公开(公告)号：US5653751A

公开(公告)日：1997-08-05

申请号：US350568

申请日：1994-12-07

申请人： Nassrollah Samiy ,  John D. T. Gerber

发明人： Nassrollah Samiy ,  John D. T. Gerber

IPC分类号： A61F2/16 ,  A61F9/00 ,  A61F9/08 ,  A61F2/14

CPC分类号： A61F2/16 ,  A61F2/142 ,  A61F9/08 ,  A61F2009/0043

摘要： Apparatus and methods are described that project images onto the retina of an eye. The apparatus can include an image memory element for storing an image signal representative of a visual image, a projection element in electrical circuit with the image memory element for generating an optical image signal of the type suitable for detection by a retina and being representative of the visual image, and a focus element that is adapted for implantation into the eye at a position in the eye which is posterior to the cornea and anterior to the retina and that is optically coupled to the projection element for focusing the optical image onto the retina. The projection element can include a display device that is dimensionally adapted for disposition within the eye at a position posterior to the cornea. The display device can be a liquid crystal display element that has an illuminator element optically coupled to the display device or alternatively can include a laser diode element that optically couples to a scanning mirror that projects light through a damaged cornea.

摘要翻译： 描述了将图像投影到眼睛的视网膜上的装置和方法。 该装置可以包括用于存储表示视觉图像的图像信号的图像存储元件，与该图像存储元件的电路中的投影元件，用于产生适于由视网膜检测的类型的光学图像信号，并代表 视觉图像和焦点元件，其适于在眼睛的位于角膜后部并在视网膜之前的位置处植入眼睛，并且光学耦合到投影元件，用于将光学图像聚焦到视网膜上。 投影元件可以包括尺寸适于在角膜后面的位置处配置在眼睛内的显示装置。 显示装置可以是具有光学耦合到显示装置的照明器元件的液晶显示元件，或者替代地可以包括光学耦合到通过损坏的角膜投射光的扫描镜的激光二极管元件。

公开(公告)号：US5464417A

公开(公告)日：1995-11-07

申请号：US243479

申请日：1994-05-16

申请人： Daniel H. Eick

发明人： Daniel H. Eick

IPC分类号： A61F2/14 ,  A61F9/013 ,  A61B17/00

CPC分类号： A61F2/142 ,  A61F2/14 ,  A61F9/007 ,  A61F9/013

摘要： A cornea holder for independently holding a predetermined portion of cornea tissue having a corneal button, an endothelial surface and an epithelial surface includes a one-piece, ring-like support member having a bore defining a passageway therethrough. One end of the ring-like member has a plurality of circumferentially spaced support fingers extending inwardly and upwardly therefrom. The support fingers have internally facing bevelled tips diverging outwardly from the passageway to independently support the predetermined portion of cornea tissue endothelial-side up such that the corneal button is suspended in the passageway. A cornea cutting system is also disclosed wherein a rotatable cutting element is moveable through the passageway and engageable solely with the predetermined portion of cornea tissue such that the predetermined portion of cornea tissue is cut along a circumference of the predetermined portion of cornea tissue in a manner which will preserve the number of cells in the endothelial and epithelial surfaces.

摘要翻译： 用于独立地保持具有角膜按钮，内皮表面和上皮表面的角膜组织的预定部分的角膜保持器包括具有限定穿过其中的通道的孔的一体式环形支撑构件。 环状构件的一端具有从其向内和向上延伸的多个周向间隔开的支撑指。 支撑指具有内部面向倾斜的尖端，从通道向外分开，以独立地支撑角膜组织内皮侧向上的预定部分，使得角膜按钮悬挂在通道中。 还公开了一种角膜切割系统，其中可旋转切割元件可移动通过该通道并且仅与角膜组织的预定部分接合，使得角膜组织的预定部分以角膜组织的预定部分的圆周以某种方式被切割 这将保留内皮和上皮表面的细胞数量。

公开(公告)号：US5458819A

公开(公告)日：1995-10-17

申请号：US170379

申请日：1993-12-20

申请人： Traian V. Chirila ,  Ian J. Constable ,  Geoffrey J. Crawford ,  Albert V. Russo

发明人： Traian V. Chirila ,  Ian J. Constable ,  Geoffrey J. Crawford ,  Albert V. Russo

IPC分类号： A61F2/14 ,  B29D11/00

CPC分类号： A61F2/142 ,  Y10S425/808

摘要： A composite device which may be implanted in the cornea of the human eye to replace damaged or diseased portions, and a method of manufacturing the said device, are disclosed. The device consists of a transparent central portion intimately attached to an opaque spongy rim. Both portions are made of hydrogel materials produced in different conditions of polymerization during a two-stage process performed in a specific moulding unit. The spongy rim promotes and maintains cellular invasion from the host corneal tissue, thus providing a tight union between implant and recipient cornea which prevents the postoperative extrusion of the implant.

