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61.发明申请公开(公告)号：US20110137002A1
公开(公告)日：2011-06-09
申请号：US13003597
申请日：2009-07-17
申请人： Bernhard Hauer , Hans Wolfgang Höffken , Cecilia Kvarnström Branneby , Helmut Schwab , Sabine Feichtenhofer , Marlene Buchebner , Brigitte Pohn
发明人： Bernhard Hauer , Hans Wolfgang Höffken , Cecilia Kvarnström Branneby , Helmut Schwab , Sabine Feichtenhofer , Marlene Buchebner , Brigitte Pohn
CPC分类号： C12P7/62 , C08F8/12 , C12N9/16 , C12N9/18 , C12Y301/01001 , C08F120/18
摘要： The invention relates to a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. According to said method, at least one polyacrylic acid ester is provided and incubated with at least one enzyme selected from enzymes (EC 3.1) acting on ester bindings, until the ester groups contained in the polyacrylic acid ester are partially or fully hydrolytically split, and optionally the modified polymer obtained thereby is isolated. The invention also relates to the enzymes used and mutants thereof, nucleic acids coding for the enzymes, vectors comprising the nucleic acids, micro-organisms comprising the vectors, and the use of the enzymes, the vectors or the micro-organisms for carrying out a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. The present application also relates to polymer reaction products that can be obtained by the method, and methods for producing esterases.
摘要翻译： 本发明涉及聚丙烯酸酯的酶催化水解方法。 根据所述方法，提供至少一种聚丙烯酸酯，并与至少一种选自作用于酯结合的酶（EC3.1）的酶一起温育，直到聚丙烯酸酯中所含的酯基部分或完全水解分裂为止，以及 由此分离获得的改性聚合物。 本发明还涉及使用的酶及其突变体，编码酶的核酸，包含核酸的载体，包含载体的微生物，以及使用酶，载体或微生物进行酶 聚丙烯酸酯酶催化水解的方法。 本申请还涉及可以通过该方法获得的聚合物反应产物和生产酯酶的方法。
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公开(公告)号：US20100267083A1
公开(公告)日：2010-10-21
申请号：US12422666
申请日：2009-04-13
申请人： Bernhard Hauer , Juergen Pleiss , Ulrich Schwaneberg , Jutta Schmitt , Markus Fischer , Rolf Schmid , Qing-shan Li
发明人： Bernhard Hauer , Juergen Pleiss , Ulrich Schwaneberg , Jutta Schmitt , Markus Fischer , Rolf Schmid , Qing-shan Li
CPC分类号： C12P7/6409 , C12N9/0071 , C12N9/0077 , C12P7/02 , C12P7/04 , C12P7/22 , C12P7/42 , C12P17/10 , C12P17/165 , C12Q1/26 , G01N2333/90245
摘要： The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to recombinant microorganisms which comprise these vectors, and to processes for the microbiological production of terminally or subterminally hydroxylated aliphatic carboxylic acids.
摘要翻译： 本发明涉及具有改变的底物轮廓的修饰的细胞色素P450单加氧酶，其编码的核酸序列，表达构建体和载体，包含这些载体的重组微生物，以及用于微生物生产末端或中性羟基化脂族羧酸的方法 酸。
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公开(公告)号：US07553648B2
公开(公告)日：2009-06-30
申请号：US10398178
申请日：2001-10-16
申请人： Bernhard Hauer , Rolf Schmid , Rainer Merkl , Francesca Blasco
发明人： Bernhard Hauer , Rolf Schmid , Rainer Merkl , Francesca Blasco
CPC分类号： C12N9/0077 , C12P1/04
摘要： The invention relates to novel cytochrome P450 monooxygenases from thermophilic bacteria, in particular the genus Thermus sp., to nucleotide sequences encoding them, to the recombinant production of these monooxygenases and to their use for the microbiological oxidation of organic compounds.
摘要翻译： 本发明涉及来自嗜热细菌，特别是栖热菌属的新型细胞色素P450单加氧酶与编码它们的核苷酸序列，重组生产这些单加氧酶及其用于微生物氧化有机化合物的新型细胞色素P450单加氧酶。
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公开(公告)号：US20060141593A1
公开(公告)日：2006-06-29
申请号：US10545075
申请日：2004-01-28
申请人： Dietmar Haring , Eva Wagner , Bernd Bruchmann , Erich Beck , Bernhard Hauer
发明人： Dietmar Haring , Eva Wagner , Bernd Bruchmann , Erich Beck , Bernhard Hauer
IPC分类号： C12P7/62
CPC分类号： C08F220/26 , C12P7/04 , C12P7/06 , C12P7/62 , C12P17/181 , Y02E50/17 , Y02T50/678
摘要： A method for the production of partially esterified (meth)acrylic acid esters of polyalcohols and the use thereof.
摘要翻译： 一种多元醇部分酯化（甲基）丙烯酸酯的制造方法及其用途。
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公开(公告)号：US20060030013A1
公开(公告)日：2006-02-09
申请号：US10535525
申请日：2003-11-21
IPC分类号： C08F118/02 , C12P7/62
摘要： The invention relates to a process for the enzymatic synthesis of polyol acrylates and also to a process for preparing polymeric polyol acrylates, to the polymers obtainable by this process, and to their use for preparing radiation-curable and thermally curable coating materials.
