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112 条记录 (耗时 0.049 秒)

    Novel PTP-20, PCP-2, BDP1, CLK, and SIRP proteins and related products and methods
    71.
    发明申请
    Novel PTP-20, PCP-2, BDP1, CLK, and SIRP proteins and related products and methods 审中-公开
    新型PTP-20，PCP-2，BDP1，CLK和SIRP蛋白及相关产品及方法

    公开(公告)号：US20080051556A1

    公开(公告)日：2008-02-28

    申请号：US11153918

    申请日：2005-06-16

    申请人： Axel Ullrich ,  Naohito Aoki ,  Yeong Woong Kim ,  Hong Yang Wang ,  Zhengjun Chen ,  Oliver Nayler ,  Alexei Kharitonenkov

    发明人： Axel Ullrich ,  Naohito Aoki ,  Yeong Woong Kim ,  Hong Yang Wang ,  Zhengjun Chen ,  Oliver Nayler ,  Alexei Kharitonenkov

    IPC分类号： C07K2/00 ,  C07H21/00 ,  C07K16/00

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K14/4703 ,  C07K16/18 ,  C07K16/40 ,  C12N9/16

    摘要： Nucleic acid molecules encoding full length PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, and SIRP polypeptides, portions of such nucleic acid molecules, nucleic acid vectors containing such nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that bind such polypeptides or abrogate their interactions with natural binding partners. Methods for diagnosing abnormal conditions in an organism with PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, and SIRP related molecules or compounds. PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, or SIRP polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for diseases related to PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, and SIRP polypeptides or conditions characterized by an abnormal interaction between such a polypeptide and its binding partner.

    摘要翻译： 编码全长PTP20，PCP-2，BDP1，mCLK2，mCLK3，mCLK4和SIRP多肽的核酸分子，这些核酸分子的部分，含有该核酸分子的核酸载体，含有该核酸载体的重组细胞，纯化的多肽 来自这样的重组细胞，对这些多肽的抗体，以及鉴定结合这些多肽的化合物或废除其与天然结合配偶体的相互作用的方法。 用于诊断具有PTP20，PCP-2，BDP1，mCLK2，mCLK3，mCLK4和SIRP相关分子或化合物的生物体的异常状况的方法。 PTP20，PCP-2，BDP1，mCLK2，mCLK3，mCLK4或SIRP多肽，编码此类多肽的核酸，含有此类核酸的细胞，组织和动物，使用此类多肽的抗体，以及与所有这些多肽相关的方法 以上。 为与PTP20，PCP-2，BDP1，mCLK2，mCLK3，mCLK4和SIRP多肽相关的疾病或特征为这种多肽与其结合配偶体之间的异常相互作用的病症提供了治疗，诊断和筛选方法。

    Extracellular signal-regulated kinase, sequences, and methods of production and use
    75.
    发明授权
    Extracellular signal-regulated kinase, sequences, and methods of production and use 失效
    细胞外信号调节激酶，序列和生产和使用方法

    公开(公告)号：US06579972B1

    公开(公告)日：2003-06-17

    申请号：US09393212

    申请日：1999-09-09

    申请人： Cornelia Lechner ,  Niels Peter Møller ,  Axel Ullrich

    发明人： Cornelia Lechner ,  Niels Peter Møller ,  Axel Ullrich

    IPC分类号： C07K1640

    CPC分类号： C07K16/40 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/12 ,  C12N2799/021 ,  Y10S530/809

    摘要： The present invention relates, in general, to an extracellular signal regulated kinase, ERK-5. In particular, the present invention relates to nucleic acid molecules coding for ERK-5; ERK-5 polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antisense ERK-5 nucleic acid constructs; antibodies having binding affinity to an ERK-5 polypeptide; hybridomes containing the antibodies; nucleic acid probes for the detecting of ERK-5 nucleic acid; a method of detecting ERK-5 nucleic acid or polypeptide in a sample; kits containing nucleic acid probes or antibodies; a method of detecting a compound capable of binding to ERK-5 or a fragment thereof; a method of detecting an agonist or antagonist of ERK-5 activity; a method of agonizing or antagonizing ERK-5 associated activity in a mammal; a method of treating diabetes mellitus, skeletal muscle diseases, Alzheimer's disease, or peripheral neuropathies in a mammal with an agonist or antagonist of ERK-5 activity; and a pharmaceutical composition comprising an ERK-5 agonist or antagonist.

    摘要翻译： 本发明一般涉及细胞外信号调节激酶ERK-5。 特别地，本发明涉及编码ERK-5的核酸分子; ERK-5多肽; 重组核酸分子; 含有重组核酸分子的细胞; 反义ERK-5核酸构建体; 对ERK-5多肽具有结合亲和力的抗体; 含有抗体的杂交瘤; 用于检测ERK-5核酸的核酸探针; 在样品中检测ERK-5核酸或多肽的方法; 含有核酸探针或抗体的试剂盒; 检测能够结合ERK-5或其片段的化合物的方法; 检测ERK-5活性的激动剂或拮抗剂的方法; 在哺乳动物中激动或拮抗ERK-5相关活性的方法; 在具有ERK-5活性的激动剂或拮抗剂的哺乳动物中治疗糖尿病，骨骼肌疾病，阿尔茨海默氏病或​​周围神经病变的方法; 和包含ERK-5激动剂或拮抗剂的药物组合物。

    Nucelotide encoding megakaryocytic protein tyrosine kinases
    77.
    发明授权
    Nucelotide encoding megakaryocytic protein tyrosine kinases 失效
    Nuclotide编码巨核细胞蛋白酪氨酸激酶

