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公开(公告)号:US10031240B2
公开(公告)日:2018-07-24
申请号:US15529554
申请日:2015-06-01
发明人: Benjiang Mao , Yixin Liu , Yang Xu , Meng He , Renhong Zhuo , Dezhi Wen , Dajie Ding , Jing Cheng , Hui Zheng
摘要: An air kerma conventional true value determining method is provided, which addresses the problem of on-site and in-situ verification or calibration of radiation protection with existing standard reference radiation, which is large in spatial volume and unable or difficult to be moved. The method includes establishing a minitype reference radiation, selecting a proper radiation source and source intensity for providing incident rays for a shielding box, selecting a plurality of gamma ray dosimeters as samples for training a prediction model to obtain the prediction model of the air kerma conventional true value of a point of test, putting a probe of a dosimeter being verified at the point of test, recording scattering gamma spectrum measured by a gamma spectrometer, with the spectrum applied as input to the prediction model to obtain the air kerma conventional true value. The results are accurate and the reference radiation is small in size.
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公开(公告)号:US20180180561A1
公开(公告)日:2018-06-28
申请号:US15853257
申请日:2017-12-22
IPC分类号: G01N23/20
CPC分类号: G01N23/20 , G01N2223/052 , G01N2223/61
摘要: A method of measuring properties of a thin film stack by GIXR divides the stack into sub-layers and represents the composition of each sub-layer by an number P. The numbers P represent the composition of each layer. For example, integers may represent pure material and fractional values represent mixtures of the adjacent pure materials. This representation is then used to fit to measured data and the best fit gives an indication of the material composition of each of the sub-layers and hence as a function of depth.
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公开(公告)号:US10008421B2
公开(公告)日:2018-06-26
申请号:US15831810
申请日:2017-12-05
IPC分类号: H01L21/00 , H01L21/66 , G01R31/265 , G01N23/20
CPC分类号: H01L22/14 , G01N23/20 , G01N23/207 , G01N2223/0566 , G01N2223/607 , G01N2223/611 , G01R31/2656 , H01L22/12
摘要: A method includes measuring a difference between a primary X-ray diffraction peak and a secondary X-ray diffraction peak, the primary X-ray diffraction peak corresponds to an unstrained portion of a semiconductor substrate and the secondary X-ray diffraction peak corresponds to a strained portion of the semiconductor substrate, the difference between the primary X-ray diffraction peak and the secondary X-ray diffraction peak includes a delta shift peak that corresponds to changes in a crystal lattice caused by a stress applied to the strained portion of the semiconductor substrate, the delta shift peak includes variations in a deep trench capacitance.
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公开(公告)号:US20180156741A1
公开(公告)日:2018-06-07
申请号:US15716921
申请日:2017-09-27
发明人: Kejun Kang , Jianping Cheng , Zhiqiang Chen , Ziran Zhao , Junli Li , Xuewu Wang , Zhi Zeng , Ming Zeng , Yi Wang , Qingjun Zhang , Jianping Gu , Xi Yi , Bicheng Liu , Guangming Xu , Yongqiang Wang
CPC分类号: G01N23/04 , G01N23/046 , G01N23/06 , G01N23/20008 , G01N2223/304 , G01N2223/33 , G01N2223/401 , G01N2223/419 , G01N2223/652 , G01V5/0016 , G01V5/0025 , G01V5/0091
摘要: Inspection devices and inspection methods are disclosed. The inspection method includes: performing X-ray scanning on an object being inspected so as to generate an image of the object being inspected; dividing the image of the object being inspected to determine at least one region of interest; detecting interaction between a cosmic ray and the region of interest to obtain a detection value; calculating a scattering characteristic value and/or an absorption characteristic value of the cosmic ray in the region of interest based on size information of the region of interest and the detection value; and discriminating a material attribute of the region of interest by means of the scattering characteristic value and/or the absorption characteristic value. With the above technical solutions, inspection accuracy and inspection efficiency may be improved.
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75.
公开(公告)号:US09989483B2
公开(公告)日:2018-06-05
申请号:US14827653
申请日:2015-08-17
申请人: THE BOEING COMPANY
发明人: Gary E. Georgeson , Morteza Safai
IPC分类号: G01N23/20 , G01N23/203 , G21K1/02 , G21K1/04
CPC分类号: G01N23/203 , G01N23/20008 , G01N23/20025 , G01N2223/053 , G01N2223/1016 , G01N2223/301 , G01N2223/40 , G21K1/043
摘要: An imaging system for generating three dimensional image data using X-ray backscattering from one side of a structure is provided. The imaging system includes at least one X-ray source, at least one rotating collimator coupled to the at least one X-ray source, an X-ray detector, and a controller coupled to the at least one X-ray source, the at least one rotating collimator and the X-ray detector. The controller is configured to emit X-rays from the at least one X-ray source through the at least one rotating collimator towards the one side of the structure. Additionally, the controller is configured to detect backscattered X-rays from the one side of the structure, using the X-ray detector, at a plurality of depths within the structure. Additionally, the controller is configured to generate three dimensional image data of the structure based on the detected backscattered X-rays.
