公开(公告)号：US20130072930A1

公开(公告)日：2013-03-21

申请号：US13677648

申请日：2012-11-15

Applicant: Yoav Ben-Haim ,  Peter J. Bentley ,  Dong Hoon Chun ,  Daniel Francis ,  Jessi E. Johnson ,  Kevin Shan ,  Ted Su ,  Steven Kim

Inventor： Yoav Ben-Haim ,  Peter J. Bentley ,  Dong Hoon Chun ,  Daniel Francis ,  Jessi E. Johnson ,  Kevin Shan ,  Ted Su ,  Steven Kim

IPC: A61B18/18

CPC classification number: A61B18/1815 ,  A61B2017/00681 ,  A61B2018/00023 ,  A61B2018/00291 ,  A61B2018/00452 ,  A61B2018/00821 ,  A61N5/04

Abstract: An tissue interface module has an applicator chamber on a proximal side of the tissue interface module and a tissue acquisition chamber on a distal side of the tissue interface module. The applicator chamber may include: an opening adapted to receive the applicator; an attachment mechanism positioned in the applicator chamber and adapted to attach the tissue interface module to the applicator; a sealing member positioned at a proximal side of the applicator chamber; and a vacuum interface positioned at a proximal side of the applicator chamber and adapted to receive a vacuum inlet positioned on a distal end of the applicator. The invention also includes corresponding methods.

公开(公告)号：US20130035680A1

公开(公告)日：2013-02-07

申请号：US13563656

申请日：2012-07-31

Applicant: Yoav Ben-Haim ,  Peter J. Bentley ,  Dong Hoon Chun ,  Daniel Francis ,  Jessi E. Johnson ,  Kevin Shan ,  Ted Su ,  Steven Kim

Inventor： Yoav Ben-Haim ,  Peter J. Bentley ,  Dong Hoon Chun ,  Daniel Francis ,  Jessi E. Johnson ,  Kevin Shan ,  Ted Su ,  Steven Kim

IPC: A61B18/18

CPC classification number: A61B18/1815 ,  A61B2017/00681 ,  A61B2018/00023 ,  A61B2018/00291 ,  A61B2018/00452 ,  A61B2018/00821 ,  A61N5/04

Abstract: An tissue interface module has an applicator chamber on a proximal side of the tissue interface module and a tissue acquisition chamber on a distal side of the tissue interface module. The applicator chamber may include: an opening adapted to receive the applicator; an attachment mechanism positioned in the applicator chamber and adapted to attach the tissue interface module to the applicator; a sealing member positioned at a proximal side of the applicator chamber; and a vacuum interface positioned at a proximal side of the applicator chamber and adapted to receive a vacuum inlet positioned on a distal end of the applicator. The invention also includes corresponding methods.

Abstract translation: 组织接口模块在组织接口模块的近侧具有施用室，在组织接口模块的远端侧具有组织采集室。 施用器室可以包括：适于接收施用器的开口; 定位在所述施用器腔室中并适于将所述组织界面模块附接到所述施用器的附接机构; 位于所述施用器腔室的近侧的密封构件; 以及真空接口，其定位在所述施用器腔室的近侧，并且适于接纳位于所述施用器的远端上的真空入口。 本发明还包括相应的方法。

公开(公告)号：US08313486B2

公开(公告)日：2012-11-20

申请号：US12696966

申请日：2010-01-29

Applicant: Steven Kim ,  Kyle R. Rick ,  Mani N. Prakash

Inventor： Steven Kim ,  Kyle R. Rick ,  Mani N. Prakash

IPC: A61B18/18

CPC classification number: A61B18/1815 ,  A61B8/12 ,  A61B18/1206 ,  A61B18/18 ,  A61B90/37 ,  A61B2018/1861 ,  A61B2018/1869 ,  A61B2090/374 ,  A61B2090/378

Abstract: An ablation device includes an antenna assembly having a radiating portion configured to deliver energy from a power source to tissue. The radiating portion has an outer conductor and an inner conductor. The inner conductor is disposed within the outer conductor. The device also includes an imaging device operably coupled to the radiating portion. The imaging device is configured to generate imaging data corresponding to tissue proximate the radiating portion of the antenna assembly.

