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    System for Coating Stents
    71.
    发明申请
    System for Coating Stents 有权
    涂层支架系统

    公开(公告)号：US20080110396A1

    公开(公告)日：2008-05-15

    申请号：US12014017

    申请日：2008-01-14

    Applicant: Syed Hossainy

    Inventor： Syed Hossainy

    IPC: B05D1/32 ,  B05B7/06 ,  B05C13/02 ,  B05C11/11 ,  B05B15/04

    CPC classification number: B05D1/34 ,  B05B13/0228 ,  B05D1/002 ,  B05D1/02

    Abstract: A system for coating implantable medical devices, such as stents, and a method of coating stents using the system is also disclosed. The system includes a barrier or barriers for isolating an area of the stent on which a composition for coating a stent is applied. Two coating compositions can be applied simultaneously to a stent by separate nozzles on different sides of a barrier. Cross-contamination of the compositions is prevented by the barrier.

    Abstract translation: 还公开了一种用于涂覆诸如支架的可植入医疗装置的系统，以及使用该系统涂覆支架的方法。 该系统包括用于隔离其上应用用于涂覆支架的组合物的支架的区域的屏障或障碍物。 两个涂层组合物可以通过在屏障的不同侧面上的分开的喷嘴同时施用于支架。 通过屏障防止组合物的交叉污染。

    METHOD OF POLISHING IMPLANTABLE MEDICAL DEVICES TO LOWER THROMBOGENECITY AND INCREASE MECHANICAL STABILITY
    72.
    发明申请
    METHOD OF POLISHING IMPLANTABLE MEDICAL DEVICES TO LOWER THROMBOGENECITY AND INCREASE MECHANICAL STABILITY 有权
    抛光可植入医疗器械以降低血栓形成并增加机械稳定性的方法

    公开(公告)号：US20080099442A1

    公开(公告)日：2008-05-01

    申请号：US11969181

    申请日：2008-01-03

    Applicant: DAVID GALE ,  Syed Hossainy

    Inventor： DAVID GALE ,  Syed Hossainy

    IPC: B44C1/22

    CPC classification number: A61L31/10 ,  A61F2/91 ,  A61F2210/0004 ,  Y10S623/901

    Abstract: The present invention relates to a method of polishing an implantable medical device. The method may include positioning an implantable medical device on a support. At least a portion of a surface of the implantable medical device may include a polymer. A fluid may be contacted with at least a portion of the surface of the positioned implantable medical device. In an embodiment, the fluid may be capable of dissolving at least a portion of the polymer at or near the surface of the implantable medical device. The method may further include allowing the fluid to modify at least a portion of the surface of the positioned medical device. A majority of the contacted fluid may be removed from the surface of the implantable medical device. In certain embodiments, the modified portion of the surface may be substantially less thrombogenetic and substantially more mechanically stable than an unmodified surface.

    Abstract translation: 本发明涉及一种抛光可植入医疗器械的方法。 该方法可以包括将可植入医疗装置定位在支撑件上。 可植入医疗装置的表面的至少一部分可以包括聚合物。 流体可以与定位的可植入医疗装置的表面的至少一部分接触。 在一个实施方案中，流体可能能够将聚合物的至少一部分溶解在可植入医疗装置的表面处或附近。 该方法还可以包括允许流体修改定位的医疗装置的表面的至少一部分。 接触流体的大部分可以从可植入医疗装置的表面移除。 在某些实施方案中，表面的改性部分可以比未修饰的表面基本上更少的血栓形成和基本上更机械稳定的。

    Therapeutic composition and a method of coating implantable medical devices
    76.
    发明申请
    Therapeutic composition and a method of coating implantable medical devices 有权
    治疗组合物和可植入医疗器械的涂敷方法

    公开(公告)号：US20070065479A1

    公开(公告)日：2007-03-22

    申请号：US11602678

    申请日：2006-11-20

    Applicant: Gina Zhang ,  Syed Hossainy ,  Eugene Park ,  Qi Wang

    Inventor： Gina Zhang ,  Syed Hossainy ,  Eugene Park ,  Qi Wang

    IPC: A61F2/02

    CPC classification number: A61L31/16 ,  A61L31/14 ,  A61L2300/416 ,  A61L2300/802

    Abstract: A method of making a therapeutic composition, as well as the therapeutic composition so made, is disclosed. The method comprises mixing a hydrophobic drug with an aqueous buffer solution and adding a surfactant to the aqueous buffer solution to form the therapeutic composition. A implantable medical device with the therapeutic composition and a method of making a coating for an implantable medical device containing the therapeutic composition is also disclosed.

