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    Sulfonate derivatives and the use thereof as latent acids
    72.
    发明申请
    Sulfonate derivatives and the use thereof as latent acids 审中-公开

    公开(公告)号：US20080286693A1

    公开(公告)日：2008-11-20

    申请号：US11999116

    申请日：2007-12-04

    Applicant: Akira Matsumoto ,  Hitoshi Yamato ,  Toshikage Asakura ,  Peter Murer

    Inventor： Akira Matsumoto ,  Hitoshi Yamato ,  Toshikage Asakura ,  Peter Murer

    IPC: G03F7/20

    CPC classification number: G03F7/0037 ,  B33Y70/00 ,  C07C323/66 ,  C07C381/00 ,  G03F7/001 ,  G03F7/0045 ,  G03F7/038 ,  G03F7/0382 ,  G03F7/0392 ,  G03F7/0397 ,  G03F7/0758 ,  Y10S430/114

    Abstract: Chemically amplified photoresist compositions comprising,(a) a compound which cures upon the action of an acid or a compound whose solubility is increased upon the action of an acid; and (b) a compound of the formula Ia, Ib, IIa, IIb, IIIa, IIIb, IVa, IVb, Va, Vb or VIa wherein n is 1 or 2; m is 0 or 1; X0 is —[CH2]h—X or —CH═CH2; h is 2, 3, 4, 5 or 6; R1, when n is 1, is for example optionally substituted phenyl, naphthyl, anthracyl, phenanthryl, or heteroaryl; R1, when n is 2, is for example optionally substituted phenylene or naphthylene; R2 for example has one of the meanings of R1; X is for example —OR20, —NR21R22, —SR23; X′ is —X1-A3-X-; X1 and X2 are for example —O—, —S— or a direct bond; A3 is e.g. phenylene; R3 has for example one of the meanings given for R1; R4 has for example one of the meaning given for R2; R5 and R6 e.g. are hydrogen; G i.a. is —S— or —O—; R7 when n is 1, e.g. is phenyl, optionally substituted, when n is 2, is for example phenylene; R8 and R9 e.g. are C1-C18alkyl; R10 has one of the meanings given for R7; R11 i.a. is C1-C18alkyl; R12, R13, R14, R15 R16, R17 and R18 for example are hydrogen or C1-C18alkyl; R20, R21, R22 and R23 i.a. are phenyl or C1-C18alkyl; give high resolution with good resist profile.

    Sulfonate derivatives and the use thereof as latent acids
    73.
    发明授权
    Sulfonate derivatives and the use thereof as latent acids 有权

    公开(公告)号：US07326511B2

    公开(公告)日：2008-02-05

    申请号：US10495710

    申请日：2003-01-28

    Applicant: Akira Matsumoto ,  Hitoshi Yamato ,  Toshikage Asakura ,  Peter Murer

    Inventor： Akira Matsumoto ,  Hitoshi Yamato ,  Toshikage Asakura ,  Peter Murer

    IPC: G03F7/00 ,  G03F7/004

    CPC classification number: G03F7/0037 ,  B33Y70/00 ,  C07C323/66 ,  C07C381/00 ,  G03F7/001 ,  G03F7/0045 ,  G03F7/038 ,  G03F7/0382 ,  G03F7/0392 ,  G03F7/0397 ,  G03F7/0758 ,  Y10S430/114

    Abstract: Chemically amplified photoresist compositions comprising, (a) a compound which cures upon the action of an acid or a compound whose solubility is increased upon the action of an acid; and (b) a compound of the formula (Ia), (Ib), (IIa), (IIb), (IIIa), (IIIb), (Iva), (Ivb), (Va), (Vb) or (VIa), wherein n is 1 or 2; m is 0 or 1; X0 is —[CH2]h—X or —CH═CH2; h is 2, 3, 4, 5 or 6; R1 when n is 1, is for example optionally substituted phenyl, naphthyl, anthracyl, phenanthryl, or heteroaryl; R1, when n is 2, is for example optionally substituted phenylene or naphthylene; R2 for example has one of the meanings of R1; X is for example —OR20, —NR21R22, —SR23; X′ is -X1-A3-X2-; X1 and X2 are for example —O—, —S— or a direct bond; A3 is e.g. phenylene; R3 has for example one of the meanings given for R1; R4 has for example one of the meaning given for R2; R5 and R6 e.g. are hydrogen; G i.a. is —S— or —O—; R7 when n is 1, e.g. is phenyl, optionally substituted, when n is 2, is for example phenylene; R8 and R9 e.g. are C1-C18alkyl; R10 has one of the meanings given for R7; R11 i.a. is C1-C18alkyl; R12, R13, R14, R15 R16, R17 and R18 for example are hydrogen or C1-C18alkyl; R20, R21, R22 and R23 i.a are phenyl or C1-C18alkyl; give high resolution with good resist profile

