公开(公告)号：US10047374B2

公开(公告)日：2018-08-14

申请号：US14971550

申请日：2015-12-16

Applicant: Dow AgroSciences LLC ,  The Board of Regents of the University of Nebraska

Inventor： Blair D. Siegfried ,  Kenneth E. Narva ,  Kanika Arora ,  Sarah E. Worden ,  Chitvan Khajuria ,  Elane Fishilevich ,  Nicholas P. Storer ,  Meghan Frey ,  Ronda L. Hamm ,  Ana Velez

IPC: C12N15/82 ,  C12N15/113 ,  A01N57/16

Abstract: This disclosure concerns nucleic acid molecules and methods of use thereof for control of hemipteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in hemipteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of hemipteran pests, and the plant cells and plants obtained thereby.

公开(公告)号：US10022325B2

公开(公告)日：2018-07-17

申请号：US13783991

申请日：2013-03-04

Applicant: Board of Regents of the University of Nebraska

Inventor： Alexander V. Kabanov ,  Daria Y. Alakhova ,  Yi Zhao

IPC: A61K9/127 ,  A61K47/10 ,  A61K9/00 ,  A61K31/704

Abstract: The present invention provides compositions and methods for the treatment of cancer are provided.

公开(公告)号：US20180194725A1

公开(公告)日：2018-07-12

申请号：US15743427

申请日：2016-07-15

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Kenneth Bayles ,  Rongshi Li ,  Yan Liu

IPC: C07D207/34 ,  C07D207/333 ,  C07D231/16 ,  C07D233/90 ,  C07D233/68 ,  C07D249/12 ,  A61P31/04 ,  A61P35/00

CPC classification number: C07D207/34 ,  A61P31/04 ,  A61P35/00 ,  C07D207/333 ,  C07D231/16 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D249/12

Abstract: Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.

公开(公告)号：US20180187215A1

公开(公告)日：2018-07-05

申请号：US15890561

申请日：2018-02-07

Applicant: Board of Regents of the University of Nebraska ,  Tokai University Educational System

Inventor： Channabasavaiah B. Gurumurthy ,  Hiromi Miura ,  Masato Ohtsuka

IPC: C12N15/90 ,  A01K67/027 ,  C12N9/96 ,  C12N9/22 ,  C12N15/11 ,  C12N15/85

CPC classification number: C12N15/907 ,  A01K67/0275 ,  A01K67/0276 ,  A01K67/0278 ,  A01K2217/058 ,  A01K2217/203 ,  A01K2227/105 ,  C12N9/22 ,  C12N9/96 ,  C12N15/102 ,  C12N15/11 ,  C12N15/8509 ,  C12N2310/20 ,  C12N2510/00 ,  C12Q2521/301

Abstract: Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally relates to compositions, methods, and kits for DNA editing using single-stranded DNA. Compositions and methods for modifying gene expression using artificial microRNAs (amiRNA) are also contemplated.

公开(公告)号：US20180140377A1

公开(公告)日：2018-05-24

申请号：US15821169

申请日：2017-11-22

Applicant: Board of Regents of the University of Nebraska

Inventor： Mark Reichenbach ,  Shane Farritor

IPC: A61B90/50 ,  A61B1/00 ,  A61B17/02

CPC classification number: A61B90/50 ,  A61B1/00149 ,  A61B17/0206 ,  A61B34/30 ,  A61B34/73 ,  A61B2017/00477 ,  A61B2034/302 ,  A61B2218/002 ,  A61B2218/007

Abstract: Disclosed herein are gross positioning systems for use with robotic surgical devices to provide gross positioning of the robotic surgical devices. The gross positioning systems have a base, a first arm link operably coupled to the base, a second arm link operably coupled to the first arm link, a third arm link operably coupled to the second arm link, and a slidable coupling component slidably coupled to the third arm link.

