公开(公告)号：US3835195A

公开(公告)日：1974-09-10

申请号：US32861173

申请日：1973-02-01

申请人： RHONE POULENC SA

发明人： MENET A

IPC分类号： C07C315/00 ,  C07C20060101 ,  C07C67/00 ,  C07C313/00 ,  C07C315/02 ,  C07C315/04 ,  C07C317/00 ,  C07C317/04 ,  C07C317/14 ,  C07C317/18 ,  C07C317/22 ,  C07C147/04 ,  C07C147/06

CPC分类号： C07C317/00

摘要： Sulphones of formula RSO2 CH2-C(CH3) CH-CH2OR1 I and RSO2CH2CH C(CH3)-CH2OR1 II wherein R and R1 are optionally substituted alkyl or aryl, are intermediates in the preparation of compounds with a saturated or unsaturated isoprene chain.

摘要翻译： 式RSO 2 CH 2 -C（CH 3）= CH-CH 2 OR 11 I和RSO 2 CH 2 -CH = C（CH 3）-CH 2 OR 1 II的砜，其中R和R 1是任选取代的烷基或芳基，是制备具有饱和或不饱和的 异戊二烯链。

公开(公告)号：US3804904A

公开(公告)日：1974-04-16

申请号：US20156371

申请日：1971-11-23

申请人： RECKITT & COLMANN PROD LTD

发明人： BENTLEY K ,  RUSHWORTH W

IPC分类号： A61K31/095 ,  A61K31/10 ,  C07C317/00 ,  C07D319/18 ,  C07C147/14

CPC分类号： C07D319/18 ,  A61K31/10 ,  C07C317/00 ,  C07C323/00 ,  Y10S514/929

摘要： THE INVENTION RELATES TO A METHOD OF PRODUCING PERIPHERAL VASODILATION WHICH COMPRISE THE ORAL OR PARENTERAL ADMINISTRATION IN UNIT DOSAGE FORM OF A COMPOUND HAVING THE FORMULA

(R2-S(=O)P-),R1,(R)N-BENZENE

WHERE N IS 1 OR 2, P IS 1 OR 2, R, R1 AND R2 REPRESENT SPECIFIED RADICALS. THE ABOVE COMPOUNDS ARE PREFERABLY ADMINISTERED TOGETHER WITH A PHARMACEUTICALLY ACCEPTABLE DILUENT OR CARRIER THEREFOR, IN THE FORM OF A PHARMACEUTICAL COMPOSITION.

公开(公告)号：US3801644A

公开(公告)日：1974-04-02

申请号：US3801644D

申请日：1971-08-25

申请人： WARNER LAMBERT CO

发明人： STRANDTMANN M ,  SHAVEL J ,  KLUTCHKO S ,  COHEN M

IPC分类号： C07C317/00 ,  C07D215/22 ,  C07D215/233 ,  C07D279/02 ,  C07D491/04 ,  C07C49/82

CPC分类号： C07D215/233 ,  C07C317/00 ,  C07D279/02

摘要： THE PRESENT INVENTION RELATES TO SUBSTITUTED-O-HYDTROXYW-(METHYLSLFINYL) ACETOPHENONES OF THE FORMULA 1

CH3-SO-CH2-CO-Z(-R1)(-R2)-OH

WHEREIN Z IS AN AROMATIC OR HEREROAROMATIC NUCLEUS SUCH AS BENZENE NAPHTHALENE, ANTHARACENE, PHENANTHRENE, PYRIDINE, QUINOLINE ISOQUINOLINE, CARBAZOLE, BENZOTHIAZINE, AND THE LIKE, WHEREIN R1 IS HALOGEN, LOWER ALKOXY, HYDROXY, ACETAMINO, ALKYL ARALKYL OR ARYL; R2 IS HYDROGEN HALOGEN, HYDROXY ALKYL OR ARYL; OR R1 AND R2 TAKEN TOGETHER MAY FORM A 1,3-DIOXOLE RING. THE COMPOUNDS OF THE PRESENT INVENTION ARE USEFUL AS INTERMEDIAES FOR THE PRODUCTION OF CHROMONED WHICH EXHIBIT ANTIALLERGENIC PROPERTIES.