    Medicinal disulfide salts
    74.
    发明授权
    Medicinal disulfide salts 有权
    药用二硫化物盐

    公开(公告)号：US07282602B2

    公开(公告)日：2007-10-16

    申请号：US10945809

    申请日：2004-09-21

    Applicant: Qiuli Huang ,  Harry Kochat ,  Xinghai Chen

    Inventor： Qiuli Huang ,  Harry Kochat ,  Xinghai Chen

    IPC: C07C309/00

    CPC classification number: C07C323/66

    Abstract: This invention relates to novel salts of medicinal disulfides. The compounds include a terminal sulfonate or phosphonate moiety, and have many uses, such as toxicity reducing agents when administered with many antineoplastic agents.

    Abstract translation: 本发明涉及药物二硫化物的新型盐。 化合物包括末端磺酸盐或膦酸盐部分，并且当与许多抗肿瘤剂一起施用时具有许多用途，例如毒性降低剂。

    Magenta dyes and inks for use in ink-jet printing
    75.
    发明授权
    Magenta dyes and inks for use in ink-jet printing 失效
    用于喷墨打印的洋红色染料和油墨

    公开(公告)号：US07270700B2

    公开(公告)日：2007-09-18

    申请号：US11292001

    申请日：2005-12-02

    Applicant: Clive Edwin Foster

    Inventor： Clive Edwin Foster

    IPC: C09D11/00 ,  C09D11/02 ,  C07C50/36 ,  B41J2/01

    CPC classification number: C09B3/64 ,  C07C323/22 ,  C07C323/66 ,  C09D11/328

    Abstract: A composition comprising:(a) a compound of Formula (1) wherein: R1, R2, R3 and R4 independently are substituents; m and p independently are 0 to 3; and n and q independently are 0 to 2: provided that the compound of Formula (1) comprises at least one water solubilising group; and (b) a liquid media. Also novel compounds and ink-jet printer inks, processes and cartridges.

    Abstract translation: 一种组合物，其包含：（a）式（1）的化合物，其中：R 1，R 2，R 3和R 3， 4个独立地是取代基; m和p独立地为0至3; 并且n和q独立地为0至2：条件是式（1）的化合物包含至少一种水溶性基团; 和（b）液体介质。 还有新型化合物和喷墨打印机墨水，工艺和墨盒。

    Magenta dyes and inks for use in ink-jet printing
    77.
    发明申请
    Magenta dyes and inks for use in ink-jet printing 失效
    用于喷墨打印的洋红色染料和油墨

    公开(公告)号：US20060117990A1

    公开(公告)日：2006-06-08

    申请号：US11292001

    申请日：2005-12-02

    Applicant: Clive Foster

    Inventor： Clive Foster

    IPC: C09D11/02 ,  C07C50/36

    CPC classification number: C09B3/64 ,  C07C323/22 ,  C07C323/66 ,  C09D11/328

    Abstract: A composition comprising: (a) a compound of Formula (1) wherein: R1, R2, R3 and R4 independently are substituents; m and p independently are 0 to 3; and n and q independently are 0 to 2: provided that the compound of Formula (1) comprises at least one water solubilising group; and (b) a liquid media. Also novel compounds and ink-jet printer inks, processes and cartridges.

