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公开(公告)号：US20140256588A1
公开(公告)日：2014-09-11
申请号：US14203638
申请日：2014-03-11
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , Sudeep Kumar , Pankaj Oberoi , George Sigal , Michael Tsionsky
IPC: C12Q1/68
CPC classification number: B01L3/50853 , B01L2300/021 , B01L2300/043 , B01L2300/0609 , B01L2300/0829 , C12Q1/6804 , C12Q1/6816 , C12Q1/6876 , G01N33/54306 , G01N33/54353 , G01N33/6845 , G01N2458/10 , C12Q2563/131
Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
Abstract translation: 本发明涉及用于进行固相结合测定的方法。 一个实例是具有改进的分析物特异性的测定方法，其中特异性受到非特异性结合相互作用的存在的限制。
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62.发明授权公开(公告)号：US08790578B2
公开(公告)日：2014-07-29
申请号：US13439309
申请日：2012-04-04
Applicant: Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
Inventor： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
IPC: G01N27/00
CPC classification number: G01N21/253 , B01L3/5085 , B01L9/50 , B01L2300/021 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/12 , G01N21/645 , G01N21/66 , G01N21/76 , G01N2035/042 , G01N2035/0425 , G01N2035/0494 , Y10T29/49155 , Y10T83/04
Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
Abstract translation: 使用具有集成电极的测定模块进行发光测试测量，所述测量模块具有适于接收测定模块的读取器设备，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。
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63.发明授权Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrate 有权N端规则泛素化的底物和测量这些底物的泛素化的方法公开(公告)号：US08530408B2
公开(公告)日：2013-09-10
申请号：US12606787
申请日：2009-10-27
Applicant: Ilia Davydov , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
Inventor： Ilia Davydov , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
IPC: C07K14/00
CPC classification number: G01N33/573 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/4703 , C07K14/4711 , C07K14/4716 , C07K14/4738 , C07K14/705 , C12Q1/25 , C12Q1/37 , G01N2500/04
Abstract: The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
Abstract translation: 本发明涉及用于通过N端规则途径检测，测量和调节蛋白质泛素化的方法，组合物，化合物和试剂盒，并用于鉴定N端规则泛素化的新基质，酶和调节剂。 本发明还涉及N端规则泛素化的特异性底物以及这些底物的活化片段，暴露这些底物中的N-脱落蛋白的蛋白酶，泛素化这些底物的泛素连接酶和这些底物泛素化的抑制剂。
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64.发明申请公开(公告)号：US20100140086A1
公开(公告)日：2010-06-10
申请号：US12591528
申请日：2009-11-23
Applicant: George B. Sigal , Jacob N. Wohlstadter , Satyanarayana Gudibande , Mark T. Martin , James L. Wilbur
Inventor： George B. Sigal , Jacob N. Wohlstadter , Satyanarayana Gudibande , Mark T. Martin , James L. Wilbur
CPC classification number: G01N33/54346 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , G01N33/532 , G01N33/533 , G01N33/54306 , G01N33/54366 , G01N33/5438 , G01N33/552 , G01N33/553 , G01N33/582 , G01N33/587 , G01N2458/30 , C12Q2563/149 , C12Q2563/113 , C12Q2537/125
Abstract: A method and apparatus for performing electrochemiluminescence assays are presented. In exemplary embodiments of the present invention an apparatus comprises an ECL-inactive electrode surface having a first assay-ligand immobilized thereon and an ECL-active microparticle having a second assay ligand immobilized thereon. In exemplary embodiments of the present invention a method comprises (a) forming a mixture comprising an electrochemiluminescent label and a microparticle having a first assay-ligand immobilized thereon, (b) applying electrochemical energy to an electrode surface in the presence of said mixture, and (c) measuring emitted electrochemiluminescence, where the microparticle is ECL-active and where the electrode surface is ECL-inactive when electrochemical energy is applied to it in the presence of said mixture.
Abstract translation: 提出了一种用于进行电化学发光测定的方法和装置。 在本发明的示例性实施方案中，一种装置包括其上固定有第一测定配体的ECL非活性电极表面和其上固定有第二测定配体的ECL活性微粒。 在本发明的示例性实施方案中，方法包括（a）形成包含电化学发光标记和其上固定有第一测定配体的微粒的混合物，（b）在所述混合物存在下将电化学能施加到电极表面，以及 （c）测量发射的电化学发光，其中微粒是ECL-活性的，并且当在所述混合物的存在下施加电化学能时，电极表面是ECL-无活性的。
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65.发明申请ASSAY BUFFER, COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME 有权测定缓冲剂，含有该组合物的组合物及其使用方法公开(公告)号：US20090170121A1
公开(公告)日：2009-07-02
申请号：US12368742
申请日：2009-02-10
Applicant: Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
Inventor： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
IPC: G01N33/53 , G01N33/536
CPC classification number: G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
Abstract: Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.