摘要翻译： 公开了一种可植入人眼角膜以代替受损或患病部位的复合装置及其制造方法。 该装置由透明的中心部分组成，紧密地连接到不透明的海绵状边缘上。 两部分由在特定模制单元中进行的两阶段工艺中在不同聚合条件下生产的水凝胶材料制成。 海绵边缘促进和维持主体角膜组织的细胞侵入，从而提供植入物和受体角膜之间的紧密结合，其防止植入物的术后挤压。

公开(公告)号：US5374515A

公开(公告)日：1994-12-20

申请号：US974740

申请日：1992-11-13

申请人： Nancy L. Parenteau ,  Valerie S. Mason ,  Bjorn R. Olsen

发明人： Nancy L. Parenteau ,  Valerie S. Mason ,  Bjorn R. Olsen

IPC分类号： A61L27/00 ,  A61F2/14 ,  A61K35/12 ,  A61L27/38 ,  C12N5/071 ,  A01N1/02 ,  C12N5/00

CPC分类号： A61L27/3891 ,  A61F2/14 ,  A61F2/142 ,  A61K35/12 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/3839 ,  A61L27/3895 ,  C12N5/0621 ,  C12N5/0697 ,  A61L2430/16 ,  C12N2500/25 ,  C12N2501/39 ,  C12N2501/395 ,  C12N2502/085 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2510/04 ,  C12N2533/54

摘要： This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an in vitro model of the eye, which can be used for transplantation or implantation in vivo or for screening compounds in vitro.

摘要翻译： 本发明涉及使用组织培养系统制造的眼睛的角膜部分的器官当量。 构建角膜等价物的方法产生类似于眼内角膜的结构。 角膜等效物是眼的体外模型，其可用于体内移植或植入或用于体外筛选化合物。

公开(公告)号：US5288436A

公开(公告)日：1994-02-22

申请号：US855367

申请日：1992-03-20

申请人： Yung S. Liu ,  Keith P. Thompson ,  Raymond P. Gailitis ,  Seth R. Banks ,  Gary C. Taylor

发明人： Yung S. Liu ,  Keith P. Thompson ,  Raymond P. Gailitis ,  Seth R. Banks ,  Gary C. Taylor

IPC分类号： A61F2/14 ,  B29D11/00 ,  B29D11/02

CPC分类号： B29D11/00009 ,  A61F2/14 ,  A61F2/142 ,  A61L27/24 ,  B29D11/00105 ,  B29D11/023

摘要： A lenticule is bonded to the eye as part of its formation process by curing or final curing the lenticule on the eye. Such lenticules provide a smooth transition from the body of the lenticule to Bowman's layer on which the lenticule is disposed. The lenticule at the time its material or precursor is placed on the eye may vary from being essentially all viscous collagen which flows and must be molded to obtain a desired lenticule configuration to a substantially stable preform which holds its own shape. Such preformed lenticules may be formed using an appropriate mold and photopolymerization or other partial curing techniques to pre-cure the lenticule material to an appropriate stage for application to the eye. In one method, such a partially cured lenticule precursor is formed in layers by depositing a quantity of curable viscous collagen in an anterior surface mold, partially curing the viscous collagen, and repeatedly depositing and partially curing subsequent collagen layers until a preform having a desired thickness has been formed.

