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公开(公告)号：US20100267083A1
公开(公告)日：2010-10-21
申请号：US12422666
申请日：2009-04-13
申请人： Bernhard Hauer , Juergen Pleiss , Ulrich Schwaneberg , Jutta Schmitt , Markus Fischer , Rolf Schmid , Qing-shan Li
发明人： Bernhard Hauer , Juergen Pleiss , Ulrich Schwaneberg , Jutta Schmitt , Markus Fischer , Rolf Schmid , Qing-shan Li
CPC分类号： C12P7/6409 , C12N9/0071 , C12N9/0077 , C12P7/02 , C12P7/04 , C12P7/22 , C12P7/42 , C12P17/10 , C12P17/165 , C12Q1/26 , G01N2333/90245
摘要： The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to recombinant microorganisms which comprise these vectors, and to processes for the microbiological production of terminally or subterminally hydroxylated aliphatic carboxylic acids.
摘要翻译： 本发明涉及具有改变的底物轮廓的修饰的细胞色素P450单加氧酶，其编码的核酸序列，表达构建体和载体，包含这些载体的重组微生物，以及用于微生物生产末端或中性羟基化脂族羧酸的方法 酸。
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公开(公告)号：US07531335B1
公开(公告)日：2009-05-12
申请号：US10031695
申请日：2000-07-27
申请人： Bernhard Hauer , Juergen Pleiss , Ulrich Schwaneberg , Jutta Schmitt , Markus Fischer , Rolf Schmid , Qing-shan Li
发明人： Bernhard Hauer , Juergen Pleiss , Ulrich Schwaneberg , Jutta Schmitt , Markus Fischer , Rolf Schmid , Qing-shan Li
IPC分类号： C12N9/02 , C12N15/00 , C12N1/20 , C12P7/00 , C12P21/04 , C12Q1/26 , C07H21/04 , C12Q1/00 , C12Q1/68
CPC分类号： C12P7/6409 , C12N9/0071 , C12N9/0077 , C12P7/02 , C12P7/04 , C12P7/22 , C12P7/42 , C12P17/10 , C12P17/165 , C12Q1/26 , G01N2333/90245
摘要： The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to recombinant microorganisms which comprise these vectors, and to processes for the microbiological production of terminally or subterminally hydroxylated aliphatic carboxylic acids.
摘要翻译： 本发明涉及具有改变的底物轮廓的修饰的细胞色素P450单加氧酶，其编码的核酸序列，表达构建体和载体，包含这些载体的重组微生物，以及用于微生物生产末端或中性羟基化脂族羧酸的方法 酸。
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公开(公告)号：US07981652B2
公开(公告)日：2011-07-19
申请号：US12422666
申请日：2009-04-13
申请人： Bernhard Hauer , Juergen Pleiss , Ulrich Schwaneberg , Jutta Schmitt , Markus Fischer , Rolf Schmid , Qing-shan Li
发明人： Bernhard Hauer , Juergen Pleiss , Ulrich Schwaneberg , Jutta Schmitt , Markus Fischer , Rolf Schmid , Qing-shan Li
CPC分类号： C12P7/6409 , C12N9/0071 , C12N9/0077 , C12P7/02 , C12P7/04 , C12P7/22 , C12P7/42 , C12P17/10 , C12P17/165 , C12Q1/26 , G01N2333/90245
摘要： The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to recombinant microorganisms which comprise these vectors, and to processes for the microbiological production of terminally or subterminally hydroxylated aliphatic carboxylic acids.
摘要翻译： 本发明涉及具有改变的底物轮廓的修饰的细胞色素P450单加氧酶，其编码的核酸序列，表达构建体和载体，包含这些载体的重组微生物，以及用于微生物生产末端或中性羟基化脂族羧酸的方法 酸。
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4.发明授权Cytochrome p450 monooxygenases and their use for oxidizing organic compounds 有权细胞色素p450单加氧酶及其用于氧化有机化合物的用途公开(公告)号：US07960155B1
公开(公告)日：2011-06-14
申请号：US10031146
申请日：2000-07-27
申请人： Bernhard Hauer , Juergen Pleiss , Ulrich Schwaneberg , Jutta Schmitt , Markus Fischer , Rolf Schmid , Qing-shan Li , Sabine Lutz-Wahl , Daniel Appel
发明人： Bernhard Hauer , Juergen Pleiss , Ulrich Schwaneberg , Jutta Schmitt , Markus Fischer , Rolf Schmid , Qing-shan Li , Sabine Lutz-Wahl , Daniel Appel
IPC分类号： C12N9/02 , C12N1/20 , C12N15/00 , C12P7/00 , C12P21/04 , C12Q1/26 , C12Q1/00 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/0071 , C12P7/02 , C12P7/04 , C12P7/22 , C12P7/6409 , C12P17/10 , C12P17/165 , C12Q1/26 , G01N2333/90245
摘要： The invention relates to novel cytochrome P450 monooxygenases comprising a modified substrate specificity, to nucleotide sequences which code therefor, to expression constructs and vectors containing these sequences, and to microorganisms transformed therewith. The invention also relates to methods for microbiologically oxidizing different organic substrates, such as methods for producing indigo and indirubin.
