公开(公告)号：US20160121401A1

公开(公告)日：2016-05-05

申请号：US14563494

申请日：2014-12-08

Applicant: Korea Basic Science Institute

Inventor： Gaehang LEE ,  Yeon Suk CHOI

IPC: B22F9/24 ,  C22B3/00 ,  B22F9/30

CPC classification number: B22F9/24 ,  B22F1/0018 ,  B22F2301/255 ,  C22B11/04 ,  C22C5/06

Abstract: Provided is a method of synthesizing silver nanoparticles including: a) a nucleation step of reacting a composition containing a silver precursor, a heterogeneous metal precursor, and an amine-based compound at 30 to 120° C. to form a nucleus; and b) a growth step of reacting the composition containing the nucleus formed therein at 155 to 350° C. to grow the nucleus. According to the present invention, significantly uniform and fine silver nanoparticles may be synthesized with high reproducibility on a large scale.

Abstract translation: 提供一种合成银纳米颗粒的方法，其包括：a）在30〜120℃下使含有银前体，异质金属前体和胺系化合物的组合物反应以形成核的成核步骤; 和b）生长步骤，使含有其中形成的细胞核的组合物在155-350℃下反应以生长细胞核。 根据本发明，可以大规模地以高再现性合成显着均匀且细小的银纳米颗粒。

公开(公告)号：US20150334815A1

公开(公告)日：2015-11-19

申请号：US14758093

申请日：2013-12-27

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Yong-Cheol HONG ,  Jung-Sik YOON ,  Ji-Hun KIM

IPC: H05H1/30 ,  H05H1/34 ,  H05H1/28

CPC classification number: H05H1/28 ,  H05H1/30 ,  H05H1/3405 ,  H05H2001/4622

Abstract: The purpose of the present invention is to solve the problems of conventional high frequency plasma torches and develop a plasma torch which enables quick quenching of high frequency plasma and which overcomes instability resulting from the quick quenching. To accomplish the abovementioned objective, according to one embodiment of the present invention, disclosed is an electromagnetic wave high frequency hybrid plasma torch. The electromagnetic wave high frequency hybrid plasma torch may comprise: an electromagnetic wave oscillator for oscillating electromagnetic waves; a power supply unit for supplying power to the electromagnetic wave oscillator; an electromagnetic wave transmission line for transmitting the electromagnetic waves generated by the electromagnetic wave oscillator; a first plasma-forming gas supply unit for injecting a plasma-forming gas; an electromagnetic wave discharge pipe for generating plasma by the electromagnetic waves introduced from the electromagnetic wave transmission line and the plasma-forming gas injected by the first plasma-forming gas supply unit; a high frequency discharge pipe for introducing an electromagnetic wave plasma flow from the electromagnetic wave discharge pipe; an induction coil structure which is coaxial with the high frequency discharge pipe and which has an interior with an induction coil inserted therein; a cooling water channel for introducing cooling water around the high frequency discharge pipe and discharging the cooling water; and a second plasma-forming gas supply unit for introducing a plasma-forming gas into the high frequency discharge pipe.

Abstract translation: 本发明的目的是解决传统的高频等离子体火炬的问题，开发能够快速淬灭高频等离子体的等离子体焰炬，其克服了由快速淬火引起的不稳定性。 为了实现上述目的，根据本发明的一个实施例，公开了一种电磁波高频混合等离子体焰炬。 电磁波高频混合等离子体焰炬可以包括：用于振荡电磁波的电磁波振荡器; 用于向电磁波振荡器供电的电源单元; 用于传输由电磁波振荡器产生的电磁波的电磁波传输线; 用于喷射等离子体形成气体的第一等离子体形成气体供给单元; 电磁波放电管，用于通过从电磁波传输线引入的电磁波和由第一等离子体形成气体供给单元喷射的等离子体形成气体产生等离子体; 用于引入来自电磁波放电管的电磁波等离子体流的高频放电管; 感应线圈结构，其与高频放电管同轴并且具有插入其中的感应线圈的内部; 冷却水通道，用于在高频排放管周围引入冷却水并排出冷却水; 以及用于将等离子体形成气体引入高频排放管的第二等离子体形成气体供给单元。

公开(公告)号：US09093576B2

公开(公告)日：2015-07-28

申请号：US14056915

申请日：2013-10-17

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Ki Soo Chang ,  Geon Hee Kim ,  Sun Cheol Yang ,  Hyo Sik Kim

IPC: H01L21/00 ,  H01L31/0232 ,  B29D11/00 ,  H01L27/146 ,  H01L31/18

CPC classification number: H01L31/0232 ,  B29D11/00365 ,  B29D11/00807 ,  H01L27/14627 ,  H01L27/14685 ,  H01L31/02327 ,  H01L31/18

