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公开(公告)号：US5965164A
公开(公告)日：1999-10-12
申请号：US642027
申请日：1996-04-29
IPC分类号： A61J3/02 , A61J1/00 , A61J7/00 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/50 , B01J2/00 , B01J2/02 , A61K9/14
CPC分类号： A61J7/0023 , A61J1/00 , A61J7/0015 , A61J7/0046 , A61K9/1688 , A61K9/1694 , A61K9/2081 , A61K9/2095 , A61K9/5026 , B01J2/00 , B01J2/02
摘要： A recipient-dosage delivery system including shearlite particles of a bio-affecting agent for delivery to a recipient. The particles are provided in a metered dose and are packaged in a bi-functional vessel. The particles are produced under liquiflash conditions and exhibit sufficient flowability so as to allow administration of the metered dose to the recipient under the force of gravity.
摘要翻译： 受体剂量递送系统，其包括用于递送至接受者的生物影响剂的剪切碎片颗粒。 颗粒以计量剂量提供并且包装在双功能容器中。 颗粒在液化条件下产生并显示出足够的流动性，以便允许在重力作用下将计量剂量给予受体。
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72.发明授权System for rendering substantially non-dissoluble bio-affecting agents bio-available 有权用于使生物可用的基本上不可溶的生物影响剂呈现的系统公开(公告)号：US06391338B1
公开(公告)日：2002-05-21
申请号：US09138194
申请日：1998-08-21
IPC分类号： A61K926
CPC分类号： B01J13/04 , A01N25/10 , A61K9/146 , A61K9/70 , Y10S514/965
摘要： The present invention is a method of preparing a system for delivering a bio-affecting agent and the composition prepared thereby. The invention includes forming a molecular dispersion of the bio-affecting agent in an increased energy state in a water-soluble polymer which is compatible with the bio-affecting agent. As a consequence of transforming the bio-affecting agent to an increased-energy condition and freezing it in such condition in a water-soluble polymer, the bio-affecting agent is made available (“bio-available”) to a bio-system upon dissolution of the polymer. This method and composition has been found extremely effective for delivery of otherwise substantially non-soluble drugs and other bio-affecting ingredients.
摘要翻译： 本发明是制备用于递送生物影响剂的系统的方法和由其制备的组合物。 本发明包括在与生物影响剂相容的水溶性聚合物中以增加的能量状态形成生物影响剂的分子分散体。 作为将生物影响剂转化为增加能量条件并在这种条件下在水溶性聚合物中冷冻的结果，生物影响剂在生物系统上可用（“生物可用”） 聚合物的溶解。 已经发现，该方法和组合物对于递送基本上不可溶的药物和其它生物影响成分非常有效。
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公开(公告)号：US06337082B1
公开(公告)日：2002-01-08
申请号：US09003996
申请日：1998-01-07
申请人： Richard C. Fuisz , Robert K. Yang
发明人： Richard C. Fuisz , Robert K. Yang
IPC分类号： A61K926
CPC分类号： A61Q19/00 , A21D2/18 , A21D2/186 , A23L13/426 , A23L23/10 , A23L25/10 , A23L27/70 , A23L27/72 , A23L29/212 , A23L29/231 , A23L29/238 , A23L29/25 , A23L29/256 , A23L29/262 , A23L29/27 , A23L29/284 , A23L29/35 , A23P10/25 , A23P10/28 , A23P10/30 , A61K8/042 , A61K8/60 , A61K8/73 , A61K8/732 , A61K8/97 , A61K9/1652 , A61K9/70
摘要： The present invention is a saccharide-bsed matrix and the product resulting therefrom made from a maltodextrin feedstock subjected to conditions which induce flash flow of the maltodextrin so that the matrix possesses a physically- or chemically-altered structure from the feedstock. The present invention also includes a method of producing the matrix and of making products which take advantage of the unique properties of the matrix. Such products include, but are not limited to, unique colloidal-like dispersions and suspensions made from the matrix.
