公开(公告)号：US06394942B2

公开(公告)日：2002-05-28

申请号：US09746419

申请日：2000-12-21

Applicant: James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

Inventor： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

IPC: H01L21302

CPC classification number: G01N30/7266 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/167 ,  Y10T29/49002 ,  Y10T436/25375 ,  Y10T436/255

Abstract: An electrospray device, a liquid chromatography device and an electrosprayliquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may-be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

公开(公告)号：US20010030285A1

公开(公告)日：2001-10-18

申请号：US09799223

申请日：2001-03-05

Inventor： Raanan A. Miller ,  Erkinjon G. Nazarov ,  Gary A. Eiceman ,  Evgeny Krylov ,  Boris Tadjikov

IPC: H01J049/00 ,  B01D059/44

CPC classification number: G01N27/624 ,  G01N27/62 ,  G01N27/64 ,  G01N30/7206 ,  G01N2030/0095 ,  H01J49/0018 ,  H01J49/0022

Abstract: Method and apparatus for chromatographic high field asymmetric waveform ion mobility spectrometry, including a gas chromatographic analyzer section intimately coupled with an ionization section, an ion filter section, and an ion detection section, in which the sample compounds are at least somewhat separated prior to ionization, and ion filtering proceeds in a planar chamber under influence of high field asymmetric periodic signals, with detection integrated into the flow path, for producing accurate, real-time, orthogonal data for identification of a broad range of chemical compounds.

Abstract translation: 用于色谱高场非对称波形离子迁移谱的方法和装置，包括与电离部分紧密耦合的气相色谱分析器部分，离子过滤部分和离子检测部分，其中样品化合物在电离之前至少有些分离 并且离子过滤在高场不对称周期信号的影响下在平面室中进行，其中检测集成到流路中，用于产生准确的实时正交数据，用于识别宽范围的化合物。

公开(公告)号：US20010007350A1

公开(公告)日：2001-07-12

申请号：US09747085

申请日：2000-12-21

Inventor： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

IPC: H01J049/00 ,  B01D059/44

CPC classification number: G01N30/7266 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/167 ,  Y10T29/49002 ,  Y10T436/25375 ,  Y10T436/255

Abstract: An electrospray device, a liquid chromatography device and an electrosprayliquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may -be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

公开(公告)号：US20010001460A1

公开(公告)日：2001-05-24

申请号：US09745652

申请日：2000-12-21

Inventor： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

IPC: B44C001/22

CPC classification number: G01N30/7266 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/167 ,  Y10T29/49002 ,  Y10T436/25375 ,  Y10T436/255

Abstract: An electrospray device, a liquid chromatography device and an electrosprayliquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may -be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

公开(公告)号：US20010001455A1

公开(公告)日：2001-05-24

申请号：US09745629

申请日：2000-12-21

Inventor： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

IPC: G01N021/01

CPC classification number: G01N30/7266 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/167 ,  Y10T29/49002 ,  Y10T436/25375 ,  Y10T436/255

Abstract: An electrospray device, a liquid chromatography device and an electrosprayliquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may -be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

公开(公告)号：US06188067B1

公开(公告)日：2001-02-13

申请号：US09436052

申请日：1999-11-08

Applicant: Ara Chutjian ,  Michael Hecht ,  Otto Orient ,  Dean Wiberg ,  Reid A. Brennen

Inventor： Ara Chutjian ,  Michael Hecht ,  Otto Orient ,  Dean Wiberg ,  Reid A. Brennen

IPC: H01J4942

CPC classification number: H01J49/0018 ,  H01J49/009 ,  H01J49/4215

Abstract: The present invention provides a quadrupole mass spectrometer and an ion filter for use in the quadrupole mass spectrometer. The ion filter includes a thin patterned layer including a two-dimensional array of poles forming one or more quadrupoles. The patterned layer design permits the use of very short poles and with a very dense spacing of the poles, so that the ion filter may be made very small. Also provided is a method for making the ion filter and the quadrupole mass spectrometer. The method involves forming the patterned layer of the ion filter in such a way that as the poles of the patterned layer are formed, they have the relative positioning and aligrnent for use in a final quadrupole mass spectrometer device.

Abstract translation: 本发明提供一种用于四极质谱仪中的四极质谱仪和离子过滤器。 离子过滤器包括薄的图案层，其包括形成一个或多个四极的二维阵列阵列。 图案层设计允许使用非常短的极点和极的非常密集的间隔，使得离子过滤器可以非常小。 还提供了制造离子过滤器和四极质谱仪的方法。 该方法包括以这样的方式形成离子过滤器的图案化层，使得当形成图案层的极时，它们具有用于最终四极质谱仪装置中的相对定位和浓度。

公开(公告)号：US6025591A

公开(公告)日：2000-02-15

申请号：US939725

申请日：1997-10-03

Applicant: Stephen Taylor ,  Thomas Tate ,  Richard Syms ,  Howard Dorey

Inventor： Stephen Taylor ,  Thomas Tate ,  Richard Syms ,  Howard Dorey

IPC: H01J49/42

CPC classification number: H01J49/4215 ,  B82Y10/00 ,  H01J49/0018

Abstract: A quadrupole mass spectrometer comprises an ion source (20), a mass filter (22) and an ion collector (24). The ion source comprises an array (30) of quantum wires. The mass filter comprises four glass fibres (32) coated with nickel and the ion collector is an a electrode connected to an integrated complementary metal oxide semiconductor temperature compensated integrated amplifier.