摘要翻译： 通过固化或最终固化眼睛上的微透镜将微透镜结合到眼睛，作为其形成过程的一部分。 这种微透镜提供从微透镜的主体到设置有微透镜的Bowman层的平滑过渡。 当它的材料或前体放置在眼睛上时，微透镜可能与基本上所有流动并且必须模制的粘性胶原变化，以获得所需的微透镜结构到保持其自身形状的基本稳定的预成型件。 可以使用适当的模具和光聚合或其它部分固化技术来形成这种预制的微透镜，以将微透镜材料预固化到适用于眼睛的阶段。 在一种方法中，通过在前表面模具中沉积一定量的可固化粘性胶原蛋白，部分固化粘性胶原蛋白，并重复沉积和部分固化后续胶原蛋白层，直到形成具有所需厚度的预制件，从而形成这种部分固化的微透镜前体 已经形成。

公开(公告)号：US4994081A

公开(公告)日：1991-02-19

申请号：US511847

申请日：1990-04-16

申请人： Linda Civerchia ,  Dennis D. Shepard

发明人： Linda Civerchia ,  Dennis D. Shepard

IPC分类号： A61F2/00 ,  A61F2/14 ,  A61F2/16 ,  A61L27/24

CPC分类号： A61F2/145 ,  A61F2/14 ,  A61F2/1602 ,  A61F2/1605 ,  A61L27/24 ,  A61F2/142 ,  A61F2310/00005 ,  A61F2310/00365 ,  Y10S623/906

摘要： A method for locating on the cornea an optical lens having a preselected geometric shape and power wherein the optical lens is formed of a collagen-hydrogel for promoting epithelial cell growth is shown. The method comprises the steps of: removing from Bowman's membrane over the area of the pupillary zone of the eye a portion of the corneal epithelium; forming on Bowman's membrane a "V" shaped annular groove having a diameter substantially equal to the maximum geometrical dimensions of the optical lens and a preselected depth; dissecting the peripheral edge of the groove forming a wing of corneal tissue having a preselected length; placing the posterior surface of the optical lens on the anterior surface of Bowman's membrane and positioning the outer edge of the optical lens under the corneal wing, and affixing the optical lens to Bowman's membrane over the pupillary zone of the eye to maintain the same on the cornea with the corneal wing overlying the edge of the optical lens. With the edge of the lens in contact with corneal epithelim, the collagen-hydrogel for promoting epithelial cell growth interacts with epithelial cells during a healing period to promote growth thereof over, and attach to, the anterior surface of the optical lens implanting the same under corneal epithelium.

摘要翻译： 示出了在角膜上定位具有预选几何形状和功率的光学透镜的方法，其中光学透镜由用于促进上皮细胞生长的胶原 - 水凝胶形成。 该方法包括以下步骤：在眼睛的瞳孔区域的一部分角膜上皮上去除Bowman膜; 在Bowman膜上形成具有基本上等于光学透镜的最大几何尺寸的直径和预选深度的“V”形环形槽; 解剖形成具有预选长度的角膜组织翼的槽的周边边缘; 将光学透镜的后表面放置在Bowman膜的前表面上，并将光学透镜的外边缘定位在角膜下方，并将光学透镜粘贴在Bowman's膜上，在眼睛的瞳孔区域上保持相同 角膜与角膜覆盖光学透镜的边缘。 随着镜片边缘与角膜上皮接触，用于促进上皮细胞生长的胶原 - 水凝胶在愈合期间与上皮细胞相互作用，以促进其生长，并附着在植入其中的光学透镜的前表面 角膜上皮。

公开(公告)号：US4806382A

公开(公告)日：1989-02-21

申请号：US037153

申请日：1987-04-10

申请人： Eugene P. Goldberg ,  Jim Burns ,  John W. Sheets ,  Jeffrey A. Larson ,  Sudesh Kumar ,  David Osborn

发明人： Eugene P. Goldberg ,  Jim Burns ,  John W. Sheets ,  Jeffrey A. Larson ,  Sudesh Kumar ,  David Osborn

IPC分类号： G02C7/04 ,  A61F2/00 ,  A61F2/14 ,  A61F2/16 ,  A61K31/727 ,  A61K31/728 ,  A61K31/79 ,  A61L27/00 ,  A61L27/16 ,  A61L27/34 ,  A61L31/00 ,  A61L31/10 ,  A61L33/00 ,  B05D3/06 ,  B05D7/02 ,  C08J7/18 ,  G02B1/04 ,  A01N1/02

