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公开(公告)号：US10080795B2
公开(公告)日：2018-09-25
申请号：US14903997
申请日：2014-07-25
IPC分类号： A61K39/145 , A61K41/00 , A61L2/00 , A61K39/00
CPC分类号： A61K39/145 , A61K41/0009 , A61K2039/5252 , A61L2/007 , A61L2202/21
摘要： The invention relates to a method for inactivating viruses, characterized in that an immunogenic composition or vaccine comprising at least one virus is irradiated with electron beams, said immunogenic composition or vaccine comprising at least one virus (i) being liquid, in particular being a suspension and (ii) comprising at least one viral immunogen, wherein the antigen structure is preferably substantially retained.
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公开(公告)号：US20180193497A1
公开(公告)日：2018-07-12
申请号：US15889473
申请日：2018-02-06
申请人： LifeCell Corporation
发明人： Gary Monteiro , Martin J. Byrne , Rick T. Owens
CPC分类号： A61L2/0011 , A01N25/00 , A01N37/16 , A61L2/007 , A61L2/0088
摘要： The present disclosure provides methods for reducing bioburden on a tissue product, as well as the tissue products produced according to the disclosed methods. In particular, the disclosure relates to methods of electroporating tissue in the presence of one or more bactericides in order to reduce bioburden. The methods allow for reduced exposure to electrical energy and/or bactericide while reducing bioburden.
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公开(公告)号：US20180055932A1
公开(公告)日：2018-03-01
申请号：US15561196
申请日：2016-03-21
发明人： Daryl Rees , Antonia Orsi
CPC分类号： A61K41/0009 , A61K31/198 , A61K38/05 , A61K41/0019 , A61L2/0029 , A61L2/0035 , A61L2/007 , A61L2202/18 , A61L2202/21 , A61P1/00
摘要： This invention provides a method of sterilising an S-nitrosothiol, for example S-nitrosoglutathione, without reduction of purity by more than about 5.0% through degradation. The invention allows sterile S-nitrosothiol or a sterile pharmaceutical pre-composition comprising S-nitrosothiol, wherein the S-nitrosothiol is in dry solid form, to be produced. The sterile pharmaceutical pre-composition is mixed with one or more diluents, excipients, carriers, additional active agents, or any combination thereof, for example sterile saline, to prepare a pharmaceutical composition of S-nitrosothiol for use.
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公开(公告)号：US09561248B2
公开(公告)日：2017-02-07
申请号：US14324889
申请日：2014-07-07
申请人： Medtronic, Inc.
IPC分类号： A61K31/722 , A61K31/717 , A61K9/00 , A61K9/06 , A61L2/00 , C08L5/08 , A61L2/08 , C08L1/28 , A61K31/045 , A61K47/36 , A61K47/38 , A61L27/20 , A61L27/26 , A61L27/56 , C08B15/00 , C08B37/08 , C08B37/00 , C08J3/12
CPC分类号： A61K31/722 , A61K9/0019 , A61K9/0024 , A61K9/0043 , A61K9/0046 , A61K9/0085 , A61K9/06 , A61K31/045 , A61K31/717 , A61K31/718 , A61K47/36 , A61K47/38 , A61L2/007 , A61L2/081 , A61L2/087 , A61L27/20 , A61L27/26 , A61L27/52 , A61L27/56 , A61L2300/404 , A61L2400/06 , C08B15/005 , C08B37/003 , C08B37/0042 , C08G2210/00 , C08J3/124 , C08L1/286 , C08L5/08 , C08L1/26 , C08L2666/26
摘要： Tissue and other body structures may be protected using a hydrated composition made from free-flowing substantially collagen-free rehydratable polysaccharide particles and rehydratable polysaccharide sponges. Rehydration of the particles without clumping may be carried out be dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated composition may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.
