公开(公告)号：US09872872B2

公开(公告)日：2018-01-23

申请号：US14879280

申请日：2015-10-09

申请人： Hayashibara Co., Ltd.

发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： C07H17/04 ,  A61K31/7048 ,  C12P19/18 ,  C12P19/60 ,  A61K9/16

CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

公开(公告)号：US09657045B2

公开(公告)日：2017-05-23

申请号：US14346410

申请日：2012-09-12

申请人： Takashi Shibuya ,  Seisuke Izawa

发明人： Takashi Shibuya ,  Seisuke Izawa

IPC分类号： C13K13/00 ,  C07H3/04 ,  C12P19/12 ,  C12P19/18 ,  C07H1/00 ,  C12P19/14 ,  C12N9/10 ,  C12P19/20

CPC分类号： C07H3/04 ,  C07H1/00 ,  C12N9/1074 ,  C12P19/12 ,  C12P19/14 ,  C12P19/18 ,  C12P19/20 ,  C12Y204/01019 ,  C13K13/007

摘要： A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an α-glycosyltrehalose-forming enzyme to act on liquefied starch derived from a microorganism of the genus Arthrobacter and a trehalose-releasing enzyme derived from a microorganism of the genus Arthrobacter along with a starch debranching enzyme and a cyclomaltodextrin glucanotransferase; allowing glucoamylase to act on the resulting mixture to obtain a saccharide solution containing α,α-trehalose; precipitating crystalline α,α-trehalose dihydrate from the above saccharide solution; collecting the precipitated crystalline α,α-trehalose dihydrate by a centrifuge; and ageing and drying the collected crystals. Cyclomaltodextrin glucanotransferase derived from a microorganism of the genus Paenibacillus or a mutant enzyme thereof is used to increase the α,α-trehalose content in the saccharide solution to over 86.0% by weight, on a dry solid basis, without passing through a fractionation step by column chromatography.

公开(公告)号：US09528134B2

公开(公告)日：2016-12-27

申请号：US14734607

申请日：2015-06-09

申请人： Hayashibara Co., Ltd

发明人： Hikaru Watanabe ,  Takuo Yamamoto ,  Tomoyuki Nishimoto ,  Keiji Tsusaki ,  Kazuyuki Oku ,  Hiroto Chaen ,  Shigeharu Fukuda

IPC分类号： C12P19/04 ,  C12P19/18 ,  A21D2/18 ,  A23C9/13 ,  A23C9/154 ,  A23L1/09 ,  A23L1/19 ,  A23L1/20 ,  A23L1/305 ,  A23L2/39 ,  A61K8/73 ,  A61K31/716 ,  A61Q19/00 ,  C08B37/00 ,  C12N9/10 ,  C12R1/06 ,  C12R1/09

CPC分类号： A23L33/21 ,  A21D2/18 ,  A23C9/1307 ,  A23C9/1544 ,  A23L2/39 ,  A23L9/20 ,  A23L11/05 ,  A23L29/35 ,  A23L33/10 ,  A23L33/18 ,  A23V2002/00 ,  A61K8/73 ,  A61K8/732 ,  A61K9/06 ,  A61K9/20 ,  A61K31/716 ,  A61K31/718 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C08B37/0009 ,  C12N9/1051 ,  C12P19/04 ,  C12P19/18 ,  C12R1/06 ,  C12R1/09 ,  Y02P20/52 ,  A23V2250/5118 ,  A23V2200/3262 ,  A23V2200/328

摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.

摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构建的特征在于甲基化分析的支链葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上 葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链葡聚糖的新型± - 葡萄糖基转移酶，其制备方法及其用途。

公开(公告)号：US09090923B2

公开(公告)日：2015-07-28

申请号：US14160749

申请日：2014-01-22

申请人： Hayashibara Co., Ltd

发明人： Hikaru Watanabe ,  Takuo Yamamoto ,  Tomoyuki Nishimoto ,  Keji Tsusaki ,  Kazuyuki Oku ,  Hiroto Chaen ,  Shigeharu Fukuda