公开(公告)号：US3732292A

公开(公告)日：1973-05-08

申请号：US3732292D

申请日：1970-05-01

申请人： MERCK & CO INC

发明人： HINKLEY D ,  CONN J

IPC分类号： A61K31/19 ,  C07C45/00 ,  C07C45/38 ,  C07C45/46 ,  C07C45/51 ,  C07C47/238 ,  C07C47/55 ,  C07C49/697 ,  C07C57/58 ,  C07C57/60 ,  C07C57/62 ,  C07C59/64 ,  C07C59/72 ,  C07C59/74 ,  C07C59/88 ,  C07C205/12 ,  C07C209/36 ,  C07C317/00 ,  C07D295/185 ,  C07D303/38 ,  C07D309/12 ,  C07D331/02 ,  C07F3/00 ,  C07F3/02 ,  C07F9/54 ,  C09B23/04 ,  C07C147/00

CPC分类号： C07D295/185 ,  A61K31/19 ,  C07C45/46 ,  C07C57/58 ,  C07C57/60 ,  C07C57/62 ,  C07C59/64 ,  C07C59/72 ,  C07C59/74 ,  C07C59/88 ,  C07C205/56 ,  C07C209/365 ,  C07C317/00 ,  C07D303/38 ,  C07D309/12 ,  C07D331/02 ,  C07F3/00 ,  C07F3/02 ,  C07F9/54 ,  C07F9/5407 ,  C09B23/04 ,  C07C49/697

摘要： 5-FLUORO-2-METHYL -1 - (4''-METHYLSULFINYLBENZYLIDENE)-3INDENYL ACETIC ACID IS PREPARED BY PROCESSES THAT FORM THE 3-ACETIC ACID SIDE CHAIN AS THE FINAL STEP.

公开(公告)号：US3673259A

公开(公告)日：1972-06-27

申请号：US3673259D

申请日：1968-10-07

申请人： CHRIS CRAFT IND INC

发明人： ROSIN JACOB ,  ANG FRANK S

IPC分类号： C07C307/02 ,  C07C317/00 ,  C07C317/14 ,  C08G75/20 ,  C07C147/06

CPC分类号： C07C317/00

摘要： In the production of aromatic sulfones by the condensation reaction of an arylsulfonyl chloride with an arene, practically quantitative yields of the aromatic sulfone are obtained without the usual purification and work-up problems by conducting the condensation reaction in the presence of relatively large amounts (based on the molar concentration of the arylsulfonyl chloride) of the particular arylsulfonic acid which corresponds to such arylsulfonyl chloride, but substantially in the absence of any metal salts. Using in conjunction with this improved method for producing the aromatic sulfone a new and unique technique for producing the arylsulfonyl chloride, which technique is based on chlorinating the aromatic sulfonic acid with chlorosulfonic acid in the presence of certain organic solvents so that equilibrium of such chlorination is displaced toward formation of the resultant arylsulfonyl chloride, an extremely efficient process has been developed for the production of aromatic sulfones. This process is described in detail in connection with the production of bis-(p-chlorophenyl) sulfone, which is a commercially important monomer in the manufacture of many thermoplastic polysulfone polymers.

摘要翻译： 在通过芳基磺酰氯与芳烃的缩合反应制备芳族砜时，通过在相对较大量的存在下进行缩合反应，可以获得芳族砜的实际定量产率而无需通常的纯化和后处理问题（基于 关于芳基磺酰氯的摩尔浓度）对应于这种芳基磺酰氯，但基本上不存在任何金属盐的特定芳基磺酸。 结合这种用于生产芳族砜的改进方法，用于生产芳基磺酰氯的新的和独特的技术，该技术基于在某些有机溶剂存在下用氯磺酸氯化芳族磺酸，使得这种氯化的平衡是 为了形成所得的芳基磺酰氯，已经开发了用于生产芳族砜的非常有效的方法。

