公开(公告)号：US09849272B2

公开(公告)日：2017-12-26

申请号：US14899146

申请日：2014-06-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki Yamamoto ,  Makoto Ogura

IPC: A61M5/00 ,  A61M37/00 ,  A61M35/00 ,  A61M25/00 ,  A61M25/02

CPC classification number: A61M37/0015 ,  A61M25/002 ,  A61M35/00 ,  A61M37/00 ,  A61M2025/0266 ,  A61M2037/0023

Abstract: An applicator of one aspect for applying a sheet member to skin includes a body having a bottom surface facing the skin and a first guide configured to guide the sheet member to a space between the skin and the bottom surface, in which the sheet member is applied to the skin after being folded in the space.

公开(公告)号：USD805208S1

公开(公告)日：2017-12-12

申请号：US29574873

申请日：2016-08-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Kimiko Komatani ,  Takahito Yoshizaki ,  Tetsushi Kubota

公开(公告)号：US20170348248A1

公开(公告)日：2017-12-07

申请号：US15537952

申请日：2015-12-14

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Keiichiro TSURUSHIMA ,  Yasuhisa KOSE ,  Takaaki YOSHINAGA

IPC: A61K9/70 ,  A61K31/618 ,  A61K47/14 ,  A61K47/26

CPC classification number: A61K9/7061 ,  A61K31/618 ,  A61K47/14 ,  A61K47/26

Abstract: The present invention provides a gel patch comprising a base fabric, an adhesive layer, and a release liner in this order, wherein the adhesive layer contains a physiologically active substance, a water-soluble (meth)acrylic polymer, water, a surfactant, and poly(methyl acrylate/2-ethylhexyl acrylate), and the surfactant comprises a polyethylene glycol fatty acid ester or a polyoxyethylene sorbitan fatty acid ester.

公开(公告)号：US09707194B2

公开(公告)日：2017-07-18

申请号：US15121534

申请日：2015-02-26

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Seiichiro Tsuru ,  Masayoshi Maki ,  Shinji Yamasoto ,  Takaaki Terahara

IPC: A61K31/192 ,  A61K9/00 ,  A61K9/70 ,  A61K31/12 ,  A61K47/10 ,  D03D15/00

CPC classification number: A61K31/192 ,  A61K9/0014 ,  A61K9/7023 ,  A61K9/7069 ,  A61K31/12 ,  A61K47/10 ,  D03D15/00

Abstract: The invention provides a gel patch comprising a support and an adhesive layer on the support, wherein the adhesive layer comprises 1.5 to 2.5 mass % of ketoprofen, 1.5 to 2.5 mass % of 4-tert-butyl-4′-methoxydibenzoylmethane and 12 to 18 mass % of propylene glycol, based on the total mass of the adhesive layer.

公开(公告)号：US20170035732A1

公开(公告)日：2017-02-09

申请号：US15331939

申请日：2016-10-24

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Masayuki SUZUKI ,  Hiroaki OKUTSU ,  Takashi YASUKOCHI ,  Yasunori TAKADA

IPC: A61K31/407 ,  A61K47/12 ,  A61K9/70

CPC classification number: A61K47/12 ,  A61K9/7038 ,  A61K9/7046 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/407 ,  A61K31/55 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61M37/00

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises:a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 μm, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 μm or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; andan adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.

Abstract translation: 通过使用通过将混合物与压力混合而获得的粘合剂层组合物形成包含二乙酸钠，阿替平或其药学上可接受的盐的粘合剂层和粘合剂基剂的粘合剂层形成步骤 敏感性粘合剂基剂。

公开(公告)号：USD778167S1

公开(公告)日：2017-02-07

申请号：US29530484

申请日：2015-06-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Sayaka Mochizuki ,  Shigeo Kusumi

公开(公告)号：US20160354322A1

公开(公告)日：2016-12-08

申请号：US15114979

申请日：2015-01-28

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yasunari MICHINAKA ,  Tomohiro SHINODA ,  Kana IMAMURA

IPC: A61K9/70 ,  A61K47/18 ,  A61K31/551

CPC classification number: A61K9/7053 ,  A61K9/70 ,  A61K9/703 ,  A61K31/551 ,  A61K47/18 ,  A61K47/32 ,  A61K47/34

Abstract: Provided is an emedastine-containing tape preparation comprising a support film, and a pressure-sensitive adhesive layer laminated on the support film, wherein the pressure-sensitive adhesive layer comprises emedastine, a fumarate salt of an organic amine, and a pressure-sensitive adhesive.

Abstract translation: 本发明提供含有依托汀的胶带制剂，其包含支撑膜和层压在支持膜上的压敏粘合剂层，其中压敏粘合剂层包含依达斯汀，有机胺的富马酸盐和压敏粘合剂 。

公开(公告)号：USD769121S1

公开(公告)日：2016-10-18

申请号：US29512661

申请日：2014-12-22

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Sayaka Mochizuki ,  Shigeo Kusumi

公开(公告)号：USD763504S1

公开(公告)日：2016-08-09

申请号：US29503873

申请日：2014-09-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Nobuchika Hirashima ,  Takeshi Hoshikado ,  Megumi Hirose

公开(公告)号：US09320728B2

公开(公告)日：2016-04-26

申请号：US14317976

申请日：2014-06-27

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takahito Yoshizaki ,  Kouji Tanaka ,  Kazunosuke Aida ,  Terumitsu Kaiho ,  Nobuo Tsutsumi

IPC: A61K31/4045 ,  A61K9/70

CPC classification number: A61K31/4045 ,  A61K9/7053

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: step A) obtaining an adhesive agent layer composition comprising free ropinirole in an amount which results in a content of 5 to 13.2% by mass in an obtained adhesive agent layer; step B) heating the adhesive agent layer composition at a temperature in a range from 50 to 76° C. for 5 minutes to 24 hours; and step C) cooling the heated adhesive agent layer composition to normal temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the free ropinirole at a supersaturated concentration in a dissolved form.

Abstract translation: 一种贴剂的制造方法，其特征在于，在支承层的至少一个表面配置有支撑层和粘合剂层，其特征在于，包括：工序A）得到粘合剂层组合物，其含有游离罗哌尼罗， 在所得粘合剂层中为5〜13.2质量％ 步骤B）将粘合剂层组合物在50至76℃的温度下加热5分钟至24小时; 和步骤C）以1〜20℃/小时的平均降温速度将加热的粘合剂层组合物冷却至常温，由此以溶解形式的过饱和浓度得到包含游离罗哌尼罗的粘合剂层。