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    Apparatus for storing and dispensing reagent beads
    61.
    发明授权
    Apparatus for storing and dispensing reagent beads 有权
    用于存储和分配试剂珠的装置

    公开(公告)号：US08409530B2

    公开(公告)日：2013-04-02

    申请号：US12512833

    申请日：2009-07-30

    申请人： Ronald Chang ,  Douglas B. Dority ,  Steve Montgomery

    发明人： Ronald Chang ,  Douglas B. Dority ,  Steve Montgomery

    IPC分类号： B01L9/00 ,  B23Q7/04 ,  G07F11/16 ,  B65H5/00 ,  B65H1/08 ,  B65H3/00

    CPC分类号： B01L3/527 ,  B01J19/0046 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00657 ,  B01L3/0289 ,  B01L2200/0647 ,  B01L2200/16 ,  G01N2035/00574 ,  Y10T436/25

    摘要： Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.

    摘要翻译： 本发明的实施方案提供了用于存储和分配试剂珠的有效和有效的技术。 在一些实施例中，提供了一种用于分配包含在珠子存储装置中的试剂珠粒的装置，其包括具有多个孔的珠粒载体; 设置在孔中的多个试剂珠; 以及可剥离地附接到胎圈载体以覆盖孔并将试剂珠保持在孔中的覆盖带。 该装置包括一个通道，在该通道中，珠子存放装置使胎圈承载件面向通道的支撑壁，盖带面向通道的剥离壁。 剥离壁包括设置在剥离边缘和相对边缘之间的剥离间隙，以及在剥离壁的与剥离边缘相对的一侧上邻近相对边缘设置的分配开口。 覆盖带可以通过剥离间隙被插入以被拉靠在剥离边缘上，以从胎圈载体上剥离覆盖带，以将通道内的胎圈载体的孔移动到分配开口，并单独暴露孔以分配试剂珠 。

    DRIVING CIRCUIT FOR LED
    63.
    发明申请
    DRIVING CIRCUIT FOR LED 审中-公开
    LED驱动电路

    公开(公告)号：US20120217894A1

    公开(公告)日：2012-08-30

    申请号：US13370149

    申请日：2012-02-09

    申请人： Charles Chang ,  Ronald Chang

    发明人： Charles Chang ,  Ronald Chang

    IPC分类号： H05B41/282 ,  H03K3/017 ,  G05F1/10

    CPC分类号： H05B33/0815 ,  H05B33/0845 ,  H05B37/0263 ,  Y02B20/346

    摘要： A driving circuit device for driving a load is provided. The driving circuit device includes a control module including a power correction module, and providing a control signal to adjust a current flowing through the load; and a pulse width modulation module being in cooperation with the power correction module to modulate the control signal, and including a voltage providing unit providing a pulse width modulation signal; and a Schmitt trigger circuit.

    摘要翻译： 提供用于驱动负载的驱动电路装置。 所述驱动电路装置包括：控制模块，包括功率校正模块，并提供控制信号以调节流过所述负载的电流; 以及脉冲宽度调制模块，与所述功率校正模块配合以调制所述控制信号，并且包括提供脉宽调制信号的电压提供单元; 和施密特触发电路。

    Cap for vessel for performing multi-stage process
    64.
    发明授权
    Cap for vessel for performing multi-stage process 有权
    用于执行多级过程的容器盖

    公开(公告)号：US08205764B2

    公开(公告)日：2012-06-26

    申请号：US12575872

    申请日：2009-10-08

    申请人： Ronald Chang

    发明人： Ronald Chang

    IPC分类号： B65D43/18 ,  B65D55/16 ,  B67D3/00

    CPC分类号： B01L3/50825 ,  B01L2200/141 ,  B01L2300/043 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2400/0683

    摘要： Embodiments of the invention provide a cap for a vessel for performing a multi-stage process for analyzing a sample, such as nested PCR or RT-PCR. In one embodiment, the cap comprises a body configured to be mated to the vessel to enclose a vessel interior, a cap cavity for holding reagents, and a cap cavity control portion that is adjustable with respect to the body between a first-stage position in which the cap cavity is enclosed and fluidicly isolated from the vessel interior and a second-stage position in which the cap cavity is fluidicly coupled with the vessel interior.

    摘要翻译： 本发明的实施方案提供了用于进行用于分析样品的多级方法（例如巢式PCR或RT-PCR）的容器的盖。 在一个实施例中，盖包括构造成与容器配合以封闭容器内部的主体，用于保持试剂的盖腔，以及帽腔控制部分，其在相对于主体的第一阶段位置之间相对于主体可调节 盖腔被封闭并与容器内部流体隔离，第二级位置中帽腔与容器内部流体连接。

    Fluid processing and control
    66.
    发明授权
    Fluid processing and control 有权
    流体加工和控制

    公开(公告)号：US08048386B2

    公开(公告)日：2011-11-01

    申请号：US10084409

    申请日：2002-02-25

    申请人： Douglas B. Dority ,  Ronald Chang

    发明人： Douglas B. Dority ,  Ronald Chang

    IPC分类号： B01L3/00

    CPC分类号： B01L3/502715 ,  B01L3/502 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/06 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/06 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0848 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2400/0421 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/0644 ,  G01N1/18 ,  G01N1/28 ,  G01N1/405 ,  Y10T436/255 ,  Y10T436/2575

    摘要： A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers. One or more of the chambers may be a processing chamber which includes two ports configured to selectively engage the at least one external port of the body, and a fluid processing material such as an enrichment material or a depletion material. In some embodiments, one or more chambers may include a separation channel, and an electric field may be applied across the separation channel.

