄担子素敏感性蛋白质的分离基因; 使用该基因或其一部分作为探针克隆该基因的方法; 核酸探针可与该基因杂交; 该基因的反义DNA或RNA; 其中含有该基因的重组体或转化体; 调节金丝桃素敏感性的分离蛋白质及其使用该转化体的方法。 蛋白质的抗体; 检测蛋白质或基因的方法; 以及通过使用蛋白质或转化体筛选抗真菌药物的方法。 本发明可用于诊断和治疗包括真菌病的疾病。

    Regulation of aureobasidin sensitivity in fungus
    67.
    发明授权
    Regulation of aureobasidin sensitivity in fungus 有权
    调控真菌中金黄色葡萄球菌敏感性

    公开(公告)号：US06348577B1

    公开(公告)日：2002-02-19

    申请号：US09414006

    申请日：1999-10-07

    申请人： Takashi Okado ,  Kazutoh Takesako ,  Ikunoshin Kato

    发明人： Takashi Okado ,  Kazutoh Takesako ,  Ikunoshin Kato

    IPC分类号： C07K1400

    CPC分类号： C07K14/38 ,  A61K38/00 ,  C07K14/37 ,  C07K14/40 ,  C07K16/14 ,  C12N15/80 ,  C12N15/90 ,  Y10S530/824

    摘要： The present invention provides a protein regulating the sensitivity of fungus to an antimycotic aureobasidin, a gene coding for this protein, the use thereof, an antibody for the protein and the use thereof. The invention is useful in the diagnosis and treatment for diseases including mycoses. The invention also provides a novel chromosome integration vector capable of imparting a novel selective marker of a drug resistance to a fungal transformant, a transformant transformed with this vector and a process for producing the same. In particular, it provides a protein capable of imparting the resistance to aureobasidin and acting as a selective marker and a DNA coding for the same.

    摘要翻译： 本发明提供调节真菌对抗真菌金黄色列生素的敏感性的蛋白质，编码该蛋白质的基因，其用途，蛋白质的抗体及其用途。 本发明可用于包括真菌病在内的疾病的诊断和治疗。 本发明还提供了一种新颖的染色体整合载体，其能够赋予对真菌转化体的耐药性的新型选择性标记，用该载体转化的转化体及其制备方法。 特别地，它提供能够赋予金黄担子素抗性并作为选择性标记的蛋白质和编码它们的DNA。

    Cyclopentenone derivative
    69.
    发明授权
    Cyclopentenone derivative 失效
    环戊烯酮衍生物

    公开(公告)号：US6136854A

    公开(公告)日：2000-10-24

    申请号：US359069

    申请日：1999-07-21

    申请人： Nobuto Koyama ,  Katsushige Ikai ,  Eiji Kobayashi ,  Ikunoshin Kato

    发明人： Nobuto Koyama ,  Katsushige Ikai ,  Eiji Kobayashi ,  Ikunoshin Kato

    IPC分类号： C07C69/013 ,  A61K31/235 ,  C07C69/52 ,  C07C69/76

    CPC分类号： C07C69/013

    摘要： Cyclopentenone derivative having a structure of 5-(R.sub.1 COO--)-4-(R.sub.2 COO--)--substituted 2-cyclopenten-1-one (R.sub.1 and R.sub.2 are some or different and each is alkyl group, alkenyl group or aryl group) or an optically active substance thereof; a method for the manufacture of the cyclopentenone derivative by the reaction of 4,5-dihydroxy-2-cyclopenten-1-one with the corresponding carboxylic acid or a reactive derivative thereof; and anticancer agent, apoptosis-inducing agent and antibacterial agent containing said derivative.

    摘要翻译： 具有5-（R 1 COO - ） - 4-（R 2 COO - ） - 取代的2-环戊烯-1-酮的结构的环戊烯酮衍生物（R 1和R 2有一些或不同，各自为烷基，烯基或芳基）或 其光学活性物质; 通过4,5-二羟基-2-环戊烯-1-酮与相应的羧酸或其活性衍生物的反应制备环戊烯酮衍生物的方法; 和抗癌剂，凋亡诱导剂和含有所述衍生物的抗菌剂。