Abstract translation: PCT No.PCT / GB96 / 00810 Sec。 371日期1998年2月17日 102（e）日期1998年2月17日PCT 1996年4月3日PCT PCT。 公开号WO96 / 31901 日期：1996年10月10日四极质谱仪包括离子源（20），质量过滤器（22）和离子收集器（24）。 离子源包括量子线阵列（30）。 质量过滤器包括涂覆有镍的四个玻璃纤维（32），离子收集器是连接到集成的互补金属氧化物半导体温度补偿集成放大器的电极。

公开(公告)号：US5248883A

公开(公告)日：1993-09-28

申请号：US883798

申请日：1992-05-12

Applicant: Richard G. Brewer ,  Ralph G. Devoe ,  Kenneth L. Foster ,  John A. Hoffnagle ,  Reinald Kallenbach

Inventor： Richard G. Brewer ,  Ralph G. Devoe ,  Kenneth L. Foster ,  John A. Hoffnagle ,  Reinald Kallenbach

IPC: G04F5/14 ,  H01J49/38 ,  H01J49/42 ,  H03L7/26

CPC classification number: H03L7/26 ,  G04F5/14 ,  H01J49/0018 ,  H01J49/424

Abstract: An ion confinement, i.e., trap, apparatus comprises electrically conductive members, including concentric, coplanar rings or parallel sheets separated by dielectric spacers disposed on the outer edges of the sheets, each of the sheets having a circular hole, the circular holes being symmetrically aligned substantially along a common axis. The trap apparatus further has means for applying an RF potential to the conductive members, such that the resulting electric field being generated in the space defined by the conductive members has a characteristic of a substantially quadrupole field. A charged particle, being injected into the space, is confined in the field, maintaining a dynamic equilibrium condition.

Abstract translation: 离子限制，即陷阱装置包括导电构件，包括同心的共面环或由设置在片的外边缘上的电介质间隔隔开的平行片，每个片具有圆形孔，圆形孔对称对准 基本上沿着公共轴线。 陷阱装置还具有用于向导电构件施加RF电势的装置，使得在由导电构件限定的空间中产生的所得电场具有基本四极场的特性。 注入空间的带电粒子被限制在现场，保持动态平衡状态。

公开(公告)号：US4746068A

公开(公告)日：1988-05-24

申请号：US924709

申请日：1986-10-29

Applicant: Paul C. Goodley ,  Harvey D. Loucks, Jr.

Inventor： Paul C. Goodley ,  Harvey D. Loucks, Jr.

IPC: G01F1/20 ,  B05B7/04 ,  G01N30/72 ,  H01J49/04 ,  B05B7/10

CPC classification number: H01J49/0018 ,  B05B7/0483 ,  G01N30/7246 ,  H01J49/045

Abstract: A nebulizer assembly particularly well adapted as a liquid chromatograph/mass spectrometer interface including a pair of nebulizer plates, a base, and a cap for tightly holding the nebulizer plates against the base. A first nebulizer plate has a centrally located outlet orifice and a radially extending groove, and the second plate has a centrally located gas inlet orifice and a radially displaced liquid inlet orifice. The gas inlet orifice aligns with the outlet orifice and an aperture provided in the cap, and the liquid inlet orifice aligns with a section of the groove provided in the first nebulizer plate. When the gas inlet orifice is coupled to a pressurized gas source and the liquid inlet orifice is coupled to a pressurized liquid source, uniform droplets having a diameter of approximately 10 microns can be formed from an outlet orifice twice that diameter.

Abstract translation: 特别适合作为液相色谱仪/质谱仪界面的喷雾器组件，包括一对雾化器板，底座和盖子，用于将喷雾器板紧紧地固定在基座上。 第一雾化器板具有位于中心的出口孔和径向延伸的槽，并且第二板具有位于中心的气体入口孔和径向移位的液体入口孔。 气体入口孔与出口孔和设置在盖中的孔对准，并且液体入口孔与设置在第一雾化器板中的槽的一部分对准。 当气体入口孔连接到加压气体源并且液体入口孔连接到加压液体源时，可以从两个直径的出口孔形成具有约10微米直径的均匀液滴。

公开(公告)号：US11721537B2

公开(公告)日：2023-08-08

申请号：US17488372

申请日：2021-09-29

Applicant: Infineon Technologies Austria AG

Inventor： Clemens Roessler ,  Silke Auchter ,  Johanna Elisabeth Roessler ,  Gerald Stocker

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/424 ,  H01J49/0018

Abstract: A device for controlling trapped ions includes a first substrate. A second substrate is disposed over the first substrate. One or a plurality of first level ion traps is configured to trap ions in a space between the first substrate and the second substrate. One or a plurality of second level ion traps is configured to trap ions in a space above the second substrate. An opening in the second substrate is provided through which ions can be transferred between a first level ion trap and a second level ion trap.