摘要翻译： 可以使用由自由流动的基本上无胶原的可再水化多糖颗粒和可再水化的多糖海绵制成的水合组合物来保护组织和其它身体结构。 可以进行将颗粒分散在生物相容性的水混溶性极性分散剂如乙醇中并将该分散体与足够的水溶剂混合以使颗粒转化为粘性水凝胶的颗粒的再水化。 水合组合物可以帮助将损伤的，发炎的或手术修复的表面恢复到正常状态，例如通过一种或多种愈合机制，例如调节炎症反应，吞噬作用，粘膜重塑，复发或其他全部或部分恢复正常 功能。
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公开(公告)号：US20160158394A1
公开(公告)日：2016-06-09
申请号：US15042974
申请日：2016-02-12
摘要： A system for sterilizing a fluid includes a sterilization container bounding a fluid flow path that can be coupled with a fluid source. The sterilization container is comprised of one or more polymeric walls. A beam generator is configured to direct a beam of electromagnetic radiation through at least a portion of the fluid flow path of the sterilization container, the beam of electromagnetic radiation being sufficient to sterilize a fluid within the fluid flow path.
摘要翻译： 用于对流体灭菌的系统包括限定可与流体源耦合的流体流动路径的灭菌容器。 灭菌容器由一个或多个聚合物壁组成。 束发生器被配置为引导电磁辐射束穿过消毒容器的流体流动路径的至少一部分，电磁辐射束足以对流体流动路径内的流体进行消毒。
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公开(公告)号：US20160158339A1
公开(公告)日：2016-06-09
申请号：US14903997
申请日：2014-07-24
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K41/0009 , A61K2039/5252 , A61L2/007 , A61L2202/21
摘要： The invention relates to a method for inactivating viruses, characterized in that an immunogenic composition or vaccine comprising at least one virus is irradiated with electron beams, said immunogenic composition or vaccine comprising at least one virus (i) being liquid, in particular being a suspension and (ii) comprising at least one viral immunogen, wherein the antigen structure is preferably substantially retained.
摘要翻译： 本发明涉及一种用于灭活病毒的方法，其特征在于用电子束照射包含至少一种病毒的免疫原性组合物或疫苗，所述免疫原性组合物或疫苗包含至少一种病毒（i）为液体，特别是悬液 和（ii）包含至少一种病毒免疫原，其中优选基本上保留抗原结构。
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公开(公告)号：US09289522B2
公开(公告)日：2016-03-22
申请号：US14381551
申请日：2013-02-27
摘要： A system for sterilizing a fluid includes a fluid source and a sterilization container bounding a fluid flow path that is in fluid communication with the fluid source. The sterilization container is comprised of one or more polymeric walls. An electron beam generator is configured to direct an electron beam through at least a portion of the fluid flow path of the sterilization container, the electron beam being sufficient to sterilize a fluid within the fluid flow path.
摘要翻译： 用于对流体灭菌的系统包括流体源和限定与流体源流体连通的流体流动路径的灭菌容器。 灭菌容器由一个或多个聚合物壁组成。 电子束发生器被配置为引导电子束通过灭菌容器的流体流动路径的至少一部分，电子束足以对流体流动路径内的流体进行消毒。
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公开(公告)号：US09180216B2
公开(公告)日：2015-11-10
申请号：US14399426
申请日：2013-05-14
申请人： Airex Co., Ltd.
发明人： Koji Kawasaki , Daisuke Kakuda , Jun Masudome
摘要： An electron beam irradiation device which can irradiate an electron beam uniformly to an entire outer surface of an object of irradiation by using a small-sized low-energy electron accelerator with a narrow irradiation window is provided. The device has electron beam irradiation means forming an electron beam irradiation zone and gripping/moving means gripping a part of an object of irradiation and causing the object of irradiation to pass through the electron beam irradiation zone, and the whole surface of the object of irradiation can uniformly pass through the electron beam irradiation zone by combining re-gripping of the object of irradiation by two gripping mechanisms provided on the gripping/moving means, rotation of the object of irradiation by two rotation mechanisms, and movement of the object of irradiation by two moving mechanisms.
