公开(公告)号：US09668894B2

公开(公告)日：2017-06-06

申请号：US14603087

申请日：2015-01-22

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： John S. Stankus ,  Hugh Zhao ,  Mikael Trollsas ,  Syed Faiyaz Ahmed Hossainy ,  Michael H. Ngo ,  Yunbing Wang ,  Benny Serna

IPC: A61F2/06 ,  A61F2/86 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16 ,  A61F2/915

CPC classification number: A61F2/86 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2210/0019 ,  A61F2230/0054 ,  A61F2230/0056 ,  A61F2230/006 ,  A61F2250/001 ,  A61L31/041 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2400/16 ,  C08L67/04

Abstract: Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed. The scaffolds are made from a random copolymer of PLLA and a rubbery polymer such as polycaprolactone.

公开(公告)号：US09642730B2

公开(公告)日：2017-05-09

申请号：US15089392

申请日：2016-04-01

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Michael H. Ngo ,  Mikael Trollsas ,  John E. Papp ,  Hung T. Nguyen ,  Dudley Jayasinghe ,  Ron Farnbach ,  Gregory C. Orr ,  Joshua Smith ,  Yongjin Xie ,  Yu-Chun Ku

IPC: B29C55/26 ,  A61F2/844 ,  A61F2/915 ,  A61F2/958 ,  A61F2/89 ,  B23K26/362 ,  B23K26/402 ,  A61F2/95 ,  B29L31/00 ,  B23K103/00 ,  B29C49/00 ,  B29C49/08 ,  B29K67/00

CPC classification number: A61F2/844 ,  A61F2/89 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2002/9522 ,  A61F2002/9583 ,  A61F2210/0071 ,  A61F2230/0054 ,  A61F2230/0056 ,  B23K26/361 ,  B23K26/362 ,  B23K26/402 ,  B23K2103/42 ,  B23K2103/50 ,  B29C49/0073 ,  B29C49/08 ,  B29C55/26 ,  B29C2049/0089 ,  B29C2793/0009 ,  B29K2067/046 ,  B29L2031/753 ,  B29L2031/7534 ,  Y10T156/1002

Abstract: Methods for making scaffolds for delivery via a balloon catheter are described. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold structure has patterns that include an asymmetric or symmetric closed cell, and links connecting such closed cells.

公开(公告)号：US09585779B2

公开(公告)日：2017-03-07

申请号：US14333354

申请日：2014-07-16

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： John E. Papp ,  Syed Faiyaz Ahmed Hossainy ,  Michael Ngo ,  Chad Abunassar ,  Boris Anukhin ,  Mikael Trollsas ,  Lewis B. Schwartz

IPC: A61F2/06 ,  A61F2/90 ,  A61F2/89 ,  A61F2/915 ,  A61F2/958 ,  A61F2/86 ,  A61F2/82

CPC classification number: A61F2/915 ,  A61F2/86 ,  A61F2/89 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/826 ,  A61F2002/9155 ,  A61F2002/91591 ,  A61F2210/00 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2240/001 ,  B29C35/0805 ,  B29C65/64 ,  B29C66/1248 ,  B29C66/71 ,  B29C2035/0838 ,  B29K2067/046 ,  B29K2995/006 ,  B29L2031/7534

Abstract: Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed.

公开(公告)号：US09517292B2

公开(公告)日：2016-12-13

申请号：US14167677

申请日：2014-01-29

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Florian N. Ludwig ,  John Stankus ,  Mikael Trollsas

IPC: A61K9/127 ,  A61K47/44 ,  A61P33/06 ,  C12N5/071 ,  C07C51/347 ,  A61K39/015 ,  A61L31/10 ,  A61L29/08 ,  A61L33/06 ,  A61K31/436 ,  A61K47/32 ,  A61L31/16 ,  C08F220/28

CPC classification number: A61L31/10 ,  A61K31/436 ,  A61K47/32 ,  A61L29/085 ,  A61L31/16 ,  A61L33/06 ,  C08F220/28 ,  Y10T428/31935

Abstract: A polymer comprising a phosphoryl choline moiety(ies), a composition comprising the polymer and optionally a bioactive agent, an implantable device such as a DES or a non-implantable device such as an angioplasty balloon comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

Abstract translation: 包含磷酰胆碱部分的聚合物，包含聚合物和任选的生物活性剂的组合物，可植入装置例如DES或非可植入装置，例如血管成形术球囊，其上包括包含聚合物的涂层和任选的 提供了生物活性剂，以及使用该装置来治疗人的病症的方法。

公开(公告)号：US09504772B2

公开(公告)日：2016-11-29

申请号：US14203339

申请日：2014-03-10

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Mikael Trollsas ,  Michael Ngo ,  Florencia Lim

IPC: A61L31/04 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  C08L67/04 ,  C08L77/12

CPC classification number: A61L31/041 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  C08L67/04 ,  C08L77/12

Abstract: The present invention provides an implantable article comprising an amorphous terpolymer and a semi-crystalline polymer. The amorphous terpolymer can be admixed with the semi-crystalline polymer or form a block copolymer with the semi-crystalline polymer.

