公开(公告)号：USRE39333E1

公开(公告)日：2006-10-10

申请号：US10705665

申请日：2000-06-02

申请人： Akira Nishiyama ,  Kenji Inoue

发明人： Akira Nishiyama ,  Kenji Inoue

IPC分类号： C07C69/66 ,  C07C59/185

CPC分类号： C12P7/62 ,  C07B2200/07 ,  C07C67/343 ,  C07C253/30 ,  C07D319/06 ,  C07C69/716 ,  C07C255/21 ,  C07C69/738

摘要： This invention provides a process for producing a 5-hydroxy-3-oxopentanoic acid, a useful pharmaceutical intermediate, easily from a readily available, inexpensive starting material without using any extraordinary production equipment such as a very-low-temperature reactor.Thus, this invention provides a process for producing a 5-hydroxy-3-oxopentanoic acid which comprises permitting a lithium amide to act upon a mixture of an acetic acid ester and a 3-hydroxypropionic acid derivative at not below −20° C. Further, this invention also provides a process for producing a 5-hydroxy-3-oxopentanoic acid which comprises treating a mixture of an acetic acid ester and a 3-hydroxypropionic acid derivative with a Grignard reagent to prepare a mixture of a compound and an acetic acid ester of the above formula (I), and permitting a lithium amide to act upon the mixture at a temperature not below −20° C. This invention provides a process for producing a 5-hydroxy-3-oxopentanoic acid, a useful pharmaceutical intermediate, easily from a readily available, inexpensive starting material without using any extraordinary production equipment such as a very-low temperature reactor. Thus, this invention provides a process for producing a 5-hydroxy-3-oxopentanoic acid which comprises permitting a lithium amide to act upon a mixture of an acetic acid ester and a 3-hydroxypropionic acid derivative at not below −20° C. Further, this invention also provides a process for producing a 5-hydroxy-3-oxopentanoic acid which comprises treating a mixture of an acetic acid ester and a 3-hydroxypropionic acid derivative with a Grignard reagent to prepare a mixture of a compound and an acetic acid ester of the above formula (I), and permitting a lithium amide to act upon the mixture at a temperature not below −20° C.

公开(公告)号：US20060203130A1

公开(公告)日：2006-09-14

申请号：US11420340

申请日：2006-05-25

申请人： Kenji Inoue ,  Takashi Tsunoda

发明人： Kenji Inoue ,  Takashi Tsunoda

IPC分类号： H04N5/60

CPC分类号： H04N5/45 ,  H04N5/60 ,  H04N21/4263 ,  H04N21/4316 ,  H04N21/4341 ,  H04N21/4394 ,  H04N21/4622 ,  H04N21/485 ,  H04N21/84

摘要： A television broadcast receiving apparatus which displays one of television programs received by two tuners on a main picture screen and displays the other on a child picture screen, where one of audios of a program of the main picture screen and a program of the child picture screen is selected and outputted, and the state of an audio signal to be outputted is switched according to the audio state of the program of the child picture screen.

摘要翻译： 一种电视广播接收装置，其在主图像屏幕上显示由两个调谐器接收的电视节目之一，并在另一个儿童图像屏幕上显示另一个，其中主图像屏幕的节目的音频和子图像屏幕的节目之一 被选择并输出，并且根据儿童图像屏幕的节目的音频状态来切换要输出的音频信号的状态。

公开(公告)号：US07105880B2

公开(公告)日：2006-09-12

申请号：US11069723

申请日：2005-02-28

申请人： Takao Noguchi ,  Kenji Inoue ,  Hisatoshi Saito

发明人： Takao Noguchi ,  Kenji Inoue ,  Hisatoshi Saito

IPC分类号： H01L29/76 ,  H01L29/94 ,  H01L31/062 ,  H01L31/113 ,  H01L31/119

CPC分类号： H01L41/316 ,  H03H9/02149 ,  H03H9/174 ,  H03H9/175

摘要： The electronic device includes a substrate, a lower conductive film provided on the substrate, a functional film provided on the lower conductive film, and a crystallinity barrier film provided between the lower conductive film and the functional film. The present invention prevents the crystallinity of the functional film being affected by the crystallinity or the material selection of the lower conductive film, so it becomes possible to use a low-cost metal such as aluminum (Al) for the lower conductive film, and to use a low-cost method for forming the film, thereby making it possible to improve the crystallinity of the functional film without using a costly film-formation method such as epitaxial growth. For the crystallinity barrier film, there can be used a material having an amorphous structure.

