公开(公告)号：US09718858B2

公开(公告)日：2017-08-01

申请号：US14773937

申请日：2014-03-13

Applicant: Trustees of Boston University

Inventor： Douglas Ewen Cameron ,  James J. Collins

IPC: A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  A61K38/06 ,  C07K5/097 ,  C07K14/30 ,  G01N33/50 ,  C07K5/083 ,  C07K5/087 ,  C07K5/09 ,  C07K5/093 ,  C07K5/103 ,  C07K5/107 ,  C07K5/11 ,  C07K5/117 ,  C07K7/06

CPC classification number: C07K5/0823 ,  C07K5/0806 ,  C07K5/0812 ,  C07K5/0817 ,  C07K5/0819 ,  C07K5/101 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1024 ,  C07K7/06 ,  C07K14/30 ,  C07K2319/95 ,  G01N33/502 ,  G01N2333/30 ,  G01N2500/10

Abstract: The methods and compositions described herein relate, in part, to the generation of a synthetic degradation system in E. coli that provides tunable control of the protein level of targeted genes by using components of the Mesoplasma florum tmRNA system. Provided herein are degradation tag variants that permit independent control of both the initial level and inducible degradation rate of attached proteins.

公开(公告)号：US09695214B2

公开(公告)日：2017-07-04

申请号：US14776870

申请日：2014-02-24

Applicant: Massachusetts Institute of Technology

Inventor： Mark David Simon ,  Bradley L. Pentelute ,  Andrea Adamo ,  Patrick Louis Heider ,  Klavs F. Jensen

IPC: A61K38/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K1/04 ,  C07K1/06 ,  C07K1/08

CPC classification number: C07K1/042 ,  C07K1/045 ,  C07K1/061 ,  C07K1/08

Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

公开(公告)号：US09611297B1

公开(公告)日：2017-04-04

申请号：US15368260

申请日：2016-12-02

Applicant: Thrasos Therapeutics Inc.

Inventor： Roger Leger ,  Gilles Dube ,  Marie-Elaine Caruso ,  Jerome Rossert

IPC: C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  A61K38/12 ,  C07K7/08 ,  A61K38/00

CPC classification number: C07K7/08 ,  A61K38/00

Abstract: Provided are novel peptides of Formula SEQ ID No. 1: J1CysX1X2X3X4X5X6ProX7ThrCysJ2J3(J4)s(J5)t;   (SEQ ID No. 1) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are effective inhibitors of light chains to uromodulin.

公开(公告)号：US09598501B2

公开(公告)日：2017-03-21

申请号：US14502013

申请日：2014-09-30

Applicant: NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY ,  DENKA SEIKEN CO., LTD.

Inventor： Yoichi Kumada ,  Michimasa Kishimoto ,  Kyoko Hamasaki ,  Aya Nakagawa

IPC: C07K17/00 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/40 ,  C07K16/24 ,  C07K16/30

CPC classification number: C07K17/00 ,  C07K16/00 ,  C07K16/18 ,  C07K16/249 ,  C07K16/2887 ,  C07K16/303 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55

Abstract: The present invention provides an antibody-immobilized carrier that can be used in antibody screening, a method of producing the antibody-immobilized carrier, and use of the antibody-immobilized carrier. Efficient antibody screening can be carried out particularly by an antibody-immobilized carrier including two or more antibody immobilized regions onto each of which a heavy-chain low-molecular-weight antibody and a light-chain low-molecular-weight antibody are separately immobilized, the two or more antibody immobilized regions each being included in an independent manner, the heavy-chain low-molecular-weight antibody including a heavy-chain variable region, the light-chain low-molecular-weight antibody including a light-chain variable region, the heavy-chain low-molecular-weight antibody and the light-chain low-molecular-weight antibody each being derived from an antibody recognizing a different antigen.

公开(公告)号：US09579317B2

公开(公告)日：2017-02-28

申请号：US14726897

申请日：2015-06-01

Applicant: JiaRui Biopharmaceuticals, Ltd.

Inventor： Shaosong Chu

IPC: A61K38/00 ,  A61K47/00 ,  A61K38/14 ,  C07K9/00 ,  A61K38/06 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  A61K31/4745 ,  A61K31/407 ,  A61K31/704 ,  A61K47/48

CPC classification number: A61K31/704 ,  A61K31/407 ,  A61K31/4745 ,  A61K47/55 ,  A61K47/65

Abstract: Peptide-drug conjugates comprising p-aminobenzyl carbamoyl or p-aminobenzolyl carbonate self-immolating linkers are disclosed. The peptide-drug conjugates comprise a peptide moiety that can be cleaved by cellular proteases, bound to the self-immolating linker, which linker is bound to a cytotoxic drug moiety. Upon cleavage of the peptide moiety, the linker self-immolates, releasing the cytotoxic drug in active form. Dimeric structures of the peptide drug conjugates comprising two molecules of cytotoxic drug per conjugate are also disclosed.