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公开(公告)号:US09947505B2
公开(公告)日:2018-04-17
申请号:US14911718
申请日:2014-08-07
IPC分类号: H01J37/20 , B08B7/00 , G01N33/543 , H01J37/26 , G01N23/20 , G01N23/04 , C01B32/182 , C01B32/194 , C01B32/196
CPC分类号: H01J37/20 , B08B7/0035 , C01B32/182 , C01B32/194 , C01B32/196 , G01N23/04 , G01N23/20025 , G01N33/54393 , H01J37/26 , H01J2237/2007 , H01J2237/2602
摘要: Some embodiments are directed to a support for receiving a biological sample, the support comprising at least one support member, and including graphene attached to the support member. The graphene is partially hydrogenated graphene. Some embodiments are also directed to use of a partially hydrogenated graphene surface to support a biological molecule for electron microscopy. Some other embodiments are also directed to a method for making a partially hydrogenated graphene. The method includes applying a hydrogen ion or hydrogen atom to the surface of graphene. The hydrogen ion or hydrogen atom is applied at an energy in the range 1 to 21 eV. A sensor comprising a surface capable of adsorbing a biological molecule thereto is also disclosed, wherein said surface includes partially hydrogenated graphene.
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77.
公开(公告)号:US20180100865A1
公开(公告)日:2018-04-12
申请号:US15819500
申请日:2017-11-21
申请人: VIB VZW , Vrije Universiteit Brussel , The Board of Trustees of the Leland Stanford Junior University
发明人: Jan Steyaert , Els Pardon , Soren G.F. Rasmussen , Juan Jose Fung , Brian Kobilka , Toon Laeremans
CPC分类号: G01N33/6872 , A61K38/00 , C07K14/705 , C07K14/723 , C07K16/28 , C07K2317/22 , C07K2317/33 , C07K2317/51 , C07K2317/56 , C07K2317/569 , C07K2317/75 , G01N23/20 , G01N33/566 , G01N33/68 , G01N33/6857 , G01N2333/726
摘要: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
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公开(公告)号:US20180088062A1
公开(公告)日:2018-03-29
申请号:US15717961
申请日:2017-09-28
CPC分类号: G01N23/20091 , G01N23/20008 , G01N23/201 , G01N2223/0563 , G01S17/08 , G01S17/48 , G01S17/88
摘要: Apparatus for X-ray scatterometry includes an X-ray source, which directs an X-ray beam to be incident at a grazing angle on an area of a surface of a sample, and an X-ray detector measures X-rays scattered from the area. A knife edge is arranged parallel to the surface of the sample in a location adjacent to the area so as to define a gap between the surface and the knife edge and to block a portion of the X-ray beam that does not pass through the gap. A motor moves the knife edge perpendicular to the surface so as to control a size of the gap. An optical rangefinder receives optical radiation reflected from the surface and outputs a signal indicative of a distance of the knife edge from the surface. Control circuitry drives the motor responsively to the signal in order to regulate the size of the gap.
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公开(公告)号:US09921173B2
公开(公告)日:2018-03-20
申请号:US14761315
申请日:2014-01-02
发明人: Paul Evans , Keith Rogers
IPC分类号: G01N23/20 , G01N23/205 , G01N23/04 , H04N5/232 , H04N5/32
CPC分类号: G01N23/2055 , G01N23/046 , G01N23/20008 , G01N23/20083 , G01N2223/419 , G01N2223/64 , H04N5/23293 , H04N5/32
摘要: A sample (106) is irradiated with electromagnetic radiation such as X-Rays and diffraction data is sampled at inner and outer caustic rims formed at a sensor surface (108) and defined by a continuum of Debye cones (130, 132) formed by diffraction of the incident radiation. Intensities of the inner and outer rims while translating and rotating the sample are converted using a tomographic technique into X-ray diffraction images and material discrimination is also possible.
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80.
公开(公告)号:US20180067126A1
公开(公告)日:2018-03-08
申请号:US15816505
申请日:2017-11-17
申请人: VIB VZW , Vrije Universiteit Brussel , The Board of Trustees of the Leland Stanford Junior University
发明人: Jan Steyaert , Els Pardon , Soren G.F. Rasmussen , Juan Jose Fung , Brian Kobilka , Toon Laeremans
CPC分类号: G01N33/6872 , A61K38/00 , C07K14/705 , C07K14/723 , C07K16/28 , C07K2317/22 , C07K2317/33 , C07K2317/51 , C07K2317/56 , C07K2317/569 , C07K2317/75 , G01N23/20 , G01N33/566 , G01N33/68 , G01N33/6857 , G01N2333/726
摘要: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
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