摘要翻译： 电子装置包括基板，设置在基板上的下导电膜，设置在下导电膜上的功能膜，以及设置在下导电膜和功能膜之间的结晶阻挡膜。 本发明防止功能膜的结晶性受到下导电膜的结晶性或材料选择的影响，因此可以使用低成本金属如铝（Al）作为下导电膜，以及 使用低成本的方法形成膜，从而可以在不使用诸如外延生长的昂贵的成膜方法的情况下提高功能膜的结晶度。 对于结晶阻挡膜，可以使用具有无定形结构的材料。

公开(公告)号：US07094594B2

公开(公告)日：2006-08-22

申请号：US10048553

申请日：2001-06-05

申请人： Akira Nishiyama ,  Miho Horikawa ,  Yoshihiko Yasohara ,  Noboru Ueyama ,  Kenji Inoue

发明人： Akira Nishiyama ,  Miho Horikawa ,  Yoshihiko Yasohara ,  Noboru Ueyama ,  Kenji Inoue

IPC分类号： C12P41/00

CPC分类号： C07D319/06 ,  C12P7/42 ,  C12P17/06

摘要： The present invention is to provide a production technology by which an optically active 2-[6-(hydroxymethyl)-1, 3-dioxan-4-yl]acetic acid derivative, which are of value as pharmaceutical intermediates, can be produced from inexpensive and readily available starting materials without using any extraordinary equipment such as an ultra-low-temperature reactor.The present invention is a production process of an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative which comprises reacting an enolate, prepared by permitting a base or a 0-valent metal to act on an acetic acid ester derivative with (S)-β-hydroxy-γ-butyrolactone at a temperature not lower than −30° C. to give a dihydroxyoxohexanoic acid derivative, treating the same with an acylating agent in the presence of a base to produce a dihydroxyoxohexanoic acid monoacyl derivative, reducing this compound with a microorganism to produce a trihydroxyhexanoic acid monoacyl derivative, treating this compound with an acetal-forming reagent in the presence of an acid catalyst to produce an acyloxymethyldioxanylacetic acid derivative, and finally, subjecting this compound to solvolysis in the presence of a base.

摘要翻译： 本发明提供一种生产技术，通过该技术，可以从廉价的方式制备价值为药物中间体的光学活性的2- [6-（羟甲基）-1,3-二恶烷-4-基]乙酸衍生物 和容易获得的起始材料，而不使用任何非常设备，例如超低温反应器。 本发明是光学活性的2- [6-（羟甲基）-1,3-二恶烷-4-基]乙酸衍生物的制备方法，该方法包括使通过使碱或0价金属 在不低于-30℃的温度下用（S）-β-羟基-γ-丁内酯在乙酸酯衍生物上作用，得到二羟基氧代己酸衍生物，在酰化剂存在下用酰化剂处理 碱化以制备二羟基氧己基单酰基衍生物，用微生物还原该化合物以产生三羟基己酸单酰基衍生物，在酸催化剂存在下用缩醛形成试剂处理该化合物，得到酰氧基甲基二恶烷基乙酸衍生物，最后， 该化合物在碱存在下溶剂解。