Abstract translation: 公开了包含对氨基苄基氨基甲酰基或对氨基苯甲酰碳酸酯自脱胶接头的肽 - 药物共轭物。 肽 - 药物缀合物包含能够被细胞蛋白酶切割的肽部分，其结合到自蜕膜接头上，该接头与细胞毒性药物部分结合。 在肽部分切割时，连接体自身脱粘，释放活性形式的细胞毒性药物。 还公开了包含每个缀合物的两分子细胞毒性药物的肽药物缀合物的二聚体结构。

公开(公告)号：US09566320B2

公开(公告)日：2017-02-14

申请号：US14494812

申请日：2014-09-24

Applicant: Board of Regents, The University of Texas System

Inventor： Rosa A. Maldonado ,  Carylinda Serna ,  Igor C. Almeida

IPC: A61K39/00 ,  A61K39/002 ,  A61K39/385 ,  A61K39/38 ,  A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  A61K39/005 ,  C07K14/14 ,  C07K14/445

CPC classification number: A61K39/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55516 ,  A61K2039/575 ,  C07K14/14 ,  C07K14/445 ,  Y02A50/414

Abstract: Use of synthetic peptides derived from Trypanosoma cruzi antigens and their use in vaccination against trypomastigote infection and Chagas disease. T. cruzi uses several surface proteins to invade the host. In their role of protection, the surface protients ensure the targeting and invasion of specific cells or tissues. A conserved region in the family of mucin-associated surface proteins (MASP) was used to analyze the expression of MASP at different points of invasion and proved to be important for host cell invasion, thus suggesting MASP as a candidate for vaccine development. A synthetic peptide, MASPsyn, was studied and showed efficacy in stimulating antibody and cytokine production necessary for resistance against the parasite.

Abstract translation: 使用衍生自锥虫克氏锥虫抗原的合成肽及其在针对锥虫病感染和恰加斯病的疫苗接种中的用途。 克鲁日使用几种表面蛋白侵入宿主。 在保护的作用下，表面质量保证特定细胞或组织的靶向和侵袭。 粘蛋白相关表面蛋白家族（MASP）的保守区域用于分析不同入侵点的MASP表达，并被证明对宿主细胞侵袭具有重要意义，从而提示MASP作为疫苗开发的候选者。 研究了合成肽MASPsyn，并且显示出在刺激抵抗寄生虫所必需的抗体和细胞因子产生方面的功效。

公开(公告)号：US09550808B2

公开(公告)日：2017-01-24

申请号：US14762177

申请日：2014-01-20

Applicant: LIMITED LIABILITY COMPANY SYNEURO

Inventor： Maxim Nurgayanovich Zhmak ,  Yury Nikolaevich Utkin ,  Tatyana Viktorovna Andreeva ,  Denis Sergeevich Kudryavtsev ,  Elena Viktorovna Kryukova ,  Viktor Ionovich Tsetlin ,  Igor Evgen'evich Kasheverov ,  Vladislav Gennad'evich Starkov ,  Irina Valer'evna Shelukhina

IPC: A61K9/127 ,  A61K38/00 ,  A61P17/00 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K7/06 ,  A61Q19/08 ,  A61K8/64 ,  C07K14/705

CPC classification number: C07K7/06 ,  A61K8/64 ,  A61K38/00 ,  A61Q19/08 ,  C07K14/70571

Abstract: The present invention refers to biochemistry, namely to new peptide compounds having the ability to selectively block the muscle-type nicotinic acetylcholine receptor. The claimed compounds have common formula (I): X1-X2-X3-Pro-X4-Pro-X5 (SEQ ID NO: 54), where X1 is chosen within H, Ac—, Palm-; X2 is chosen within Trp, Tyr; X3 is chosen within Trp, Tyr; X4 is chosen within Lys, Orn, Dbu, Dpr, Arg; X5 is chosen within —OH, —NH2, —OCH3, —OC2H5, —NH—C6H5. The invention can be applied in cosmetics for smoothing mimic and age-related Wrinkles.

