公开(公告)号：US20230357390A1

公开(公告)日：2023-11-09

申请号：US18356489

申请日：2023-07-21

Applicant: OSAKA UNIVERSITY

Inventor： Naoki Hosen ,  Haruo Sugiyama ,  Atsushi Kumanogoh

IPC: C07K16/28 ,  C07K16/30 ,  C07K19/00 ,  A61P35/00 ,  C12N15/62

CPC classification number: C07K16/28 ,  C07K16/3061 ,  C07K16/2896 ,  C07K19/00 ,  A61P35/00 ,  C12N15/62 ,  C07K2317/734 ,  C07K2317/34 ,  C07K2317/33 ,  A61K2039/505

Abstract: Provided is an antibody effective in treating tumors and the like. The antibody recognizes an epitope that contains an N-glycosylation site of human CD98hc and that is exposed by inhibiting N-linked glycosylation.

公开(公告)号：US11795573B2

公开(公告)日：2023-10-24

申请号：US17359949

申请日：2021-06-28

Applicant: OSAKA UNIVERSITY ,  Panasonic Corporation

Inventor： Yusuke Mori ,  Masashi Yoshimura ,  Masayuki Imanishi ,  Akira Kitamoto ,  Junichi Takino ,  Tomoaki Sumi ,  Yoshio Okayama

IPC: C30B25/16 ,  C30B25/02 ,  H01L21/02 ,  C23C16/30 ,  C30B29/40

CPC classification number: C30B25/02 ,  C23C16/303 ,  C30B29/406 ,  H01L21/0254 ,  H01L21/0262

Abstract: A method of manufacturing a group III nitride crystal according to a first aspect includes: preparing a seed substrate; generating a group III element oxide gas; supplying the group III element oxide gas; supplying a nitrogen element-containing gas; supplying an oxidizing gas containing nitrogen element containing at least one selected from the group consisting of NO gas, NO2 gas, N2O gas, and N2O4 gas; and growing the group III nitride crystal on the seed substrate.

公开(公告)号：US11788948B2

公开(公告)日：2023-10-17

申请号：US17115657

申请日：2020-12-08

Applicant: ThinkCyte, Inc. ,  University of Tokyo ,  Osaka University

Inventor： Sadao Ota ,  Ryoichi Horisaki ,  Yoko Kawamura ,  Masashi Ugawa ,  Issei Sato

IPC: G01N15/14 ,  G01N15/10

CPC classification number: G01N15/1434 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/145 ,  G01N2015/149 ,  G01N2015/1497

Abstract: The present disclosure provides methods and systems for ghost cytometry (GC), which may be used to produce an image of an object without using a spatially resolving detector. This may be used to perform image-free ultrafast fluorescence “imaging” cytometry, based on, for example, a single pixel detector. Spatial information obtained from the motion of cells relative to a patterned optical structure may be compressively converted into signals that arrive sequentially at a single pixel detector. Combinatorial use of the temporal waveform with the intensity distribution of the random or pseudo-random pattern may permit computational reconstruction of cell morphology. Machine learning methods may be applied directly to the compressed waveforms without image reconstruction to enable efficient image-free morphology-based cytometry. Image-free GC may achieve accurate and high throughput cell classification as well as selective sorting based on cell morphology without a specific biomarker, which have been challenging using conventional flow cytometers.

公开(公告)号：US11786162B2

公开(公告)日：2023-10-17

申请号：US16332723

申请日：2017-08-17

Applicant: OSAKA UNIVERSITY ,  NIPPON MEKTRON, LTD.

Inventor： Tsuyoshi Sekitani ,  Takafumi Uemura ,  Teppei Araki ,  Shusuke Yoshimoto ,  Masayuki Iwase ,  Akio Yoshida ,  Hideki Satake

IPC: A61B5/24 ,  A61B5/05 ,  A61B5/291 ,  A61B5/282

CPC classification number: A61B5/291 ,  A61B5/282 ,  A61B2562/0215 ,  A61B2562/164

Abstract: Provided is an electrode sheet allowing easy connection of a wiring that is extended, when required, to a measurement position on a living body. The electrode sheet (main sheet (1), auxiliary sheet (10)) includes a sheet-shaped flexible substrate (2, 11), wirings (3, 12) formed on the flexible substrate (2, 11), electrodes (5, 14) formed on the flexible substrate (2, 11) and electrically connected to the wirings (3, 12), and an insulating layer (4, 13) laid on the flexible substrate (2, 11) in such a manner that the wirings (3, 12) are overlaid with the insulating layer (4, 13) while the electrodes (5, 14) are exposed. The electrodes (5, 14) are formed of a conductive material in which conductive particles are dispersed in a thermoplastic resin.