公开(公告)号：US20060155136A1

公开(公告)日：2006-07-13

申请号：US10563635

申请日：2004-07-05

申请人： Kazumi Okuro ,  Tatsuyoshi Tanaka ,  Masaru Mitsuda ,  Kenji Inoue

发明人： Kazumi Okuro ,  Tatsuyoshi Tanaka ,  Masaru Mitsuda ,  Kenji Inoue

IPC分类号： C07D301/27

CPC分类号： C07C67/29 ,  C07B2200/07 ,  C07C29/10 ,  C07D301/24 ,  C07C33/46

摘要： The present invention provides an industrially safe, easily operable process for producing an optically active epoxy alcohol derivative useful as an intermediate for pharmaceuticals from inexpensively available materials, and also provides a novel halohydrin derivative serving as an important intermediate for the epoxy alcohol derivative. Furthermore, the present invention provides a process for producing an intermediate for a triazole antifungal agent by allowing a halohydrin to react with a triazole sulfonamide, the process including a small number of steps. A process for producing an optically active epoxy alcohol derivative includes allowing an optically active α-substituted propionate derivative to react with a haloacetic acid derivative in the presence of a base to prepare an optically active haloketone derivative, allowing the resulting haloketone derivative to react with an aryl metal compound to stereoselectively prepare a halohydrin derivative, eliminating a substituent for the hydroxy group of the halohydrin derivative, and performing epoxidation with a base. Furthermore, a process for producing an intermediate for a triazole antifungal agent includes allowing a halohydrin derivative to react with a triazole sulfonamide, the process including a small number of steps.

公开(公告)号：US07075214B2

公开(公告)日：2006-07-11

申请号：US11061883

申请日：2005-02-22

申请人： Kenji Inoue ,  Hisatoshi Saito ,  Takao Noguchi

发明人： Kenji Inoue ,  Hisatoshi Saito ,  Takao Noguchi

IPC分类号： H01L41/08 ,  H03H9/54

CPC分类号： H03H9/589 ,  H03H9/584 ,  H03H9/585 ,  H03H9/588

摘要： A piezoelectric resonator according to an embodiment of the present invention is a piezoelectric resonator for obtaining a signal of a predetermined resonance frequency from a bulk acoustic wave propagating inside a piezoelectric film. This piezoelectric resonator has a plurality of transducers stacked in a predetermined direction, and a propagation area of the bulk acoustic wave varies in a propagation direction of the bulk acoustic wave.

摘要翻译： 根据本发明的实施例的压电谐振器是用于从在压电膜内传播的体声波获得预定谐振频率的信号的压电谐振器。 该压电谐振器具有沿预定方向堆叠的多个换能器，并且体声波的传播面积在体声波的传播方向上变化。

公开(公告)号：US20060125349A1

公开(公告)日：2006-06-15

申请号：US11352338

申请日：2006-02-13

申请人： Kenji Inoue ,  Seisuke Mochizuka

发明人： Kenji Inoue ,  Seisuke Mochizuka

IPC分类号： H03H9/25

CPC分类号： H03H9/6483 ,  H03H9/14588

摘要： A surface acoustic wave device is provided with an input signal electrode 15 and an output signal electrode 16 to and from which an electric signal is inputted or outputted; a first surface acoustic wave resonator 18 including an input terminal 18a connected to the input signal electrode 15 and having a plurality of comb electrodes, an output terminal 18b connected to the output signal electrode 16 and having a plurality of comb electrodes, a common terminal 18c which has a plurality of comb electrodes and which forms interdigital transducers A and B together with the comb electrodes of the input terminal 18a and the comb electrodes of the output terminal 18b; and a second surface acoustic wave resonator 19 connected between the common terminal 18c of the first surface acoustic wave resonator 18 and a pair of grounding terminals 17.

公开(公告)号：US20060105435A1

公开(公告)日：2006-05-18

申请号：US10515658

申请日：2003-06-05

申请人： Takahiro Ohishi ,  Hirokazu Nanba ,  Masanobu Sugawara ,  Masashi Izumida ,  Tatsuya Honda ,  Kohei Mori ,  Satohiro Yanagisawa ,  Nobuo Nagashima ,  Kenji Inoue

发明人： Takahiro Ohishi ,  Hirokazu Nanba ,  Masanobu Sugawara ,  Masashi Izumida ,  Tatsuya Honda ,  Kohei Mori ,  Satohiro Yanagisawa ,  Nobuo Nagashima ,  Kenji Inoue

IPC分类号： C12P13/12 ,  C12P17/00

CPC分类号： C12P13/12 ,  C07C319/06 ,  C07D233/76 ,  C12P17/04 ,  C12P17/10 ,  C12P41/009 ,  C07C323/58

摘要： The present invention provides a simple industrial process for producing an L- or D-optically active α-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active α-methylcysteine derivative or its salt, a racemic N-carbamoyl-α-methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl-α-methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis.