Abstract translation: 组合物，试剂，试剂盒，系统，系统组分和用于进行测定的方法。 更具体地说，本发明涉及使用新颖的试剂组合来提供改进的测定性能。
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Patent Agency Ranking
公开(公告)号：US20090075299A1
公开(公告)日：2009-03-19
申请号：US12209701
申请日：2008-09-12
Applicant: Anu Mathew , Martin Stengelin , Eli Glezer
Inventor： Anu Mathew , Martin Stengelin , Eli Glezer
IPC: G01N33/573 , G01N33/53
CPC classification number: G01N33/57442 , G01N33/57449 , G01N2333/475 , G01N2333/71 , G01N2333/91215 , G01N2333/96419 , G01N2800/60
Abstract: The present invention relates to methods of diagnosing cancerous conditions in a patient, as well as methods of monitoring the progression of a cancerous condition and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
Abstract translation: 本发明涉及诊断患者癌症状况的方法，以及监测癌症状态进展的方法和/或监测治疗剂或化疗方案治疗方案的方法。 本发明还涉及结合本文所述的诊断方法使用的测定方法。
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67.发明授权Assay buffer, compositions containing the same, and methods of using the same 有权测定缓冲液，含有该组合物的组合物及其使用方法公开(公告)号：US07491540B2
公开(公告)日：2009-02-17
申请号：US11055472
申请日：2005-02-09
Applicant: Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
Inventor： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
CPC classification number: G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
Abstract: Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.
Abstract translation: 组合物，试剂，试剂盒，系统，系统组分和用于进行测定的方法。 更具体地说，本发明涉及使用新颖的试剂组合来提供改进的测定性能。
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68.发明授权Assay buffer, compositions containing the same, and methods of using the same 有权测定缓冲液，含有该组合物的组合物及其使用方法公开(公告)号：US07288410B2
公开(公告)日：2007-10-30
申请号：US11054672
申请日：2005-02-09
Applicant: Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
Inventor： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
CPC classification number: G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
Abstract: Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.
Abstract translation: 组合物，试剂，试剂盒，系统，系统组分和用于进行测定的方法。 更具体地说，本发明涉及使用新颖的试剂组合来提供改进的测定性能。
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公开(公告)号：US07052861B2
公开(公告)日：2006-05-30
申请号：US10007526
申请日：2001-12-05
Applicant: Richard J. Massey , Mark T. Martin , Liwen Dong , Ming Lu , Alan Fischer , Fabian Jameison , Pam Liang , Robert Hoch , Jonathan K. Leland
Inventor： Richard J. Massey , Mark T. Martin , Liwen Dong , Ming Lu , Alan Fischer , Fabian Jameison , Pam Liang , Robert Hoch , Jonathan K. Leland
IPC: G01N33/573 , G01N33/533 , G01N33/553 , G01N21/76 , C12Q1/32
CPC classification number: C01B31/0213 , B82Y30/00 , B82Y40/00 , C01B32/152 , C01B32/174 , C01B2202/34 , C01B2202/36 , C07K17/06 , D01F9/12 , D01F11/14 , G01N21/69 , G01N21/76 , G01N33/54373 , G01N33/5438 , G01N33/582 , G01N2030/8863 , G11C13/025 , H01M4/60 , Y10S435/968 , Y10S436/805 , Y10S436/806 , Y10S977/737 , Y10S977/742
Abstract: Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.
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公开(公告)号：USD516221S1
公开(公告)日：2006-02-28
申请号：US29167119
申请日：2002-09-09
Applicant: Jacob N. Wohlstadter , Eli N. Glezer , Charles Clinton , Brian A. Self , John Mattson , Lance Hussey , Nasahn Sheppard , Hirotomi Teranishi , Ravi Sawhney
Designer： Jacob N. Wohlstadter , Eli N. Glezer , Charles Clinton , Brian A. Self , John Mattson , Lance Hussey , Nasahn Sheppard , Hirotomi Teranishi , Ravi Sawhney
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