CPC分类号： A61F2/142 ,  A61F2/14 ,  A61F2/16 ,  A61F2/1613 ,  A61K31/727 ,  A61K31/728 ,  A61K31/79 ,  A61L27/14 ,  A61L27/16 ,  A61L27/34 ,  A61L31/08 ,  A61L31/10 ,  B05D7/02 ,  C08J7/18 ,  G02B1/043 ,  A61F2/145 ,  A61F2002/0086 ,  A61F2002/009 ,  A61L2400/18 ,  A61L2430/16 ,  B05D3/061 ,  B05D3/068 ,  Y10T428/31507 ,  Y10T428/3154 ,  Y10T428/31663 ,  Y10T428/31794

摘要： A method for modifying a PMMA surface by the gamma-irradiation induced polymerization thereon of N-vinylpyrrolidone, 2-hydroxyethylmethacrylate or a mixture thereof while maintaining the following conditions:(a) monomer concentration in the range of from about 0.5% to about 50%, by weight;(b) total gamma dose in the range of from about 0.01 to less than about 0.50 Mrad;(c) gamma dose rate in the range of from about 10 to about 2500 rads/minute; and(d) maintaining the molecular weight of the polymer in solution in the range of from about 250,000 to about 5,000,000.The invention also relates to modifying polypropylene, polyvinylidene fluoride, polycarbonate and silicon surfaces according to a similar method as well as materials produced by the above methods which are useful as ocular implants.

公开(公告)号：US4715858A

公开(公告)日：1987-12-29

申请号：US889174

申请日：1986-07-25

申请人： Richard L. Lindstrom

发明人： Richard L. Lindstrom

IPC分类号： A61F2/14

CPC分类号： A61F2/142 ,  A61F2/14

摘要： A synthetic epicorneal lens for use in the treatment of refractive errors. The lens is of a plastic that is compatible with the cornea, may be gas permeable or metabolite permeable, and may be coated with a basement membrane material such as fibronectin or laminen. The lens can be made from polymers, hydrogel, silicone, fluoropolymer, cellulose acetate butyrate, or other like material.

摘要翻译： 用于治疗屈光不正的合成上皮膜镜片。 透镜是与角膜相容的塑料，可以是透气的或代谢物可渗透的，并且可以用基底膜材料如纤连蛋白或层粘连涂层。 透镜可以由聚合物，水凝胶，硅酮，含氟聚合物，乙酸丁酸纤维素或其它类似材料制成。

公开(公告)号：US4664110A

公开(公告)日：1987-05-12

申请号：US713220

申请日：1985-03-18

申请人： David J. Schanzlin

发明人： David J. Schanzlin

IPC分类号： A01N1/02 ,  A61B18/02 ,  A61F2/14 ,  A61F9/013 ,  A61L27/36

CPC分类号： A61F9/013 ,  A01N1/02 ,  A01N1/0284 ,  A61B18/02 ,  A61F2/14 ,  A61F2/142 ,  A61L27/36 ,  A61L2430/16

摘要： A method for freezing corneal tissue prior to cryorefractive surgery, including the controlled rate freezing of the tissue at a rate of less than seven degrees centigrade per minute.

摘要翻译： 在冷冻手术之前冷冻角膜组织的方法，包括以每分钟小于7摄氏度的速度控制组织的速率冷冻。

公开(公告)号：US4563779A

公开(公告)日：1986-01-14

申请号：US574677

申请日：1984-01-27

申请人： Charles D. Kelman

发明人： Charles D. Kelman

IPC分类号： A61F2/14

CPC分类号： A61F2/142

摘要： A corneal implant and method of making the same utilizes a corneal plug removed from an eye, frozen solid, and centrally bored to, but not through, its Bowman's or its Descemet's membrane. An artificial plug which is optically clear is inserted in the bore of the corneal plug and attached thereto. The corneal plug with the artificial plug therein is thereafter implanted in a corresponding opening in the cornea of the patient's eye providing a transparent window free of fluid leakage.

摘要翻译： 角膜植入物及其制造方法利用从眼睛中取出的角膜塞，冷冻固体，并将其中心钻孔但不通过其Bowman's或其Descemet膜。 将光学透明的人工插头插入角膜塞的孔中并附着在其上。 然后将其中具有人造塞子的角膜塞插入到患者眼睛的角膜中的相应开口中，提供没有流体泄漏的透明窗口。