摘要翻译： 本发明涉及一种用于酶促合成多元醇丙烯酸酯的方法，还涉及一种制备聚合多元醇丙烯酸酯的方法，可通过该方法获得的聚合物及其用于制备可辐射固化和可热固化涂料的用途。
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公开(公告)号：US20050255571A1
公开(公告)日：2005-11-17
申请号：US10493210
申请日：2002-10-17
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/20 , C12N15/55 , C12P41/00 , C12P7/62 , C12P7/40
CPC分类号： C12N9/20
摘要： The invention relates to a lipase variant which can be prepared by carrying out, on the amino acid sequence of a starting lipase selected from the lipase homologous family I.1 or I.2, at least one amino acid substitution in those positions which correspond to the positions 17, 29, 30, 52, 86, 117, 122, 160, 163, 167, 265, 266, 286, 289 in the prototype lipase sequence SEQ ID NO: 1.
摘要翻译： 本发明涉及脂酶变体，其可通过在选自脂肪酶同源家族I.1或I.2的起始脂肪酶的氨基酸序列上进行至少一个氨基酸取代而制备， 原型脂肪酶序列SEQ ID NO：1中的位置17,29,30,25,66,117,122,160,163,167,265,266,286,289。
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公开(公告)号：US06828115B1
公开(公告)日：2004-12-07
申请号：US10031702
申请日：2002-01-23
IPC分类号： C12Q134
摘要： A description is given of epoxide hydrolases from bacteria of the genus Streptomyces, a novel process for the enzymatic separation of epoxide enantiomeric mixtures, of a novel detection method for epoxide hydrolase activity, a screening method for detecting epoxide hydrolase activity and the use of bacteria of the genus Streptomyces and of the resultant epoxide hydrolases for enantioselective epoxide hydrolysis.
摘要翻译： 描述了链霉菌属细菌的环氧化物水解酶，环氧化物对映异构体混合物的酶分离的新方法，环氧化物水解酶活性的新型检测方法，环氧化物水解酶活性的筛选方法和细菌的使用 链霉菌属和所得环氧化物水解酶用于对映选择性环氧化物水解。
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68.发明授权公开(公告)号：US06432685B1
公开(公告)日：2002-08-13
申请号：US09673149
申请日：2000-10-11
申请人： Bernhard Hauer , Wolfgang Wohlleben , Peter Fischer , Sabine Lutz-Wahl , Claudia Schmidt-Dannert , Rolf D. Schmid , Oliver Scherr
发明人： Bernhard Hauer , Wolfgang Wohlleben , Peter Fischer , Sabine Lutz-Wahl , Claudia Schmidt-Dannert , Rolf D. Schmid , Oliver Scherr
IPC分类号： C12P704
摘要： The invention relates to a process for the oxidation of substituted trimethylcyclohexenyl compounds in the presence of microorganisms of the order Actinomycetales and to the use of microorganisms in oxidation reactions.
摘要翻译： 本发明涉及一种在放线菌纲的微生物存在下氧化取代的三甲基环己烯基化合物的方法以及在氧化反应中使用微生物的方法。
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69.发明授权Process for the hydroxylation of aromatic acids using strains of the fungus Beauveria 失效使用真菌白僵菌株的芳香酸羟基化的方法
公开(公告)号：US5928912A
公开(公告)日：1999-07-27
申请号：US566589
申请日：1995-12-04
申请人： Wolfgang Ladner , Horst Ralf Staudenmaier , Bernhard Hauer , Ursula Mueller , Uwe Pressler , Joachim Meyer , Hardo Siegel
发明人： Wolfgang Ladner , Horst Ralf Staudenmaier , Bernhard Hauer , Ursula Mueller , Uwe Pressler , Joachim Meyer , Hardo Siegel
IPC分类号： C12P7/42
CPC分类号： C12P7/42 , Y10S435/911
摘要： A process for hydroxylating compounds of the formula ##STR1## where n, A and R.sup.1 to R.sup.4 have the meanings stated in the description, with the aid of microorganisms of the genus Beauveria.
摘要翻译： 羟基化下式化合物的方法其中n，A和R1至R4具有说明书中所述的含义，借助于白僵菌属的微生物。
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公开(公告)号：US5663329A
公开(公告)日：1997-09-02
申请号：US641773
申请日：1996-04-30
申请人： Horst Ralf Staudenmaier , Bernhard Hauer , Friedhelm Balkenhohl , Wolfgang Ladner , Ursula Schnell , Uwe Pressler
发明人： Horst Ralf Staudenmaier , Bernhard Hauer , Friedhelm Balkenhohl , Wolfgang Ladner , Ursula Schnell , Uwe Pressler
IPC分类号： C12P17/10 , C12P41/00 , C12R1/01 , C12R1/38 , C07D205/08 , C07D201/02 , C07D207/26 , C07D211/88
CPC分类号： C12P17/10 , C12P41/001
摘要： A process for preparing enantiomerically pure lactams of the formula I ##STR1## where R.sup.1 and R.sup.2 are each, independently of one another, H, unsubstituted or substituted C.sub.1 -C.sub.4 -alkyl, unsubstituted or substituted C.sub.2 -C.sub.4 -alkenyl, unsubstituted or substituted aryl, (CH.sub.2).sub.n --COOH with n=0, 1, 2, 3, and X is 1, 2, 3, 4, 5, from a racemate of the formula I by. allowing a biocatalyst which selectively converts one enantiomer from I to act on the racemic mixture of I, and isolating the unconverted enantiomer from the resulting mixture of products.
摘要翻译： 制备式I的对映体纯的内酰胺的方法其中R 1和R 2各自独立地为H，未取代或取代的C 1 -C 4 - 烷基，未取代或取代的C 2 -C 4 - 烯基，未取代或取代的 芳基，（CH 2）n -COOH，其中n = 0,1,2,3和X为1,2,3,4,5，式I的外消旋物为。 允许选择性地将I的一种对映异构体转化为I的外消旋混合物的生物催化剂，并从所得产物混合物中分离未转化的对映异构体。
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