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    Method for Making Microchip Reservoir Device
    71.
    发明申请
    Method for Making Microchip Reservoir Device 审中-公开
    制作Microchip储存器件的方法

    公开(公告)号：US20080047926A1

    公开(公告)日：2008-02-28

    申请号：US11930328

    申请日：2007-10-31

    申请人： John Santini ,  Michael Cima ,  Robert Langer

    发明人： John Santini ,  Michael Cima ,  Robert Langer

    IPC分类号： C25F7/00 ,  A61K9/22

    CPC分类号： A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  A61M5/14276 ,  A61M37/00 ,  A61M2205/0244 ,  C25F5/00 ,  C25F7/00 ,  Y10T137/8242

    摘要： Methods are provide for fabricating a microchip device having containment reservoirs. In one embodiment, the method includes providing a substrate; forming a plurality of reservoirs in the substrate, each reservoir having an opening in a surface of the substrate; fabricating a plurality of metal reservoir caps, each of which closes off one of said openings; and sealing each of said reservoirs. The method may further include loading chemical molecules, such a drug, into each of said reservoirs before said sealing of the reservoirs.

    摘要翻译： 提供制造具有容纳储存器的微芯片装置的方法。 在一个实施例中，该方法包括提供基板; 在所述基板中形成多个储存器，每个储存器在所述基板的表面中具有开口; 制造多个金属容器盖，每个金属容器盖封闭所述开口中的一个; 并密封每个所述储存器。 该方法还可以包括在储存器的所述密封之前将化学分子（例如药物）加载到每个所述储存器中。

    Medical Devices and Coatings with Non-Leaching Antimicrobial Peptides
    73.
    发明申请
    Medical Devices and Coatings with Non-Leaching Antimicrobial Peptides 审中-公开
    具有非浸出性抗菌肽的医疗器械和涂料

    公开(公告)号：US20070254006A1

    公开(公告)日：2007-11-01

    申请号：US11675500

    申请日：2007-02-15

    申请人： Christopher Loose ,  William O'Shaughnessy ,  LinO Ferreira ,  Andreas Zumbuehl ,  Robert Langer ,  Gregory Stephanopoulos

    发明人： Christopher Loose ,  William O'Shaughnessy ,  LinO Ferreira ,  Andreas Zumbuehl ,  Robert Langer ,  Gregory Stephanopoulos

    IPC分类号： A61K9/70 ,  A61F2/00 ,  A61K38/00

    CPC分类号： A61L27/54 ,  A61K38/10 ,  A61L2/16 ,  A61L2/232 ,  A61L15/46 ,  A61L27/227 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/404

    摘要： Antimicrobial peptides enable an alternate approach to developing antimicrobial coatings due to their targeting of the membranes of the bacteria. High specific activity is achieved by orienting the peptides so that the antimicrobial ends of the peptides maximally contact the bacteria. In one embodiment, one end of the peptide is covalently attached directly to the substrate. In another embodiment, the peptides are immobilized on the substrate using a coupling agent or tether. Non-covalent methods include coating the peptide onto the substrate or physiochemically immobilizing the peptides on the substrate using highly specific interactions, such as the biotin/avidin or streptavidin system. The compositions are substantially non-leaching, antifouling, and non-hemolytic. The immobilized peptides retain sufficient flexibility and mobility to interact with and de endocytosed by the bacteria, viruses, and/or fungi upon exposure. Immobilizing the peptides to the substrate reduces concerns regarding toxicity of the peptides and the development of antimicrobial resistance, while presenting substantially all of the peptide at the site of action at the surface of the substrate.

