公开(公告)号：US20060222677A1

公开(公告)日：2006-10-05

申请号：US10757632

申请日：2004-01-14

申请人： Bianca Baroli ,  Robert Langer ,  Venkatram Shastri

发明人： Bianca Baroli ,  Robert Langer ,  Venkatram Shastri

IPC分类号： A61K38/43 ,  A61F13/00

CPC分类号： A61K48/0008 ,  A61K9/0024 ,  A61K9/2077 ,  A61K9/2095 ,  A61K47/32 ,  A61K48/0041 ,  A61K48/0091

摘要： In one embodiment, the present invention is a substrate system of photopolymerizable monomers and bioactive molecules admixed with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature. Upon polymerization, the monomers produce a cross-linked structure and the shielded bioactive molecules are protected from attack in the polymerized environment. In different aspects, the substrate system is used for drug delivery and tissue engineering and protection of enzymes, proteins and growth factors. In another embodiment, the present invention is a drug delivery system of photopolymerizable monomers, drug molecules associated with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature, and a photopolymerizing means for polymerizing the monomers to produce a cross-linked structure including the drug molecules.

摘要翻译： 在一个实施方案中，本发明是可光聚合单体和与单体混合的生物活性分子的底物体系，并通过在体温下经历固体凝胶转变的不溶性材料与单体屏蔽。 在聚合时，单体产生交联结构，并且保护的生物活性分子免受聚合环境的侵袭。 在不同方面，底物系统用于药物递送和组织工程和酶，蛋白质和生长因子的保护。 在另一个实施方案中，本发明是可光聚合单体的药物递送系统，与单体相关的药物分子和通过在体温下经历固体 - 凝胶转变的不溶性材料与单体屏蔽的药物分子和用于聚合单体的光聚合装置 以产生包括药物分子的交联结构。

公开(公告)号：US20100009914A1

公开(公告)日：2010-01-14

申请号：US12496680

申请日：2009-07-02

申请人： Bianca Baroli ,  Robert Langer ,  Venkatram Prasad Shastri

发明人： Bianca Baroli ,  Robert Langer ,  Venkatram Prasad Shastri

IPC分类号： A61K38/16 ,  A61P43/00

CPC分类号： A61K48/0008 ,  A61K9/0024 ,  A61K9/2077 ,  A61K9/2095 ,  A61K47/32 ,  A61K48/0041 ,  A61K48/0091

摘要： In one embodiment, the present invention is a substrate system of photo-polymerizable monomers and bioactive molecules admixed with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature. Upon polymerization, the monomers produce a cross-linked structure and the shielded bioactive molecules are protected from attack in the polymerized environment. In different aspects, the substrate system is used for drug delivery and tissue engineering and protection of enzymes, proteins and growth factors. In another embodiment, the present invention is a drug delivery system of photo-polymerizable monomers, drug molecules associated with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature, and a photopolymerizing means for polymerizing the monomers to produce a cross-linked structure including the drug molecules.

摘要翻译： 在一个实施方案中，本发明是可光聚合单体和生物活性分子的底物体系，其与单体混合，并通过在体温下经历固体凝胶转变的不溶性材料与单体屏蔽。 在聚合时，单体产生交联结构，并且保护的生物活性分子免受聚合环境的侵袭。 在不同方面，底物系统用于药物递送和组织工程和酶，蛋白质和生长因子的保护。 在另一个实施方案中，本发明是可光聚合单体的药物递送系统，与单体相关的药物分子，并通过在体温下经历固体凝胶转变的不溶性材料与单体屏蔽，以及用于聚合的光聚合装置 所述单体产生包括药物分子的交联结构。

公开(公告)号：US20060088579A1

公开(公告)日：2006-04-27

申请号：US10503826

申请日：2003-02-07

申请人： Venkatram Shastri ,  Philip Lee ,  Samir Mitragotri ,  Robert Langer

发明人： Venkatram Shastri ,  Philip Lee ,  Samir Mitragotri ,  Robert Langer

IPC分类号： A61F13/02 ,  A61L15/16

CPC分类号： A61K47/10 ,  A61K9/0014 ,  A61K9/1075 ,  A61K47/06 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22

摘要： One aspect of the invention provides a transdermal delivery system including a drug formulated with a transport chaperone moiety that reversibly associates with the drug. The chaperone moiety is associated with the drug in the formulation so as to enhance transport of the drug across dermal tissue and releasing the drug after crossing said dermal tissue.