公开(公告)号：US09970059B2

公开(公告)日：2018-05-15

申请号：US14540302

申请日：2014-11-13

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Arizona Board of Regents on behalf of the University of Arizona ,  Queen Mary University of London ,  Board of Regents of the University of Nebraska ,  Oslo University Hospital HF ,  Oregon Health & Science University ,  University of Rochester ,  Hospital Clinic de Barcelona ,  Universitat De Barcelona ,  British Columbia Cancer Agency Branch ,  Julius-Maximilians-University of Wuerzburg

Inventor： Lisa Rimsza ,  Andrew T. Lister ,  Wing C. Chan ,  Dennis Weisenburger ,  Jan Delabie ,  Erlend B. Smeland ,  Harald Holte ,  Stein Kvaloy ,  Rita M. Braziel ,  Richard I. Fisher ,  Pedro Jares ,  Armando Lopez-Guillermo ,  Elias Campo Guerri ,  Elaine S. Jaffe ,  Georg Lenz ,  Wyndham H. Wilson ,  George Wright ,  Sandeep S. Dave ,  Louis M. Staudt ,  Randy D. Gascoyne ,  Joseph M. Connors ,  Hans-Konrad Muller-Hermelink ,  Andreas Rosenwald ,  German Ott

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  G01N33/57407 ,  G01N2800/52 ,  G01N2800/56

Abstract: The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.

公开(公告)号：US20180125398A1

公开(公告)日：2018-05-10

申请号：US15861362

申请日：2018-01-03

Applicant: Board of Regents of the University of Nebraska

Inventor： Dimitrios Miserlis ,  Kim Cluff ,  Abby M. Kelly ,  Suzanne J. Higgins ,  Max H. Twedt

IPC: A61B5/145 ,  A61B5/08

CPC classification number: A61B5/14507 ,  A61B5/08 ,  A61B5/0813 ,  A61B5/091 ,  A61M1/0025 ,  A61M2202/0225 ,  A61M2202/025 ,  A61M2202/0275 ,  A61M2210/101

Abstract: The disclosure is directed to intrapleural air leak detection and monitoring. According to various embodiments of the disclosure, an air leak may be detected utilizing at least one sensor to determine whether fluid extracted from a pleural cavity of a patient includes carbon dioxide and/or a second substance. The second substance may be a foreign substance inhaled by the patient to confirm presence of the air leak. The air leak may be further monitored over a period of time by collecting temporally successive measurements associated with detected concentrations of carbon dioxide. Therefore, tissue damage and recovery may be assessed according to objectively collected criteria.

公开(公告)号：US09962352B2

公开(公告)日：2018-05-08

申请号：US15344835

申请日：2016-11-07

Applicant: Vireo Systems, Inc. ,  Board of Regents of the University of Nebraska

Inventor： Donald W. Miller ,  Jonathan L. Vennerstrom ,  Mark C. Faulkner

IPC: A61K31/195 ,  A61K31/198 ,  A61K31/661 ,  A23L2/52 ,  A61K31/185 ,  A23K20/105 ,  A23K20/142 ,  A23K50/10 ,  A23L33/10 ,  A23L33/175 ,  A23K20/10 ,  A61K9/00 ,  A23P10/40

CPC classification number: A61K31/198 ,  A23K20/10 ,  A23K20/105 ,  A23K20/142 ,  A23K50/10 ,  A23L2/52 ,  A23L33/10 ,  A23L33/175 ,  A23P10/40 ,  A23V2002/00 ,  A61K9/0053 ,  A61K31/185 ,  A61K31/195 ,  A61K31/661 ,  A23V2250/306 ,  A23V2200/33 ,  A23V2200/316

Abstract: The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater than creatine monohydrate, where the oral supplement drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.

公开(公告)号：US20180071036A1

公开(公告)日：2018-03-15

申请号：US15661147

申请日：2017-07-27

Applicant: Board of Regents of the University of Nebraska

Inventor： Shane Farritor ,  Erik Mumm ,  Philip Chu ,  Nishant Kumar ,  Jason Dumpert ,  Yutaka Tsutano

IPC: A61B34/30 ,  A61B17/00 ,  A61B34/37

CPC classification number: A61B34/30 ,  A61B17/00234 ,  A61B17/29 ,  A61B34/00 ,  A61B34/37 ,  A61B90/30 ,  A61B90/361 ,  A61B2017/2906 ,  A61B2034/302 ,  A61B2217/005 ,  A61B2217/007

Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various modular medical devices for in vivo medical procedures.

公开(公告)号：US20180055584A1

公开(公告)日：2018-03-01

申请号：US15691087

申请日：2017-08-30

Applicant: Board of Regents of the University of Nebraska

Inventor： Shane Farritor ,  Thomas Frederick ,  Lou Cubrich

IPC: A61B34/30 ,  B25J9/00

Abstract: The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations and at least three degrees of freedom. Other embodiments relate to various medical device components, including forearms having grasper or cautery end effectors, that can be incorporated into certain robotic and/or in vivo medical devices.