摘要:
Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for therapeutic purposes. Antagonist against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要:
A battery economising circuit for use with one or more operating circuits, for example a part or parts of a radio circuit. In the battery economizing circuit an opposed current mirror type of current reference circuit determines entirely the current consumed by the operating circuit. A control circuit is connected to a point in the reference circuit from which current can be extracted. The control circuit in response to an OFF signal causes a portion of the current in the reference circuit to be diverted so that the reference circuit cannot sustain its normal ON- state and in response thereto assumes its OFF- state in which the operating and control circuits do not take current. The control circuit further includes means whereby current can be injected into the current reference circuit to cause it to assume its ON state and in consequence the operating circuit takes current.In the case of there being several current reference circuits and associated control circuits, the inputs of the control circuits are all connected to a common signalling bus.
摘要:
A lamp is disclosed comprising a light source, an outer glass envelope having at least one dimple, a metallic base having at least one dimple, and a plastics skirt having means for complementary engaging and fastening to each of the dimples of the glass envelope and of the metallic base. The complementary engagement of the plastics skirt to the glass envelope is accomplished by snap-lock ramp-like extensions that fit into and engage an inner portion of the dimples of the glass envelope.
摘要:
The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
摘要:
The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
摘要:
Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.
摘要:
A multi-mode radio transmitter for use in mobile radio cellular standards, such as 2G, 2.5G and 3G, and a method of operating the transmitter in which an input signal is modulated independently of controlling the drive of a power amplifier (PA) module (40). The transmitter comprises circuitry (12, 60) for extracting the phase (θ) and amplitude (R) components from envelope information in the input signal. A modulator (110) uses the phase component (θ) to produce a constant-envelope signal comprising a phase modulated real signal at the transmitter frequency. This signal is multiplied in a multiplier (72) with either a fixed bias voltage (Vg1) to produce a constant envelope signal or a low level envelope tracking signal derived from an amplitude component (R) by a first amplitude control circuit (78) to produce a signal modulated exactly by the amplitude component. An output from the multiplier is applied to the PA module (40) having a control input (41). The PA module is controllable in a plurality of manners dependent on the characteristics and the required output power of the signal being transmitted. These manners include applying a predetermined fixed voltage to the control input or a less precise envelope tracking signal which is derived by a second amplitude control circuit (120) from the amplitude component (R).
摘要:
A communications receiver such as an integrated zero IF receiver comprises an input for receiving an input signal and a zero IF frequency down conversion circuit coupled said input and constructed to provide quadrature related signals (I,Q) at a substantially zero intermediate frequency. In order to balance the signal paths, at least one capacitance in each of the quadrature related zero IF signal paths of the frequency down conversion circuit comprises at least two integrated capacitors connected in anti-parallel. By fabricating the integrated capacitances in this way the symmetry of the circuit is maintained which enhances significantly the second-order inter-modulation performance.
摘要:
A radio receiver has a frequency down conversion stage including a first passive filter tuned to a lower frequency. An amplifier functioning as a voltage-to-current converter includes a resistor (60) which can be shunted by a second passive filter in response to actuation of symmetrically arranged switching devices. When the second passive filter shunts the resistor, the overall pass band is raised to a higher frequency. Additionally, the amplifier has a lower noise figure when the second passive filter shunts the transconductor.
摘要:
A four quadrant multiplier circuit having a high dynamic range and capable of operating at low voltages includes a dual transconductance amplifier circuit (TAC) consisting of NPN transistors (20 to 23 and 64 to 67), coupled to a first input port (36), first and second folded Darlington circuits (57,58), and a resistive element (78). Each Darlington circuit includes first and second NPN transistors (68,70 and 69,71) whose emitter-collector paths are connected in series and a third PNP transistor (72,73) having its emitter-collector path connected between the collector of the first transistor (68,69) and the base electrode of the second transistor (70,71). The emitter-collector junction (76,77) of the first and second transistors (68,70 and 69,71) is connected to the base electrode of the third transistor (72,73). The resistive element (78) is connected between the base electrodes of the third transistors (72,73). A second input port (56) is connected to the base electrodes of the first transistors (68,69). The emitter currents of the dual transconductance amplifier are supplied by way of current mirror circuits (80,81) from the emitter currents of the second transistors (70,71). The transconductance amplifier circuit (TAC) may be of any suitable type which has its transconductance linearly proportional to its emitter currents. In a refinement of the circuit, the current-to-voltage converter function of the current mirrors is carried out by the second transistors (70,71) and the transistors (82,83) of the current mirror circuits (80,81) are omitted.