Abstract translation: 消融装置包括天线组件，其具有被配置为将能量从电源传送到组织的辐射部分。 辐射部分具有外部导体和内部导体。 内导体设置在外导体内。 该装置还包括可操作地耦合到辐射部分的成像装置。 成像装置被配置为产生对应于靠近天线组件的辐射部分的组织的成像数据。

公开(公告)号：US08192423B2

公开(公告)日：2012-06-05

申请号：US13214503

申请日：2011-08-22

Applicant: Roman Turovskiy ,  Ted Su ,  Mani Prakash ,  Steven Kim

Inventor： Roman Turovskiy ,  Ted Su ,  Mani Prakash ,  Steven Kim

IPC: A61B18/18

CPC classification number: A61B18/1815 ,  A61B18/18 ,  A61B2018/00011 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/1838 ,  A61B2018/1846 ,  A61B2018/1853 ,  H01Q9/22

Abstract: High-strength microwave antenna assemblies and methods of use are described herein. The microwave antenna has a radiating portion connected by a feedline to a power generating source, e.g., a generator. Proximal and distal radiating portions of the antenna assembly are separated by a junction member. A reinforcing member is disposed within the junction member to increase structural rigidity.

Abstract translation: 这里描述了高强度微波天线组件和使用方法。 微波天线具有通过馈线连接到发电源（例如发电机）的辐射部分。 天线组件的近端和远端辐射部分由连接部件分开。 加强构件设置在接合构件内以增加结构刚度。

公开(公告)号：US20120022622A1

公开(公告)日：2012-01-26

申请号：US13246820

申请日：2011-09-27

Applicant: Jessi Ernest Johnson ,  Mark E. Deem ,  Daniel Francis ,  Steven Kim ,  Alexey Salamini ,  Ted Su ,  Peter Smith ,  Daniel Hallock ,  Yoav Ben-Haim ,  Shailendhar Saraf

Inventor： Jessi Ernest Johnson ,  Mark E. Deem ,  Daniel Francis ,  Steven Kim ,  Alexey Salamini ,  Ted Su ,  Peter Smith ,  Daniel Hallock ,  Yoav Ben-Haim ,  Shailendhar Saraf

IPC: A61N5/02

CPC classification number: A61N5/022 ,  A61N5/04

Abstract: The present invention is directed to systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy. In one embodiment of the invention a medical device and associated apparatus and procedures are used to treat dermatological conditions using microwave energy.

Abstract translation: 本发明涉及使用微波能量对组织进行非侵入性处理的系统，装置，方法和程序。 在本发明的一个实施例中，使用医疗装置和相关联的装置和程序来使用微波能量来治疗皮肤病学条件。

公开(公告)号：US08070768B2

公开(公告)日：2011-12-06

申请号：US11407701

申请日：2006-04-19

Applicant: Steven Kim ,  Joshua Makower

Inventor： Steven Kim ,  Joshua Makower

IPC: A61M29/00

CPC classification number: A61F5/003 ,  A61B17/0401 ,  A61B2017/00557 ,  A61B2017/0414 ,  A61B2017/0417 ,  A61B2017/0441

Abstract: Implantable devices, instruments, kits and methods for treatment of obesity. One or more devices can be implanted adjacent to or in contact with the stomach to occupy a space to prevent the stomach from expanding into that space as food is taken into the stomach. Alternatively, one or more devices may be implanted and expanded to displace at least a portion of the wall of the stomach to decrease the internal volume of the stomach that is available to receive food. Devices may be anchored to one or more internal structures at one or more locations without piercing through the wall of the stomach. Devices can be implanted using minimally invasive methods, such as percutaneous or laparoscopic methods. Delivery instruments are also provided. An intra-gastric sizing device is provided to facilitate implantation of an extra-gastric device in some method embodiments.

