利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

206 条记录 (耗时 0.106 秒)

    Monoclonal antibodies to membrane neutrokine-&agr;
    71.
    发明授权
    Monoclonal antibodies to membrane neutrokine-&agr; 有权
    膜中性粒细胞α的单克隆抗体

    公开(公告)号：US06635482B1

    公开(公告)日：2003-10-21

    申请号：US09589286

    申请日：2000-06-08

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： C12N506

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Antibodies to HNFIP24 polypeptides
    73.
    发明授权
    Antibodies to HNFIP24 polypeptides 失效
    HNFIP24多肽的抗体

    公开(公告)号：US08106165B2

    公开(公告)日：2012-01-31

    申请号：US11745580

    申请日：2007-05-08

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng

    IPC分类号： C07K16/26 ,  C07K16/00 ,  C12N5/12

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  G01N33/566 ,  G01N2800/00

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

    Methods of inhibiting an immune response with anti-human endokine alpha antibodies
    75.
    发明授权
    Methods of inhibiting an immune response with anti-human endokine alpha antibodies 失效
    用抗人内因素α抗体抑制免疫应答的方法

    公开(公告)号：US07514081B2

    公开(公告)日：2009-04-07

    申请号：US11427956

    申请日：2006-06-30

    申请人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen

    发明人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： A61K39/395

    CPC分类号： C07K14/7151 ,  A61K38/00 ,  C07K14/5255 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S514/885

    摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.

    摘要翻译： 本发明涉及细胞因子的肿瘤坏死因子（TNF）家族的新成员。 特别地，提供了分离的核酸分子，其编码内丝蛋白α蛋白。 还提供了内含子α多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还提供了关于TNF家族相关疾病的诊断和治疗方法。

    Tumor necrosis factor-gamma
    76.
    发明授权
    Tumor necrosis factor-gamma 失效
    肿瘤坏死因子-γ

    公开(公告)号：US06824767B2

    公开(公告)日：2004-11-30

    申请号：US09246129

    申请日：1999-02-08

    申请人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen ,  Jun Zhang

    发明人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen ,  Jun Zhang

    IPC分类号： A61K3819

    CPC分类号： C07K14/525 ,  A61K38/00 ,  A61K48/00 ,  Y02A50/411 ,  Y10S530/866

    摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexperession of the TNF-gamma-alpha and TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

    摘要翻译： 公开了人类TNF-γ-α和TNF-γ-β多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽抑制细胞生长的方法，例如在肿瘤或癌症中，用于促进伤口愈合，提供抗感染，诱导炎症活性和刺激某些细胞类型的生长以治疗疾病， 示例再狭窄。 还公开了用于检测TNF-γ-α和TNF-γ-β核酸序列中的突变或TNF-γ-α和TNF-γ-β多肽的过度表达的诊断方法。 还公开了抗这些多肽的拮抗剂及其作为治疗性恶病质，败血性休克，脑疟疾，炎症，关节炎和移植排斥的治疗剂的用途。

    Polynucleotides encoding natural killer cell enhancing factor C
    79.
    发明授权
    Polynucleotides encoding natural killer cell enhancing factor C 失效

    公开(公告)号：US5985612A

    公开(公告)日：1999-11-16

    申请号：US467265

    申请日：1995-06-06

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Craig A. Rosen

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Craig A. Rosen

    摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    Natural killer cell enhancing factor C
    80.
    发明授权
    Natural killer cell enhancing factor C 失效
    自然杀伤细胞增强因子C

    公开(公告)号：US06294164B1

    公开(公告)日：2001-09-25

    申请号：US09407891

    申请日：1999-09-29

    申请人： Jiar Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Craig A. Rosen

    发明人： Jiar Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Craig A. Rosen

    IPC分类号： A61K3819

    CPC分类号： C07K14/52 ,  A61K38/00 ,  Y10S514/885

    摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    摘要翻译： 公开了一种编码这种多肽的人类天然杀伤细胞增强因子C和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽预防和/或治疗病毒感染，炎症，瘤形成和超氧自由基损伤的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。