Abstract translation: 本发明涉及生物化学，即具有选择性阻断肌肉型烟碱乙酰胆碱受体的能力的新肽化合物。 要求保护的化合物具有通式（I）：X1-X2-X3-Pro-X4-Pro-X5（SEQ ID NO：54），其中X1选自H，Ac-，Palm-; X2选择在Trp，Tyr; X3在Trp，Tyr中选择; X4选自Lys，Orn，Dbu，Dpr，Arg; X5选自-OH，-NH 2，-OCH 3，-OC 2 H 5，-NH-C 6 H 5。 本发明可应用于化妆品中，用于平滑模拟和年龄相关的皱纹。

公开(公告)号：US09526757B2

公开(公告)日：2016-12-27

申请号：US14358875

申请日：2012-11-16

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventor： Francoise Ochsenbein ,  Raphael Guerois ,  Albane Gaubert ,  Regis Courbeyrette

IPC: A61K38/16 ,  A61K38/00 ,  A61K38/10 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  A61K38/03 ,  C07K14/00 ,  C07K14/47

CPC classification number: A61K38/16 ,  A61K38/00 ,  A61K38/03 ,  C07K14/00 ,  C07K14/001 ,  C07K14/47

Abstract: The present invention relates to peptides capable of inhibiting the formation of the complex between the Asf1 histone chaperone and histones H3-H4, and to the use thereof as a drug, particularly for treating cancer.

Abstract translation: 本发明涉及能够抑制Asf1组蛋白伴侣和组蛋白H3-H4之间复合物形成的肽及其作为药物的用途，特别是用于治疗癌症。

公开(公告)号：US09522965B2

公开(公告)日：2016-12-20

申请号：US14353823

申请日：2012-10-24

Applicant: Washington State University

Inventor： Shulin Chen ,  Moumita Chakraborty ,  Chao Miao

IPC: A01N65/00 ,  A61K36/02 ,  A61K36/00 ,  C07K1/00 ,  C07K14/00 ,  C07K14/37 ,  C07K16/00 ,  C07K17/00 ,  C12N1/12 ,  C12N1/00 ,  C08B37/00 ,  C10L1/02 ,  B01J6/00 ,  C07K1/14 ,  C11C1/00 ,  C11B1/10 ,  A61K36/05 ,  C12N1/20 ,  A61K8/97 ,  C07K14/415 ,  A01G33/00

CPC classification number: C08B37/0003 ,  A01G33/00 ,  A61K8/9706 ,  A61K36/05 ,  B01J6/00 ,  C07K1/145 ,  C07K14/415 ,  C10L1/02 ,  C11B1/10 ,  C11C1/007 ,  C12N1/12 ,  C12N1/20 ,  Y02P30/20

Abstract: Methods of producing bio-fuel and other high-value products from oleaginous biomass (e.g. algae biomass) are provided. The two-step methods use a first step of subcritical water extraction of the biomass at low temperatures to produce polysaccharides and other high value products of interest, followed by, ii) hydrothermal liquefaction of remaining solid biomass at high temperatures to produce bio-oil.

Abstract translation: 提供了从油质生物质（例如藻类生物质）生产生物燃料和其它高价值产品的方法。 两步法在低温下使用亚临界水提取生物质的第一步，以产生多糖和其他高价值产品，其次是在高温下对剩余的固体生物质进行水热液化生产生物油。

公开(公告)号：US09499606B2

公开(公告)日：2016-11-22

申请号：US13958443

申请日：2013-08-02

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Leland Shapiro

IPC: A61K39/00 ,  A61K45/00 ,  A61K47/00 ,  A61K39/42 ,  A61K39/395 ,  A61K39/38 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K14/81 ,  A61K31/519 ,  A61K45/06 ,  A61K38/57 ,  C07K14/47 ,  C07K16/00

CPC classification number: C07K14/8125 ,  A61K31/519 ,  A61K38/57 ,  A61K45/06 ,  C07K14/473 ,  C07K14/811 ,  C07K16/00 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/30 ,  C07K2319/43 ,  C07K2319/50 ,  A61K2300/00

Abstract: A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of Gram negative, Gram positive and acid fast bacilli in general and tuberculosis (TB), mycobacterium avium complex (MAC), and anthrax in particular. Thus, the invention relates to modulation of cellular activities, including macrophage activity, and the like. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine protease.

Abstract translation: 提供了一种治疗和预防细菌性疾病的新方法。 特别地，本发明涉及一般抑制革兰氏阴性，革兰氏阳性和酸性快速杆菌，结核病（TB），鸟分枝杆菌复合体（MAC）和特别是炭疽的组合物和方法。 因此，本发明涉及细胞活性的调节，包括巨噬细胞活性等。 更具体地，本发明涉及包含天然存在的和人造丝氨酸蛋白酶抑制剂的抑制化合物。