Abstract translation: 用于治疗肥胖的可植入装置，器械，试剂盒和方法。 一个或多个装置可以被植入在胃附近或与胃接触以占据一个空间，以防止胃在胃中被引入到该空间中。 或者，可以将一个或多个装置植入和扩张以置换胃壁的至少一部分以减小可用于接收食物的胃的内部体积。 设备可以在一个或多个位置处锚定到一个或多个内部结构，而不穿透胃的壁。 可以使用微创方法植入装置，例如经皮或腹腔镜方法。 还提供交货工具。 在一些方法实施例中提供胃内施加装置以便于植入胃外装置。

公开(公告)号：US08035570B2

公开(公告)日：2011-10-11

申请号：US12419395

申请日：2009-04-07

Applicant: Mani N. Prakash ,  Francesca Rossetto ,  Anthony C. Lee ,  Steven Kim ,  Ted Su ,  Jonathan L. Glassman

Inventor： Mani N. Prakash ,  Francesca Rossetto ,  Anthony C. Lee ,  Steven Kim ,  Ted Su ,  Jonathan L. Glassman

IPC: H01Q9/04

CPC classification number: A61B18/1815 ,  A61B18/18 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00136 ,  A61B2018/00142 ,  A61B2018/00178 ,  A61B2018/00577 ,  A61B2018/1823 ,  A61B2018/1838 ,  A61B2018/1853 ,  A61B2018/1869 ,  A61B2018/1892 ,  Y10T29/49005 ,  Y10T29/49007 ,  Y10T29/49016 ,  Y10T29/49018

Abstract: Various high-strength microwave antenna assemblies are described herein. The microwave antenna has a radiating portion connected by a feedline to a power generating source, e.g., a generator. The antenna is a dipole antenna with the distal end of the radiating portion being tapered and terminating at a tip to allow for direct insertion into tissue. Antenna rigidity comes from placing distal and proximal radiating portions in a pre-stressed state, assembling them via threaded or overlapping joints, or fixedly attaching an inner conductor to the distal portion. The inner conductor is affixed to the distal portion by, e.g., welding, brazing, soldering, or by adhesives. A junction member made from a hard dielectric material, e.g., ceramic, can be placed between the two portions and can have uniform or non-uniform shapes to accommodate varying antenna designs. Electrical chokes may also be used to contain returning currents to the distal end of the antenna.

Abstract translation: 本文描述了各种高强度微波天线组件。 微波天线具有通过馈线连接到发电源（例如发电机）的辐射部分。 天线是偶极天线，其辐射部分的远端是锥形的并且终止于尖端，以允许直接插入组织。 天线刚度来自将远端和近端辐射部分置于预应力状态，通过螺纹或重叠接头组装它们，或将内部导体固定地附接到远端部分。 内导体通过例如焊接，钎焊，焊接或通过粘合剂固定到远端部分。 由硬介电材料（例如陶瓷）制成的接合构件可以放置在两个部分之间，并且可以具有均匀或不均匀的形状以适应不同的天线设计。 电扼流圈也可用于将回流电流包含在天线的远端。

公开(公告)号：US20110196365A1

公开(公告)日：2011-08-11

申请号：US13123756

申请日：2009-10-22

Applicant: Steven Kim ,  Daniel Francis ,  Jessi E. Johnson ,  Alexey Salamini ,  Ted Su ,  Dong Hoon Chun ,  Yoav Ben-Haim ,  Christopher Loew ,  Leo Kopelow ,  Sunmi Chew

Inventor： Steven Kim ,  Daniel Francis ,  Jessi E. Johnson ,  Alexey Salamini ,  Ted Su ,  Dong Hoon Chun ,  Yoav Ben-Haim ,  Christopher Loew ,  Leo Kopelow ,  Sunmi Chew

IPC: A61B18/18

CPC classification number: A61B18/18 ,  A61B18/1815 ,  A61B2017/00115 ,  A61B2017/00199 ,  A61B2017/00477 ,  A61B2017/306 ,  A61B2018/00023 ,  A61B2018/00702 ,  A61B2018/183 ,  A61B2034/252 ,  A61B2034/254 ,  A61B2090/372 ,  A61H9/0057 ,  A61N5/02

Abstract: A system applies, in a non-invasive manner, energy to a targeted tissue region employing a controlled source of energy, a multiple use applicator, and a single use, applicator-tissue interface carried by the applicator. The system can generate and apply energy in a controlled fashion to form a predefined pattern of lesions that provide therapeutic benefit, e.g., to moderate or interrupt function of the sweat glands in the underarm (axilla).

