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公开(公告)号：US20080076893A1
公开(公告)日：2008-03-27
申请号：US11830885
申请日：2007-07-31
CPC分类号： C08G77/382 , C07F9/3808 , C08F230/02 , C08F230/08 , C08F283/12 , C08G77/395 , C08L51/085 , C08L53/00 , C08L2666/02
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain hydrophilic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymeric compositions comprise polymerized hydrophilic siloxanyl monomers.
摘要翻译： 本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。 更具体地说，本发明涉及能够聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些亲水性单体。 聚合物组合物包含聚合的亲水硅氧烷基单体。
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公开(公告)号：US20070287752A1
公开(公告)日：2007-12-13
申请号：US11691555
申请日：2007-03-27
申请人： Susan E. Burke , Joseph C. Salamone
发明人： Susan E. Burke , Joseph C. Salamone
IPC分类号： A61K31/16 , A61K31/08 , A61K31/135
CPC分类号： C11D3/48 , A61K9/0048 , A61K31/08 , A61K31/133 , A61K31/155 , A61K45/06 , A61K47/02 , A61K47/18 , A61K47/186 , A61K47/34 , A61L12/141 , A61L12/142 , A61L12/143 , C11D3/0078 , C11D3/2068 , C11D3/30 , C11D3/3427 , A61K2300/00
摘要： An aqueous ophthalmic composition comprising a branched glycerol compound selected from the group consisting of a branched, glycerol monoalkyl ether, a branched, glycerol monoalkyl amine, a branched, glycerol monoalkyl sulfide, or any mixture thereof, present in a total amount of from 0.05 ppm to 1,000 ppm; a cationic antimicrobial component, and having an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg. The presence of the branched glycerol compound enhances the biocidal efficacy of the aqueous ophthalmic composition containing one or more cationic antimicrobial components.
摘要翻译： 一种眼用组合物，其含有支链甘油化合物，其选自支链甘油单烷基醚，支链甘油单烷基胺，支链甘油单烷基硫醚或其任何混合物，其总量为0.05ppm 至1,000ppm; 阳离子抗微生物组分，并且其重量摩尔渗透压浓度范围为200mOsmol / kg至400mOsmol / kg。 支链甘油化合物的存在增强含有一种或多种阳离子抗微生物组分的水性眼用组合物的杀生物功效。
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73.发明授权High refractive-index, hydrophilic, arylsiloxy-containing macromonomers and polymers, and ophthalmic devices comprising such polymers 失效高折射率，亲水性，含芳基甲硅烷氧基的大分子单体和聚合物，以及包含这种聚合物的眼科装置公开(公告)号：US07297160B2
公开(公告)日：2007-11-20
申请号：US11153674
申请日：2005-06-15
CPC分类号： C08G77/38 , C08G77/20 , G02B1/043 , Y10S525/937 , C08L83/04
摘要： Hydrophilic, arylsiloxy-containing macromonomers have at least a terminal hydrophilic group attached to an arylsiloxy group. The aryl groups attached to siloxy groups can be substituted with other hydrophilic groups. Polymers comprising such hydrophilic, arylsiloxy-containing macromonomers avoid or reduce the risk of forming vacuoles of absorbed water. Furthermore, such polymers have high refractive index, and, thus, are advantageously used for making ophthalmic devices, such as intraocular lenses, contact lenses, corneal rings, corneal inlays, and keratoprostheses.
摘要翻译： 亲水性，芳基甲硅烷氧基的大分子单体具有至少一个与芳基甲硅烷氧基连接的亲水基团。 连接到甲硅烷氧基的芳基可以被其它亲水基取代。 包含这种亲水的含芳基甲硅烷氧基的大分子单体的聚合物避免或降低形成吸收水的空泡的风险。 此外，这种聚合物具有高折射率，因此有利地用于制造眼科装置，例如眼内透镜，隐形眼镜，角膜环，角膜嵌体和角膜假体。
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74.发明申请SILOXANE PREPOLYMER CONTAINING PENDANT AND END-CAPPING CATIONIC AND POLYMERIZABLE GROUPS 有权含有底物和端基的阳离子和聚合物组合物的硅氧烷预聚物公开(公告)号：US20070160649A1
公开(公告)日：2007-07-12
申请号：US11565151
申请日：2006-11-30
IPC分类号： C08F230/08 , C07F7/10
CPC分类号： C08G77/388 , C08G77/452 , G02B1/043
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic random copolymers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise siloxane prepolymer containing pendant and end-capping cationic and polymerizable groups.