Abstract: The present invention relates to an image sensor comprising a microlens array, and to a manufacturing method thereof. The method of the present invention includes gradually increasing the aluminum composition ratio of a compound semiconductor as the latter gradually gets farther from a substrate, to enable a microlens-forming layer to grow, and making the oxidation rate of the region adjacent to the substrate slower and the oxidation rate of the region farther from the substrate faster, making the interface between the oxidized region and the unoxidized region into a lens shape after the completion of oxidation. The thus-made lens is integrated into an image sensor. The present invention reduces costs for manufacturing image sensors in which a microlens is integrated, increases the signal-to-noise ratio and resolution of the image sensor, and achieves improved sensitivity.

Abstract translation: 本发明涉及一种包括微透镜阵列的图像传感器及其制造方法。 本发明的方法包括逐渐增加化合物半导体的铝组成比，随着后者从衬底逐渐变得越远，以使微透镜形成层生长，并且使与邻近衬底的区域的氧化速率变慢 并且距离衬底更远的区域的氧化速率更快，使氧化区域和未氧化区域之间的界面在氧化完成后成为透镜形状。 这样制成的镜头被集成到图像传感器中。 本发明降低了其中集成微透镜的图像传感器的制造成本，增加了图像传感器的信噪比和分辨率，并且实现了改进的灵敏度。

公开(公告)号：US20150147765A1

公开(公告)日：2015-05-28

申请号：US14303939

申请日：2014-06-13

Applicant: Korea Basic Science Institute

Inventor： Yeong Hee Ahn ,  Jong Shin Yoo ,  Eun Sun Ji

IPC: G01N33/68

CPC classification number: G01N33/6818 ,  G01N33/57484

Abstract: The present invention relates to a method for diagnosing cancer using information on the aberrant glycosylation of a glycoprotein involved in cancer progress. More particularly, the present invention relates to a cancer diagnosis peptide marker which is screened by the steps of: separating a glycoprotein aberrantly glycosylated according to the occurrence and progress of cancer from the blood of a lung cancer patient by using lectin; and selecting a marker peptide produced by the hydrolysis of the glycoprotein isolated by lectin. The marker peptide can be effectively used as a cancer diagnosis marker and for the diagnosis of cancer.

Abstract translation: 本发明涉及使用涉及癌症进展的糖蛋白异常糖基化的信息来诊断癌症的方法。 更具体地，本发明涉及通过以下步骤进行筛选的癌症诊断肽标记：通过使用凝集素从根据癌症患者的血液的癌症的发生和进展而异糖基化的糖蛋白分离; 并选择由凝集素分离的糖蛋白的水解产生的标记肽。 标记肽可以有效地用作癌症诊断标记物和用于诊断癌症。

公开(公告)号：US20140335535A1

公开(公告)日：2014-11-13

申请号：US14205974

申请日：2014-03-12

Applicant: Korea Basic Science Institute

Inventor： Yeong Hee AHN ,  Jong Shin YOO

IPC: G01N33/574

CPC classification number: G01N33/57423

Abstract: The present invention relates to a peptide marker for cancer diagnosis and a cancer diagnosis method using the same, more precisely to a peptide marker for cancer diagnosis screened by the following steps: separating and concentrating glycoproteins including a certain glycan chain related to the occurrence of cancer; hydrolyzing the glycoproteins to obtain polypeptides; and quantitatively analyzing the polypeptides to identify certain polypeptides that can track quantitative changes in glycoproteins glycosylated in a specific manner by the occurrence of cancer, and to a cancer diagnosis method using the said peptide marker.

Abstract translation: 本发明涉及用于癌症诊断的肽标记物和使用该标记物的癌症诊断方法，更准确地说涉及通过以下步骤筛选的癌症诊断用肽标记物：分离和浓缩包括与癌症发生相关的某种聚糖链的糖蛋白 ; 水解糖蛋白以获得多肽; 并且定量分析多肽以鉴定可以通过癌症的发生以特定方式糖基化的糖蛋白的定量变化以及使用所述肽标记物的癌症诊断方法来鉴定某些多肽。

公开(公告)号：US20140284470A1

公开(公告)日：2014-09-25

申请号：US14351524

申请日：2012-10-10

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Myoung Choul Choi ,  Sang Hwan Choi ,  Se Gyu Lee ,  Jeong Min Lee

IPC: H01J49/06 ,  H01J49/00

CPC classification number: H01J49/067 ,  H01J49/0027 ,  H01J49/0054 ,  H01J49/062 ,  H01J49/38

Abstract: A lens for electron capture dissociation may include: a first electrode and a second electrode spaced apart from each other and arranged along a first direction; and a third electrode and a fourth electrode spaced apart from each other and arranged along a second direction perpendicular to the first direction. The first electrode and the second electrode may be disposed in a space in which a magnetic field is formed in the first direction and trap electrons. The third electrode and the fourth electrode may be in the form of a flat plate and may apply an electric field to the trapped electrons in the second direction.