摘要翻译： 本发明提供了一种用于从容易得到的廉价原料生产L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的简单工业方法，其是有用的药物中间体。 在制备L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的方法中，外消旋的N-氨基甲酰基-α-甲基半胱氨酸衍生物或其盐与乙内酰脲酶D选择性环化以产生D-5-甲基 - 5-硫代甲基乙内酰脲衍生物或其盐和N-氨基甲酰基-α-甲基-L-半胱氨酸衍生物或其盐，然后对氨基和硫原子进行脱保护和水解。

公开(公告)号：US06998495B2

公开(公告)日：2006-02-14

申请号：US10492507

申请日：2002-10-24

申请人： Masanobu Sugawara ,  Kenji Inoue

发明人： Masanobu Sugawara ,  Kenji Inoue

IPC分类号： C07C51/36

CPC分类号： C07C67/31 ,  C07B2200/07 ,  C07C67/29 ,  C07C69/78 ,  C07C69/675

摘要： A method for producing an optically active 3,5-dihydroxyhexanoic acid derivative by stereoselectively reducing an optically active 3-oxo-5-hydroxyhexanoic acid derivative is provided. The method, which requires neither an ultralow-temperature reactor, an incubator, nor protection of the 5-position hydroxy group, is simple and economical.An optically active 3,5-dihydroxyhexanoic acid derivative is produced by asymmetrical hydrogenation of an optically active 3-oxo-5-hydroxyhexanoic acid derivative catalyzed by an RuBr2BINAP complex prepared from a ruthenium complex and a ruthenium-optically active phosphine complex, i.e., 2,2′-bisdiarylphosphino-1,1′-binaphthyl (BINAP), while using extremely inexpensive hydrogen as the reductant.

摘要翻译： 提供了通过立体选择性还原旋光性3-氧代-5-羟基己酸衍生物制备光学活性3,5-二羟基己酸衍生物的方法。 既不需要超低温反应器，培养箱也不需要保护5位羟基的方法简单经济。

公开(公告)号：US20050189846A1

公开(公告)日：2005-09-01

申请号：US11028992

申请日：2005-01-03

申请人： Hisatoshi Saito ,  Takao Noguchi ,  Kenji Inoue

发明人： Hisatoshi Saito ,  Takao Noguchi ,  Kenji Inoue

IPC分类号： H01L41/09 ,  H01L41/08 ,  H01L41/18 ,  H01L41/22 ,  H01L41/29 ,  H01L41/319 ,  H03H9/02 ,  H03H9/17

CPC分类号： H03H9/02094 ,  H03H9/175 ,  H03H9/176

摘要： A film bulk acoustic wave resonator of the invention includes a substrate; a resonant structure provided on the substrate constituted by a lower electrode, a piezoelectric film and an upper electrode; and an acoustic multilayer of a plurality of reflective films provided between the substrate and the resonant structure. At least one of the reflective films of the acoustic multilayer has a specified crystal plane orientation, and an X-ray rocking curve full width at half maximum that is preferably not greater than 10 degrees, and more preferably is not greater than 3 degrees. This makes it possible to obtain better resonance characteristics than in the case of the prior art, by increasing the efficiency with which bulk waves propagating towards the substrate are reflected.

摘要翻译： 本发明的薄膜体声波谐振器包括：基板; 设置在由下电极，压电膜和上电极构成的基板上的谐振结构; 以及设置在所述基板和所述谐振结构之间的多个反射膜的声学多层。 声学多层反射膜中的至少一个具有指定的晶面取向，并且X射线摇摆曲线半峰全宽优选不大于10度，更优选不大于3度。 这使得通过提高向衬底传播的体波的效率被反射，可以获得比现有技术的情况更好的谐振特性。