摘要翻译： 本发明涉及包含修饰的底物特异性的新型细胞色素P450单加氧酶，其编码的核苷酸序列，含有这些序列的表达构建体和载体以及与其转化的微生物。 本发明还涉及用于微生物氧化不同有机底物的方法，例如生产靛蓝和靛玉红的方法。
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公开(公告)号：US09187737B2
公开(公告)日：2015-11-17
申请号：US12306703
申请日：2007-06-26
CPC分类号： C12N9/16 , C12P7/62 , C12P41/003
摘要： The invention relates to novel proteins having esterase activity, to mutants thereof, to nucleic acid sequences coding therefor, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.
摘要翻译： 本发明涉及具有酯酶活性的新型蛋白质，其突变体与其编码的核酸序列，表达盒，载体和重组微生物; 涉及用于制备所述蛋白质的方法及其用于酶，特别是对映选择性酶，酯水解或酯交换有机酯的用途。
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公开(公告)号：US20100068760A1
公开(公告)日：2010-03-18
申请号：US12306703
申请日：2007-06-26
CPC分类号： C12N9/16 , C12P7/62 , C12P41/003
摘要： The invention relates to novel proteins having esterase activity, to mutants thereof, to nucleic acid sequences coding therefor, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.
摘要翻译： 本发明涉及具有酯酶活性的新型蛋白质，其突变体与其编码的核酸序列，表达盒，载体和重组微生物; 涉及用于制备所述蛋白质的方法及其用于酶，特别是对映选择性酶，酯水解或酯交换有机酯的用途。
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公开(公告)号：US20100189777A1
公开(公告)日：2010-07-29
申请号：US12669581
申请日：2008-07-07
CPC分类号： A61K9/1273 , A61K47/6911 , A61K47/6919 , B82Y5/00 , Y10T428/2984
摘要： The invention is directed to vesicles comprising at least one transmembrane triggered transport system for controlled transmembrane efflux and/or influx.
摘要翻译： 本发明涉及包含至少一个跨膜触发的转运系统用于受控跨膜流出和/或流入的囊泡。
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公开(公告)号：US20130005637A1
公开(公告)日：2013-01-03
申请号：US13583602
申请日：2011-03-10
申请人： Petra Siegert , Ulrich Schwaneberg , Ronny Martinez , Marion Merkel , Astrid Spitz , Susanne Wieland , Hendrik Hellmuth , Karl-Heinz Maurer
发明人： Petra Siegert , Ulrich Schwaneberg , Ronny Martinez , Marion Merkel , Astrid Spitz , Susanne Wieland , Hendrik Hellmuth , Karl-Heinz Maurer
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681
摘要： Proteases encompassing an amino acid sequence that is at least 70% identical to the amino acid sequence indicated in SEQ ID NO. 1 over its entire length, and exhibit the amino acid substitution I21V in the count in accordance with SEQ ID NO. 1, resp. agents that encompass such proteases, display very good cleaning performance on protease-sensitive stains.
摘要翻译： 包含与SEQ ID NO：1所示的氨基酸序列至少70％相同的氨基酸序列的蛋白酶。 1，并且按照SEQ ID NO：1显示计数中的氨基酸取代度I21V。 1，或 包含这种蛋白酶的试剂在蛋白酶敏感染色剂上表现出非常好的清洁性能。
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公开(公告)号：US20120295311A1
公开(公告)日：2012-11-22
申请号：US13466656
申请日：2012-05-08
CPC分类号： C12N15/66 , C12N15/1027
摘要： The present invention is concerned with the field of nucleic acid manipulation and particularly DNA manipulation, and uses thereof. Specifically, the invention pertains to methods involving the joining of nucleic acids and uses of such joined nucleic acids, for example for creating transformed microorganisms. Also, the invention pertains to materials useful in such methods.
摘要翻译： 本发明涉及核酸操作领域，特别是DNA操作领域及其应用。 具体地，本发明涉及涉及核酸的连接和这种连接的核酸的用途的方法，例如用于产生转化的微生物。 此外，本发明涉及在这些方法中有用的材料。
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公开(公告)号：US20090182137A1
公开(公告)日：2009-07-16
申请号：US10588205
申请日：2005-02-02
CPC分类号： C12N15/1006 , C12Q2563/119 , C12Q2563/161
摘要： The invention relates to methods of separating substances from liquid media and to separating agents suitable therefor.
摘要翻译： 本发明涉及从液体介质和分离剂分离物质的方法。
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