摘要翻译： 本发明的一个方面提供了一种透皮递送系统，其包括与可与药物可逆地结合的转运伴侣部分配制的药物。 分子伴侣部分与制剂中的药物相关联，以便增强药物穿过真皮组织的转运并在穿过所述皮肤组织后释放药物。

公开(公告)号：US20050079159A1

公开(公告)日：2005-04-14

申请号：US10480682

申请日：2002-06-13

申请人： Venkatram Shastri ,  Molly Stevens ,  Robert Langer

发明人： Venkatram Shastri ,  Molly Stevens ,  Robert Langer

IPC分类号： A01K67/027 ,  A61K31/70 ,  A61K35/12 ,  A61K45/00 ,  A61P43/00 ,  C12N5/00 ,  C12N5/02 ,  C12N5/077

CPC分类号： A01K67/0271 ,  A61K31/70 ,  A61K35/12 ,  C12N5/0068 ,  C12N5/0654 ,  C12N5/0655 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2533/40 ,  C12N2533/74

摘要： The present invention relates to an in vivo method of promoting the growth of autologous tissue and its use to form corrective structures, including tissue that can be explanted to other locations in the animal. In particular, the invention relates to methods and systems for (a) the site-specific regeneration of tissue, and (b) the synthesis of neotissue for transplantation.

摘要翻译： 本发明涉及促进自体组织生长的体内方法及其用于形成矫正结构的用途，包括可移植到动物其他位置的组织。 特别地，本发明涉及用于（a）组织的位点特异性再生的方法和系统，和（b）用于移植的新组织的合成。

公开(公告)号：US06569654B2

公开(公告)日：2003-05-27

申请号：US09753407

申请日：2001-01-02

申请人： Venkatram Shastri ,  Ivan Martin ,  Robert Langer ,  Nahid Rahman

发明人： Venkatram Shastri ,  Ivan Martin ,  Robert Langer ,  Nahid Rahman

IPC分类号： C12N1300

CPC分类号： A61K41/0052 ,  C12M35/02 ,  C12N5/0068 ,  C12N13/00 ,  C12N2533/30 ,  Y10S977/91 ,  Y10S977/925

摘要： Compositions, methods and systems are provided for the stimulation of biological activities within stem cells by applying electromagnetic stimulation to an electroactive material, wherein the electromagnetic stimulation is coupled to the electromagnetic material. In general the present invention involves attaching or associating the desired cells to or with a surface comprising an electroactive material, and applying electromagnetic radiation directly to the desired area. In preferred embodiments, the stimulation of biological activities within cells results from inducing one or more activities including, but not limited to, gene expression, cell growth, cell differentiation, signal transduction, membrane permeability, cell division, contraction, and cell signaling. In exemplary embodiments, the electroactive materials used in the present invention are either two-dimensional substrates such as thin films having at least one surface of an electroactive material, or in alternative embodiments, the electroactive materials are three-dimensional substrates comprising a matrix having at least one surface of an electroactive material.

公开(公告)号：US09981068B2

公开(公告)日：2018-05-29

申请号：US14115451

申请日：2012-05-04

申请人： Paul Williams ,  Morgan Russell Alexander ,  Martyn Christopher Davies ,  Robert Langer ,  Daniel Griffith Anderson

发明人： Paul Williams ,  Morgan Russell Alexander ,  Martyn Christopher Davies ,  Robert Langer ,  Daniel Griffith Anderson

IPC分类号： A61L29/16 ,  A01N37/12 ,  A01N37/20 ,  A61L29/08 ,  A61L31/14 ,  A61L31/10 ,  A61L27/50 ,  A61L27/34 ,  A61L29/14 ,  C08F220/56 ,  C08F220/24 ,  C08F220/18 ,  C08F220/22 ,  C08F222/10

CPC分类号： A61L29/16 ,  A01N37/12 ,  A01N37/20 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  C08F220/18 ,  C08F220/22 ,  C08F220/24 ,  C08F220/56 ,  C08F222/1006 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26 ,  A01N25/10 ,  A01N25/34

摘要： The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(═O)—O—]nR  (I) [H2C═CR′—C(═O)—NH—]nR  (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.