IPC分类号： C12P19/18 ,  A21D2/18 ,  A23C9/13 ,  A23C9/154 ,  A23L1/09 ,  A23L1/19 ,  A23L1/20 ,  A23L1/305 ,  A23L2/39 ,  A61K8/73 ,  A61K31/716 ,  A61Q19/00 ,  C08B37/00 ,  C12N9/10 ,  C12P19/04 ,  C12R1/06 ,  C12R1/09

CPC分类号： A23L33/21 ,  A21D2/18 ,  A23C9/1307 ,  A23C9/1544 ,  A23L2/39 ,  A23L9/20 ,  A23L11/05 ,  A23L29/35 ,  A23L33/10 ,  A23L33/18 ,  A23V2002/00 ,  A61K8/73 ,  A61K8/732 ,  A61K9/06 ,  A61K9/20 ,  A61K31/716 ,  A61K31/718 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C08B37/0009 ,  C12N9/1051 ,  C12P19/04 ,  C12P19/18 ,  C12R1/06 ,  C12R1/09 ,  Y02P20/52 ,  A23V2250/5118 ,  A23V2200/3262 ,  A23V2200/328

摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitolis 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.

摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构成的特征在于甲基化分析的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）在部分甲基化的葡萄糖醇中的2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的总含量为60％以上 醋酸盐 （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡糖基转移酶，其制备方法及其用途。

公开(公告)号：US09066968B2

公开(公告)日：2015-06-30

申请号：US14169518

申请日：2014-01-31

申请人： HAYASHIBARA CO. LTD

发明人： Hitomi Ohta ,  Toshiharu Hanaya ,  Shigeharu Fukuda ,  Yoshikatsu Miwa ,  Toshio Miyake

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K31/715 ,  A61K31/716 ,  A61K31/702 ,  A61K31/7048 ,  A61M1/28

CPC分类号： A61K31/716 ,  A61K31/702 ,  A61K31/7048 ,  A61M1/287 ,  A61K2300/00

摘要： The present invention has an object to provide a fluid for peritoneal dialysis with satisfactory body fluid removability, high biocompatibility, and improved storage stability, and the object is attained by a fluid for peritoneal dialysis containing one or more saccharides selected from cyclonigerosylnigerose, cyclomaltosylmaltose, and L-ascorbic acid 2-glucoside.

摘要翻译： 本发明的目的是提供一种用于腹膜透析的流体，其具有令人满意的体液清除性，高生物相容性和改善的储存稳定性，并且目的是通过含有一种或多种选自旋风黑素糖， L-抗坏血酸2-葡萄糖苷。

公开(公告)号：US08940715B2

公开(公告)日：2015-01-27

申请号：US12033654

申请日：2008-02-19

申请人： Kazuyuki Oku ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

发明人： Kazuyuki Oku ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： A61K31/702 ,  A61K31/575 ,  A23D9/007 ,  A23K1/16 ,  A23L1/30 ,  C07H3/06

CPC分类号： A23D9/007 ,  A23K20/163 ,  A23L33/10 ,  A61K31/702 ,  C07H3/06

摘要： The object of the present invention is to provide a lipid-regulating agent or a composition for regulating the amount of lipids comprising the agent. The present invention solves the above object by providing a lipid-regulating agent comprising a cyclic tetrasaccharide and/or its saccharide-derivative(s) and a composition for regulating the amount of lipids comprising the lipid-regulating agent.

摘要翻译： 本发明的目的是提供一种脂质调节剂或用于调节包含该药剂的脂质的量的组合物。 本发明通过提供包含环状四糖和/或其糖衍生物的脂质调节剂和用于调节包含脂质调节剂的脂质的量的组合物来解决上述目的。

公开(公告)号：US08821934B2

公开(公告)日：2014-09-02

申请号：US10484216

申请日：2002-07-17

申请人： Toshiyuki Sugimoto ,  Toshio Miyake

发明人： Toshiyuki Sugimoto ,  Toshio Miyake

IPC分类号： A61K9/14 ,  C12P19/10 ,  C07H1/00

CPC分类号： C08J3/12 ,  A23L29/274 ,  A23P20/20 ,  A61K8/0212 ,  A61K8/11 ,  A61K8/73 ,  A61Q5/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C08B37/0018 ,  C08J3/14 ,  C08J2305/00 ,  C08K5/15 ,  C08L5/00 ,  C08L5/16 ,  C08L2666/26