Abstract translation: 用于电子捕获解离的透镜可以包括：第一电极和彼此间隔开并沿着第一方向布置的第二电极; 以及与第一方向垂直的第二方向配置的第三电极和第四电极。 第一电极和第二电极可以设置在其中在第一方向上形成磁场并捕获电子的空间中。 第三电极和第四电极可以是平板的形式，并且可以在第二方向上对捕获的电子施加电场。

公开(公告)号：US20140275198A1

公开(公告)日：2014-09-18

申请号：US14178090

申请日：2014-02-11

Applicant: Korea Basic Science Institute

Inventor： Gun-Hwa Kim ,  Soohyun Kim ,  Jong-Soon Choi ,  Seung II Kim ,  Edmond Changkyun Park

IPC: A61K31/4192 ,  A61K31/4174 ,  A61K31/201 ,  A61K31/15 ,  A61K31/18

CPC classification number: A61K31/4192 ,  A61K31/15 ,  A61K31/155 ,  A61K31/18 ,  A61K31/201 ,  A61K31/4174

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating diabetes or fatty liver, and more specifically relates to a pharmaceutical composition for preventing or treating diabetes or fatty liver containing a CYP4A (cytochrome P450A) inhibitor as an active ingredient. According to the present invention, the CYP4A inhibitor suppresses endoplasmic reticulum stress, reduces the blood insulin concentration and suppresses apoptosis of liver cells, and hence exhibits effects in preventing or treating diabetes or fatty liver.

Abstract translation: 本发明涉及用于预防或治疗糖尿病或脂肪肝的药物组合物，更具体地涉及含有CYP4A（细胞色素P450A）抑制剂作为活性成分的糖尿病或脂肪肝的预防或治疗药物组合物。 根据本发明，CYP4A抑制剂抑制内质网应激，降低血胰岛素浓度，抑制肝细胞凋亡，因此具有预防或治疗糖尿病或脂肪肝的作用。

公开(公告)号：US20220157554A1

公开(公告)日：2022-05-19

申请号：US17454998

申请日：2021-11-15

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Sang Ju LEE ,  Myoung Choul CHOI ,  Chang Min CHOI ,  Aram HONG ,  Ji Young BAEK

IPC: H01J37/08

Abstract: A mixed gas cluster ion beam generator may include a nozzle chamber to contain a first mixed gas which is a mixed gas that is a mix of a first gas and a second gas, a cluster nozzle to spray gas received from the nozzle chamber in a cluster form, an ionizer to ionize a gas cluster sprayed by the cluster nozzle, and an ion accelerator to emit an ion beam to the outside by accelerating the gas cluster ionized by the ionizer by generating a potential difference to the ionized gas cluster.

公开(公告)号：US20220133913A1

公开(公告)日：2022-05-05

申请号：US17431357

申请日：2019-07-24

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Ki-Yuk CHANG ,  Kwan-Soo HONG ,  Chan-Woo KIM ,  Hyeon-Seung LEE ,  Hyun-Min KIM

IPC: A61K49/00 ,  G01N33/574 ,  C07K16/28

Abstract: Disclosed are an αvβ3 integrin targeting single-domain antibody and various applications thereof. The αvβ3 integrin targeting single-domain antibody exhibits high binding ability to αvβ3 integrin related to angiogenesis, excellent tissue permeability, and biostability compared to conventional antibodies. Further, the single-domain antibody may be combined with fluorescent particles and thus may be easily measured in vitro, in vivo or ex vivo, and may be effective in detecting angiogenesis and diagnosing angiogenesis related diseases, therefore it may be usefully used in related industries.

公开(公告)号：US11215620B2

公开(公告)日：2022-01-04

申请号：US16296154

申请日：2019-03-07

Applicant: Korea Basic Science Institute

Inventor： Jin Young Kim ,  Gun Wook Park ,  Eun Sun Ji ,  Jong Shin Yoo

IPC: G01N33/68 ,  G16B15/00 ,  G06F17/16

Abstract: The preset invention relates to a high resolution mass spectrometry based novel bioinformatics platform for the identification of glycation proteins and advanced glycation end-product. Particularly, the bioinformatics platform of the present invention facilitates an efficient and accurate investigation of quantitative changes of glycation proteins and advanced glycation end-products which are included in various types of samples but had not been informed yet, and uses a high resolution mass spectrometry, and thereby can be effectively used for the prediction or diagnosis of a disease including cancer by examining a disease marker in a sample.