公开(公告)号：US09412476B2

公开(公告)日：2016-08-09

申请号：US13373139

申请日：2011-11-03

申请人： Philip A. Eckhoff ,  William H. Gates, III ,  Peter L. Hagelstein ,  Roderick A. Hyde ,  Jordin T. Kare ,  Robert Langer ,  Erez Lieberman ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael Schnall-Levin ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

发明人： Philip A. Eckhoff ,  William H. Gates, III ,  Peter L. Hagelstein ,  Roderick A. Hyde ,  Jordin T. Kare ,  Robert Langer ,  Erez Lieberman ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael Schnall-Levin ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

IPC分类号： G21F1/00 ,  G21F1/06 ,  G21F1/08 ,  G21F1/10 ,  G21F1/02 ,  G21F3/00 ,  A61B6/10 ,  G21F3/02

CPC分类号： G21F1/06 ,  A61B6/10 ,  C09D5/32 ,  G21F1/02 ,  G21F1/08 ,  G21F1/10 ,  G21F3/00 ,  G21F3/02

摘要： Systems, devices, methods, and compositions are described for providing an x-ray shielding system including a flexible layer including a support structure having a plurality of interconnected interstitial spaces that provide a circulation network for an x-ray shielding fluid composition.

公开(公告)号：US09144488B2

公开(公告)日：2015-09-29

申请号：US13495252

申请日：2012-06-13

申请人： Edward S. Boyden ,  Gregory J. Della Rocca ,  Daniel Hawkins ,  Roderick A. Hyde ,  Robert Langer ,  Eric C. Leuthardt ,  Terence Myckatyn ,  Parag Jitendra Parikh ,  Dennis J. Rivet ,  Joshua S. Shimony ,  Michael A. Smith ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene

发明人： Edward S. Boyden ,  Gregory J. Della Rocca ,  Daniel Hawkins ,  Roderick A. Hyde ,  Robert Langer ,  Eric C. Leuthardt ,  Terence Myckatyn ,  Parag Jitendra Parikh ,  Dennis J. Rivet ,  Joshua S. Shimony ,  Michael A. Smith ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene

IPC分类号： A61F2/12 ,  A61B5/07 ,  A61B5/00 ,  A61B5/145

CPC分类号： A61F2/12 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/14546 ,  A61B5/4312 ,  A61B5/686 ,  A61B5/6867 ,  A61B2560/0219 ,  A61F2250/0085 ,  A61F2250/0096

摘要： Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; and a plurality of sensor modules attached to the shell and positioned at a distance from each other, each of the plurality of sensor modules oriented to detect one or more analytes in a fluid adjacent to the shell, wherein each of the plurality of sensor modules includes a unique identifier and is configured to utilize energy transmitted from an external source.

摘要翻译： 本文描述了包括传感器模块和相关方法的乳房植入物。 乳房植入物包括具有：壳体被构造为基本上被粘性材料填充的植入物; 以及多个传感器模块，其附接到壳体并且彼此间隔一定距离，多个传感器模块中的每一个被定向成检测与壳体相邻的流体中的一种或多种分析物，其中多个传感器模块中的每一个包括 唯一的标识符并被配置为利用从外部源发送的能量。

公开(公告)号：US09061075B2

公开(公告)日：2015-06-23

申请号：US11900776

申请日：2007-09-12

申请人： Ed Harlow ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Lowell L. Wood, Jr.

发明人： Ed Harlow ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Lowell L. Wood, Jr.

IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N11/00 ,  C12N11/16 ,  A61K47/48 ,  A61K9/00 ,  C12N5/077 ,  A61K35/12

CPC分类号： A61K47/48776 ,  A61K9/0024 ,  A61K47/6901 ,  A61K2035/126 ,  B33Y80/00 ,  C12N5/0654 ,  C12N2510/00

摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.

公开(公告)号：US09006694B2

公开(公告)日：2015-04-14

申请号：US13373135

申请日：2011-11-03

申请人： Philip A. Eckhoff ,  William H. Gates, III ,  Peter L. Hagelstein ,  Roderick A. Hyde ,  Jordin T. Kare ,  Robert Langer ,  Erez Lieberman ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael Schnall-Levin ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

发明人： Philip A. Eckhoff ,  William H. Gates, III ,  Peter L. Hagelstein ,  Roderick A. Hyde ,  Jordin T. Kare ,  Robert Langer ,  Erez Lieberman ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael Schnall-Levin ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

IPC分类号： G21F3/02 ,  A61B6/10 ,  G21F1/02 ,  G21F3/00

CPC分类号： G21F3/02 ,  A61B6/10 ,  G21F1/02 ,  G21F3/00

摘要： Systems, devices, methods, and compositions are described for providing an x-ray shielding system including a flexible layer including a support structure having a plurality of interconnected interstitial spaces that provide a circulation network for an x-ray shielding fluid composition.

摘要翻译： 描述了用于提供包括柔性层的x射线屏蔽系统的系统，装置，方法和组合物，所述柔性层包括具有多个互连的间隙空间的支撑结构，所述多个互连间隙空间提供用于x射线屏蔽流体组合物的循环网络。