摘要： The object of the present invention is to overcome conventional demerits of pullulan powders prepared by conventional techniques, i.e., they could not be homogeneously mixed with non-reducing saccharides composed of glucose units when mixed together, and the resulting mixtures do not easily dissolve in water; and to provide a pullulan-containing powder with an improved rate of water dissolution, as well as to provide preparations and uses thereof. The present invention solves the above object by providing a pullulan-containing powder which uniformly comprises pullulan as a main ingredient and a non-reducing saccharide, and their process and uses; wherein the pullulan-containing powder is prepared by the steps of preparing a solution dissolving pullulan and a non-reducing saccharide homogeneously, pulverizing the solution, and collecting the resulting pullulan-containing powder. The powder has an improved rate of water dissolution, while retaining satisfactory resistance to humidity without fear of causing separation between the pullulan and the non-reducing saccharide.

摘要翻译： 本发明的目的是克服通过常规技术制备的支链淀粉粉末的常规缺点，即当它们混合在一起时不能与由葡萄糖单元组成的非还原性糖类均匀混合，并且所得混合物不容易溶于水 ; 并提供具有改善的水溶解速率的含支链淀粉的粉末，以及提供其制备和用途。 本发明通过提供均匀地包含支链淀粉作为主要成分和非还原性糖的支链淀粉粉末及其工艺和用途来解决上述目的。 其中含有支链淀粉的粉末通过以下步骤制备：均匀地制备溶解支链淀粉和非还原性糖的溶液，粉碎溶液，并收集所得的含支链淀粉粉末。 粉末具有改善的水溶解速率，同时保持令人满意的耐湿性，而不用担心支链淀粉与非还原性糖之间的分离。

公开(公告)号：US20140148409A1

公开(公告)日：2014-05-29

申请号：US14169518

申请日：2014-01-31

申请人： HAYASHIBARA CO. LTD

发明人： Hitomi OHTA ,  Toshiharu HANAYA ,  Shigeharu FUKUDA ,  Yoshikatsu MIWA ,  Toshio MIYAKE

IPC分类号： A61K31/716

CPC分类号： A61K31/716 ,  A61K31/702 ,  A61K31/7048 ,  A61M1/287 ,  A61K2300/00

摘要： The present invention has an object to provide a fluid for peritoneal dialysis with satisfactory body fluid removability, high biocompatibility, and improved storage stability, and the object is attained by a fluid for peritoneal dialysis containing one or more saccharides selected from cyclonigerosylnigerose, cyclomaltosylmaltose, and L-ascorbic acid 2-glucoside.

摘要翻译： 本发明的目的是提供一种用于腹膜透析的流体，其具有令人满意的体液清除性，高生物相容性和改善的储存稳定性，并且目的是通过含有一种或多种选自旋风黑素糖， L-抗坏血酸2-葡萄糖苷。

公开(公告)号：US20130165399A1

公开(公告)日：2013-06-27

申请号：US13805215

申请日：2011-06-16

申请人： Keizo Kohno ,  Emiko Ohashi ,  Hajime Kusano ,  Shigeharu Fukuda ,  Tatsuya Ishihara

发明人： Keizo Kohno ,  Emiko Ohashi ,  Hajime Kusano ,  Shigeharu Fukuda ,  Tatsuya Ishihara

IPC分类号： A61K31/7076 ,  A61K45/06

CPC分类号： A61K31/7076 ,  A61K8/602 ,  A61K31/7052 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/708 ,  A61K45/06 ,  A61K2800/10 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  C07H19/067 ,  C07H19/167

摘要： The present invention has an object to provide an effective and safe therapeutic agent for inflammatory diseases such as sepsis, hepatitis, and inflammatory bowel disease, and solves the above object by providing a therapeutic agent for inflammatory diseases containing adenosine N1-oxide or a derivative thereof as an effective ingredient.

摘要翻译： 本发明的目的是提供一种用于炎症性疾病如败血症，肝炎和炎症性肠病的有效且安全的治疗剂，并且通过提供含有腺苷N1氧化物或其衍生物的炎性疾病的治疗剂来解决上述目的 作为有效成分。