公开(公告)号：US3652646A

公开(公告)日：1972-03-28

申请号：US3652646D

申请日：1967-03-15

申请人： ICI LTD

发明人： LEIGH THOMAS ,  THORP JEFFREY MEYRICK ,  WARING WILSON SHAW

IPC分类号： A61K31/19 ,  A61K31/165 ,  A61K31/215 ,  A61P3/06 ,  A61P9/10 ,  C07C51/00 ,  C07C51/367 ,  C07C51/41 ,  C07C59/125 ,  C07C59/68 ,  C07C59/70 ,  C07C67/00 ,  C07C69/66 ,  C07C69/712 ,  C07C205/35 ,  C07C233/02 ,  C07C313/00 ,  C07C317/00 ,  C07C317/22 ,  C07C319/14 ,  C07C323/52 ,  C07C65/00 ,  C07C69/76

CPC分类号： C07C205/35 ,  C07C51/367 ,  C07C51/412 ,  C07C59/68 ,  C07C309/00 ,  C07C317/00 ,  C07C323/00 ,  Y10S514/824 ,  Y10S516/06

摘要： BIPHENYLYLOXY-AND BIPHENYLYTHIO-ALKANOIC ACID DERIVATIVES WHICH LOWER THE CONCENTRATION OF CHOLESTEROL AND-OR TRIGLYCERIDES IN THE BLOOD SERUM AND REDUCE THE LEVEL OF FIBRINOGEN IN BLOOD PLASMA, AND WHICH POSSESS ANTI-INFLAMMATORY ACTIVITY. PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS AND A METHOD OF USING SUCH COMPOUNDS IN THE TREATMENT OF CORONOARY ARTERY DISEASE AND ATHEROSCLEROSIS.

公开(公告)号：US3649695A

公开(公告)日：1972-03-14

申请号：US3649695D

申请日：1969-08-06

申请人： AMERICAN CYANAMID CO

发明人： MILIONIS JERRY PETER

IPC分类号： C07C317/00 ,  C07C317/24 ,  C08K5/41 ,  C07C49/82

CPC分类号： C08K5/41 ,  C07C317/00 ,  C07C317/24

摘要： SULFINYL AND SULFONYL BIS(2-HYDROXYBENZOPHENONES) ARE PROVIDED HAVING THE GENERAL FORMULA:

(O)N-S(-(2-(R1-O-),4-(HO-)-1,5-PHENYLENE)-CO-1,2-

PHENYLENE-R2)2

WHEREIN R1 IS HYDROGEN OR ALKYL HAVING FROM 1 TO 8 CARBON ATOMS OR ARALKYL HAVING FROM 7 TO 18 CARBON ATOMS; R2 IS HYDROGEN OR ALKYL HAVING FROM 1 TO 8 CARBON ATOMS; AND N IS AN INTEGER FROM 1 TO 2, INCLUSIVE.

公开(公告)号：US3576846A

公开(公告)日：1971-04-27

申请号：US3576846D

申请日：1967-06-14

申请人： NORMAN A LEISTER

发明人： LEISTER NORMAN A

IPC分类号： C07C317/00 ,  C08F8/14 ,  C08F8/34 ,  C10L1/24 ,  C10M135/08 ,  C10M169/00 ,  C07C69/40

CPC分类号： C10L10/08 ,  C07C317/00 ,  C10L1/2493 ,  C10L10/04 ,  C10M1/08 ,  C10M3/00 ,  C10M135/08 ,  C10M2203/108 ,  C10M2205/026 ,  C10M2207/023 ,  C10M2207/024 ,  C10M2207/027 ,  C10M2207/123 ,  C10M2207/125 ,  C10M2207/129 ,  C10M2207/144 ,  C10M2207/146 ,  C10M2207/22 ,  C10M2207/282 ,  C10M2207/304 ,  C10M2207/34 ,  C10M2209/00 ,  C10M2209/02 ,  C10M2209/04 ,  C10M2209/06 ,  C10M2209/062 ,  C10M2209/082 ,  C10M2209/084 ,  C10M2209/086 ,  C10M2209/10 ,  C10M2209/102 ,  C10M2209/108 ,  C10M2209/109 ,  C10M2215/04 ,  C10M2215/044 ,  C10M2215/06 ,  C10M2215/062 ,  C10M2215/065 ,  C10M2215/066 ,  C10M2215/086 ,  C10M2215/22 ,  C10M2215/221 ,  C10M2215/224 ,  C10M2215/225 ,  C10M2215/226 ,  C10M2215/26 ,  C10M2215/28 ,  C10M2215/30 ,  C10M2217/022 ,  C10M2217/023 ,  C10M2217/028 ,  C10M2217/06 ,  C10M2219/022 ,  C10M2219/024 ,  C10M2219/04 ,  C10M2219/044 ,  C10M2219/046 ,  C10M2219/082 ,  C10M2219/108 ,  C10M2221/00 ,  C10M2221/02 ,  C10M2223/04 ,  C10M2223/041 ,  C10M2223/042 ,  C10M2223/045 ,  C10M2227/06 ,  C10M2227/061 ,  C10M2229/02 ,  C10M2229/05 ,  C10N2210/00 ,  C10N2210/02 ,  C10N2210/03 ,  C10N2210/08 ,  C10N2230/08 ,  C10N2240/02 ,  C10N2240/08 ,  C10N2240/12 ,  C10N2240/121 ,  C10N2250/10