摘要翻译： 本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。 更具体地，本发明涉及能聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些阳离子无规共聚物。 这些性质包括用水提取聚合的医疗装置的能力。 这避免了使用本领域典型的有机溶剂。 聚合物组合物包含含有侧基和封端阳离子和可聚合基团的硅氧烷预聚物。
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75.发明申请Use of aroma compounds as defoaming agents for ophthalmic solutions with high concentrations of surfactants 审中-公开使用芳香化合物作为具有高浓度表面活性剂的眼用溶液的消泡剂公开(公告)号：US20070148099A1
公开(公告)日：2007-06-28
申请号：US11611331
申请日：2006-12-15
IPC分类号： A61K9/12 , A61K31/045 , A61K31/05 , A61K31/075
CPC分类号： A61L12/08 , A61K9/0048 , A61K31/00 , A61K31/045 , A61K31/05 , A61K31/075
摘要： A method of reducing foam formation and improving odor in ophthalmic solutions, such as multipurpose cleaning and conditioning solutions and contact lens packing solutions. The ophthalmic solutions contain surfactant and aroma compound in an amount effective to decrease foam formation. The aroma compound has a low molecular weight and pleasing smell.
摘要翻译： 一种减少泡沫形成并改善眼科溶液中气味的方法，如多用途清洁和调理溶液和隐形眼镜包装溶液。 眼用溶液含有有效降低泡沫形成量的表面活性剂和芳香化合物。 芳香化合物具有低分子量和令人愉悦的气味。
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公开(公告)号：US07091299B2
公开(公告)日：2006-08-15
申请号：US11041175
申请日：2005-01-21
IPC分类号： C08G77/04
CPC分类号： C08G77/045 , A61L27/16 , C07F7/0838 , G02B1/043 , C08L51/085 , C08L51/08
摘要： Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more siloxysilane monomers or the copolymerization of one or more siloxysilane monomers with one or more aromatic or non-aromatic non-siloxy monomers, hydrophobic monomers or hydrophilic monomers.
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77.发明授权公开(公告)号：US06906162B2
公开(公告)日：2005-06-14
申请号：US10692378
申请日：2003-10-23
IPC分类号： G02C7/02 , A61L27/18 , C07F7/08 , C08F283/12 , C08F290/06 , C08G77/20 , C08G77/38 , G02B1/04 , C08G77/00
CPC分类号： C08G77/38 , A61L27/18 , A61L2430/16 , C07F7/0838 , C08F283/12 , C08F290/068 , G02B1/043 , Y10S623/905 , C08L51/085 , C08L83/04
摘要： Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, corneal inlays and contact lenses made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based siloxane macromonomers or the copolymerization of one or more aromatic-based siloxane macromonomers with one or more non-siloxy aromatic-based monomers, non-aromatic-based hydrophobic monomers or non-aromatic-based hydrophilic monomers.
摘要翻译： 本文描述了光学透明，相对高折射率的聚合物组合物和眼科装置，例如眼内透镜，角膜嵌体和由其制成的隐形眼镜。 优选的聚合物组合物通过一种或多种芳族基硅氧烷大分子单体的聚合或一种或多种芳族基硅氧烷大分子单体与一种或多种非甲硅烷氧基芳族基单体，非芳族基疏水单体或 非芳香族亲水单体。
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78.发明授权公开(公告)号：US06852793B2
公开(公告)日：2005-02-08
申请号：US10175715
申请日：2002-06-19
IPC分类号： A61F2/14 , A61F2/16 , A61L27/16 , C08F2/44 , C08F4/34 , C08F212/04 , C08F220/00 , C08F220/12 , C08F122/10 , C08F212/08
CPC分类号： C08F220/12 , A61L27/16 , C08F212/04 , C08L33/06
摘要： Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more copolymers with one or more hydrophilic monomers and optionally one or more aromatic-based monomers, hydrophobic monomers or a combination thereof.
