公开(公告)号：US20070231365A1

公开(公告)日：2007-10-04

申请号：US11395048

申请日：2006-03-31

Applicant: Yunbing Wang ,  David Gale ,  Bin Huang ,  Syed Hossainy ,  Vincent Gueriguian

Inventor： Yunbing Wang ,  David Gale ,  Bin Huang ,  Syed Hossainy ,  Vincent Gueriguian

IPC: A61F2/02

CPC classification number: A61F2/91 ,  A61F2210/0004 ,  A61F2230/0013 ,  A61F2240/001 ,  A61F2250/0031 ,  A61L31/041 ,  A61L31/148 ,  C08G63/08 ,  C08L67/04 ,  C08L2666/18

Abstract: The invention provides an implantable medical device comprising: a structural element, wherein the structural element includes: a continuous phase comprising a first polymer; a discrete phase within the continuous phase, wherein the discrete phase has a second polymer including discrete phase segments; and anchor segments that have substantially the same chemical make up as the first polymer of the continuous phase; wherein at least some of the anchor segments have partially or completely phase-separated from the discrete phase into the continuous phase.

Abstract translation: 本发明提供了一种可植入医疗装置，其包括：结构元件，其中所述结构元件包括：包含第一聚合物的连续相; 在连续相中的离散相，其中离散相具有包括离散相段的第二聚合物; 以及具有与连续相的第一聚合物基本上相同的化学成分的锚段; 其中至少一些所述锚固段具有从所述离散相部分或完全相分离成连续相。

公开(公告)号：US20070148251A1

公开(公告)日：2007-06-28

申请号：US11317837

申请日：2005-12-22

Applicant: Syed Hossainy ,  Florian Ludwig ,  Srinivasan Sridharan

Inventor： Syed Hossainy ,  Florian Ludwig ,  Srinivasan Sridharan

IPC: A61K9/14

CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/624 ,  A61L2300/626 ,  A61L2400/12 ,  A61L2420/04

Abstract: Nanoparticles comprising a matrix or shell material and a bioactive agent and medical devices containing the nanoparticles are provided.

Abstract translation: 提供了包含基质或壳材料和生物活性剂的纳米颗粒和含有纳米颗粒的医疗装置。

公开(公告)号：US20070110787A1

公开(公告)日：2007-05-17

申请号：US11644771

申请日：2006-12-21

Applicant: Syed Hossainy ,  Murthy Simhambhatla

Inventor： Syed Hossainy ,  Murthy Simhambhatla

IPC: A61L33/00 ,  A61F2/02

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/606 ,  A61L2300/62 ,  A61L2400/12

Abstract: Coatings for implantable medical devices including nanoparticles incorporating an active agent, and methods for fabricating the coatings.

Abstract translation: 用于可植入医疗装置的涂层，包括掺入活性剂的纳米颗粒，以及制造涂层的方法。

公开(公告)号：US20070065479A1

公开(公告)日：2007-03-22

申请号：US11602678

申请日：2006-11-20

Applicant: Gina Zhang ,  Syed Hossainy ,  Eugene Park ,  Qi Wang

Inventor： Gina Zhang ,  Syed Hossainy ,  Eugene Park ,  Qi Wang

IPC: A61F2/02

CPC classification number: A61L31/16 ,  A61L31/14 ,  A61L2300/416 ,  A61L2300/802

Abstract: A method of making a therapeutic composition, as well as the therapeutic composition so made, is disclosed. The method comprises mixing a hydrophobic drug with an aqueous buffer solution and adding a surfactant to the aqueous buffer solution to form the therapeutic composition. A implantable medical device with the therapeutic composition and a method of making a coating for an implantable medical device containing the therapeutic composition is also disclosed.

Abstract translation: 公开了制备治疗组合物的方法以及如此制备的治疗组合物。 该方法包括将疏水性药物与缓冲水溶液混合，并将表面活性剂加入到缓冲液水溶液中以形成治疗组合物。 还公开了具有治疗组合物的可植入医疗装置和制备用于含有治疗组合物的可植入医疗装置的涂层的方法。

公开(公告)号：US20060271165A1

公开(公告)日：2006-11-30

申请号：US11497652

申请日：2006-08-01

Applicant: Philip Yip ,  James Jacobs ,  Syed Hossainy ,  Jon Becker ,  Timothy Limon

Inventor： Philip Yip ,  James Jacobs ,  Syed Hossainy ,  Jon Becker ,  Timothy Limon

IPC: A61F2/90

CPC classification number: A61F2/91 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2250/0036 ,  A61F2250/0067 ,  A61F2250/0071 ,  Y10S623/903

Abstract: An intravascular stent includes an eluting sheath fabricated from a mesh for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. The eluting sheath is attached to at least a portion of an outside surface area of the stent structure and is fabricated from a mesh designed to neck down in response to a radially outward directed force resulting in the uniform expansion of the stent. The eluting sheath can be loaded with at least one therapeutic drug for the release thereof at a treatment site to facilitate repair of a damaged vessel. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen.