摘要翻译： 本发明是一种糖基基质，由麦芽糖糊精原料制成的产物经受引起麦芽糖糊精闪蒸的条件，使得基质具有来自原料的物理或化学改变的结构。 本发明还包括制造基质的方法，以及利用基质的独特性质制造产品的方法。 这些产品包括但不限于由基质制成的独特的胶体状分散体和悬浮液。
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公开(公告)号：US5874110A
公开(公告)日：1999-02-23
申请号：US898306
申请日：1997-07-22
CPC分类号： A61K9/1623 , Y10S514/951 , Y10S514/963
摘要： The present invention is a method of entrapping an additive within carbohydrate bodies. The additive is drawn into the internal structure as a fluid during transformation of the bodies from a substantially amorphous state to a crystalline state. The present invention is also a delivery system including a carbohydrate body having an internal free volume space defined by an at least partially crystalline structure at equilibrium conditions, and an additive loaded within the carbohydrate body.
摘要翻译： 本发明是在碳水化合物体内捕获添加剂的方法。 在将体从基本无定形状态转变为结晶状态时，添加剂作为流体被吸入内部结构。 本发明还是一种递送系统，其包括在平衡条件下具有由至少部分结晶结构限定的内部自由体积空间的碳水化合物体和在碳水化合物体内加载的添加剂。
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公开(公告)号：US09848634B2
公开(公告)日：2017-12-26
申请号：US12494960
申请日：2009-06-30
申请人： Richard C. Fuisz
发明人： Richard C. Fuisz
CPC分类号： A24B15/14 , A24B13/00 , A24B15/245 , A24B15/30
摘要： A melt spun tobacco composition, e.g., in flake or particle form, for oral use in a mammal made by melt spinning comprising tobacco and/or a tobacco extract and at least one material which is solid at room temperature, which melts at or below 500° F., and carries from 1% to 70% of tobacco when processed through melt spinning, and solidifies again in less than 5 seconds after melt spinning.
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公开(公告)号：US08856830B2
公开(公告)日：2014-10-07
申请号：US13023657
申请日：2011-02-09
申请人： Richard C. Fuisz
发明人： Richard C. Fuisz
IPC分类号： H04N5/445 , H04N21/4725 , G06F17/30 , H04N7/173 , H04N21/858 , H04N21/2381 , H04N21/643 , H04N21/61 , G06Q30/02 , H04N21/462
CPC分类号： H04N21/23424 , G06F17/30017 , G06F17/30828 , G06F17/30858 , G06F17/30864 , G06Q30/02 , G06Q30/0257 , G06Q30/0269 , G06Q30/0277 , H04N7/17318 , H04N21/23412 , H04N21/23418 , H04N21/235 , H04N21/2381 , H04N21/435 , H04N21/4622 , H04N21/4722 , H04N21/4725 , H04N21/6125 , H04N21/64307 , H04N21/812 , H04N21/8133 , H04N21/8455 , H04N21/8545 , H04N21/858 , H04N21/8583 , H04N21/8586
摘要： VISUAL IMAGE MARKETING (VIM) is a system whereby the visual image on a film or television program is utilized to market that specific product. In VIM, film.backslash.television is combined with computer technology to provide real-time or delayed access to product data. Viewers identify a product or object displayed in a video, television show or movie and by merely pointing and clicking on the object to obtain marketing and other data.
摘要翻译： 视觉图像营销（VIM）是一种将电影或电视节目上的视觉图像用于销售该特定产品的系统。 在VIM中，film.backslash.television与计算机技术相结合，可以实时或延迟访问产品数据。 观众识别在视频，电视节目或电影中显示的产品或对象，只需指向并点击对象即可获取营销和其他数据。
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公开(公告)号：US20110290694A1
公开(公告)日：2011-12-01
申请号：US12788760
申请日：2010-05-27
申请人： Richard C. Fuisz , Madhu Hariharan
发明人： Richard C. Fuisz , Madhu Hariharan
CPC分类号： A61K9/7007 , A61J3/00 , A61J3/007 , A61K9/0056 , A61K9/2072 , G09F3/02 , G09F3/0297
摘要： The present invention relates to rapidly dissolving edible film dosage form incorporating indicia. The indicia may correspond to an active ingredient that may be evenly distributed throughout the film. The indicia may be associated with at least one surface of the film composition and provide information to the consumer that is relevant to the edible film dosage form.