Abstract translation: 本发明提供一种包含无定形三元共聚物和半结晶聚合物的可植入制品。 无定形三元共聚物可与半结晶聚合物混合，或与半结晶聚合物形成嵌段共聚物。

公开(公告)号：US20160278952A1

公开(公告)日：2016-09-29

申请号：US15089392

申请日：2016-04-01

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Michael H. Ngo ,  Mikael Trollsas ,  John E. Papp ,  Hung T. Nguyen ,  Dudley Jayasinghe ,  Ron Farnbach ,  Gregory C. Orr ,  Joshua Smith ,  Yongjin Xie ,  Yu-Chun Ku

IPC: A61F2/844 ,  B23K26/402 ,  A61F2/89 ,  B23K26/362 ,  A61F2/958 ,  A61F2/915

CPC classification number: A61F2/844 ,  A61F2/89 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2002/9522 ,  A61F2002/9583 ,  A61F2210/0071 ,  A61F2230/0054 ,  A61F2230/0056 ,  B23K26/361 ,  B23K26/362 ,  B23K26/402 ,  B23K2103/42 ,  B23K2103/50 ,  B29C49/0073 ,  B29C49/08 ,  B29C55/26 ,  B29C2049/0089 ,  B29C2793/0009 ,  B29K2067/046 ,  B29L2031/753 ,  B29L2031/7534 ,  Y10T156/1002

Abstract: Methods for making scaffolds for delivery via a balloon catheter are described. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold structure has patterns that include an asymmetric or symmetric closed cell, and links connecting such closed cells.

Abstract translation: 描述了通过球囊导管进行支架制备的方法。 支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。 支架结构具有包括不对称或对称闭孔的图案，以及连接这种闭孔的连接。

公开(公告)号：US20160175044A1

公开(公告)日：2016-06-23

申请号：US14992379

申请日：2016-01-11

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Chad Abunassar ,  John Stankus ,  Jesus Magana ,  David Mackiewicz ,  Mikael Trollsas ,  Syed Hossainy ,  Scott Perrin

IPC: A61B18/14 ,  A61N1/40 ,  A61F7/12

CPC classification number: A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61F7/12 ,  A61N1/403

Abstract: A catheter apparatus for treatment of a human patient is described, the catheter apparatus having a central axis and comprising a shaping structure moveable between a delivery state having a first helical shape, and a deployed state having a second helical shape. The shaping structure is configured to have a reverse taper with a structural diameter that varies over the length of the shaping structure such that the structural diameter of the shaping structure at the proximal end is smaller than the structural diameter of the shaping structure at the distal end.

Abstract translation: 描述了用于治疗人类患者的导管装置，所述导管装置具有中心轴线，并且包括可在具有第一螺旋形状的输送状态和具有第二螺旋形状的展开状态之间移动的成形结构。 成型结构被配置为具有在成形结构的长度上变化的结构直径的倒锥形，使得近端处的成形结构的结构直径小于远端处的成形结构的结构直径 。

公开(公告)号：US20150182360A1

公开(公告)日：2015-07-02

申请号：US14656553

申请日：2015-03-12

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Mikael Trollsas ,  Dariush Davalian ,  Michael Huy Ngo ,  Hao-Ming Hsiao ,  Boris Anukhin ,  Syed Hossainy ,  David Gale

IPC: A61F2/89

CPC classification number: A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/828 ,  A61F2210/0004 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61L31/06 ,  A61L31/10 ,  A61L31/148 ,  C08L67/04

Abstract: A bioabsorbable polymeric stent with time dependent structure and properties and methods of treating a diseased blood vessel with the bioabsorable polymeric stent are disclosed. The structure and properties of the stent change with time and allow the vessel to be restored to a natural unstented state. The bioabsorbable stent loses mechanical integrity in a controlled manner due to modification of selected structural elements.

Abstract translation: 公开了具有时间依赖性结构的生物可吸收聚合物支架，以及用生物可吸收聚合物支架治疗患病血管的特性和方法。 支架的结构和性质随时间而变化，并允许血管恢复到自然不稳定状态。 由于选择的结构元件的修饰，生物可吸收的支架以受控的方式失去机械完整性。

公开(公告)号：US20140370072A1

公开(公告)日：2014-12-18

申请号：US14476597

申请日：2014-09-03

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed Faiyaz Ahmed Hossainy ,  Mikael Trollsas ,  Lothar Walter Kleiner

IPC: A61L31/10 ,  A61L31/08 ,  C08F214/22 ,  C08F114/22 ,  C08F214/28 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2420/02 ,  A61L2420/04 ,  B05D3/14 ,  C08F14/22 ,  C08F114/22 ,  C08F214/22 ,  C08F214/28

Abstract: Provided herein is a prohealing piezoelectric coating and the method of making and using the same.

Abstract translation: 本文提供了一种预热压电涂层及其制造和使用方法。

公开(公告)号：US20140363563A1

公开(公告)日：2014-12-11

申请号：US14308412

申请日：2014-06-18

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed F.A. Hossainy ,  Mikael Trollsas ,  Thierry Glauser ,  Yiwen Tang

IPC: A61L31/10 ,  B05D3/00

CPC classification number: A61L31/10 ,  A61K38/08 ,  A61K38/39 ,  A61L27/227 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L31/047 ,  A61L31/16 ,  A61L2300/25 ,  A61L2420/02 ,  B05D3/007 ,  C07K14/001 ,  C08H1/00 ,  Y10T428/3154 ,  Y10T428/31909

Abstract: A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided.

Abstract translation: 提供了包含弹性蛋白五肽嵌段的共聚物以及制备和使用该共聚物的方法。