摘要翻译： 本文描述了光学透明的相对高折射率的聚合物组合物和眼科装置，例如由其制成的眼内透镜和角膜嵌体。 优选的聚合物组合物通过一种或多种共聚物与一种或多种亲水单体和任选的一种或多种芳族基单体，疏水单体或其组合的聚合来制备。
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公开(公告)号：US06428839B1
公开(公告)日：2002-08-06
申请号：US09586941
申请日：2000-06-02
IPC分类号： A61L3110
CPC分类号： C08J7/047 , A61L27/34 , A61L29/085 , A61L31/10 , C08J2433/00 , C08L33/02 , C08L33/26
摘要： The invention provides a method for improving the wettability of a medical device, comprising the steps of: (a) providing a medical device formed from a monomer mixture comprising a hydrophilic monomer and a silicone-containing monomer, wherein said medical device has not been subjected to a surface oxidation treatment; (b) contacting a surface of the medical device with a solution comprising a proton-donating wetting agent, whereby the wetting agent forms a complex with the hydrophilic monomer on the surface of the medical device in the absence of a surface oxidation treatment step and without the addition of a coupling agent.
摘要翻译： 本发明提供了一种改善医疗装置的润湿性的方法，包括以下步骤：（a）提供由包含亲水性单体和含硅酮单体的单体混合物形成的医疗装置，其中所述医疗装置未经受 进行表面氧化处理;（b）使医疗装置的表面与包含质子递送润湿剂的溶液接触，由此在不存在聚合物的情况下，润湿剂与医疗装置的表面上的亲水性单体形成络合物 表面氧化处理步骤，而不加入偶联剂。
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公开(公告)号：US6143028A
公开(公告)日：2000-11-07
申请号：US063624
申请日：1998-04-20
CPC分类号： A61F2/1605 , A61F2/147 , A61L27/34 , A61L33/0011 , A61L33/0094 , A61L2430/16 , Y10S623/901
摘要： A minus power anterior chamber ocular implant for placement in the anterior chamber of a phakic eye having an anatomic lens in situ comprises a negative artificial refracting lens having at least one concave surface, a surface coating which comprises a compatible sulfated polysaccharide medicament coating, such as heparin, and having a structure which positions the artificial lens in the anterior chamber of the eye to prevent contact between the implant and the anatomic lens. The implant compensates for refractive errors or creates a specific refraction to assist in visual function and has increased biocompatibility in the anterior chamber of the eye, thereby preventing or mitigating detrimental effects typically associated with the implantation of an uncoated refractive anterior chamber implant in the eye. A method of preparing such a minus power anterior chamber ocular implant comprises first exposing an uncoated implant to a plasma to generate a plasma-treated implant having a surface containing amines, carboxylic acids, active free radicals or passive free radicals, and thereafter bonding the medicament to the plasma-treated implant surface. A method of treating myopia comprises surgically implanting and anchoring the implant in the phakic eye to compensate for refractive errors.
摘要翻译： 用于放置在具有解剖镜片的晶状体眼的前房中的负功率前房眼植入物包括具有至少一个凹表面的负人造折射透镜，包含相容的硫酸化多糖药物涂层的表面涂层，例如 肝素，并且具有将人造镜片定位在眼睛前房中以防止植入物和解剖镜片之间接触的结构。 植入物补偿屈光不正或产生特定折射以辅助视觉功能，并且增加眼睛前房中的生物相容性，从而防止或减轻通常与眼睛中未涂覆的折射性前房植入物植入有关的有害影响。 制备这种负电源前房眼植入物的方法包括首先将未涂覆的植入物暴露于等离子体以产生具有包含胺，羧酸，活性自由基或被动自由基的表面的等离子体处理的植入物，然后将药物 到等离子体处理的植入物表面。 治疗近视的方法包括将植入物手术植入和固定在晶状体眼中以补偿屈光不正。
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