摘要翻译： 提供一种可以通过使用具有窄照射窗口的小尺寸低能电子加速器将电子束均匀地照射到照射对象的整个外表面的电子束照射装置。 该装置具有形成电子束照射区域的电子束照射装置和夹持/移动装置，其夹持照射物体的一部分并使照射物体通过电子束照射区域，并且照射物体的整个表面 可以通过将设置在夹持/移动装置上的两个夹持机构重新夹持照射物体，通过两个旋转机构的照射物体的旋转以及被照射物体的移动来均匀地通过电子束照射区域 两个移动机制。
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69.发明授权Method and arrangement for sterilization, in particular for the sterilization of an adsorber 有权用于灭菌的方法和装置，特别是用于吸附器的灭菌公开(公告)号：US09011765B2
公开(公告)日：2015-04-21
申请号：US13125344
申请日：2009-10-22
CPC分类号： A61L2/007 , A61L2/0035 , A61L2/08 , A61L2202/122 , A61M1/168 , A61M1/169
摘要： A method and an arrangement for sterilizing, in particular for sterilizing an adsorber, which has an adsorber housing that is to be filled with an adsorbent, are such that, instead of the adsorbent-filled adsorber housing being sterilized, the adsorbent is sterilized in a separate container, which is dimensioned such that the adsorbent spreads out in a thin layer in the container. Together with the adsorber housing, the container for sterilizing the adsorbent forms a closed system, such that the adsorbent can be transferred into the adsorber housing without the need for an aseptic environment. The container for receiving the adsorbent is preferably a bag, in which the adsorbent spreads out in a thin layer when the bag is lying flat on a plane surface. Since the adsorbent in the bag spreads out in a thin layer, the sterilization requires only a relatively small dose of radiation, which cannot damage the adsorbent. The bag is irradiated with high-energy radiation, in particular ionizing radiation. The adsorbent is then transferred from the bag into the adsorber housing. During the transfer of the adsorbent into the adsorber housing, the air and/or excess liquid present in the adsorber housing is removed from the adsorber housing preferably into one or more empty bags.
摘要翻译： 特别是消毒吸附器的方法和装置，其特征在于，具有吸附器壳体的要被填充吸附剂的灭菌器是这样的：代替吸附剂填充的吸附器壳体被消毒，吸附剂在 分离的容器的尺寸使得吸附剂在容器中的薄层中展开。 与吸附器壳体一起，用于消毒吸附剂的容器形成封闭系统，使得吸附剂可以被转移到吸附器壳体中，而不需要无菌环境。 用于接收吸附剂的容器优选为袋，当袋平躺在平面上时，吸附剂以薄层展开。 由于袋中的吸附剂散布在薄层中，所以灭菌只需要较小剂量的辐射，这不会损伤吸附剂。 用高能量辐射照射袋子，特别是电离辐射。 然后将吸附剂从袋中转移到吸附器壳体中。 在将吸附剂转移到吸附器壳体期间，存在于吸附器壳体中的空气和/或多余的液体优选地从吸附器壳体移除到一个或多个空袋中。
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公开(公告)号：US20110044847A1
公开(公告)日：2011-02-24
申请号：US12858065
申请日：2010-08-17
申请人： Benjamin Kibalo
发明人： Benjamin Kibalo
CPC分类号： A61L2/0011 , A61K35/36 , A61L2/0035 , A61L2/0041 , A61L2/007 , A61L2/0088
摘要： Methods for processing tissue are provided. In some embodiments, the methods comprise methods for decellularizing tissue samples by applying high hydrostatic pressure to the tissues samples. In some embodiments, the methods comprise methods for thawing tissue samples and/or reducing the bioburden in a sample by applying high hydrostatic pressure to the tissue samples.
摘要翻译： 提供了处理组织的方法。 在一些实施方案中，所述方法包括通过对组织样品施加高静水压力来使组织样品脱细胞化的方法。 在一些实施方案中，所述方法包括通过对组织样品施加高静水压力来解冻组织样品和/或减少样品中的生物负载的方法。
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