    摘要翻译： 由于抗菌肽靶向细菌膜，抗微生物肽能够开发抗微生物涂层。 通过使肽定向以使肽的抗微生物末端最大程度地接触细菌来实现高比活性。 在一个实施方案中，肽的一端直接共价连接到底物上。 在另一个实施方案中，使用偶联剂或系链将肽固定在底物上。 非共价方法包括将肽涂覆到底物上或者使用高度特异性相互作用如生物素/抗生物素蛋白或链霉亲和素系统在肽上生理化学地固定在底物上。 组合物基本上是非浸出，防污和非溶血性的。 固定的肽保持足够的灵活性和移动性，以在暴露时与细菌，病毒和/或真菌相互作用和内吞。 将肽固定到底物可减少对肽的毒性和抗微生物耐药性的发展的担忧，同时在基底表面的作用部位呈现基本上所有的肽。

    Method of protecting sensitive molecules from a photo-polymerizing environment
    78.
    发明申请
    Method of protecting sensitive molecules from a photo-polymerizing environment 审中-公开
    保护敏感分子免受光聚合环境的方法

    公开(公告)号：US20060222677A1

    公开(公告)日：2006-10-05

    申请号：US10757632

    申请日：2004-01-14

    申请人： Bianca Baroli ,  Robert Langer ,  Venkatram Shastri

    发明人： Bianca Baroli ,  Robert Langer ,  Venkatram Shastri

    IPC分类号： A61K38/43 ,  A61F13/00

    CPC分类号： A61K48/0008 ,  A61K9/0024 ,  A61K9/2077 ,  A61K9/2095 ,  A61K47/32 ,  A61K48/0041 ,  A61K48/0091

    摘要： In one embodiment, the present invention is a substrate system of photopolymerizable monomers and bioactive molecules admixed with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature. Upon polymerization, the monomers produce a cross-linked structure and the shielded bioactive molecules are protected from attack in the polymerized environment. In different aspects, the substrate system is used for drug delivery and tissue engineering and protection of enzymes, proteins and growth factors. In another embodiment, the present invention is a drug delivery system of photopolymerizable monomers, drug molecules associated with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature, and a photopolymerizing means for polymerizing the monomers to produce a cross-linked structure including the drug molecules.

    摘要翻译： 在一个实施方案中，本发明是可光聚合单体和与单体混合的生物活性分子的底物体系，并通过在体温下经历固体凝胶转变的不溶性材料与单体屏蔽。 在聚合时，单体产生交联结构，并且保护的生物活性分子免受聚合环境的侵袭。 在不同方面，底物系统用于药物递送和组织工程和酶，蛋白质和生长因子的保护。 在另一个实施方案中，本发明是可光聚合单体的药物递送系统，与单体相关的药物分子和通过在体温下经历固体 - 凝胶转变的不溶性材料与单体屏蔽的药物分子和用于聚合单体的光聚合装置 以产生包括药物分子的交联结构。

    In vitro development of tissues and organs
    79.
    发明申请
    In vitro development of tissues and organs 审中-公开
    组织器官的体外发育

    公开(公告)号：US20050147960A1

    公开(公告)日：2005-07-07

    申请号：US10960743

    申请日：2004-10-07

    申请人： Douglas Levinson ,  Robert Langer ,  John Lucas

    发明人： Douglas Levinson ,  Robert Langer ,  John Lucas

    IPC分类号： A61K38/00 ,  C12N20060101 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0735 ,  C12N11/00 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/24 ,  C12N5/08

    CPC分类号： C12N5/0606 ,  C12N5/0697 ,  C12N2533/00

    摘要： A method for producing a differentiated tissue is provided, which method comprises isolating at least one population of homogeneous multipotent cells, and culturing the cells in the presence of at least one differentiation factor, wherein the cells are supported by a solid phase scaffold. Differentiated tissues produced by this method, and there medical uses are also described. A method of screening for a process of producing a given differentiated tissue, and a method of optimizing a process of producing a given differentiated tissue are also described.

    摘要翻译： 提供了用于产生分化组织的方法，该方法包括分离至少一个同质多能细胞群，并在至少一种分化因子存在下培养细胞，其中细胞由固相支架支持。 还描述了通过该方法产生的分化组织，以及医疗用途。 还描述了筛选产生给定分化组织的方法的方法，以及优化产生给定分化组织的方法的方法。