摘要翻译： 本发明涉及快速溶解含有标记的可食用膜剂型。 标记可以对应于可以均匀分布在整个膜中的活性成分。 标记可以与膜组合物的至少一个表面相关联，并且向消费者提供与可食用膜剂型相关的信息。
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78.发明申请EXTRUDABLE AND EXTRUDED COMPOSITIONS FOR DELIVERY OF BIOACTIVE AGENTS, METHOD OF MAKING SAME AND METHOD OF USING SAME 有权用于递送生物活性剂的可挤出和挤出的组合物，其制备方法和使用它们的方法公开(公告)号：US20100247612A1
公开(公告)日：2010-09-30
申请号：US12757936
申请日：2010-04-09
申请人： Richard C. Fuisz
发明人： Richard C. Fuisz
IPC分类号： A61K9/70 , A61K31/722 , A61K31/465 , A61K9/00 , A61K31/74
摘要： A nonaqueous, extrudable composition includes at least one thermoplastic polymer in an amount of more than 20 wt % of the whole composition and tobacco. An extruded bioactive product in the form of a sheet can be made by extruding or hot melt shaping a nonaqueous composition comprising at least one thermoplastic polymer and a bioactive agent, the sheet being soluble in a user's mouth and resulting in sustained release of bioactive to the user. The sheet can be in a form that may be placed in contact with the mucosa of the user, and have an average dissolution time of 5 to 50 minutes for delivering the bioactive to the user.
摘要翻译： 非水可挤出组合物包含至少一种热塑性聚合物，其量超过整个组合物的20重量％和烟草。 片状形式的挤出的生物活性产品可以通过挤出或热熔成型包含至少一种热塑性聚合物和生物活性剂的非水性组合物来制备，该片材可溶于使用者的口中并导致生物活性物质持续释放至 用户。 片材可以是可以与使用者的粘膜接触的形式，并且具有5至50分钟的平均溶解时间以将生物活性递送给使用者。
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公开(公告)号：US20100221309A1
公开(公告)日：2010-09-02
申请号：US12779316
申请日：2010-05-13
申请人： Garry L. Myers , Richard C. Fuisz
发明人： Garry L. Myers , Richard C. Fuisz
IPC分类号： A61K9/70
CPC分类号： A61K9/7007 , A61K8/0204 , A61K8/0208 , A61K8/0216 , A61K8/0291 , A61K8/0295 , A61K8/355 , A61K8/731 , A61K8/86 , A61K31/74 , A61K47/10 , A61K47/38 , A61K2800/413 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q9/02 , A61Q15/00 , A61Q17/005 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B29C41/28 , B29K2001/00 , B29K2001/12 , B29K2003/00 , B29K2005/00 , B82Y5/00
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films contain at least one active agent, which may be administered to a user topically, transmucosally, vaginally, ocularly, aurally, nasally, transdermally or orally.
摘要翻译： 本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。 期望地，膜在水中分解并且可以通过受控的干燥过程或保持膜所需的均匀性的其它方法形成。 期望地，膜包含至少一种活性剂，其可以局部，经粘膜，阴道，眼睛，耳朵，鼻腔，经皮或口服施用于使用者。
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公开(公告)号：US20090241483A1
公开(公告)日：2009-10-01
申请号：US12409972
申请日：2009-03-24
CPC分类号： B65D75/5805 , B65D2215/04
摘要： An aspect of the invention provides a tearable package for a pharmaceutical product including: (i) a first layer including a sheet of flexible material; (ii) a second layer including a sheet of flexible material; the layers being overlaid and fused together at a perimetrical sealing region, the fused layers defining a cavity therebetween for the storage of the pharmaceutical product; wherein one of the layers has a discontinuous region in the sealing region; and wherein the package may be folded through the discontinuous region to be torn such that the pharmaceutical contents may be removed.
摘要翻译： 本发明的一个方面提供了用于药物产品的可撕裂包装，包括：（i）包含柔性材料片的第一层; （ii）包括柔性材料片的第二层; 所述层在周边密封区域被覆盖并熔合在一起，所述熔融层在其间限定了用于储存药物的空腔; 其中所述层中的一个在所述密封区域中具有不连续区域; 并且其中所述包装可以通过所述不连续区域折叠以被撕裂，使得可以去除所述药物内容物。
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