公开(公告)号：US11732011B2

公开(公告)日：2023-08-22

申请号：US17523174

申请日：2021-11-10

Applicant: UNIVERSITY OF WASHINGTON ,  INSTITUTE FOR RESEARCH IN BIOMEDICINE

Inventor： Neil P. King ,  David Baker ,  Brooke Fiala ,  Lance Joseph Stewart ,  Laurent Perez ,  Antonio Lanzavecchia ,  Jessica Marcandalli

IPC: C12N7/00 ,  C12N1/15 ,  C12N15/45 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61P31/14 ,  B82Y5/00 ,  A61K39/00

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61P31/14 ,  B82Y5/00 ,  C12N7/00 ,  A61K2039/575 ,  C07K2319/735 ,  C12N2760/18022 ,  C12N2760/18322 ,  C12N2760/18522

Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.

公开(公告)号：US20220348609A1

公开(公告)日：2022-11-03

申请号：US17763772

申请日：2020-10-23

Applicant: UNIVERSITY OF WASHINGTON ,  CHILDREN'S MEDICAL CENTER CORPORATION

Inventor： Anindya Roy ,  Lei Shi ,  Xianchi Dong ,  Jing Li ,  Timothy Springer ,  David Baker

IPC: C07K7/00 ,  A61P35/00 ,  C07K14/495

Abstract: Alpha(v) beta (6) integrin (avb6) binding polypeptides are disclosed herein, and their use in treating and detecting tumors, and their use in treating pulmonary fibrosis.

公开(公告)号：US11485759B2

公开(公告)日：2022-11-01

申请号：US16427493

申请日：2019-05-31

Applicant: UNIVERSITY OF WASHINGTON

Inventor： David Baker ,  Jacob B. Bale ,  Neil P. King ,  William H. Sheffler ,  Daniel Ellis

IPC: C07K14/00

Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.

公开(公告)号：US10988748B2

公开(公告)日：2021-04-27

申请号：US16719183

申请日：2019-12-18

Applicant: UNIVERSITY OF WASHINGTON ,  The Regents of the University of California

Inventor： Ingrid Swanson Pultz ,  Clancey Wolf ,  Justin Bloomfield Siegel ,  Christine Elaine Tinberg ,  Lance Stewart ,  David Baker

IPC: C12N9/50 ,  C12N9/52 ,  A61K38/00 ,  A61P1/14

Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1, are provided, wherein (a) the polypeptide degrades a PFQPQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.

公开(公告)号：US20200347109A1

公开(公告)日：2020-11-05

申请号：US16909210

申请日：2020-06-23

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  Umut Ulge ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Carl Walkey ,  Alfredo Quijano Rubio ,  Brian Weitzner

IPC: C07K14/55 ,  C07K14/54

Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγcheterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US20200339648A1

公开(公告)日：2020-10-29

申请号：US16905669

申请日：2020-06-18

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  Umut Ulge ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Carl Walkey ,  Alfredo Quijano Rubio ,  Kevin Jude ,  Brian Weitzner

IPC: C07K14/55 ,  C07K14/54 ,  A61K47/62 ,  A61K47/60

Abstract: De novo designed polypeptides that bind to IL-2 receptor βνc heterodimer (IL-2Rβνc), IL-4 receptor ανc heterodimer (IL-4Rανc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US20170306029A1

公开(公告)日：2017-10-26

申请号：US15508779

申请日：2015-09-11

Applicant: The Board of Trustees of the Leland Stanford Junior University ,  University of Washington

Inventor： Kenan Christopher Garcia ,  David Baker ,  Claudia Yvonne Janda ,  Luke Dang ,  James Daniel Moody

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/00

Abstract: Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.

公开(公告)号：US09750814B2

公开(公告)日：2017-09-05

申请号：US15262716

申请日：2016-09-12

Applicant: University of Washington

Inventor： Erik Procko ,  David Baker ,  Geoffrey Y. Berguig ,  Patrick S. Stayton ,  Yifan Song ,  Stephanie Ann Berger ,  Daniel-Adriano Silva

IPC: A61K47/32 ,  C07K14/47 ,  A61K38/17 ,  A61K39/395 ,  C07K14/00 ,  G01N33/569 ,  C07K16/08 ,  C07K14/005 ,  C12N5/0781 ,  A61K39/12

CPC classification number: A61K47/32 ,  A61K38/1709 ,  A61K39/395 ,  A61K47/645 ,  C07K14/4747 ,  C07K16/085 ,  C07K14/005 ,  C07K2317/76 ,  C12N5/0635 ,  C12N2710/16211 ,  C12N5/0636 ,  C12N2710/16234 ,  C12N7/00 ,  A61K39/245 ,  A61K39/12 ,  A61K35/17 ,  C07K2317/34 ,  C07K14/001 ,  G01N33/56994 ,  G01N2333/05 ,  C07K14/4748

Abstract: The present invention provides designed polypeptides that selectively bind to and inhibit Epstein Barr protein BHFR1, and B cell lymphoma family proteins, and are thus useful for treating Epstein Barr-related diseases and cancer.

公开(公告)号：US20160376333A1

公开(公告)日：2016-12-29

申请号：US15262716

申请日：2016-09-12

Applicant: University of Washington

Inventor： Erick Procko ,  David Baker ,  Geoffrey Y. Berguig ,  Patrick S. Stayton ,  Yifan Song ,  Stephanie Ann Berger ,  Daniel-Adriano Silva

IPC: C07K14/47 ,  G01N33/574 ,  A61K47/32 ,  A61K38/17 ,  A61K39/395

CPC classification number: A61K47/32 ,  A61K38/1709 ,  A61K39/395 ,  A61K47/645 ,  C07K14/4747 ,  C07K16/085 ,  C07K14/005 ,  C07K2317/76 ,  C12N5/0635 ,  C12N2710/16211 ,  C12N5/0636 ,  C12N2710/16234 ,  C12N7/00 ,  A61K39/245 ,  A61K39/12 ,  A61K35/17 ,  C07K2317/34 ,  C07K14/001 ,  G01N33/56994 ,  G01N2333/05 ,  C07K14/4748

Abstract: The present invention provides designed polypeptides that selectively bind to and inhibit Epstein Barr protein BHFR1, and B cell lymphoma family proteins, and are thus useful for treating Epstein Barr-related diseases and cancer.

Abstract translation: 本发明提供了选择性结合并抑制爱泼斯坦巴尔蛋白BHFR1和B细胞淋巴瘤家族蛋白质的设计的多肽，因此可用于治疗爱泼斯坦巴尔相关疾病和癌症。

公开(公告)号：US09493547B2

公开(公告)日：2016-11-15

申请号：US14387699

申请日：2013-03-25

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： David Baker ,  Eva-Maria Strauch ,  Sarel Jacob Fleishman

IPC: A61K38/16 ,  A61K38/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K1/00 ,  C07K1/22 ,  C07K14/00 ,  A61K38/50 ,  C12N9/80 ,  G01N33/68

CPC classification number: C07K16/00 ,  A61K38/50 ,  C07K1/22 ,  C07K14/001 ,  C12N9/80 ,  C12Y305/01019 ,  G01N33/6854

Abstract: The present invention provides polypeptides that bind to immunoglobulin G and methods for their use.

Abstract translation: 本发明提供了结合免疫球蛋白G的多肽及其使用方法。