Abstract translation: 血管内支架包括由用于控制释放治疗药物的网格和用于在血管中局部药物治疗中递送治疗药物的筛网制成的洗脱鞘。 洗脱鞘附着到支架结构的外表面区域的至少一部分上，并且由设计成颈部向下的网眼制成，以响应径向向外的力而导致支架的均匀膨胀。 洗脱鞘可以装载至少一种用于在治疗部位释放的治疗药物，以便于修复受损血管。 支架在纵向具有高度的柔性，但具有足够的容器壁覆盖和径向强度足以保持打开动脉或其他体腔。

公开(公告)号：US20060246109A1

公开(公告)日：2006-11-02

申请号：US11119020

申请日：2005-04-29

Applicant: Syed Hossainy ,  Fuh-Wei Tang ,  Andrew McNiven ,  Joseph Eppert ,  Gregory Kevorkian

Inventor： Syed Hossainy ,  Fuh-Wei Tang ,  Andrew McNiven ,  Joseph Eppert ,  Gregory Kevorkian

IPC: A61F2/00

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/604 ,  A61L2300/606

Abstract: The present invention generally encompasses the control of the release rate of agents from a polymeric matrix. This control over the release rate of agents provides for control over, inter alia, the therapeutic, prophylactic, diagnostic, and ameliorative effects that are realized by a patient in need of such treatment. In addition, the control of the release rate of agents also has an effect upon the mechanical integrity of the polymeric matrix, as well as a relationship to a subject's absorption rate of the absorbable polymers.

Abstract translation: 本发明通常包括对来自聚合物基质的试剂的释放速率的控制。 这种对药剂释放速率的控制提供了对需要这种治疗的患者实现的治疗，预防，诊断和改善效果的控制。 此外，试剂的释放速率的控制也对聚合物基质的机械完整性以及与受试者吸收聚合物的吸收速率的关系有影响。

公开(公告)号：US07105018B1

公开(公告)日：2006-09-12

申请号：US10334034

申请日：2002-12-30

Applicant: Philip S. Yip ,  James Jacobs ,  Syed Hossainy ,  Jon Becker ,  Timothy A. Limon

Inventor： Philip S. Yip ,  James Jacobs ,  Syed Hossainy ,  Jon Becker ,  Timothy A. Limon

IPC: A61F2/06

CPC classification number: A61F2/91 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2250/0036 ,  A61F2250/0067 ,  A61F2250/0071 ,  Y10S623/903

Abstract: An intravascular stent includes an eluting sheath fabricated from a mesh for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. The eluting sheath is attached to at least a portion of an outside surface area of the stent structure and is fabricated from a mesh designed to neck down in response to a radially outward directed force resulting in the uniform expansion of the stent. The eluting sheath can be loaded with at least one therapeutic drug for the release thereof at a treatment site to facilitate repair of a damaged vessel. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen.

公开(公告)号：US20060147412A1

公开(公告)日：2006-07-06

申请号：US11027955

申请日：2004-12-30

Applicant: Syed Hossainy ,  Stephen Pacetti

Inventor： Syed Hossainy ,  Stephen Pacetti

IPC: C08L89/00 ,  A61K31/765 ,  A61K31/785

CPC classification number: C08G63/912 ,  C08B37/0072 ,  C08B37/0075 ,  C08G63/06 ,  C08G63/664 ,  C08L1/08 ,  C08L1/286 ,  C08L5/02 ,  C08L5/08 ,  C08L5/10 ,  C08L25/18 ,  C08L33/26 ,  C08L39/06 ,  C08L67/04 ,  C08L71/02 ,  C08L77/12 ,  C09D101/286 ,  C09D105/02 ,  C09D105/08 ,  C09D105/10 ,  C09D167/04 ,  C08L2666/04 ,  C08L2666/26 ,  C08L2666/20 ,  C08L2666/06 ,  C08L2666/22

Abstract: Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a poly(hydroxyalkanoate).

Abstract translation: 公开了含有聚（羟基链烷酸酯）的聚合物和用于医疗制品的试剂及其制造方法。 医疗制品通常包括具有涂层的可植入基底，并且该涂层含有聚（羟基链烷酸酯）。

公开(公告)号：US20060136048A1

公开(公告)日：2006-06-22

申请号：US11015313

申请日：2004-12-16

Applicant: Stephen Pacetti ,  Jessica DesNoyer ,  Yung-Ming Chen ,  Lothar Kleiner ,  Syed Hossainy

Inventor： Stephen Pacetti ,  Jessica DesNoyer ,  Yung-Ming Chen ,  Lothar Kleiner ,  Syed Hossainy

IPC: A61F2/82

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/608 ,  A61L2420/08

Abstract: Embodiments of coatings for implantable medical devices, such as stents, are disclosed. The devices may include at least one structural element having an abluminal side, luminal side, and sidewalls between the abluminal and luminal sides. The coating may include at least two continuous coating layers. In some embodiments, the luminal side, and all or a majority of the sidewalls are free of at least two of the coating layers.

公开(公告)号：US07008411B1

公开(公告)日：2006-03-07

申请号：US10262151

申请日：2002-09-30

Applicant: Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy

Inventor： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy

IPC: A61M31/00 ,  A61M5/178

CPC classification number: A61M25/0084 ,  A61B2017/22081 ,  A61M25/0026 ,  A61M25/1006 ,  A61M2025/0096

Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.

Abstract translation: 一种治疗易损斑块的装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送生物活性剂以稳定易损斑块。