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公开(公告)号：US07989455B2
公开(公告)日：2011-08-02
申请号：US11640476
申请日：2006-12-14
申请人： Bradley P. Morgan , David J. Morgans, Jr. , Alex Muci , Pu-Ping Lu , Erica A. Kraynack , Todd Tochimoto
发明人： Bradley P. Morgan , David J. Morgans, Jr. , Alex Muci , Pu-Ping Lu , Erica A. Kraynack , Todd Tochimoto
IPC分类号： A61K31/06 , A61K31/497 , C07D401/06 , C07D401/08
CPC分类号： C07D213/75 , C07D261/14 , C07D401/12 , C07D401/14 , C07D413/12
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的脲衍生物选择性地调节心肌肉瘤，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US20090312365A1
公开(公告)日：2009-12-17
申请号：US12350094
申请日：2009-01-07
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/437 , C07D471/04 , A61P35/00
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20090306127A1
公开(公告)日：2009-12-10
申请号：US12350114
申请日：2009-01-07
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/437 , C07D471/04 , A61P35/00
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20090247544A1
公开(公告)日：2009-10-01
申请号：US12371499
申请日：2009-02-13
IPC分类号： A61K31/497
CPC分类号： A61K31/195 , A61K31/496 , A61K31/498 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Certain substituted urea derivatives modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and are useful in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, cachexia, neuromuscular diseases (e.g., amyotrophic lateral sclerosis, spinal muscular atrophy, familial or acquired myopathies or muscular dystrophies), post-surgical and post-traumatic muscle weakness, and other conditions.
摘要翻译： 某些取代的脲衍生物调节骨骼肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌钙蛋白C，骨骼肌钙蛋白I，骨骼肌钙蛋白T和骨骼肌，包括其片段和同种型，以及骨骼肌节，并且可用于治疗 肥胖，肌肉减少症，消瘦综合征，虚弱，肌肉痉挛，恶病质，神经肌肉疾病（例如肌萎缩性侧索硬化，脊髓性肌萎缩，家族性或获得性肌病或肌营养不良），手术后和创伤后肌肉无力等条件。
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公开(公告)号：US20090192168A1
公开(公告)日：2009-07-30
申请号：US12340492
申请日：2008-12-19
IPC分类号： A61K31/496 , C07D401/12 , A61P9/00
CPC分类号： C07D401/12 , C07D213/75
摘要： Certain substituted urea derivatives modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的脲衍生物可调节心脏肌节，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US07538223B2
公开(公告)日：2009-05-26
申请号：US11498986
申请日：2006-08-04
申请人： Bradley P. Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David J. Morgans, Jr.
发明人： Bradley P. Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David J. Morgans, Jr.
IPC分类号： C07D211/68 , C07D401/00 , C07D459/00
CPC分类号： C07D417/12 , C07D513/04
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号：US20080132548A1
公开(公告)日：2008-06-05
申请号：US11888903
申请日：2007-08-01
申请人： Xiangping Qian , Jeffrey T. Finer , Pu-Ping Lu , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans
发明人： Xiangping Qian , Jeffrey T. Finer , Pu-Ping Lu , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans
IPC分类号： A61K31/41 , C07D257/04 , A61K31/4439 , C07D401/12 , C07D413/12 , A61K31/422 , A61P21/00
CPC分类号： C07D257/04 , C07D403/10
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
摘要翻译： 描述了调节平滑肌肌球蛋白和/或非肌肉肌球蛋白的化学实体，治疗与平滑肌肌球蛋白和/或非肌肉肌球蛋白相关的疾病和病症的药物组合物和方法。
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公开(公告)号：US06699893B2
公开(公告)日：2004-03-02
申请号：US10080174
申请日：2002-02-19
IPC分类号： C07D21302
CPC分类号： C07D455/06 , C07C49/747 , C07C49/755 , C07C69/76 , C07C215/74 , C07C235/66 , C07C251/44 , C07C251/52 , C07C251/60 , C07C255/53 , C07C255/54 , C07C271/44 , C07C271/52 , C07C281/04 , C07C307/02 , C07C309/65 , C07C309/66 , C07C309/73 , C07C311/04 , C07C311/08 , C07C311/51 , C07C317/18 , C07C333/04 , C07C2603/00 , C07C2603/26 , C07D207/09 , C07D211/46 , C07D213/22 , C07D213/30 , C07D213/40 , C07D213/75 , C07D231/40 , C07D231/56 , C07D239/34 , C07D241/18 , C07D241/20 , C07D249/08 , C07D249/14 , C07D257/04 , C07D271/06 , C07D271/07 , C07D277/24 , C07D277/28 , C07D277/56 , C07D295/088 , C07D295/13 , C07D295/185 , C07D295/205 , C07D303/14 , C07D317/36 , C07D333/16 , C07D413/04
摘要： The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.
摘要翻译： 本发明提供了类固醇受体的选择性调节剂（即激动剂和拮抗剂），特别是糖皮质激素受体的式I的非类固醇化合物。 本发明还提供含有这些化合物的药物组合物和使用这些化合物治疗需要糖皮质激素受体激动剂或拮抗剂治疗的动物的方法。 糖皮质激素受体调节剂可用于治疗如下所述的疾病，例如肥胖，糖尿病，炎症等。 本发明还提供了制备这些化合物的中间体和方法。
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