    公开(公告)号：US06506578B1

    公开(公告)日：2003-01-14

    申请号：US08232545

    申请日：1994-04-22

    申请人： Axel Ullrich ,  Mikhail Gishizky ,  Irman Gard Sures

    发明人： Axel Ullrich ,  Mikhail Gishizky ,  Irman Gard Sures

    IPC分类号： C12P2106

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K16/40 ,  C07K2319/00 ,  C12N2799/027 ,  C12P21/02

    摘要： The present invention relates to novel cytoplasmic tyrosine kinases isolated from megakaryocytes (megakaryocyte kinases or MKKs) which are involved in cellular signal transduction pathways and to the use of these novel proteins in the diagnosis and treatment of disease. The present invention further relates to specific megakaryocyte kinases, designated MKK1, MKK2 and MKK3, and their use as diagnostic and therapeutic agents.

    摘要翻译： 本发明涉及从涉及细胞信号转导途径的巨核细胞（巨核细胞激酶或MKK）分离的新型细胞质酪氨酸激酶以及这些新型蛋白在诊断和治疗疾病中的用途。 本发明还涉及称为MKK1，MKK2和MKK3的特异性巨核细胞激酶及其作为诊断和治疗剂的用途。

    PTP-S31: a novel protein tyrosine phosphatase
    78.
    发明授权
    PTP-S31: a novel protein tyrosine phosphatase 失效
    PTP-S31：一种新型蛋白酪氨酸磷酸酶

    公开(公告)号：US06492495B1

    公开(公告)日：2002-12-10

    申请号：US09361096

    申请日：1999-07-26

    申请人： Niels Peter Hundahl Moller ,  Karin Bach Moller ,  Axel Ullrich

    发明人： Niels Peter Hundahl Moller ,  Karin Bach Moller ,  Axel Ullrich

    IPC分类号： C07K1600

    CPC分类号： C12N9/16 ,  A61K38/00

    摘要： A novel protein tyrosine phosphatase designated PTP-S31 and its subfamily are identified, as are nucleic acid molecule coding therefor. Included in this;family are PTP-S31 proteins or glycoproteins having one, two, or three identified amino acid changes in previously defined consensus sequences in the catalytic phosphatase domains of known protein tyrosine phosphatases. The PTP-S31 proteins or glycoproteins may be produced by recombinant means. Antibodies to PTP-S31 proteins or glycoproteins and nucleic acid constructs coding therefor, and methods for screening molecules which can bind to PTP-S31 proteins or glycoproteins and inhibit or stimulate their enzymatic activity, are provided.

    摘要翻译： 鉴定了称为PTP-S31及其亚家族的新型蛋白酪氨酸磷酸酶，编码该核酸分子的核酸分子也是如此。 包括在这个家族中的PTP-S31蛋白或糖蛋白在已知蛋白酪氨酸磷酸酶的催化​​磷酸酶结构域中具有一个，两个或三个鉴定的氨基酸变化。 PTP-S31蛋白或糖蛋白可以通过重组方法产生。 提供了针对PTP-S31蛋白或糖蛋白的抗体及其编码的核酸构建体，以及用于筛选可结合PTP-S31蛋白或糖蛋白并抑制或刺激其酶活性的分子的方法。

    Method for the determination of the activity of specific phosphotyrosine phosphatases and specific effectors thereof in intact cells
    79.
    发明授权
    Method for the determination of the activity of specific phosphotyrosine phosphatases and specific effectors thereof in intact cells 失效
    确定完整细胞中特异性磷酸酪氨酸磷酸酶及其特异性效应物的活性的方法

    公开(公告)号：US5958719A

    公开(公告)日：1999-09-28

    申请号：US544427

    申请日：1995-11-06

    申请人： Axel Ullrich ,  Sylvia-Annette Bohmer ,  Frank Bohmer ,  Axel Obermeier

    发明人： Axel Ullrich ,  Sylvia-Annette Bohmer ,  Frank Bohmer ,  Axel Obermeier

    IPC分类号： A61K31/423 ,  A61K31/498 ,  A61K31/553 ,  C12Q1/42 ,  A61K38/18

    CPC分类号： A61K31/553 ,  A61K31/423 ,  A61K31/498 ,  C12Q1/42

    摘要： For the determination of the activity of a specific protein tyrosine phosphatase (PTPase) in intact cells one incubates intact cells which contain a substrate of the specific PTPase, if desired after stimulating the substrate phosphorylation, with a substance which can penetrate into the intact cells and can selectively inhibit phosphorylation of the substrate, the degree of phosphorylation of the substrate is measured, if desired several times, at various time points and the activity of the specific PTPase is determined from the measured degree of phosphorylation of the substrate. An additional measurement is carried out in the presence of a test substance to determine effectors of the specific PTPase and the effector action of the test substance is determined by comparing the degrees of phosphorylation.

    摘要翻译： 为了确定完整细胞中特异性蛋白质酪氨酸磷酸酶（PTPase）的活性，如果需要，在刺激底物磷酸化后，可以用可渗透到完整细胞中的物质孵育含有特异性PTPase底物的完整细胞， 可以选择性地抑制底物的磷酸化，如果需要，在各个时间点测量底物的磷酸化程度，并根据测量的底物的磷酸化程度确定特异性PTPase的活性。 在测试物质的存在下进行另外的测量以确定特异性PTPase的效应物，并且通过比较磷酸化程度来确定测试物质的效应物作用。