Hybrid superparamagnetic iron oxide nanoparticles and polyethylenimine as a magnetoplex for gene transfection
    75.
    发明授权
    Hybrid superparamagnetic iron oxide nanoparticles and polyethylenimine as a magnetoplex for gene transfection 有权
    混合超顺磁性氧化铁纳米颗粒和聚乙烯亚胺作为基质转染的磁复合物

    公开(公告)号:US08445025B2

    公开(公告)日:2013-05-21

    申请号:US13074491

    申请日:2011-03-29

    Abstract: Disclosed are the nanoparticle and the method for the same, and the preparing method includes steps of mixing polyethylenimine (PEI) with the poly(acrylic acid)-bound iron oxide (PAAIO) to form a PEI-PAAIO polyelectrolyte complex (PEC) and mixing the PEI-PAAIO PEC with genetic material such as plasmid DNA to form the PEI-PAAIO/pDNA magnetic nanoparticle. The PEI-PAAIO/pDNA magnetoplex is highly water dispersible and suitable for long term storage, shows superparamagnetism, low cytotoxicity, high stability and nice transfection efficiency, and thus the PEI-PAAIO PEC can replace PEI as a non-viral gene vector.

    Abstract translation: 公开了纳米颗粒及其制备方法,其制备方法包括将聚乙烯亚胺(PEI)与聚(丙烯酸)键合的氧化铁(PAAIO)混合以形成PEI-PAAIO聚电解质络合物(PEC)和混合 PEI-PAAIO PEC与遗传物质如质粒DNA形成PEI-PAAIO / pDNA磁性纳米颗粒。 PEI-PAAIO / pDNA磁复合物具有高水分散性,适合长期保存,显示出超顺磁性,低细胞毒性,高稳定性和良好的转染效率,因此PEI-PAAIO PEC可代替PEI作为非病毒基因载体。

    POLYMER MICROGEL BEADS
    77.
    发明申请
    POLYMER MICROGEL BEADS 失效
    聚合物微珠

    公开(公告)号:US20110190566A1

    公开(公告)日:2011-08-04

    申请号:US12993047

    申请日:2009-05-15

    Abstract: The present invention relates to polymer microgel beads having a polymeric matrix with nanomagnetic particles dispersed substantially uniformly therethrough, wherein a steric stabiliser is associated with the particles, the steric stabiliser being a polymeric material that (i) does not form part of the polymeric matrix of the beads, and (ii) comprises a steric stabilising polymeric segment and an anchoring polymeric segment, wherein the steric stabilising polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the nanomagnetic particles and secures the stabiliser to the particles.

    Abstract translation: 本发明涉及具有基本均匀地分散有纳米磁性颗粒的聚合物基质的聚合物微凝胶珠粒,其中空间稳定剂与颗粒缔合,空间稳定剂是聚合物材料,(i)不形成聚合物基质的一部分 所述珠粒和(ii)包含空间稳定聚合物链段和锚定聚合物链段,其中所述空间稳定聚合物链段不同于所述锚定聚合物链段,并且其中所述锚定聚合物链段对所述纳米磁性颗粒的表面具有亲和性, 将稳定剂固定在颗粒上。

    MAGNETIC RUBBER COMPOSITION FOR ENCODER
    79.
    发明申请
    MAGNETIC RUBBER COMPOSITION FOR ENCODER 审中-公开
    编码器用磁性橡胶组合物

    公开(公告)号:US20110017939A1

    公开(公告)日:2011-01-27

    申请号:US12894567

    申请日:2010-09-30

    Abstract: A magnetic rubber composition for encoder having a magnetic characteristic in sufficient application range, used as encoder after magnetization as well as heat resistance, water resistance and oil resistance required for use as encoder, and excellent processing property, and capable of being bonded by vulcanization with a metal, is provided. Furthermore, a magnetic rubber composition for encoder capable of obtaining sufficient magnetic force required for encoder on a circumference of the molded encoder as well as capable of effectively restraining variation of the level of magnetic force, is provided. It is provided by comprising 300 to 1,800 parts of strontium-ferrite, or 300 to 1,800 parts of barium-ferrite, or 300 to 1,800 parts of a mixture of strontium-ferrite and barium-ferrite, 0.5 to 2 parts of silane coupling agent, and 1 to 10 parts of lubricating agent, per 100 parts of a hydrogenated nitrile butadiene rubber with 15 to 50% of acrylonitrile amount and 80 to 99% of hydrogenation ratio.

    Abstract translation: 一种用于编码器的磁性橡胶组合物,其具有足够应用范围的磁特性,用作磁化后的编码器以及用作编码器所需的耐热性,耐水性和耐油性,以及优异的加工性能,并且能够通过硫化与 提供金属。 此外,提供了一种用于编码器的磁性橡胶组合物,其能够在模制编码器的圆周上获得编码器所需的足够的磁力,并且能够有效地抑制磁力水平的变化。 通过将锶铁氧体300〜1,800份,钡铁氧体300〜1800份,锶铁氧体和钡铁氧体的混合物300〜1,800份,硅烷偶联剂0.5〜2份, 和1至10份润滑剂,每100份氢化丁腈橡胶中丙烯腈含量为15-50%,氢化率为80-99%。

    Method for manufacturing a rubber magnet with a colored facial gum material layer and a rubber magnet thereof
    80.
    发明申请
    Method for manufacturing a rubber magnet with a colored facial gum material layer and a rubber magnet thereof 审中-公开
    用于制造具有彩色面胶材料层的橡胶磁体及其橡胶磁体的方法

    公开(公告)号:US20090311546A1

    公开(公告)日:2009-12-17

    申请号:US12458738

    申请日:2009-07-22

    Abstract: A method for manufacturing a rubber magnet with a colored facial gum material layer and a rubber magnet thereof. A colored gum material layer is paved on a surface of the rubber magnet. A surfactant is added into the colored gum material layer. An identical surfactant or a surfactant with very close polarity is added into the material of the rubber magnet, whereby the surfaces of the gum material layer and the rubber magnet can tightly adhere to each other without easy peeling. In addition, antiscaling agent, wetting/spreading agent and defoaming agent are added into the gum material layer to fully wet the color and uniformly spread the color over the gum material so as to enhance the evenness of the color.

    Abstract translation: 一种用彩色面胶材料层及其橡胶磁体制造橡胶磁体的方法。 在橡胶磁体的表面上铺上着色的胶质材料层。 将有色胶料层中加入表面活性剂。 将相同的表面活性剂或非常接近极性的表面活性剂添加到橡胶磁体的材料中,由此胶料层和橡胶磁体的表面可以彼此紧密粘合而不易剥离。 此外,将防垢剂,润湿/铺展剂和消泡剂加入到胶质材料层中以使颜色完全润湿,并将颜色均匀地分散在口香糖材料上,以增强颜色的均匀性。

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