    Abstract translation: 公开了制备治疗组合物的方法以及如此制备的治疗组合物。 该方法包括将疏水性药物与缓冲水溶液混合，并将表面活性剂加入到缓冲液水溶液中以形成治疗组合物。 还公开了具有治疗组合物的可植入医疗装置和制备用于含有治疗组合物的可植入医疗装置的涂层的方法。

    Drug-eluting stent cover and method of use
    77.
    发明申请
    Drug-eluting stent cover and method of use 有权
    药物洗脱支架盖及使用方法

    公开(公告)号：US20060271165A1

    公开(公告)日：2006-11-30

    申请号：US11497652

    申请日：2006-08-01

    Applicant: Philip Yip ,  James Jacobs ,  Syed Hossainy ,  Jon Becker ,  Timothy Limon

    Inventor： Philip Yip ,  James Jacobs ,  Syed Hossainy ,  Jon Becker ,  Timothy Limon

    IPC: A61F2/90

    CPC classification number: A61F2/91 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2250/0036 ,  A61F2250/0067 ,  A61F2250/0071 ,  Y10S623/903

    Abstract: An intravascular stent includes an eluting sheath fabricated from a mesh for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. The eluting sheath is attached to at least a portion of an outside surface area of the stent structure and is fabricated from a mesh designed to neck down in response to a radially outward directed force resulting in the uniform expansion of the stent. The eluting sheath can be loaded with at least one therapeutic drug for the release thereof at a treatment site to facilitate repair of a damaged vessel. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen.

    Abstract translation: 血管内支架包括由用于控制释放治疗药物的网格和用于在血管中局部药物治疗中递送治疗药物的筛网制成的洗脱鞘。 洗脱鞘附着到支架结构的外表面区域的至少一部分上，并且由设计成颈部向下的网眼制成，以响应径向向外的力而导致支架的均匀膨胀。 洗脱鞘可以装载至少一种用于在治疗部位释放的治疗药物，以便于修复受损血管。 支架在纵向具有高度的柔性，但具有足够的容器壁覆盖和径向强度足以保持打开动脉或其他体腔。

    Concentration gradient profiles for control of agent release rates from polymer matrices
    78.
    发明申请
    Concentration gradient profiles for control of agent release rates from polymer matrices 审中-公开
    用于控制聚合物基质的试剂释放速率的浓度梯度曲线

    公开(公告)号：US20060246109A1

    公开(公告)日：2006-11-02

    申请号：US11119020

    申请日：2005-04-29

    Applicant: Syed Hossainy ,  Fuh-Wei Tang ,  Andrew McNiven ,  Joseph Eppert ,  Gregory Kevorkian

    Inventor： Syed Hossainy ,  Fuh-Wei Tang ,  Andrew McNiven ,  Joseph Eppert ,  Gregory Kevorkian

    IPC: A61F2/00

    CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/604 ,  A61L2300/606

    Abstract: The present invention generally encompasses the control of the release rate of agents from a polymeric matrix. This control over the release rate of agents provides for control over, inter alia, the therapeutic, prophylactic, diagnostic, and ameliorative effects that are realized by a patient in need of such treatment. In addition, the control of the release rate of agents also has an effect upon the mechanical integrity of the polymeric matrix, as well as a relationship to a subject's absorption rate of the absorbable polymers.

    Abstract translation: 本发明通常包括对来自聚合物基质的试剂的释放速率的控制。 这种对药剂释放速率的控制提供了对需要这种治疗的患者实现的治疗，预防，诊断和改善效果的控制。 此外，试剂的释放速率的控制也对聚合物基质的机械完整性以及与受试者吸收聚合物的吸收速率的关系有影响。

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