公开(公告)号：US20230310561A1

公开(公告)日：2023-10-05

申请号：US18023573

申请日：2021-09-07

Applicant: OSAKA UNIVERSITY

Inventor： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Shuko TAKEDA ,  Hiroki HAYASHI

IPC: A61K39/00 ,  A61P25/28

CPC classification number: A61K39/0005 ,  A61P25/28 ,  A61K2039/6031 ,  A61K2039/575

Abstract: The present invention provides an immunogenic composition comprising an antigenic peptide and a carrier protein, wherein the antigenic peptide is capable of eliciting production of an antibody against a phosphorylated tau protein and is a human tau protein fragment containing (1) YSpSPGpSPG (SEQ ID NO: 2), (2) AKpSpTPpTAE (SEQ ID NO: 5), (3) AKpSpTPTAE (SEQ ID NO: 31), (4) AKpSTPpTAE (SEQ ID NO: 32), (5) AKSpTPpTAE (SEQ ID NO: 33), or (6) IVpYKpSPV (SEQ ID NO: 24).

公开(公告)号：US11766133B2

公开(公告)日：2023-09-26

申请号：US17022061

申请日：2020-09-15

Applicant: FUNAI ELECTRIC CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Naoyuki Wakabayashi ,  Fuminori Tanaka ,  Jun Sugimoto ,  Masayuki Hirata ,  Yuka Omura ,  Kanae Kusakabe

IPC: A47C20/04 ,  A61G7/00 ,  A61G7/07 ,  A61G7/057

CPC classification number: A47C20/048 ,  A61G7/001 ,  A61G7/05776 ,  A61G7/07 ,  A61G2203/34

Abstract: A mattress 100 includes a movable part 1 and a mattress body 2 including a first mattress part 21 disposed above the movable part 1, and a second mattress part 22 provided separately from the first mattress part 21 and disposed to surround the first mattress part in a plan view. The first mattress part 21 is configured to rotate upward about the predetermined rotation axis by the movable part 1.

公开(公告)号：US20230288318A1

公开(公告)日：2023-09-14

申请号：US18152354

申请日：2023-01-10

Applicant: The University of Tokyo ,  Osaka University

Inventor： Sadao Ota ,  Ryoichi Horisaki ,  Kazuki Hashimoto

IPC: G01N21/01 ,  G01B11/00 ,  G01N21/64 ,  H03M7/30 ,  G01N21/53 ,  G01N21/59

CPC classification number: G01N21/01 ,  G01B11/00 ,  G01N21/64 ,  H03M7/3062 ,  G01N21/53 ,  G01N21/59 ,  G01N21/6456

Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.

公开(公告)号：US20230280317A1

公开(公告)日：2023-09-07

申请号：US18010963

申请日：2021-06-03

Applicant: Shimadzu Corporation ,  Osaka University

Inventor： Shinji KANAZAWA ,  Fumio MATSUDA

IPC: G01N30/86

CPC classification number: G01N30/8631 ,  G01N30/8693 ,  G01N2030/027

Abstract: A data generation device according to the present invention is a data generation device configured to simulatively generate data used when creating, by machine learning, a discriminator configured to detect a peak observed in a signal waveform, the data generation device including: a parameter frequency information acquisition unit configured to acquire information on frequency of a predetermined shape parameter which characterizes a shape of a signal waveform from a plurality of signal waveforms collected only in a target field of machine learning for creating the discriminator; and a simulated waveform generation unit configured to generate a simulated signal waveform which is able to include overlapping of a plurality of peaks and noise using the information on frequency of the shape parameter, in which the simulated signal waveform is provided as data for training or evaluating machine learning.

公开(公告)号：US11739204B2

公开(公告)日：2023-08-29

申请号：US17325471

申请日：2021-05-20

Applicant: Osaka University

Inventor： Yoshinori Takashima ,  Akira Harada ,  Motofumi Osaki ,  Kensaku Takahashi ,  Junsu Park

IPC: C08L25/06 ,  C08L5/16

CPC classification number: C08L25/06 ,  C08L5/16

Abstract: An object is to provide a macromolecular composite material that can be produced by a simple process, and that has excellent mechanical properties. The macromolecular composite material of the present invention contains a polymer component and a cyclodextrin compound, the polymer component containing a thermoplastic resin, and the cyclodextrin compound being at least one member selected from the group consisting of cyclodextrin and cyclodextrin derivatives. The macromolecular composite material of the present invention can be produced by a simple process, and has excellent mechanical properties.

公开(公告)号：US11731917B2

公开(公告)日：2023-08-22

申请号：US16636236

申请日：2018-08-03

Applicant: OSAKA UNIVERSITY

Inventor： Yoshifumi Shirakami ,  Hayato Ikeda ,  Yasukazu Kanai ,  Eku Shimosegawa ,  Jun Hatazawa ,  Tadashi Watabe ,  Kazuko Kaneda

IPC: C07B59/00 ,  C07F13/00 ,  C07F5/02

CPC classification number: C07B59/001 ,  C07B59/004 ,  C07F5/025 ,  C07F13/00 ,  C07F13/005 ,  C07B2200/05

Abstract: The invention relates to a method of producing the radiolabeled aryl compound (I) Ar—X, or a salt thereof, wherein X is 211At, 210At, 123I, 124I, 125I, or 131I. The method involves reacting the aryl boronic acid compound (II) Ar—Y, or a salt thereof, wherein Y is a borono group (—B(OH)2) or an ester group thereof, with a radionuclide selected from 211At, 210At, 123I, 124I, 125I and 131I, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.