    摘要翻译： 用于控制多个室之间的流体流动的流体控制和处理系统包括主体，其包括与流体位移区域流体连续耦合的流体处理区域。 流体位移区域是可减压的，以将流体吸入流体移动区域并且可加压以从流体位移区域排出流体。 身体至少包括一个外部端口。 流体处理区域与至少一个外部端口流体耦合。 流体位移区域与主体的至少一个外部端口流体耦合。 主体相对于多个室可调节以将至少一个外部端口选择性地与多个室流体连通。 一个或多个室可以是处理室，其包括构造成选择性地接合主体的至少一个外部端口的两个端口，以及诸如富集材料或耗尽材料的流体处理材料。 在一些实施例中，一个或多个腔室可以包括分离通道，并且可以跨越分离通道施加电场。

    Ultra wideband and fast hopping frequency synthesizer for MB-OFDM wireless application
    67.
    发明授权
    Ultra wideband and fast hopping frequency synthesizer for MB-OFDM wireless application 有权
    用于MB-OFDM无线应用的超宽带和快速跳频合成器

    公开(公告)号：US07589597B2

    公开(公告)日：2009-09-15

    申请号：US11868200

    申请日：2007-10-05

    申请人： Ronald Chang ,  Sheng Yen ,  Wei Gao

    发明人： Ronald Chang ,  Sheng Yen ,  Wei Gao

    IPC分类号： H03B21/01 ,  H03B21/02 ,  H03L7/16 ,  H04B1/26

    CPC分类号： H03L7/16 ,  H03B21/02 ,  H04B1/7136

    摘要： A frequency synthesizer with a single PLL and multiple SSB mixers is presented. The frequency synthesizer includes a single PLL outputting a reference signal that is fed to a plurality of dividers coupled in sequence. The outputs from the dividers are mixed by the SSB mixers to produce signals with different frequencies. These signals with different frequencies can be selected through use of multiple selectors.

    摘要翻译： 提出了具有单个PLL和多个SSB混频器的频率合成器。 频率合成器包括单个PLL，其输出被馈送到依次耦合的多个分频器的参考信号。 分频器的输出由SSB混频器混合，产生不同频率的信号。 可以通过使用多个选择器来选择具有不同频率的这些信号。

    Method and apparatus for storing and dispensing reagent beads
    68.
    发明授权
    Method and apparatus for storing and dispensing reagent beads 有权
    用于存储和分配试剂珠的方法和装置

    公开(公告)号：US07575721B2

    公开(公告)日：2009-08-18

    申请号：US11146304

    申请日：2005-06-06

    申请人： Ronald Chang ,  Douglas B. Dority ,  Steven Michael Montgomery

    发明人： Ronald Chang ,  Douglas B. Dority ,  Steven Michael Montgomery

    IPC分类号： B01L3/00 ,  G01N31/00 ,  B01L3/02 ,  G01N21/03 ,  G01N1/00 ,  G01N33/543 ,  B23Q7/04 ,  G07F11/16 ,  B65H5/00 ,  B65H1/08 ,  B65H3/00

    CPC分类号： B01L3/527 ,  B01J19/0046 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00657 ,  B01L3/0289 ,  B01L2200/0647 ,  B01L2200/16 ,  G01N2035/00574 ,  Y10T436/25

    摘要： Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In one embodiment, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.

    摘要翻译： 本发明的实施方案提供了用于存储和分配试剂珠的有效和有效的技术。 在一个实施例中，提供了一种用于分配包含在珠子存储装置中的试剂珠粒的装置，其包括具有多个孔的珠粒载体; 设置在所述孔中的多个试剂珠; 以及可剥离地附接到胎圈载体以覆盖孔并将试剂珠保持在孔中的覆盖带。 该装置包括一个通道，在该通道中，珠子存放装置使胎圈承载件面向通道的支撑壁，盖带面向通道的剥离壁。 剥离壁包括设置在剥离边缘和相对边缘之间的剥离间隙，以及在剥离壁的与剥离边缘相对的一侧上邻近相对边缘设置的分配开口。 覆盖带可以通过剥离间隙被插入以被拉靠在剥离边缘上，以从胎圈载体上剥离覆盖带，以将通道内的胎圈载体的孔移动到分配开口，并单独暴露孔以分配试剂珠 。

    Method and apparatus for storing and dispensing reagent beads
    69.
    发明申请
    Method and apparatus for storing and dispensing reagent beads 有权

    公开(公告)号：US20060275178A1

    公开(公告)日：2006-12-07

    申请号：US11146304

    申请日：2005-06-06

    申请人： Ronald Chang ,  Douglas Dority ,  Steven Montgomery

    发明人： Ronald Chang ,  Douglas Dority ,  Steven Montgomery

    IPC分类号： B01L9/00

    CPC分类号： B01L3/527 ,  B01J19/0046 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00657 ,  B01L3/0289 ,  B01L2200/0647 ,  B01L2200/16 ,  G01N2035/00574 ,  Y10T436/25

    摘要： Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In one embodiment, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.