摘要： THE NOVEL SULFINYL-CONTAINING ALKENYLSUCCINATES OF THIS INVENTION ARE USEFUL AS DISPERSANTS, CORROSION INHIBITORS AND ANTI-WEAR AGENTS PARTICULARLY IN LUBRICATING OIL AND FUEL COMPOSITIONS. THE NOVEL SULFINYL COMPOUNDS ARE PREPARED BY REACTING (1) AN ALKENYLSUCCINIC ANHYDRIDE, AN ALKENYLSUCCINIC ACID OR AN ALKENYLSUCCINAMIC ACID AND (2) AT LEAST ONE SULFINYL-CONTAINING HYDROXY COMPOUND HAVING THE FORMULAS:

R1-S(=O)-(R2-O)Y-H, R1-S(=O)-R2-(O-R3-S(=O)-R4)N-OH OR

HO-(R2-S(=O)-R4-O)N-H

WHEREIN

Y IS AN INTEGER FROM 1 TO ABOUT 50 OR MORE AND N IS AN INTEGER FROM 1 TO 40, R1 IS SELECTED FROM THE GROUP CONSISTING OF (A) ALKYL RADICAL CONTAINING FROM 1 TO 2J CARBON ATOMS, (B) AN ARYL RADICAL (C) AN ARALKYL RADICAL WHEREIN THE ALKYL PORTION OF THE RADICAL CONTAINS FROM 1 TO 4 CARBON ATOMS AND (D) AN ALKARYL RADICAL WHEREIN THE ALKYL PORTION CONTAINS FROM 1 TO 24 CARBON ATOMS, R2 IS ALKYLENE RADICAL HAVING 2 TO 5 CARBON ATOMS, AND R3 AND R4 ARE ALKYLENE RADICALS HAVING 2 TO 5 CARBON ATOMS, A PHENYLENE RADICAL OR A (C1-C4) ALKYL SUBSTITUTED PHENYLENE RADICAL WITH THE PROVISIO THAT N IS 1 WHEN R3 AND R4 ARE PHENYLENE OR (C1-C4) ALKYL SUBSTITUTED PHENYLENE.