    Abstract translation: 一种组合物，其包含：（a）式（1）的化合物，其中：R 1，R 2，R 3和R 3， 4个独立地是取代基; m和p独立地为0至3; 并且n和q独立地为0至2：条件是式（1）的化合物包含至少一种水增溶基团; 和（b）液体介质。 还有新型化合物和喷墨打印机墨水，工艺和墨盒。

    Method for preparing disodium 2,2'-dithiobis(ethanesulphonate)
    78.
    发明授权
    Method for preparing disodium 2,2'-dithiobis(ethanesulphonate) 有权
    2,2'-二硫代二（二乙磺酸）二钠的制备方法

    公开(公告)号：US06936733B2

    公开(公告)日：2005-08-30

    申请号：US10333422

    申请日：2001-07-17

    Applicant: Jean-Bernard Cazaux ,  Eric Manginot ,  Marc Veyrat

    Inventor： Jean-Bernard Cazaux ,  Eric Manginot ,  Marc Veyrat

    IPC: C07C319/02 ,  C07C319/24 ,  C07C319/28 ,  C07C323/65 ,  C07C323/66

    CPC classification number: C07C319/02 ,  C07C319/24 ,  C07C323/66

    Abstract: The invention concerns a novel method for industrial preparation of disodium 2,2′-dithiobis(alkylsulphonates), and in particular disodium 2,2′-dithiobis(ethanesulphate) (dimesna). Said novel method is summarized by the reaction diagram (A). In diagram (A), Hal represents a halogen atom, and preferably a bromine atom; M represents a sodium or potassium atom; and n represents an integer ranging between 0 and 2.

    Abstract translation: 本发明涉及用于工业制备2,2'-二硫代二（二烷基磺酸二钠），特别是2,2'-二硫代二（二硫代氨基）二（二甲苯）二钠的新方法。 所述新颖方法由反应图（A）总结。 在图（A）中，Hal表示卤素原子，优选溴原子; M表示钠或钾原子; n表示0〜2的整数。

    Process for preparing aminoguanidines and alkoxyguanidines as protease inhibitors
    80.
    发明授权
    Process for preparing aminoguanidines and alkoxyguanidines as protease inhibitors 有权
    制备氨基胍和烷氧基胍作为蛋白酶抑制剂的方法

    公开(公告)号：US06730783B2

    公开(公告)日：2004-05-04

    申请号：US10419972

    申请日：2003-04-22

    Applicant: Bruce E. Tomczuk ,  Richard M. Soll ,  Tianbao Lu ,  Cynthia L. Fedde ,  Carl R. Illig ,  Thomas P. Markotan

    Inventor： Bruce E. Tomczuk ,  Richard M. Soll ,  Tianbao Lu ,  Cynthia L. Fedde ,  Carl R. Illig ,  Thomas P. Markotan

    IPC: A61K31255

    CPC classification number: C07C309/73 ,  C07C309/75 ,  C07C309/76 ,  C07C309/77 ,  C07C311/16 ,  C07C311/17 ,  C07C311/18 ,  C07C311/19 ,  C07C311/21 ,  C07C317/14 ,  C07C323/66 ,  C07C2601/02 ,  C07C2601/14 ,  C07D211/96 ,  C07D213/42 ,  C07D213/74 ,  C07D215/36 ,  C07D217/02 ,  C07D217/22 ,  C07D239/42 ,  C07D295/13 ,  C07D295/26 ,  C07D307/66

    Abstract: Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra, Rb, Rc, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin, or are intermediates useful for forming compounds having antithrombotic activity. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents.

    Abstract translation: 氨基胍和烷氧基胍化合物，包括下式的化合物：其中X是O或NR 9和R 1 -R 4，R 6 -R 9，R 11，R 12， 说明书中列出的R a，R b，R c，Y，Z，n和m以及抑制蛋白水解酶如凝血酶的水合物，溶剂合物或其药学上可接受的盐是 描述。 还描述了制备式I化合物的方法。本发明的新化合物是蛋白酶的有效抑制剂，特别是胰蛋白酶样丝氨酸蛋白酶，例如胰凝乳蛋白酶，胰蛋白酶，凝血酶，纤溶酶和因子Xa。 某些化合物通过直接，选择性抑制凝血酶表现出抗血栓形成活性，或者是用于形成具有抗血栓形成活性的化合物的中间体。 本发明包括用于抑制血小板损失，抑制血小板聚集体形成，抑制纤维蛋白形成，抑制血栓形成和抑制哺乳动物栓塞形成的组合物，其包含本发明化合物在药学上可接受的载体中。 本发明化合物的其它用途是作为凝血剂或者物理上连接于用于血液收集，血液循环和血液储存（例如导管，血液透析机，采血注射器和管）中使用的装置的制造中使用的材料的抗凝剂， 血线和支架。

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