Abstract translation: 系统以非侵入性的方式将能量应用于使用受控的能量源，多用途施用器和由施用器承载的单次使用的施用器 - 组织界面的目标组织区域。 该系统可以以受控的方式产生和施加能量以形成提供治疗益处（例如中度或中断腋下（腋窝）内的汗腺的功能的预定模式的病变）。

公开(公告)号：US20110190754A1

公开(公告)日：2011-08-04

申请号：US12696671

申请日：2010-01-29

Applicant: Steven Kim ,  Kyle R. Rick ,  Mani N. Prakash

Inventor： Steven Kim ,  Kyle R. Rick ,  Mani N. Prakash

IPC: A61B18/18

CPC classification number: A61B18/1815 ,  A61B18/18 ,  A61B2018/00107 ,  A61B2018/00178 ,  A61B2018/00404 ,  A61B2018/00416 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00595 ,  A61B2018/0063 ,  A61B2018/00982 ,  A61B2018/1407 ,  A61B2018/144 ,  A61B2018/1465 ,  A61B2018/147 ,  A61B2018/183 ,  A61B2018/1846 ,  A61B2018/1861 ,  A61B2018/1869 ,  A61B2018/1892

Abstract: An electrosurgical apparatus is provided. The electrosurgical apparatus includes a cannula insertable into a patient and positionable adjacent abnormal tissue. The electrosurgical apparatus includes a microwave antenna that includes a distal end having a radiating section receivable within the cannula and positionable within a patient adjacent abnormal tissue. The microwave antenna is adapted to connect to a source of electrosurgical energy for transmitting electrosurgical energy to the radiating section. A portion of the radiating section substantially encompasses a portion of the abnormal tissue and may be configured to apply pressure thereto. The microwave antenna is actuated to electrocautery treat tissue to reduce blood flow to the abnormal tissue.

Abstract translation: 提供电外科设备。 电外科设备包括插入患者体内的插管和相邻的异常组织。 电外科设备包括微波天线，其包括远端，其具有可接收在套管内的辐射部分，并且能够定位在患者体内邻近异常组织。 微波天线适于连接到用于将电外科能量传输到辐射部分的电外科能源。 辐射部分的一部分基本上包围异常组织的一部分，并且可以构造成向其施加压力。 微波天线被致动以电烙治疗组织以减少血液流向异常组织。

公开(公告)号：US20110027830A1

公开(公告)日：2011-02-03

申请号：US12600652

申请日：2008-05-21

Applicant: Marguerite A. Cervin ,  Steven Kim

Inventor： Marguerite A. Cervin ,  Steven Kim

IPC: C12P21/02 ,  C07K14/00 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12N1/15

CPC classification number: C12N9/58 ,  C07K2319/02 ,  C07K2319/036 ,  C12N9/0061 ,  C12N9/16 ,  C12N15/62 ,  C12P21/02

Abstract: The invention relates to heterologous polypeptide expression and secretion by filamentous fungi and vectors and processes for expression and secretion of such polypeptides. More particularly, the invention discloses the use of a signal sequence form an aspartic protease obtained from Trichoderma and referred to as an NSP24 signal sequence.

Abstract translation: 本发明涉及丝状真菌和载体的异源多肽表达和分泌以及这些多肽的表达和分泌过程。 更具体地说，本发明公开了使用信号序列形成从木霉属得到的天门冬氨酸蛋白酶，称为NSP24信号序列。