公开(公告)号：US3556997A

公开(公告)日：1971-01-19

申请号：US3556997D

申请日：1969-08-26

申请人： ROHM & HAAS

发明人： LEISTER NORMAN A

IPC分类号： C07C317/00 ,  C08F8/14 ,  C08F8/34 ,  C10L1/24 ,  C10M135/08 ,  C10M169/00

CPC分类号： C10L10/08 ,  C07C317/00 ,  C10L1/2493 ,  C10L10/04 ,  C10M1/08 ,  C10M3/00 ,  C10M135/08 ,  C10M2203/108 ,  C10M2205/026 ,  C10M2207/023 ,  C10M2207/024 ,  C10M2207/027 ,  C10M2207/123 ,  C10M2207/125 ,  C10M2207/129 ,  C10M2207/144 ,  C10M2207/146 ,  C10M2207/22 ,  C10M2207/282 ,  C10M2207/304 ,  C10M2207/34 ,  C10M2209/00 ,  C10M2209/02 ,  C10M2209/04 ,  C10M2209/06 ,  C10M2209/062 ,  C10M2209/082 ,  C10M2209/084 ,  C10M2209/086 ,  C10M2209/10 ,  C10M2209/102 ,  C10M2209/108 ,  C10M2209/109 ,  C10M2215/04 ,  C10M2215/044 ,  C10M2215/06 ,  C10M2215/062 ,  C10M2215/065 ,  C10M2215/066 ,  C10M2215/086 ,  C10M2215/22 ,  C10M2215/221 ,  C10M2215/224 ,  C10M2215/225 ,  C10M2215/226 ,  C10M2215/26 ,  C10M2215/28 ,  C10M2215/30 ,  C10M2217/022 ,  C10M2217/023 ,  C10M2217/028 ,  C10M2217/06 ,  C10M2219/022 ,  C10M2219/024 ,  C10M2219/04 ,  C10M2219/044 ,  C10M2219/046 ,  C10M2219/082 ,  C10M2219/108 ,  C10M2221/00 ,  C10M2221/02 ,  C10M2223/04 ,  C10M2223/041 ,  C10M2223/042 ,  C10M2223/045 ,  C10M2227/06 ,  C10M2227/061 ,  C10M2229/02 ,  C10M2229/05 ,  C10N2210/00 ,  C10N2210/02 ,  C10N2210/03 ,  C10N2210/08 ,  C10N2230/08 ,  C10N2240/02 ,  C10N2240/08 ,  C10N2240/12 ,  C10N2240/121 ,  C10N2250/10

摘要： THE NOVEL SULFINYL-CONTAINING ALKENYLSUCCINATES OF THIS INVENTION ARE USEFUL AS DISPERANTS, CORROSION INHIBITORS AND ANTIWEAR AGENTS PARTICULARLY IN LUBRICATING OIL AND FUEL COMPOSITIONS. THE NOVEL SULFINYL COMPOUNDS ARE PREPARED BY REACTING (1) AN ALKENYLSUCCINIC ANHYDRIDE, AN ALKENYLSUCCINIC ACID OR AN ALKENYLSUCCINAMIC ACID AND (2) AT LEAST ONE SULFINYL-CONTAINING HYDROXY COMPOUND HAVING THE FORMULAS:

R1-SO-(R2-O)Y-H, R1-SO-R2-(O-R3-SO-R4)N-OH OR

HO-(R3-SO-R4-O)N-H

WHEREIN Y IS AN INTEGER FROM 1 TO ABOUT 50 OR MORE AND N IS AN INTEGER FROM 1 TO 40, R1 IS SELECTED FROM THE GROUP CONSISTING OF (A) AN ALKYL RADICAL CONTAINING FROM 1 TO 24 CARBON ATOMS, (B) AN ARYL RADICAL (C) AN ARALKYL RADICAL WHEREIN THE ALKYL PORTION OF THE RADICAL CONTAINS FROM 1 TO 4 CARBON ATOMS AND (D) AN ALKARYL RADICAL WHEREIN THE ALKYL PORTION CONTAINS FROM 1 TO 24 CARBON ATOMS, R2 IS AN ALKYLENE RADICAL HAVING 2 TO 5 CARBON ATOMS, AND R3 AND R4 ARE ALKYLENE RADICALS HAVING 2 TO 5 CARBON ATOMS, A PHENYLENE RADICAL OR A (C1-C4) ALKYL SUBSTITUTED PHENYLENE RADICAL WITH THE PROVISO THAT N IS 1 WHEN R3 AND R4 ARE PHENYLENE OR (C1-C4) ALKYL SUBSTITUTED PHENYLENE.

公开(公告)号：US3538151A

公开(公告)日：1970-11-03

申请号：US3538151D

申请日：1967-03-03

申请人： SANDOZ AG

发明人： BAUMANN HANS-PETER ,  KELLER ROBERT-CHRISTIAN

IPC分类号： C07C309/28 ,  C07C317/00 ,  C07C317/14 ,  C07C317/22 ,  C07C323/66 ,  C07D307/91 ,  C07D333/76 ,  D06P1/56 ,  D06P1/62 ,  D06P3/24 ,  D06P3/82

CPC分类号： C07D307/91 ,  C07C317/00 ,  C07C317/14 ,  C07C317/22 ,  C07C323/66 ,  C07D333/76 ,  D06P1/56 ,  D06P1/62 ,  D06P1/621 ,  D06P1/625 ,  D06P3/24 ,  D06P3/8209 ,  Y10S8/924 ,  Y10S8/926 ,  Y10S8/927